Keck constraints on a varying fine-structure constant: wavelength calibration errors

The Keck telescope's HIRES spectrograph has previously provided evidence for a smaller fine-structure constant, alpha, compared to the current laboratory value, in a sample of 143 quasar absorption systems: da/a=(-0.57+/-0.11)x10^{-5}. This was based on a variety of metal-ion transitions which, if alpha varies, experience different relative velocity shifts. This result is yet to be robustly contradicted, or confirmed, by measurements on other telescopes and spectrographs; it remains crucial to do so. It is also important to consider new possible instrumental systematic effects which may explain the Keck/HIRES results. Griest et al. (2009, arXiv:0904.4725v1) recently identified distortions in the echelle order wavelength scales of HIRES with typical amplitudes +/-250m/s. Here we investigate the effect such distortions may have had on the Keck/HIRES varying alpha results. We demonstrate that they cause a random effect on da/a from absorber to absorber because the systems are at different redshifts, placing the relevant absorption lines at different positions in different echelle orders. The typical magnitude of the effect on da/a is ~0.4x10^{-5} per absorber which, compared to the median error on da/a in the sample, ~1.9x10^{-5}, is relatively small. Consequently, the weighted mean value changes by less than 0.05x10^{-5} if the corrections we calculate are applied. Nevertheless, we urge caution, particularly for analyses aiming to achieve high precision da/a measurements on individual systems or small samples, that a much more detailed understanding of such intra-order distortions and their dependence on observational parameters is important if they are to be avoided or modelled reliably. [Abridged]Comment: 9 pages, 2 figures, 2 tables. Invited contribution to Proc. IAU XXVIIth General Assembly, Joint Discussion 9, "Are the fundamental constants varying with time?". To appear in P. Molaro, E. Vangioni-Flam, eds, Memorie della Societa Astronomica Italiana (MmSAIt), Vol. 80. Complete version of Table 1 available at http://astronomy.swin.edu.au/~mmurphy/pub.htm

Combined roles for breeding synchrony, habitat and scale as predictors of extrapair paternity

publishedVersio

The host galaxies of strong CaII QSO absorption systems at z<0.5

We present new imaging and spectroscopic observations of the fields of five QSOs with very strong intervening CaII absorption systems at redshifts z<0.5 selected from the Sloan Digital Sky Survey. Recent studies of these very rare absorbers indicate that they may be related to damped Lyman alpha systems (DLAs). In all five cases we identify a galaxy at the redshift of the CaII system with impact parameters up to ~24 kpc. In four out of five cases the galaxies are luminous (L ~L*), metal-rich (Z ~Zsun), massive (velocity dispersion, sigma ~100 km/s) spirals. Their star formation rates, deduced from Halpha emission, are high, in the range SFR = 0.3 - 30 Msun/yr. In our analysis, we paid particular attention to correcting the observed emission line fluxes for stellar absorption and dust extinction. We show that these effects are important for a correct SFR estimate; their neglect in previous low-z studies of DLA-selected galaxies has probably led to an underestimate of the star formation activity in at least some DLA hosts. We discuss possible links between CaII-selected galaxies and DLAs and outline future observations which will help clarify the relationship between these different classes of QSO absorbers.Comment: Accepted for publication in MNRAS, 14 pages, 9 figures. Version with full resolution images available at http://www.ast.cam.ac.uk/~bjz/papers/Zych_etal_2007a.pd

Spatial variation in the fine-structure constant -- new results from VLT/UVES

(abridged) We present a new analysis of a large sample of quasar absorption-line spectra obtained using UVES (the Ultraviolet and Visual Echelle Spectrograph) on the VLT (Very Large Telescope) in Chile. In the VLT sample (154 absorbers), we find evidence that alpha increases with increasing cosmological distance from Earth. However, as previously shown, the Keck sample (141 absorbers) provided evidence for a smaller alpha in the distant absorption clouds. Upon combining the samples an apparent variation of alpha across the sky emerges which is well represented by an angular dipole model pointing in the direction RA=(17.3 +/- 1.0) hr, dec. = (-61 +/- 10) deg, with amplitude (0.97 +0.22/-0.20) x 10^(-5). The dipole model is required at the 4.1 sigma statistical significance level over a simple monopole model where alpha is the same across the sky (but possibly different to the current laboratory value). The data sets reveal a number of remarkable consistencies: various data cuts are consistent and there is consistency in the overlap region of the Keck and VLT samples. Assuming a dipole-only (i.e. no-monopole) model whose amplitude grows proportionally with `lookback-time distance' (r=ct, where t is the lookback time), the amplitude is (1.1 +/- 0.2) x 10^(-6) GLyr^(-1) and the model is significant at the 4.2 sigma confidence level over the null model [Delta alpha]/alpha = 0). We apply robustness checks and demonstrate that the dipole effect does not originate from a small subset of the absorbers or spectra. We present an analysis of systematic effects, and are unable to identify any single systematic effect which can emulate the observed variation in alpha.Comment: 47 pages, 35 figures. Accepted for publication by Monthly Notices of the Royal Astronomical Society. Please see http://astronomy.swin.edu.au/~mmurphy/pub.html for an ASCII version of table A1 and the full set of Voigt profile fits for appendix

VRContour: Bringing Contour Delineations of Medical Structures Into Virtual Reality

Contouring is an indispensable step in Radiotherapy (RT) treatment planning. However, today's contouring software is constrained to only work with a 2D display, which is less intuitive and requires high task loads. Virtual Reality (VR) has shown great potential in various specialties of healthcare and health sciences education due to the unique advantages of intuitive and natural interactions in immersive spaces. VR-based radiation oncology integration has also been advocated as a target healthcare application, allowing providers to directly interact with 3D medical structures. We present VRContour and investigate how to effectively bring contouring for radiation oncology into VR. Through an autobiographical iterative design, we defined three design spaces focused on contouring in VR with the support of a tracked tablet and VR stylus, and investigating dimensionality for information consumption and input (either 2D or 2D + 3D). Through a within-subject study (n = 8), we found that visualizations of 3D medical structures significantly increase precision, and reduce mental load, frustration, as well as overall contouring effort. Participants also agreed with the benefits of using such metaphors for learning purposes.Comment: C. Chen, M. Yarmand, V. Singh, M.V. Sherer, J.D. Murphy, Y. Zhang and N. Weibel, "VRContour: Bringing Contour Delineations of Medical Structures Into Virtual Reality", 2022 IEEE International Symposium on Mixed and Augmented Reality (ISMAR), 2022, pp. 1-10, doi: 10.1109/ISMAR55827.2022.0002

Advanced Glycation End Products Acutely Impair Ca2+ Signaling in Bovine Aortic Endothelial Cells

Post-translational modification of proteins in diabetes, including formation of advanced glycation end products (AGEs) are believed to contribute to vascular dysfunction and disease. Impaired function of the endothelium is an early indicator of vascular dysfunction in diabetes and as many endothelial cell processes are dependent upon intracellular [Ca2+] and Ca2+ signalling, the aim of this study was to examine the acute effects of AGEs on Ca2+ signalling in bovine aortic endothelial cells (BAEC). Ca2+ signalling was studied using the fluorescent indicator dye Fura2-AM. AGEs were generated by incubating bovine serum albumin with 0 - 250 mM glucose or glucose-6-phosphate for 0 to 120 days at 37&#186;C. Under all conditions, the main AGE species generated was carboxymethyl lysine (CML) as assayed using both GC-MS and HPLC. In Ca2+-replete solution, exposure of BAEC to AGEs for 5 min caused an elevation in basal [Ca2+] and attenuated the increase in intracellular [Ca2+] caused by ATP (100 &#181;M). In the absence of extracellular Ca2+, exposure of BAEC to AGEs for 5 min caused an elevation in basal [Ca2+] and attenuated subsequent intracellular Ca2+ release caused by ATP, thapsigargin (0.1 &#181;M) and ionomycin (3 &#181;M), but AGEs did not affect extracellular Ca2+ entry induced by the re-addition of Ca2+ to the bathing solution in the presence of any of these agents. The anti-oxidant α-lipoic acid (2 &#181;M) and NAD(P)H oxidase inhibitors apocynin (500 &#181;M) and diphenyleneiodonium (DPI, 1 &#181;M) abolished these effects of AGEs on BAECs, as did the IP3 receptor antagonist xestospongin C (1 &#181;M). In summary, AGEs caused an acute depletion of Ca2+ from the intracellular store in BAECs, such that the Ca2+ signal stimulated by the subsequent application other agents acting upon this store is reduced. The mechanism may involve generation of ROS from NAD(P)H oxidase and possible activation of the IP3 receptor

Persistent Currents and Dissipation in Narrow Bilayer Quantum Hall Bars

Bilayer quantum Hall states support a flow of nearly dissipationless staggered current which can only decay through collective channels. We study the dominant finite-temperature dissipation mechanism which in narrow bars is driven by thermal nucleation of pseudospin solitons. We find the finite-temperature resistivity, predict the resulting staggered current-voltage characteristics, and calculate the associated zero-temperature critical staggered current and gate voltage.Comment: 4 pgs. REVTeX, 3 eps figure

Measurement of H₂O₂ within living drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix

Hydrogen peroxide (H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;) is central to mitochondrial oxidative damage and redox signaling, but its roles are poorly understood due to the difficulty of measuring mitochondrial H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; in vivo. Here we report a ratiometric mass spectrometry probe approach to assess mitochondrial matrix H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; levels in vivo. The probe, MitoB, comprises a triphenylphosphonium (TPP) cation driving its accumulation within mitochondria, conjugated to an arylboronic acid that reacts with H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; to form a phenol, MitoP. Quantifying the MitoP/MitoB ratio by liquid chromatography-tandem mass spectrometry enabled measurement of a weighted average of mitochondrial H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; that predominantly reports on thoracic muscle mitochondria within living flies. There was an increase in mitochondrial H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; with age in flies, which was not coordinately altered by interventions that modulated life span. Our findings provide approaches to investigate mitochondrial ROS in vivo and suggest that while an increase in overall mitochondrial H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; correlates with aging, it may not be causative