21 research outputs found
1H nuclear magnetic resonance spectroscopy characterisation of metabolic phenotypes in the medulloblastoma of the SMO transgenic mice
- Author
- A Moreno-Torres
- A Panigrahy
- A Peet
- A Peet
- AA Tzika
- AC Kuesel
- AC Peet
- AC Peet
- AR Hallahan
- BA Hatton
- BA Hatton
- C Majos
- EI Fomchenko
- F Podo
- I Tkac
- J L Griffin
- JC Allen
- JF Schneider
- JL Griffin
- JL Griffin
- JM Hakumäki
- JM Hakumäki
- JM Hakumäki
- JP O'Connor
- JP Usenius
- KS Opstad
- LG Astrakas
- LV Goodrich
- M Garwood
- M Rosol
- M Wilson
- M Wilson
- M Wilson
- MJ Albers
- MN Hart
- N Girard
- N Jerome
- NK Srivastava
- NP Davies
- NP Davies
- PS Murphy
- R A Kauppinen
- R Callies
- R Gruetter
- R Gruetter
- R M Salek
- RD Team
- RE McLendon
- RE Taylor
- S K Hekmatyar
- S Zoula
- SJ Nelson
- SL Pomeroy
- V Govindaraju
- V Righi
- V Tugnoli
- W Negendank
- Publication venue
- Nature Publishing Group
- Publication date
- 01/01/2010
- Field of study
BACKGROUND: Human medulloblastomas exhibit diverse molecular pathology. Aberrant hedgehog signalling is found in 20-30% of human medulloblastomas with largely unknown metabolic consequences. METHODS: Transgenic mice over-expressing smoothened (SMO) receptor in granule cell precursors with high incidence of exophytic medulloblastomas were sequentially followed up by magnetic resonance imaging (MRI) and characterised for metabolite phenotypes by ¹H MR spectroscopy (MRS) in vivo and ex vivo using high-resolution magic angle spinning (HR-MAS) ¹H MRS. RESULTS: Medulloblastomas in the SMO mice presented as T₂ hyperintense tumours in MRI. These tumours showed low concentrations of N-acetyl aspartate and high concentrations of choline-containing metabolites (CCMs), glycine, and taurine relative to the cerebellar parenchyma in the wild-type (WT) C57BL/6 mice. In contrast, ¹H MRS metabolite concentrations in normal appearing cerebellum of the SMO mice were not different from those in the WT mice. Macromolecule and lipid ¹H MRS signals in SMO medulloblastomas were not different from those detected in the cerebellum of WT mice. The HR-MAS analysis of SMO medulloblastomas confirmed the in vivo ¹H MRS metabolite profiles, and additionally revealed that phosphocholine was strongly elevated in medulloblastomas accounting for the high in vivo CCM. CONCLUSIONS: These metabolite profiles closely mirror those reported from human medulloblastomas confirming that SMO mice provide a realistic model for investigating metabolic aspects of this disease. Taurine, glycine, and CCM are potential metabolite biomarkers for the SMO medulloblastomas. The MRS data from the medulloblastomas with defined molecular pathology is discussed in the light of metabolite profiles reported from human tumours
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
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- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
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- Ainsworth P
- Ais G
- Ais G
- Aisoni F
- Akbari K
- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
- Al-Khafaji N
- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
- Alhammali T
- Alhammali T
- Ali M
- Aljorfi A
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- Allington J
- Alonzo A
- Alshafei A
- Altomare Ma
- Alvarez Cm
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- Alvarez-Gallego M
- Amaducci E
- Amarasinghe R
- Amayo A
- Ambrona-Zafra D
- Amin V
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- Cavallo D
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- Choolani-Bhojwani E
- Choong Jh
- Choong Jh
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- Chowdhary M
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- Christian L
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- Chudek D
- Chui K
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- Cidoncha A
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- Cillara N
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- Clements Jm
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- Clements Js
- Clerici F
- Clingan R
- Cloney L
- Clough E
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- Coccolini F
- Cocorullo G
- Coe Po
- Cohen Ja
- Colangelo E
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- Coletti M
- Collado-Roura F
- Collier-Wakefield O
- Colombo F
- Colombo F
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- Compagnoni B
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- Connelly Tm
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- Connor Kl
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- Conti D
- Contine Ac
- Contreras Rg
- Contreras-Saiz E
- Cook V
- Cooke F
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- Cynthia G
- Cánovas-Moreno G
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- D'Amico Fe
- D'Amico Fe
- D'Auria M
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- D'Souza N
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- Daniels I
- Danquah-Boateng D
- Dar Fa
- Dar Fa
- Dart K
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- Daureeawoo R
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- Davidson S
- Davies Pl
- Davis S
- De Andres U
- De Burgos Cb
- De Chaves-Rodríguez Pg
- De Freitas S
- De Luca E
- De Marchi F
- De Marco P
- De Nardi P
- De Nardi P
- De Nisco C
- De Padua C
- De Prizio M
- De-La-Herranz-Guerrero P
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- De-Manzoni-Garberini A
- De-Manzoni-Garberini A
- De-Marchi Ja
- De-Marchi Ja
- De-Soto-Cardenal B
- Dean Ea
- Dean S
- Del Basso C
- Del Pozo E
- Del-Valle-Ruiz Sr
- Delgado-Plasencia Lj
- Delimpalta C
- Delimpalta C
- Delogu D
- Denley S
- Dennison G
- Depalma N
- Deserra A
- Desiderio J
- Devezas V
- Devine Aa
- Dhar M
- Dharamavaram S
- Dhari Aa
- Dhesi S
- Di Cintio A
- Di Franco F
- Di Gioia P
- Di Saverio S
- Di Zitti L
- Diaz A
- Dickson Ea
- Divekar Ga
- Dixon F
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- Donaldson G
- Donaldson G
- Donohoe No
- Donohoe No
- Douka E
- Doulias T
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- Doyle C
- Drake T. M.
- Drake Tm
- Drye N
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- Dubois As
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- Dudek Jg
- Dujovne P
- Dujovne P
- Dunning Pg
- Duran-Muñoz-Cruzado Vm.
- Durbacz M
- Dyal A
- Dyson S
- Díaz-Vico T
- Eardley Nj
- Earnshaw L
- Easdon S
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- Echazarreta E
- Edwards Se
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- Egan Rj
- Eguaras I
- Eiben I
- Eiben Ie
- Eiben P
- El-Masry S
- El-Tayar O
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- Elgaddal S
- Elia M
- Ellis B
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- Elshaer M
- Emslie Km
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- English Wj
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- Erdas E
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- Eretta Co
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- Fairfield Cj
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- Fareleira A
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- Feleppa C
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- Fernández-Candela A
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- Fijo Lm
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- García-Catalá L
- García-Catalá L
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- Harder G
- Hardy E
- Harlinska A
- Harper F
- Harries Rl
- Harris G
- Harris Mp
- Hartnett J
- Hasan R
- Hassane A
- Hatt Jr
- Haveliwala Z
- Hawkins W
- Hayat Z
- Hayes C
- Hebbar K
- Hebbar K
- Henderson L
- Henderson L
- Hernaez A
- Hernandez-Gimenez L
- Hernando A
- Herrod P
- Herrod P
- Herrod P
- Herrod P. J. J.
- Hever P
- Hickey Lm
- Hickey Lm
- Hickey Lm
- Hicks G
- Hicks G
- Hidalgo-Rosas Jm
- Hill Ad
- Hill Ad
- Hill J
- Hobson Bm
- Hodgson Jm
- Hoff M
- Hollingsworth A
- Hollyman M
- Hollyman M
- Hontoria Ms
- Hook A
- Hornby St
- Hornby St
- Horsfield E
- Howie Ee
- Hraishawi I
- Huang J
- Hudson-Peacock Nj
- Hudson-Peacock Nj
- Hunter I
- Hureibi Ka
- Hureibi Ka
- Hussain A
- Hussain N
- Hussaini Sa
- Hussein A
- Hussein A
- Hutchinson B
- Iannone I
- Ibrahim Y
- Ikram S
- Ilozue T
- Imperatore M
- Inama M
- Inama M
- Infante H
- Iosif E
- Iqbal Mr
- Iqbal Mr
- Irukulla S
- Irwin R
- Isherwood Jd
- Islam N
- Islam S
- Isolani Sm
- Issa E
- Issa E
- Itsurg
- Ivey P
- Jackson A
- Jackson Nj
- Jah S
- Jain A
- Jain S
- Jain S
- Jama Gm
- Jamieson Nb
- Jamieson Nb
- Jamieson Nb
- Janardanan S
- Jansen T
- Jasinski B
- Jenkins M
- Jenner D
- Jerome E
- Jimenez-Ballester Ma
- Jiménez-Rosellón R
- Johnson J
- Johnston Z
- Johnstone A
- Jokhan S
- Jones A
- Jones Cs
- Jones E
- Jones E
- Jones L
- Jones N
- José Hs
- João Aa
- Julià D
- Jung J
- Kabir M
- Kabir U
- Kabwama S
- Kalia K
- Kamal M
- Kamande Iw
- Kamande Iw
- Kanakala V
- Kannegieser-Bailey M
- Kaptanis S
- Kara A
- Kara A
- Karim Mj
- Karim Mj
- Karwal Rs
- Kaubrys M
- Kaur G
- Kay Oh
- Kay Oh
- Keegan R
- Kelly M
- Kelly Sd
- Kennedy Nd
- Kennedy Nd
- Kennedy Nd
- Kent Da
- Khair A
- Khan K
- Khan Ms
- Khan S
- Khasria A
- Khaw Ra
- Kho H
- Kilkenny J
- Kinross J
- Kirkby-Bott J
- Kirkham En
- Knight B
- Knight Ka
- Knight Sr
- Knight Sr
- Kochupapy R
- Kong Cy
- Kosti A
- Kosti A
- Kouli O
- Kouroumpas E
- Krishnamoorthy A
- Krivan S
- Kumar K
- Kumar S
- Kung V
- Kung V
- Kuo R
- Kälviäinen Hk
- La Valle G
- Ladwa N
- Lafaurie G
- Lai Cw
- Lal N
- Lal N
- Landaluce-Olavarria A
- Landaluce-Olavarria A
- Lara Mc
- Lara-Fernandez Y
- Lau E
- Laughlin Dm
- Laurenson M
- Laviano E
- Law Jj
- Lawday S
- Lawday S
- Layman S
- Layton Gr
- Lazzari G
- Lazzaro A
- Lecky-Thompson L
- Lee Ka
- Lee Ka
- Lee Kj
- Lee M
- Leighton Pa
- Leitch Rp
- Lek C
- Lennox-Warburton Hc
- Leon C
- Leung El
- Leusink A
- Li Ch
- Liaw G
- Licari L
- Lim Jm
- Lima F
- Lima M
- Limb C
- Limbada M
- Listorti C
- Littlehales Dj
- Lizzi V
- Ljungqvist G
- Llacer E
- Llewelyn O
- Lloyd G
- Lodhia S
- Lodhia S
- Logan Pc
- Long M
- Long P
- Long Rh
- Longheu A
- Longshaw A
- Lopez M
- Lopez M
- Lopez M
- Lopez-Duran Bl
- Lopez-Ruiz Ja
- Lorettu A
- Louro Hc
- Louw C
- Lucchi A
- Lucchi A
- Lui Dh
- Lund Jn
- Lund Jn
- Luzzi Ap
- Ly C
- Lynch L
- Lyons A
- López Af
- Ma J
- Macinnes E
- Macinnes E
- Macleod C
- Maderuelo Vm
- Maffioli A
- Magalhães Js
- Magnoli M
- Magro T
- Mahapatra R
- Mahendran B
- Mahmood F
- Mahmood F
- Mahmoud A
- Mahon D
- Mahon-Daly Fp
- Mahoney R
- Mai D
- Maina A
- Makhija R
- Malabarba S
- Malam Y
- Malik A
- Malik A
- Malik K
- Malik Sn
- Malik Y
- Mambrilla-Herrero S
- Manas Oc
- Manda Vm
- Manektella Km
- Manias T
- Mann C
- Manoharan P
- Manson R
- Mansoor S
- Mansour Mm
- Mansour S
- Maqboul F
- Maragouthakis D
- Marangoni G
- Marano A
- Marano L
- Marano L
- Mardhiah S
- Maretto I
- Marinello F
- Maripi H
- Marriott P
- Marriott P
- Marsh L
- Marshall Cm
- Marshall G
- Martin A
- Martin A
- Martin Lm
- Martin-Prieto L
- Martinez Et
- Martinez J
- Martino A
- Martinou E
- Martins Fm
- Martorelli G
- Martínez Cc
- Martínez-Almeida R
- Mashar R
- Maslekar Su
- Mason C
- Mason J
- Masood M
- Massaiu C
- Mathew G
- Matos Ml
- Matos Ml
- Matthews J. H.
- Matthews Jh
- Matthews Jh
- Maude K
- Mazumdar E
- Mazzeo C
- Mc-Dermott A
- Mcarthur D
- Mccain Rs
- Mccain S
- Mccann C
- Mccaughey P
- Mccullough J
- Mcdonnell D
- Mcdowall Na
- Mcdowall Na
- Mcglynn K
- Mcgrath D
- Mcgucken O
- Mcilwaine S
- Mcilwrath Ac
- Mcintyre R
- Mckay Sc
- Mckelvie Ma
- Mckenna M
- Mckeon J
- Mckevitt Kl
- Mckinley Nc
- Mckinley Nc
- Mcmahon Sv
- Mcmorran D
- Mcnally L
- Mcquaid M
- Mcwhirter Dm
- Mealy K
- Medina-Arana V
- Mehigan B
- Melis A
- Melis M
- Mella A
- Melone S
- Menendez P
- Menendez P
- Menzies D
- Menéndez-Moreno A
- Merai H
- Merichal-Resina M
- Merker L
- Merlini Da
- Mersh Rj
- Mersh Rj
- Messias Fm
- Messina A
- Mestres-Petit N
- Michelini M
- Miegge A
- Miegge A
- Miguras M
- Milgrom D
- Millan M
- Miller B
- Miller K
- Milward J
- Miranda E
- Mirza S
- Misky At
- Misky At
- Mistry D
- Mitchard Mj
- Mitchell Jh
- Mitru Rm
- Moggia E
- Mohamed I
- Mohamed I
- Mohamed I.
- Mohamed Im
- Mohamed Mn
- Mohamed Mn
- Mohamed Tm
- Mohamed Tm
- Mohamed Wo
- Mohd N
- Montanelli P
- Montori G
- Monzón-Abad Ja
- Moore C
- Moradzadeh J
- Morandi E
- Moratalla Cn
- Moreda R
- Moreno-Gijón M
- Moreno-Suero F
- Moretto G
- Morgan R
- Morley G. L.
- Morley Gl
- Morley Gl
- Moroni P
- Morowala A
- Morrish S
- Morrison F
- Morrison T
- Morrison T
- Morrison-Jones V
- Morton Dg
- Mothe Bs
- Mothe Bs
- Motiwala Fh
- Motter D
- Mowbray Ng
- Mowbray Ng
- Mozo As
- Mughal Z
- Muhibullah N
- Muinelo M
- Muinelo-Lorenzo M
- Mulas S
- Mulas S
- Mulas S
- Mulsow J
- Mundkur N
- Muntean A
- Mura Fa
- Muriel-Álvarez P
- Murphy C
- Murphy R
- Murray Mp
- Murru Ml
- Mustafa Ak
- Muzaffar M
- Muñoz-Muñoz E
- Myatt A
- Nadeem A
- Nagarajan D
- Nagendram S
- Nair A
- Nair Mk
- Nair Ms
- Naismith Kn
- Nambiar K
- Nana Gr
- Nana Gr
- Napetti S
- Nascimento Ca
- Nash D
- Nash Z
- Nastro P
- Naumann D. N.
- Naumann Dn
- Navarro G
- Navarro-Morales L
- Navas-Cuéllar Ja
- Navas-Cuéllar Ja
- Navas-Cuéllar Ja
- Navas-Cuéllar Ja
- Navidad Ms
- Navidad Ms
- Nazarian S
- Nazarian S
- Neagle G
- Neale A
- Neary Pm
- Nehikhare I
- Nelli T
- Neophytou Gi
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D.
- Newton Rc
- Newton Rc
- Ng J
- Ng M
- Ng S
- Ngu Ws
- Ngu Ws
- Niaz O
- Nickson S
- Nicol D
- Nicolosi A
- Nigro A
- Nimako E
- Niolu P
- Nistri C
- Nitti D
- Nogueira St
- Nora Mf
- Norcia Gg
- Nyeko-Lacek M
- O'Brien J
- O'Connor Br
- O'Connor Br
- O'Hagan Sc
- O'Leary Dp
- O'Neill E
- O'Neill M
- O'Neill N
- O'Neill R
- O'Sullivan D
- Oakey M
- Obeid N
- Occhioni G
- Odeh A
- Ogboru S
- Ogbuokiri C
- Ojea-Ruiz-Yherla L
- Okekunle B
- Okorocha E
- Olagbaiye O
- Oliva I
- Olivares-Oliver C
- Oliver Jr
- Olivier Jb
- Olivier Jb
- Olmos V
- Ooi R
- Orawiec P
- Orizu M
- Orizu M
- Orlando G
- Orme N
- Ormiston R
- Ormiston R
- Osterberg A
- Padilla E
- Padilla-Valverde D
- Paget C
- Pais M
- Pala M
- Palani-Velu Lk
- Palani-Velu Lk
- Pan Y
- Panagiotopoulos Sp
- Panda N
- Panda N
- Panda N
- Pandey V
- Pandya D
- Pandya R
- Paniagua M
- Pankin Gp
- Papandrea M
- Parajó Ae
- Paramasevon Kr
- Pareja-Ciuró F
- Parisi A
- Park Jh
- Park Jh
- Parkola Mj
- Parra Jm
- Parwaiz I
- Pascua-Sole M
- Pascual-Miguelañez I
- Pasquali S
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F.
- Pata G
- Pata G
- Pata G
- Patel As
- Patel By
- Patel By
- Patel C
- Patel H
- Patel Mm
- Patel N
- Patel Pk
- Patel Rt
- Patil Sd
- Patti S
- Pau R
- Payne Cj
- Payne Re
- Payá-Llorente C
- Payá-Llorente C
- Peacock M
- Pearce J
- Pearce J
- Pearce L
- Pearce L
- Pearson R
- Pedder A
- Peirce Cb
- Peiris Gb
- Peixoto R
- Peleki A
- Peleki A
- Pellegrino L
- Pellicanò Ga
- Pellicer-Franco E
- Pellino G
- Pento V
- Pento V
- Peponis C
- Peprah D
- Pereira A
- Pereira Am
- Pereira J
- Pereira-Mosquera E
- Perera Mi
- Perez-Calvo J
- Perin A
- Pertile D
- Pertile D
- Peña-Barturen C
- Phelan L
- Photiou D
- Pierre R
- Pietrabissa A
- Pigem A
- Pila U
- Pilkington Jp
- Pineño-Flores C
- Pinillos-Somalo A
- Pinkney Td
- Pinkney Td
- Pinkney Td
- Pinna E
- Pino-Perez O
- Pirari Pf
- Pisanu A
- Piu F
- Planellas P
- Plua-Muniz Kt
- Poacher A
- Podda F
- Podda M
- Podda M
- Podda M
- Poillucci G
- Pollard H
- Ponchietti L
- Popova D
- Poudevigne M
- Prats Ma
- Prideaux A
- Prieto-Nieto Mi
- Primo Jc
- Pronin S
- Provenza G
- Puerta E
- Pulighe F
- Pullabatla-Venkata Up
- Punj S
- Pérez-Sanchez Le
- Quddus A
- Quill S
- Quinn Em
- Quinn Hc
- Rabie M
- Rabie Ma
- Rabie Mr
- Radwan Rw
- Radwan Rw
- Rahim A
- Rahman M
- Rahmani Ls
- Rajagopal S
- Rajaram R
- Rajaretnam N
- Rajjoub Y
- Rallage H
- Ramcharan S
- Ramirez L
- Ramirez-Redondo Aa
- Ramos Xh
- Ramos-Bernado Mi
- Ramírez-Faraco M
- Ranathunga S
- Rangarajan K
- Rao M
- Rao V
- Raofi A
- Rashid M
- Rate A
- Ravindran R
- Raymond M
- Raza Ss
- Recreo Ac
- Reddy A
- Reddy A
- Redmond Ae
- Redondo E
- Redondo E
- Redondo-Calvo Fj
- Reese G
- Regina G
- Rehman S
- Rehman S
- Rekhraj S
- Ren Kz
- Renshaw S
- Renshaw S
- Renzi Cr
- Resende Fm
- Rezacova M
- Rezvani S
- Riaz W
- Riba-Combatti L
- Ribaudo M
- Ribeiro B
- Rich Je
- Richardson Td
- Ridaura N
- Riera E
- Rigby S
- Rigney B
- Rinkoff S
- Ripoli Mc
- Robb Hd
- Robertson C
- Robinson A
- Robinson A
- Robinson D
- Robinson D
- Rocha R
- Rodger V
- Rodicio-Miravalles Jl
- Rodriguez L
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodríguez Ec
- Rojo Ja
- Roldán-Ortiz S
- Rolph R
- Romano J
- Romano R
- Romario Uf
- Romoli L
- Roncero Ls
- Ronda Rn
- Roomi S
- Rosa Mj
- Rosat A
- Roscio F
- Roscio F
- Roscio F
- Rossi C
- Rossi D
- Rossi Gm
- Roth N
- Rothnie K
- Roxburgh C
- Roy C
- Ruano A
- Rubbini M
- Rudland I
- Ruffolo C
- Rufo E
- Ruggiu Gv
- Ruiz-Marín M
- Ruiz-Marín M
- Rupani S
- Rupasinghe Sn
- Rupasinghe Sn
- Rutherford Dg
- Ruzvidzo F
- Ruzzenente A
- Saad M
- Saad M
- Saavedra-Chacón M
- Saba A
- Sabia D
- Sacco R
- Sacks R
- Sadek S
- Saghir N
- Sagnotta A
- Sagnotta A
- Saha A
- Sahay Sj
- Sahnan K
- Sahnan K
- Sainz B
- Sainz B
- Sajid Ms
- Salama Y
- Salamone G
- Salamone G
- Salamone G
- Salamone G
- Salandini Mc
- Salem A
- Salim S
- Salva Ab
- Salvador H
- Samartin C
- Sammarco G
- Sammarco G
- Samuel M
- Sana S
- Sanchez Er
- Sanchez Er
- Sanchez L
- Sanchez-Garcia S
- Sanchez-Guillen L
- Sanchez-Guillen L
- Sanchez-Martinez A
- Sancho-Muriel J
- Sandu L
- Sanna S
- Santamaria C
- Santamaría Pc
- Santarrufina-Martínez S
- Santos Sc
- Santurro L
- Sanz-Navarro S
- Sarmah P
- Sarmah P
- Sarmah P
- Sarveswaran J
- Sasia D
- Sasia D
- Saunders S
- Savill A
- Savino G
- Savino G
- Savioli F
- Scabini S
- Scabini S
- Scabini S
- Scandroglio Is
- Scanlon K
- Scatizzi M
- Scialandrone G
- Scricciolo M
- Sebastian Jf
- Sebastián-Tomás Jc
- Seddon Tc
- Segalini E
- Segura-Sampedro Jj
- Sena G
- Sena-Ruiz F
- Seneviratne N
- Sepe C
- Serventi F
- Serventi F
- Seth M
- Setshwaelo T
- Sezen E
- Sgardelis P
- Sgrò A
- Sgrò A
- Sgrò A
- Shah J
- Shah K
- Shah Sm
- Shah Sm
- Shaikh Ia
- Shakoor Z
- Shanmuganathan V
- Shanmugarajah K
- Sharma A
- Sharma A
- Sharma P
- Sharp Ol
- Sharp Ol
- Shaw Av
- Shepherd Ja
- Sherif Ma
- Shet S
- Shetty Vd
- Shingler G
- Shiwani Mh
- Shrestha D
- Shurlock J
- Sian T
- Siaw O
- Siddique K
- Siddiqui Mn
- Siddiqui Za
- Sierra-Grañón Je
- Siggens Kl
- Sihra N
- Silva A
- Silva I
- Silvestri V
- Simioni A
- Simmonds L
- Simmonds L
- Simo V
- Simoes J
- Simpson Dj
- Singh A
- Singh J
- Singh P
- Singh S
- Singhal T
- Singhal T
- Sivaloganathan P
- Skalamera I
- Skerritt C
- Slezak I
- Smallcombe N
- Smart Cj
- Smart Cj
- Smart Nj
- Smart Nj
- Smoker H
- Soares A. S.
- Soares As
- Soares As
- Soares As
- Soares As
- Soares As
- Soh B
- Solaini L
- Solar-García L
- Soliani P
- Solinas L
- Sooriyamoorthy T
- Soria-Aledo V
- Soria-Aledo V
- Soriano Jt
- Sorrentino L
- Sousa Hs
- Souter J
- Sparta C
- Spaziani A
- Speake D
- Speake D
- Springate El
- Sreedharan L
- Sreedharan L
- Staderini F
- Stecca T
- Stella M
- Stephens Gf
- Stephens Gf
- Stevenson R
- Stewart Dj
- Stoica I
- Storey R
- Stoyanov Ti
- Strachan E
- Strange Ja
- Stubbs Bm
- Stupalkowska W
- Stupalkowska W
- Suarez-Cabrera A
- Suero Ca
- Sultana A
- Summerfield L
- Sunter H
- Surg Pt
- Suriyakumar S
- Suárez-Sánchez A
- Swords C
- Symons N
- Szentpali K
- Szucs A
- Szucs A
- Sánchez-Cifuentes A
- Sánchez-Fuentes Mn
- Sánchez-Rubio M
- Tabain V
- Taglietti L
- Tague Le
- Tahir W
- Tailor K
- Tallon-Aguilar L
- Tallon-Aguilar L
- Tamayo-López Mj
- Tamborska A
- Tamini N
- Tamini N
- Tamini N
- Tan Cy
- Tan Cy
- Tan E
- Tan Hl
- Tan S
- Tang Am
- Tapiolas I
- Tarazi M
- Tatulli F
- Tay Yh
- Tayeh S
- Taylor M
- Taylor Ns
- Taylor Ns
- Taze D
- Tee A
- Tejero-Pintor Fj
- Tenconi Sm
- Tezas S
- Thaha Ma
- Thakral N
- Thakur D
- Thava B
- Thavanesan N
- Thavanesan N
- Thaventhiran Aj
- Theodoropoulou K
- Thomas At
- Thomas L
- Thompson C
- Thompson Db
- Thompson Db
- Thompson R
- Thompson R
- Thoukididou Sn
- Tiedt La
- Tiedt La
- Ting N
- Tinoco-González J
- Tinsley Bj
- Tognarelli Jm
- Tojal A
- Tokidis E
- Tomasoni M
- Tonini V
- Toomey D
- Toomey Db
- Torkington J
- Torkington J
- Torrado Aa
- Torrance A
- Torrance A
- Townsend Dc
- Townsend Dc
- Tozer Pj
- Trail M
- Trail M
- Trastulli S
- Trew F
- Trostchansky I
- Trujillo-Diaz Jj
- Tsang B
- Tudyka V
- Tudyka V
- Turnbull A
- Turner Ej
- Tutino R
- Twum-Barima Cs
- Twum-Barima Cs
- Tyler R
- Tyler R
- Ugarte-Sierra B
- Vacca A
- Vaccari S
- Vakis S
- Valente Pm
- Valiani Sv
- Vallejo-Bernad C
- Vallve-Bernal M
- Van Boxel Gi
- Vance-Daniel J
- Vannucchi A
- Varcada M
- Vargas-Pierola Hj
- Vaughan Em
- Vaughan Em
- Vazquez-Fernandez Ap
- Vega L
- Velchuru Vr
- Velho R
- Venkata Up
- Venkatasubramaniam Ak
- Venn Ml
- Venn Ml
- Venugopal R
- Verea S
- Veres T
- Veres T
- Verroiotou M
- Vescio G
- Vettoretto N
- Vigorita V
- Vijay V
- Vila-Zarate C
- Villarejo-Campos P
- Vinnicombe Z
- Viscosi F
- Vitish-Sharma P
- Viviani E
- Viñas Nl
- Vohra R
- Vohra R
- Vulcano I
- Waite K
- Walji Hd
- Walsh E
- Walsh Tn
- Walters Kj
- Walters U
- Wardle Bg
- Wardle Bg
- Wardle Sd
- Warren O
- Warren Oj
- Warusavitarne J
- Watfah J
- Watson N
- Wauchope J
- Weatherburn Lw
- Weaver J
- Weegenaar Cr
- Weegenaar Cr
- Welsh S
- Wensley F
- West H
- West H
- Wheatstone S
- Wheeler C
- Whewell He
- White F
- Whitehorn Se
- Whitehorn Se
- Whitehouse P
- Whiteman E
- Whittaker L
- Wiggill S
- Wijesundera K
- Wilcox G
- Wilkin R
- Wilkin R
- Wilkin R
- Wilkin R
- Wilkin R. J. W.
- Williams Gl
- Williams M
- Williams R
- Williams S
- Wilson Ej
- Wilson M
- Winter Dc
- Winter Dc
- Wolff J
- Wong A
- Wong C
- Wong J
- Wong J
- Wong Ml
- Wong Sy
- Woo R
- Wood Cs
- Woodrow C
- Woodward A
- Woodward B
- Woodward B
- Worku D
- Worku D
- Wright E
- Wright Hl
- Wu F
- Xidas A
- Yalamarthi S
- Yang P
- Yanni F
- Yardimci E
- Yasin T
- Yen Sk
- Yeung K
- Yeung K
- Yoganathan S
- Yoong S
- Youssef H
- Yow L
- Yow L
- Zaborowski A
- Zadi Az
- Zalla T
- Zarka Za
- Zarka Za
- Zarog Ma
- Zelazek M
- Zerpa C
- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
The Holy Land : An archaeological guide from earliest time to 1700
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/1980
- Field of study
Oxfordxvi, 320 p.; 20 c
Body and Flesh Implications in Paul's Corinthian Dialogue (1 Cor 6)
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Was Jesus of Nazareth a Monotheist? Conversation with Cultural Studies
- Author
- Batten Alicia
- Bauckham Richard
- Black Matthew
- Blok Anton
- Christopher Seitz
- Daube David
- Davis P. J.
- Denaux Adelbert
- Elliott John H.
- France R. T.
- Golden Judah
- Harris Horton
- Hurtado Larry W.
- Jerome H. Neyrey
- Malina Bruce J.
- McGrath John
- Moberly R. W. L.
- Moxnes Halvor
- Murphy–O'Connor Jerome
- Newman Cary C.
- Neyrey Jerome H.
- North J. Lionel
- Richardson Neil
- Segal Alan F.
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Paul's Riposte and Praise of the Thessalonians
- Author
- Aristotle.
- Best Ernest.
- Bruce F.F.
- Chow J.K.
- Cicero.
- Clarke Andrew D.
- Collins R.F.
- deSilva David A.
- Hanson K.C.
- Hendrix Holland.
- Hock Roland F.
- Jewett Robert.
- Keck Leander.
- Lohse Eduard.
- Malina Bruce J.
- Malina Bruce J.
- Marshall I. Howard.
- Morris Leon.
- Murphy-O'Connor Jerome.
- Neyrey Jerome H.
- Pilch John J.
- Pitt-Rivers Julian.
- Quintilian.
- Schmithals Walter.
- Stowers Stanley K.
- Thucydides.
- Wanamaker Charles A.
- Williams David J.
- Witherington III Ben.
- Zeba Antonin Crook
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Anamnesis and Absence in the Lord's Supper
- Author
- Attridge Harold W.
- Barr James
- Barth Markus
- Bornkamm Günther
- Childs Brevard
- Conzelmann Hans
- Crossan John Dominic
- Gaster Theodor
- Hahn Ferdinand
- Jeremias Joachim
- Kelber Werner
- Kosmala Hans
- Lohmeyer Ernst
- Magness J. Lee
- Marxsen Willi
- Murphy-O'Connor Jerome
- Pedersen Johannes
- Pesch Rudolf
- Richardson Robert
- Robbins Vernon K.
- Robinson James M.
- Schweizer Eduard
- Talbert Charles
- Thistleton A.C.
- Weeden Theodore
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
SUBGOVERNMENT CONFLICT IN PUBLIC POLICY
- Author
- Bardach Eugene
- Baumer Donald C.
- Cater Douglass
- Davidson Roger H.
- Derthick Martha
- Edelman Murray
- Fiorina Morris P.
- Freeman J. Leiper
- Griffith Ernest S.
- Hayes Michael T.
- Heclo Hugh
- Horn Carl E.
- Keefe William J.
- Lowi Theodore J.
- Mayhew David R.
- Mazmania Daniel A.
- Mills C. Wright
- Murphy Jerome
- O'Connor James
- Pressman Jeffrey
- Ripley Randall B.
- Ripley Randall B.
- Scott A.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
The Problem Tongues in 1 Cor 14: A Reexamination
- Author
- Aker Benny C.
- Barclay William.
- Barrett C.K.
- Blackwelder Boyce W.
- Calvin John.
- Carson D.A.
- Clark Gordon.
- Conzelmann Hans.
- Crystal David.
- Fee Gordon.
- Forbes Christopher.
- Hasel Gerhard F.
- Hodge Charles.
- Keener Craig S.
- Lenski R.C.H.
- Martin Dale B.
- Meyer H.A.W.
- Mitchell Margaret M.
- Murphy-O'Connor Jerome.
- Orlinsky Harry M.
- Orr W.F.
- Poythress Vern.
- Robertson A.
- Thomas Robert L.
- Wire Antoinette C.
- Zodhiates Spiros.
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study