A Minority within a Minority? Social Justice for Traveller and Roma Children in ECEC

Following years of lobbying by Human Rights NGOs working with Roma and Travellers and despite centuries of oppression, Roma issues have only recently become prominent on the EU policy agenda. Similarly, Children’s Rights issues, and in particular Early Childhood Care and Education, have surfaced after years of being the second class citizen to ‘formal’ education. Why is this happening now? This article discusses the recent policy developments in Europe regarding Roma and Traveller integration and Early Childhood Provision, drawing at the same time on the Irish experience for analysis and insights on policy and practice. We are all aware of initiatives that have been supported through EU or national funding streams which have little impact on the structures or operations of the general education or training systems. International reports highlight this deficit stating that such initiatives are unlikely to bring about the necessary ideological and systemic changes and, for this reason, their added value as well as their sustainability remains questionable. This paper concludes by arguing that that programmes like the ‘éist’ project demonstrate that it is possible to move on from fragmented initiatives and bring about systemic change

After the Crash: Examining Pedagogical Approaches to Teaching Business Ethics

Research has shown that business students are less ethical than students in other disciplines (Segal et al., 2011), which is a worrying finding, considering that unethical business practices are seen as a major feature leading to the world economic recession in 2008. However, business schools across the globe have consistently taught the subject of ethics in order to instil an ethical mind-set in their graduates. The way business ethics is embedded in the curriculum has been the subject of much debate, with a range of pedagogical approaches taken. This paper examines the current teaching of ethics, by examining two business programmes that take different pedagogical approaches at Cork Institute of Technology. The findings suggest that there is little difference in how business ethics is perceived by students regardless of how it is taught, and points to ethical values and principles being formed much earlier in a person’s life

Confronting and Countering Bias and Oppression through Early Childhood Policy and Practice: An Introduction. [Special issue]

Across the globe, there has been sustained anti-bias and anti-oppressive scholarship and policywork addressing social inclusion in early childhood and teacher education, grounded in the work of Louise Derman-Sparks and the ABC Task Force, 1989 (Kumishiro, 2000; Murray & Urban, 2012; Swadener, Aquino-Sterling, Nagasawa, & Bartlett, 2009). In this special issue, contributors address a range of social inclusion focused policies and practices across continents, including the challenges and opportunities of implementing anti-bias education. This kind of research takes a principled stance as it works to ameliorate, and eventually eliminate, exclusionary practices impacting young children and their families. The primary goal of this special issue is to rethink the importance, conceptualizations, and enactments of scholarship on anti-bias and socially inclusive approaches in early childhood education contexts

Are the patterns of cytomegalovirus viral load seen after solid organ transplantation affected by circadian rhythm?

Background: Cytomegalovirus (CMV) is an important opportunistic pathogen after transplantation. Some virological variation in transplant recipients is explained by donor and recipient CMV serostatus, but not all. Circadian variability of herpesviruses has been described, so we investigated the effect of time of day of transplantation on posttransplant CMV viremia. Methods: We performed a retrospective analysis of 1517 patients receiving liver or kidney allografts at a single center from 2002 to 2018. All patients were given preemptive therapy with CMV viremia monitoring after transplantation. Circulatory arrest and reperfusion time of donor organ were categorized into 4 periods. Patients were divided into serostatus groups based on previous CMV infection in donor and recipient. CMV viremia parameters were compared between time categories for each group. Factor analysis of mixed data was used to interrogate this complex data set. Results: Live-donor transplant recipients were less likely to develop viremia than recipients of deceased-donor organs (48% vs 61%; P < .001). After controlling for this, there was no evidence of time of day of transplantation affecting CMV parameters in any serostatus group, by logistic regression or factor analysis of mixed data. Discussion: We found no evidence for a circadian effect of transplantation on CMV viremia, but these novel results warrant confirmation by other centers

Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level

Abstract Background Targeted re-sequencing of candidate genes in individuals at the extremes of a quantitative phenotype distribution is a method of choice to gain information on the contribution of rare variants to disease susceptibility. The endocannabinoid system mediates signaling in the brain and peripheral tissues involved in the regulation of energy balance, is highly active in obese patients, and represents a strong candidate pathway to examine for genetic association with body mass index (BMI). Results We sequenced two intervals (covering 188 kb) encoding the endocannabinoid metabolic enzymes fatty-acid amide hydrolase (FAAH) and monoglyceride lipase (MGLL) in 147 normal controls and 142 extremely obese cases. After applying quality filters, we called 1,393 high quality single nucleotide variants, 55% of which are rare, and 143 indels. Using single marker tests and collapsed marker tests, we identified four intervals associated with BMI: the FAAH promoter, the MGLL promoter, MGLL intron 2, and MGLL intron 3. Two of these intervals are composed of rare variants and the majority of the associated variants are located in promoter sequences or in predicted transcriptional enhancers, suggesting a regulatory role. The set of rare variants in the FAAH promoter associated with BMI is also associated with increased level of FAAH substrate anandamide, further implicating a functional role in obesity. Conclusions Our study, which is one of the first reports of a sequence-based association study using next-generation sequencing of candidate genes, provides insights into study design and analysis approaches and demonstrates the importance of examining regulatory elements rather than exclusively focusing on exon sequences

Short-term losses and long-term gains: the non-native species Austrominius modestus in Lough Hyne Marine Nature Reserve

The non-native barnacle species Austrominius modestus was first recorded in Ireland, close to Lough Hyne marine nature reserve in 1957. This species was not recorded inside the Lough until 1980, but by 2001 was the dominant intertidal barnacle within the reserve. It has been suggested that increases in the abundance of this species at other locations in Europe may be linked to increasing sea surface temperatures, and that A. modestus is an “ecological sleeper”. Despite an overall trend for increasing sea surface temperatures, this long term warming is punctuated by extreme events such as severely cold winters. A. modestus is warm water adapted, and has been recorded to decrease in abundance following cold winters. The winters of 2009/2010 and 2010/2011 were amongst the coldest recorded in Ireland in past decades. In the present study, higher levels of mortality were recorded for A. modestus than native barnacle species in Lough Hyne following these cold winters. Additionally, this species was recorded at lower abundances at the majority of sites surveyed in Lough Hyne in 2011 compared with 2009. Despite this, A. modestus remains the dominant barnacle species in the Lough and monitoring the recruitment of intertidal barnacles within Lough Hyne during 2014e2015 revealed that A. modestus was the most abundant recruit at study sites, both in removal plots and in the pre-existing community. The year-round breeding of A. modestus in addition to the closed nature of the Lough promotes A. modestus within the reserve. Despite this, native barnacle species continue to persist in Lough Hyne, though generally at low abundances, with the exception of exposed locations such as the Rapids and Bullock Island where natives outnumber A. modestus. The future intertidal barnacle community within the Lough is likely to be dominated by A. modestus with Chthamalus montagui and C. stellatus being abundant at sites which are not suitable for A. modestus. While the consequences of this are unknown, it is possible that the presence of A. modestus may alter trophic interactions and energy flow within the reserve

Spatio-Temporal Dynamics of Yeast Mitochondrial Biogenesis: Transcriptional and Post-Transcriptional mRNA Oscillatory Modules

Examples of metabolic rhythms have recently emerged from studies of budding yeast. High density microarray analyses have produced a remarkably detailed picture of cycling gene expression that could be clustered according to metabolic functions. We developed a model-based approach for the decomposition of expression to analyze these data and to identify functional modules which, expressed sequentially and periodically, contribute to the complex and intricate mitochondrial architecture. This approach revealed that mitochondrial spatio-temporal modules are expressed during periodic spikes and specific cellular localizations, which cover the entire oscillatory period. For instance, assembly factors (32 genes) and translation regulators (47 genes) are expressed earlier than the components of the amino-acid synthesis pathways (31 genes). In addition, we could correlate the expression modules identified with particular post-transcriptional properties. Thus, mRNAs of modules expressed “early” are mostly translated in the vicinity of mitochondria under the control of the Puf3p mRNA-binding protein. This last spatio-temporal module concerns mostly mRNAs coding for basic elements of mitochondrial construction: assembly and regulatory factors. Prediction that unknown genes from this module code for important elements of mitochondrial biogenesis is supported by experimental evidence. More generally, these observations underscore the importance of post-transcriptional processes in mitochondrial biogenesis, highlighting close connections between nuclear transcription and cytoplasmic site-specific translation