600 research outputs found
Exploring Patterns in Student Dialogue While Using a Digital Platform Designed to Support Online Inquiry
Online inquiry, or using the Internet to generate questions and then search for, analyse, and synthesise information about these questions, is an essential part of digital literacy. However, processes involved in online inquiry are substantially complex. Prior research suggests that digital platforms can scaffold online inquiry processes. Moreover, the value of scaffolding dialogue in collaborative activities has been shown to enhance critical thinking, an important part of online inquiry. This study investigates whether the use of digital platforms designed to scaffold online inquiry can support productive dialogue when used collaboratively. Data from four pairs of high school students was collected as they worked together using both the digital platform and multiple online sources outside the platform to complete an online inquiry task. Each pair’s interactions were analysed to investigate whether features of the digital platform prompted productive dialogue. In line with research suggesting the use of academic language influences content understanding, each pair’s use of certain academic terms related to the task and digital platform’s interface were also statistically examined. Results suggested that most productive dialogue occurred when using the digital platform. Additionally, two of the four academic terms investigated occurred more often in talk while interacting with the digital platform, compared to talk when on another website. A comparison of timelines associated with these terms offered examples of how initially they were said exclusively while on the tool, and then progressed towards independent use
Recommended from our members
Spontaneous cognition in dysphoria: reduced positive bias in imagining the future.
Anomalies in future-oriented cognition are implicated in the maintenance of emotional disturbance within cognitive models of depression. Thinking about the future can involve mental imagery or verbal-linguistic mental representations. Research suggests that future thinking involving imagery representations may disproportionately impact on-going emotional experience in daily life relative to future thinking not involving imagery (verbal-linguistic representation only). However, while higher depression symptoms (dysphoria) are associated with impaired ability to deliberately generate positive relatively to negative imagery representations of the future (when instructed to do so), it is unclear whether dysphoria is associated with impairments in the tendency to do so spontaneously (when not instructed to deliberately generate task unrelated cognition of any kind). The present study investigated dysphoria-linked individual differences in the tendency to experience spontaneous future-oriented cognition as a function of emotional valence and representational format. Individuals varying in dysphoria level reported the occurrence of task unrelated thoughts (TUTs) in real time while completing a sustained attention go/no-go task, during exposure to auditory cues. Results indicate higher levels of dysphoria were associated with lower levels of positive bias in the number of imagery-based future TUTs reported, reflecting higher negative imagery-based future TUT generation (medium to large effect size), and lower positive imagery-based TUT generation (small to medium effect size). Further, this dysphoria-linked bias appeared to be specific in temporal orientation (future, not past) and representational format (imagery, not non-imagery). Reduced tendency to engage in positive relative to negative imagery-based future thinking appears to be implicated in dysphoria
Alzheimer's genetic risk effects on cerebral blood flow are spatially consistent and proximal to gene expression across the lifespan
Cerebrovascular dysregulation is a hallmark feature of Alzheimer’s disease (AD), where alterations in cerebral blood flow (CBF) are observed decades prior to symptom onset. Genome-wide association studies (GWAS) show that AD has a polygenic aetiology, providing a tool for studying AD susceptibility across the lifespan. Here, we ascertain whether AD genetic risk effects on CBF previously observed (Chandler et al., 2019) remain consistent across the lifespan. We further provide a causal mechanism to AD genetic risk scores (AD-GRS) effects by establishing spatial convergence between AD-GRS associated regional reductions in CBF and mRNA expression of the proximal AD transcripts using independent data from the Allen Brain Atlas. We analysed grey matter (GM) CBF in a young cohort (N=75; aged 18-35) and an older cohort (N=90; aged 55-85). Critically, we observed that AD-GRS was negatively associated with whole brain GM CBF in the older cohort (standardised β −0.38 [−0.68 – −0.09], P = 0.012), consistent with our prior observation in younger healthy adults (Chandler et al., 2019). We then demonstrate that the regional impact of AD-GRS on GM CBF was spatially consistent across the younger and older samples (r = 0.233, P = 0.035). Finally, we show that CBF across the cortex was related to the regional expression of the genes proximal to SNP’s used to estimate AD-GRS in both younger and older cohorts (ZTWO-TAILED = −1.99, P= 0.047; ZTWO-TAILED = −2.153 P = 0.032, respectively). These observations collectively demonstrate that AD risk alleles have a negative influence on brain vascular function and likely contribute to cerebrovascular changes preceding the onset of clinical symptoms, potentially driven by regional expression of proximal AD risk genes across the brain. Our observations suggest that reduced CBF is an early antecedent of AD and a key modifiable target for therapeutic intervention in individuals with a higher cumulative genetic risk for AD. This study will further enable identification of key molecular processes that underpin AD genetic risk related reductions in CBF that could be targeted decades prior to the onset of neurodegeneration
Recommended from our members
Economic Slowdown: Issues and Policies
This report discusses about the Issues and Policies on Economic Slowdown. recent policies have sought to contain damages spilling over from housing and financial markets to border economy
Mitochondrial DNA deletions in muscle satellite cells: implications for therapies.
Progressive myopathy is a major clinical feature of patients with mitochondrial DNA (mtDNA) disease. There is limited treatment available for these patients although exercise and other approaches to activate muscle stem cells (satellite cells) have been proposed. The majority of mtDNA defects are heteroplasmic (a mixture of mutated and wild-type mtDNA present within the muscle) with high levels of mutated mtDNA and low levels of wild-type mtDNA associated with more severe disease. The culture of satellite cell-derived myoblasts often reveals no evidence of the original mtDNA mutation although it is not known if this is lost by selection or simply not present in these cells. We have explored if the mtDNA mutation is present in the satellite cells in one of the commonest genotypes associated with mitochondrial myopathies (patients with single, large-scale mtDNA deletions). Analysis of satellite cells from eight patients showed that the level of mtDNA mutation in the satellite cells is the same as in the mature muscle but is most often subsequently lost during culture. We show that there are two periods of selection against the mutated form, one early on possibly during satellite cell activation and the other during the rapid replication phase of myoblast culture. Our data suggest that the mutations are also lost during rapid replication in vivo, implying that strategies to activate satellite cells remain a viable treatment for mitochondrial myopathies in specific patient groups
Learning to prescribe - pharmacists' experiences of supplementary prescribing training in England
Background: The introduction of non-medical prescribing for professions such as pharmacy and nursing in
recent years offers additional responsibilities and opportunities but attendant training issues. In the UK and in contrast to some international models, becoming a non-medical prescriber involves the completion of an
accredited training course offered by many higher education institutions, where the skills and knowledge
necessary for prescribing are learnt.
Aims: to explore pharmacists' perceptions and experiences of learning to prescribe on supplementary prescribing (SP) courses, particularly in relation to inter-professional learning, course content and subsequent use of prescribing in practice.
Methods: A postal questionnaire survey was sent to all 808 SP registered pharmacists in England in April 2007,
exploring demographic, training, prescribing, safety culture and general perceptions of SP.
Results: After one follow-up, 411 (51%) of pharmacists responded. 82% agreed SP training was useful, 58%
agreed courses provided appropriate knowledge and 62% agreed that the necessary prescribing skills were gained.
Clinical examination, consultation skills training and practical experience with doctors were valued highly;
pharmacology training and some aspects of course delivery were criticised. Mixed views on inter-professional
learning were reported – insights into other professions being valued but knowledge and skills differences
considered problematic. 67% believed SP and recent independent prescribing (IP) should be taught together, with more diagnostic training wanted; few pharmacists trained in IP, but many were training or intending to train. There was no association between pharmacists' attitudes towards prescribing training and when they undertook training between 2004 and 2007 but earlier cohorts were more likely to be using supplementary prescribing in practice.
Conclusion: Pharmacists appeared to value their SP training and suggested improvements that could inform
future courses. The benefits of inter-professional learning, however, may conflict with providing professionspecific training. SP training may be perceived to be an instrumental 'stepping stone' in pharmacists' professional project of gaining full IP status
A search for radio afterglows from gamma-ray bursts with the Australian Square Kilometre Array Pathfinder
We present a search for radio afterglows from long gamma-ray bursts using the
Australian Square Kilometre Array Pathfinder (ASKAP). Our search used the Rapid
ASKAP Continuum Survey, covering the entire celestial sphere south of
declination , and three epochs of the Variables and Slow Transients
Pilot Survey (Phase 1), covering square degrees per epoch. The
observations we used from these surveys spanned a nine-month period from 2019
April 21 to 2020 January 11. We crossmatched radio sources found in these
surveys with 779 well-localised (to ) long gamma-ray bursts
occurring after 2004 and determined whether the associations were more likely
afterglow- or host-related through the analysis of optical images. In our
search, we detected one radio afterglow candidate associated with GRB 171205A,
a local low-luminosity gamma-ray burst with a supernova counterpart SN 2017iuk,
in an ASKAP observation 511 days post-burst. We confirmed this detection with
further observations of the radio afterglow using the Australia Telescope
Compact Array at 859 days and 884 days post-burst. Combining this data with
archival data from early-time radio observations, we showed the evolution of
the radio spectral energy distribution alone could reveal clear signatures of a
wind-like circumburst medium for the burst. Finally, we derived semi-analytical
estimates for the microphysical shock parameters of the burst: electron
power-law index , normalised wind-density parameter ,
fractional energy in electrons , and fractional energy in
magnetic fields .Comment: 18 pages, 7 figures; accepted for publication in MNRA
Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: crossover randomised controlled studies
Objective To compare the safety and efficacy of overnight closed loop delivery of insulin (artificial pancreas) with conventional insulin pump therapy in adults with type 1 diabetes
- …