Study on the sources of stress among lectures and instructors of WIT College

This is a study on occupational stress expe1ienced by lecturers and instructors of WIT College in the state of Selangor. The objective of this study is to prove that the cause of stress among lecturers and instructors is due to mainly five independent variables such as demand on staff, relationship with the management, control exercised, role to be played and support from management. A total set of 38 questionnaires were distributed and findings tabulated. The results of the findings of this study showed that generally lecturers and instructors of WIT College experience occupational stress. The most common factors that caused occupational stress among lecturers and instructors were lack of support from management, lack of facilities, lack of information about what is going on, lack of participation in decision making and feeling work not valued. It is also clear that there were no significant differences in the occupational stress levels among the different demographic variables such as gender, teaching program, marital status and education level. Based on the research findings it is recommended that organisation concerned should help the staff to achieve mental, emotional and physical preparedness to cope with occupational stress effectively

Oxo-Biodegradation of Full Carbon Backbone Polymers under Different Environmental Conditions

The research activity undertaken during the present PhD thesis provides important information with respect to synergistic effects of microbial/enzymatic attack and physical-chemical parameters in promoting the degradation of partially oxidized full-carbon backbone polymers, thus allowing for a better design of oxo-biodegradable materials to be really and ultimately biodegraded under different natural environments

Formulation and Evaluation of Ticagrelor Sublingual Tablets

The aim of the present study was to develop oral sublingual tablets of ticagrelor to give quick onset of action by rapidly disintegrating in a few seconds without the need of water with better patient compliance. In such cases, bioavailability of drug is significantly greater and adverse event is reduced than those observed from conventional tablet dosage form. The work done is summarized as follows: Ticagrelor is very slightly soluble in water; so the study plan was done, to improve the solubility of ticagrelor by solid dispersion, and then was to formulate sublingual tablets. Solid dispersion was prepared by melting method using water soluble carrier polyethylene glycol 6000 showed better in vitro release studies in phosphate buffer pH6.8 using USP Type II apparatus. The results revealed that the increase in the carrier concentration increased the dissolution rate (1:4 ratios). The in vitro release studies revealed that the solid dispersion formulations showed a faster drug release when compared to the physical mixture and pure drug. By performing Drug - Excipients compatibility studies by IR spectrophotometry, no interaction drug-excipients was confirmed. Oral disintegrating tablets were formulated by direct compression method and suitable analytical method based on UV-Visible spectrophotometer was developed for the model drug. Standard calibration curve prepared to determine the drug content in the prepared tablets and UV analysis was performed to determine the drug during in vitro release studies. Prior to compression, the blend of drug and excipients were evaluated for flow properties such as Angle of repose, loose bulk density, Tapped density, % Compressibility, and Hausner’s ratio. All the formulations showed good flow properties. Sublingual tablets were prepared by direct compression technique using 12-Station D/B Tooling Compression Machine, equipped with concave round punch of 8 mm diameter. Post compression evaluation of prepared sublingual tablets were carried out with the help of different pharmacopoeial tests. The shape and colour of all the formulations were found to be circular and white in colour. The thickness was found to be uniform in specific formulations. The hardness, weight variation, diameter are also within the permitted limits. The friability of all the tablets was found to be ˂ 1%, which indicates the good mechanical resistance. The wetting time of sublingual tablets containing crosspovidone (7.5%) was found to be 54 seconds. CONCLUSION: The study conclusively demonstrated significant results for ticagrelor sublingual tablets. The sublingual tablets of ticagrelor was more palatable, and it is mostly helpful to the patients for the treatment of acute coronary syndrome, cardiac angina. The sublingual tablets of ticagrelor can be successfully prepared by direct compression method using selected superdisintegrants with Crosscarmellose sodium 1.5%, 3%, 4.5%, 6%, 7.5%, Crosspovidone 1.5%, 3%, 4.5%, 6%, 7.5% and Sodium starch glycolate 1.5%, 3%, 4.5%, 6%, 7.5% for the better patient compliance and effective therapy the relative efficiency to improve the disintegration and dissolution rate of tablets were found. The disintegration time of F10 with 7.5% Crosspovidone formulation to be as 55.8 seconds respectively and is almost better than other formulations. Invitro dissolution studies were performed for all formulations. The formulation F10 showed 98.21% release within the 30 minutes. Crosspovidone shows good result as compare to other superdisintegrants. Crosspovidone > crosscarmellose sodium > sodium starch glycolate

A Behavioural and Histological Approach to Dose Dependent Chronic Toxicity Screening of Cyclotide in Zebrafishes

Parkinson's disease (PD) is the second most common neurodegenerative illness worldwide. It is an age-related sickness. An illness treatment plan is urgently required. Such secondary metabolites from plants may undoubtedly be the source of the medications with less adverse effects. 6-Hydroxydopamine (6-OHDA) is used experimentally to mimic Parkinson's disease in adult zebrafish. In the realm of medicine, there are no ideal cures for ailments. For the past few decades, a number of plant secondary chemicals have been tested in preclinical settings to cure this illness. Many references have been made to cyclotide's neuroprotective, anti-inflammatory, and antioxidant properties. Furthermore, it has recently been demonstrated that amantadine (AMA), an aminoadamantane well-known for its mild antiparkinsonian action, counteracts central nervous system dysfunction. Apart from oxidative stress and mitochondrial damage, 6-OHDA may also cause decreased cytosolic levels of Tyrosine Hydroxylase (TH). Since this is primarily thought to be in charge of dopamine production in the central nervous system, an antagonist of TH may be the best medication option when treating Parkinson's disease. Since Amantadine (AMA) is the conventional medication, the current study compares the potential of Cyclotide as Tyrosine Hydroxylase Inhibitors to examine the molecular anti-TH interactions in 6-OHDA-induced adult zebrafishes

Identification of fibre content in edible flours using microwave dielectric cell: Concise review and experimental insights

The quality of edible intake decides the health of the human body and is also responsible for building a healthy immune system in the body. A healthy immune system can protect the body even from invisible attacks of viral or bacterial infections. The assessment of the quality of edible items is not well defined and standardized in many developing countries due to quality assessment difficulties in practice. An alternative well-defined quality assessment approach for edible flours is presented in this paper. Every edible substance has dielectric properties, and it varies from material to material in nature. Edible flours and liquid have different microwave absorption capabilities, based on their natural molecular structure. Based on the microwave energy absorption characteristics of materials, the attenuation constant of edible flours is derived by the waveguide method in this work. In this approach, microwave energy absorption of the edible samples of different types of wheat, rice and millets are observed, and the attenuation constant factors of the samples are then calculated from the tabulated values. The work focuses on the identification of fibre content present in the edible flours. Inferences are made based on the attenuation and its variations with the number of samples, dielectric loss and dielectric constant of the samples. A systematic and concise review of the topic is also included for the benefit of future researchers.Web of Science1516art. no. 564

Evaluation of microalgae’s plastic biodeterioration property by a consortium of chlorella sp. and cyanobacteria sp.

Malaysia is one of the top eight countries that has a drawback of mismanaged plastic waste. This study intended to investigate polymer degradation using the biological technique with the help of microalgae to minimise the time required for biodegradation. This research article aims to identify the collected sample with the most suitable microalgae for the biodegradation of microplastic and to analyse the biodegradation of the polymer by microalgae. The results revealed that the consortium of Chlorella sp. and Cyanobacteria sp. were able to deteriorate low-density polyethene (LDPE sample) through several stages, and this was confirmed by UV-Spec, FESEM, EDX, CHNO, FTIR and DSC analysis. The results obtained revealed that microalgae producing exopolysaccharides (EPS) decreased the carbon and oxygen ratio. According to SEM micrographs, microalga may colonise, agglomerate, and adhere microplastics to its surface, regardless of its fractional size. The EDX analysis showed that the initial composition of carbon was 92.30±1.23%, while after the incubation, the carbon composition started decreasing from 53.18% to 39.12±1.08%. Finally, there was a 37.91% decrease in carbon weight from elemental analysis

Indian Tourism Websites with Special Reference to the Selected States: A Webometrics

Webometrics studies the quantitative aspects of the construction and use of information resources, structures, technologies on the web, and informetric approaches. Webometrics is concerned with measuring characteristics of the web: websites, web pages, and parts of web pages, words in web pages, hyperlinks, and web search engine results. This study investigates and explores the websites of 18 selected Indian Tourism websites based on their external backlinks, Edu backlines, Gov backlinks, Edu domains, Gov domains, Global Rank, PR quality, and desktop and mobile website loading time of state tourism in India. This study collected data from Check page rank and other SEO-analyzer search engines. The researcher suggested that Indian Tourism websites need to attract more external backlinks and the global level by introducing creative online sources and services and updates of news and information. Identify and analyze global Rank and PR quality websites of Indian Tourism

Green Synthesis of Sodium Cyanide Using Hydrogen Cyanide Extracted under Vacuum from Cassava (<i>Manihot esculenta</i> Crantz) Leaves

This study was carried out to develop a green approach to synthesising sodium cyanide (NaCN) using hydrogen cyanide (HCN) extracted from cassava (Manihot esculenta Crantz) leaves after 120 min of maceration at 30 °C and 45 min of recovery under vacuum at 35–40 °C. The CN- ion released via autolysis was reacted with the Na+ ion following vacuum extraction of the former to produce NaCN by saturating the absorbing sodium hydroxide (NaOH) solution. This specific extraction method avoided direct contact between the cassava leaves homogenate and the absorbing solution. NaCN was crystallised by drying the NaCN slurry at 100 °C in an air oven. A total of 15.70 kg of fresh cassava leaves was needed to produce 32.356 g of NaCN (green-NaCN) (% NaCN yield = 0.21%). The results of X-ray diffraction, attenuated total reflectance–Fourier transform infrared spectroscopy and scanning electron microscopy with energy-dispersive X-ray spectroscopy, show that NaCN was successfully prepared using the proposed method. These spectral techniques showed that the control and green-NaCN contained sodium carbonate impurities. The latter was quantified by the titration experiments and was found to be 0.61% and 2.29% in the control and green-NaCN, respectively. Furthermore, the titration experiments revealed that the residual NaOH content was 1.63% in control NaCN and 4.68% in green-NaCN. The aim of modifying the green synthesis route for producing NaCN from cassava, developed by the Attahdaniel research group in 2013 and 2020, was achieved

Preliminary verification of Bacopa monniera and network pharmacology research for the treatment of non-alcoholic fatty liver disease

Bacoside - A, a dynamic component of Bacopa monniera is utilized in different ailments. The pharmacodynamics and cellular pathways overseeing the impacts of Bacoside- A on NAFLD stay unclear. In this study, we examined Bacoside - A pharmacology through evaluation of its chemical constituents and assessed and screened its components using drug likeness, pharmacokinetic characteristics (absorption, distribution, metabolism, excretion, and toxicity), and appropriate compensation mechanisms. We performed expectations of the dynamic BM fixings based on invert pharmacophore matching and compared different NAFLD-related genes to decide potential BM targets. Atomic docking experiments of the dynamic components were performed to uncover cellular targets. Explanation examination of both target qualities and related pathways were evaluated through the DAVID database. Cytoscape computer program was utilized to build a “component-target- path” network for the treatment of NAFLD by BM. Through data analysis, 9 active BM substances and 10 targets related to NAFLD encompassing 4 cellular pathways were identified. Data were verified through enzyme-linked immunosorbent assay and Western blot analysis. These findings provide new references for the network pharmacology of Ayurvedic medicinal compounds and NAFLD treatment