Optimizing Anaerobic Digestion of Food Waste and Industrial Sludge for Biogas Production

Food waste is a major contributor to municipal solid waste, and its disposal at landfills has significant environmental and economic impacts. Opportunities need to be identified for the sustainable management of food waste at large scales. Pulp and paper mills throughout the country commonly use anaerobic digestion to treat their waste sludge; however, this sludge can consist of over 50% lignin, which is slowly or negligibly digested. This research aims to explore the sustainability of co-digestion of food waste and paper mill sludge. Lab-scale studies were used to assess the feasibility of anaerobic digestion by measuring treatment efficiencies and biogas production. Results demonstrate that adding food waste to pulp and paper mill sludge increased methane production by 103% compared to anaerobically digested pulp and paper mill sludge on its own. The results from this work demonstrate how food waste can be diverted from landfills, while potentially providing paper mills with the opportunity to enrich their sludge for better digestion and increased biogas production

Co-living, gentlemen's clubs, and residential hotels : a long view of shared housing infrastructures for single young professionals

Shared housing is an important infrastructure for young single professionals living and working in the city. Co-living is a contemporary shared housing infrastructure. But it certainly is not the first. We advocate for what Flanagan and Jacobs (2019) call taking a “long view” by drawing connections between early 19th-century gentlemen’s clubs, mid-19th-century residential hotels and contemporary co-living. We argue each have been dynamic infrastructures of mobility, work, and sociality that make certain practices more or less possible and reflect on how the socio-material form of these infrastructures connects with the infrastructural work it does. We draw on our own research study into co-living, connecting our findings with research on the historical housing types. Our findings show that shrinking private spaces, maximizing productive spaces, and integrating services are strategies that animate the infrastructural work of these housing types. By linking co-living with historical housing types, we demonstrate the importance of taking a “long view” when thinking infrastructurally about novel housing practices

Ngrams and Engrams: the use of structural and conceptual features to discriminate between English translations of religious texts

In this paper, we present experiments using the Linguistic Inquiry and Word Count (LIWC) program, a ‘closed-class keyword’ (CCK) analysis and a ‘correspondence analysis’ (CA) to examine whether the Scientology texts of L. Ron Hubbard are linguistically and conceptually like those of other religions. A Kruskal–Wallis test comparing the frequencies of LIWC category words in the Scientology texts and the English translations of the texts of five other religions showed that there were eighteen categories for which the Scientology texts differed from the others, and between one and seventeen for the other religions. In the CCK experiment, keywords typical of each religion were found, both by comparing the religious texts with one another and with the Brown corpus of general English. The most typical keywords were looked up in a concordancer and were manually coded with conceptual tags. The set of categories found for the Scientology texts showed little overlap with those found for the others. Our CA experiments produced fairly clear clusters of texts by religion. Scientology texts were seen at one pole on the first factor, with Christian and Islamic texts at the other. It appears that, in several ways, the Scientology texts are dissimilar to the texts of some of the world's major religions

Undergraduate Student Perspectives on Employability : A Mixed Methods Exploration of Nutrition Student Career Awareness, Confidence, and Preparedness

There is a growing need for nutrition graduates to fill diverse roles that will address emerging health priorities including community-based chronic disease prevention, personalised nutrition, digital health, and innovations in food and agriculture. Little is known about how well universities are preparing nutrition students to fill these roles. The aim of this study was to explore undergraduate nutrition students’ career awareness, confidence, and preparedness. A secondary aim was to explore their perspectives regarding employability initiatives within the university curriculum. A mixed methods approach was used, including semi-structured focus groups to gain in-depth insights and surveys to expand and diversify the study population, enhancing validity and transferability of the findings. Results of the focus groups were analysed thematically using an inductive approach. Initial themes informed the survey with closed questions analysed using descriptive statistics and open questions analysed thematically. Seven students participated in focus groups and 73 completed the survey. Common themes arising from the focus group and survey responses included a lack of awareness of roles available to nutritionists, lack of placement experience seen as a link to understanding what nutritionists do and getting that first job, and life experiences and personal circumstances influencing career pathways. Practical opportunities for nutrition students to develop their career awareness, confidence, and preparedness should be a key consideration in the design of the undergraduate nutrition curricula

Investigating the biological properties of carbohydrate derived fulvic acid (CHD-FA) as a potential novel therapy for the management of oral biofilm infections.

Background: A number of oral diseases, including periodontitis, derive from microbial biofilms and are associated with increased antimicrobial resistance. Despite the widespread use of mouthwashes being used as adjunctive measures to control these biofilms, their prolonged use is not recommended due to various side effects. Therefore, alternative broad-spectrum antimicrobials that minimise these effects are highly sought after. Carbohydrate derived fulvic acid (CHD-FA) is an organic acid which has previously demonstrated to be microbiocidal against Candida albicans biofilms, therefore, the aims of this study were to evaluate the antibacterial activity of CHD-FA against orally derived biofilms and to investigate adjunctive biological effects.<p></p> Methods: Minimum inhibitory concentrations were evaluated for CHD-FA and chlorhexidine (CHX) against a range of oral bacteria using standardised microdilution testing for planktonic and sessile. Scanning electron microscopy was also employed to visualise changes in oral biofilms after antimicrobial treatment. Cytotoxicity of these compounds was assessed against oral epithelial cells, and the effect of CHD-FA on host inflammatory markers was assessed by measuring mRNA and protein expression.<p></p> Results: CHD-FA was highly active against all of the oral bacteria tested, including Porphyromonas gingivalis, with a sessile minimum inhibitory concentration of 0.5%. This concentration was shown to kill multi-species biofilms by approximately 90%, levels comparable to that of chlorhexidine (CHX). In a mammalian cell culture model, pretreatment of epithelial cells with buffered CHD-FA was shown to significantly down-regulate key inflammatory mediators, including interleukin-8 (IL-8), after stimulation with a multi-species biofilm.<p></p> Conclusions: Overall, CHD-FA was shown to possess broad-spectrum antibacterial activity, with a supplementary function of being able to down-regulate inflammation. These properties offer an attractive spectrum of function from a naturally derived compound, which could be used as an alternative topical treatment strategy for oral biofilm diseases. Further studies in vitro and in vivo are required to determine the precise mechanism by which CHD-FA modulates the host immune response.<p></p&gt

Prediction of 7-year psychopathology from mother-infant joint attention behaviours: a nested case–control study

<br>Background: To investigate whether later diagnosis of psychiatric disorder can be predicted from analysis of mother-infant joint attention (JA) behaviours in social-communicative interaction at 12 months.</br> <br>Method: Using data from a large contemporary birth cohort, we examined 159 videos of a mother-infant interaction for joint attention behaviour when children were aged one year, sampled from within the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Fifty-three of the videos involved infants who were later considered to have a psychiatric disorder at seven years and 106 were same aged controls. Psychopathologies included in the case group were disruptive behaviour disorders, oppositional-conduct disorder, attention-deficit/hyperactivity disorder, pervasive development disorder, anxiety and depressive disorders. Psychiatric diagnoses were obtained using the Development and Wellbeing Assessment when the children were seven years old.</br> <br>Results: None of the three JA behaviours (shared look rate, shared attention rate and shared attention intensity) showed a significant association with the primary outcome of case–control status. Only shared look rate predicted any of the exploratory sub-diagnosis outcomes and was found to be positively associated with later oppositional-conduct disorders (OR [95% CI]: 1.5 [1.0, 2.3]; p = 0.041).</br><br>Conclusions: JA behaviours did not, in general, predict later psychopathology. However, shared look was positively associated with later oppositional-conduct disorders. This suggests that some features of JA may be early markers of later psychopathology. Further investigation will be required to determine whether any JA behaviours can be used to screen for families in need of intervention.</br&gt

What is the Definition of Cure in Non-small Cell Lung Cancer?

The concept of cure from cancer is important to patients, but can be difficult to communicate in terms that are meaningful. This is because there are a number of definitions of cure that are applied by clinicians, patients and the public, and by policymakers that have a different meaning and significance. In this article, we provide a narrative review of the evidence concerning cure in lung cancer and show how the different definitions may apply in different settings. A better understanding of the various concepts of cure will improve communication with patients on this important topic. This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors

Characterization of renal cell carcinoma-associated constitutional chromosome abnormalities by genome sequencing.

Constitutional translocations, typically involving chromosome 3, have been recognized as a rare cause of inherited predisposition to renal cell carcinoma (RCC) for four decades. However, knowledge of the molecular basis of this association is limited. We have characterized the breakpoints by genome sequencing (GS) of constitutional chromosome abnormalities in five individuals who presented with RCC. In one individual with constitutional t(10;17)(q11.21;p11.2), the translocation breakpoint disrupted two genes: the known renal tumor suppressor gene (TSG) FLCN (and clinical features of Birt-Hogg-Dubé syndrome were detected) and RASGEF1A. In four cases, the rearrangement breakpoints did not disrupt known inherited RCC genes. In the second case without chromosome 3 involvement, the translocation breakpoint in an individual with a constitutional t(2;17)(q21.1;q11.2) mapped 12 Kb upstream of NLK. Interestingly, NLK has been reported to interact indirectly with FBXW7 and a previously reported RCC-associated translocation breakpoint disrupted FBXW7. In two cases of constitutional chromosome 3 translocations, no candidate TSGs were identified in the vicinity of the breakpoints. However, in an individual with a constitutional chromosome 3 inversion, the 3p breakpoint disrupted the FHIT TSG (which has been reported previously to be disrupted in two apparently unrelated families with an RCC-associated t(3;8)(p14.2;q24.1). These findings (a) expand the range of constitutional chromosome rearrangements that may be associated with predisposition to RCC, (b) confirm that chromosome rearrangements not involving chromosome 3 can predispose to RCC, (c) suggest that a variety of molecular mechanisms are involved the pathogenesis of translocation-associated RCC, and (d) demonstrate the utility of GS for investigating such cases

'Soldiering by consent' amd military-civil relations: Military transition into the public space of policing

Growth in the Armed Forces undertaking public policing is occurring in the United Kingdom and elsewhere and as such a complex security landscape emerges, both practically and conceptually. The aim here is to pose questions of the manifest and latent issues in the assemblage of multiple actors in public policing. It aks to reader to consider the implications of military actors transitioning from defence duties ordinarily associated with military work, to policing activities in public spaces. Taking the London 2012 Olympic Games as our point of reference, this article argues that to understand military presence, their role must be considered in the broader context of military and policing functions, the ‘war on terror’, accountability, and future priorities for public policing. We must be careful not to assign the presence of the military into pre-existing understandings of how mega-events should be secured – the military patrolling the streets of London represents more. Instead, as their presence comes to be legitimate in certain geopolitical contexts, critical questions must be asked especially as public and private arrangements are continually reworked in the domestic fight against terrorism

Reef Cover, a coral reef classification for global habitat mapping from remote sensing

Coral reef management and conservation stand to benefit from improved high-resolution global mapping. Yet classifications underpinning large-scale reef mapping to date are typically poorly defined, not shared or region-specific, limiting end-users’ ability to interpret outputs. Here we present Reef Cover, a coral reef geomorphic zone classification, developed to support both producers and end-users of global-scale coral reef habitat maps, in a transparent and version-based framework. Scalable classes were created by focusing on attributes that can be observed remotely, but whose membership rules also reflect deep knowledge of reef form and functioning. Bridging the divide between earth observation data and geo-ecological knowledge of reefs, Reef Cover maximises the trade-off between applicability at global scales, and relevance and accuracy at local scales. Two case studies demonstrate application of the Reef Cover classification scheme and its scientific and conservation benefits: 1) detailed mapping of the Cairns Management Region of the Great Barrier Reef to support management and 2) mapping of the Caroline and Mariana Island chains in the Pacific for conservation purposes