1,364 research outputs found
Why Some Interfaces Cannot be Sharp
A central goal of modern materials physics and nanoscience is control of
materials and their interfaces to atomic dimensions. For interfaces between
polar and non-polar layers, this goal is thwarted by a polar catastrophe that
forces an interfacial reconstruction. In traditional semiconductors this
reconstruction is achieved by an atomic disordering and stoichiometry change at
the interface, but in multivalent oxides a new option is available: if the
electrons can move, the atoms don`t have to. Using atomic-scale electron energy
loss spectroscopy we find that there is a fundamental asymmetry between
ionically and electronically compensated interfaces, both in interfacial
sharpness and carrier density. This suggests a general strategy to design sharp
interfaces, remove interfacial screening charges, control the band offset, and
hence dramatically improving the performance of oxide devices.Comment: 12 pages of text, 6 figure
Considering the Case for Biodiversity Cycles: Reexamining the Evidence for Periodicity in the Fossil Record
Medvedev and Melott (2007) have suggested that periodicity in fossil
biodiversity may be induced by cosmic rays which vary as the Solar System
oscillates normal to the galactic disk. We re-examine the evidence for a 62
million year (Myr) periodicity in biodiversity throughout the Phanerozoic
history of animal life reported by Rohde & Mueller (2005), as well as related
questions of periodicity in origination and extinction. We find that the signal
is robust against variations in methods of analysis, and is based on
fluctuations in the Paleozoic and a substantial part of the Mesozoic.
Examination of origination and extinction is somewhat ambiguous, with results
depending upon procedure. Origination and extinction intensity as defined by RM
may be affected by an artifact at 27 Myr in the duration of stratigraphic
intervals. Nevertheless, when a procedure free of this artifact is implemented,
the 27 Myr periodicity appears in origination, suggesting that the artifact may
ultimately be based on a signal in the data. A 62 Myr feature appears in
extinction, when this same procedure is used. We conclude that evidence for a
periodicity at 62 Myr is robust, and evidence for periodicity at approximately
27 Myr is also present, albeit more ambiguous.Comment: Minor modifications to reflect final published versio
Hidden Magnetism and Quantum Criticality in the Heavy Fermion Superconductor CeRhIn5
With understood exceptions, conventional superconductivity does not coexist
with long-range magnetic order[1]. In contrast, unconventional
superconductivity develops near a boundary separating magnetically ordered and
magnetically disordered phases[2,3]. A maximum in the superconducting
transition temperature Tc develops where this boundary extrapolates to T=0 K,
suggesting that fluctuations associated with this magnetic quantum-critical
point are essential for unconventional superconductivity[4,5]. Invariably
though, unconventional superconductivity hides the magnetic boundary when T <
Tc, preventing proof of a magnetic quantum-critical point[5]. Here we report
specific heat measurements of the pressure-tuned unconventional superconductor
CeRhIn5 in which we find a line of quantum-phase transitions induced inside the
superconducting state by an applied magnetic field. This quantum-critical line
separates a phase of coexisting antiferromagnetism and superconductivity from a
purely unconventional superconducting phase and terminates at a quantum
tetracritical point where the magnetic field completely suppresses
superconductivity. The T->0 K magnetic field-pressure phase diagram of CeRhIn5
is well described with a theoretical model[6,7] developed to explain
field-induced magnetism in the high-Tc cuprates but in which a clear
delineation of quantum-phase boundaries has not been possible. These
experiments establish a common relationship among hidden magnetism, quantum
criticality and unconventional superconductivity in cuprate and heavy-electron
systems, such as CeRhIn5.Comment: journal reference adde
Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study
Enhancing antiviral host defense responses through nutritional supplementation would be an attractive strategy in the fight against influenza. Using inoculation with live attenuated influenza virus (LAIV) as an infection model, we have recently shown that ingestion of sulforaphane-containing broccoli sprout homogenates (BSH) reduces markers of viral load in the nose. To investigate the systemic effects of short-term BSH supplementation in the context of LAIV-inoculation, we examined peripheral blood immune cell populations in non-smoking subjects from this study, with a particular focus on NK cells. We carried out a randomized, double-blinded, placebo-controlled study measuring the effects of BSH (N = 13) or placebo (alfalfa sprout homogenate, ASH; N = 16) on peripheral blood mononuclear cell responses to a standard nasal vaccine dose of LAIV in healthy volunteers. Blood was drawn prior to (day-1) and post (day2, day21) LAIV inoculation and analyzed for neutrophils, monocytes, macrophages, T cells, NKT cells, and NK cells. In addition, NK cells were enriched, stimulated, and assessed for surface markers, intracellular markers, and cytotoxic potential by flow cytometry. Overall, LAIV significantly reduced NKT (day2 and day21) and T cell (day2) populations. LAIV decreased NK cell CD56 and CD158b expression, while significantly increasing CD16 expression and cytotoxic potential (on day2). BSH supplementation further increased LAIV-induced granzyme B production (day2) in NK cells compared to ASH and in the BSH group granzyme B levels appeared to be negatively associated with influenza RNA levels in nasal lavage fluid cells. We conclude that nasal influenza infection may induce complex changes in peripheral blood NK cell activation, and that BSH increases virus-induced peripheral blood NK cell granzyme B production, an effect that may be important for enhanced antiviral defense responses
Von Bezold assimilation effect reverses in stereoscopic conditions
Lightness contrast and lightness assimilation are opposite phenomena: in contrast,
grey targets appear darker when bordering bright surfaces (inducers) rather than dark ones; in
assimilation, the opposite occurs. The question is: which visual process favours the occurrence
of one phenomenon over the other? Researchers provided three answers to this question. The
first asserts that both phenomena are caused by peripheral processes; the second attributes their
occurrence to central processes; and the third claims that contrast involves central processes,
whilst assimilation involves peripheral ones. To test these hypotheses, an experiment on an IT
system equipped with goggles for stereo vision was run. Observers were asked to evaluate the
lightness of a grey target, and two variables were systematically manipulated: (i) the apparent
distance of the inducers; and (ii) brightness of the inducers. The retinal stimulation was kept
constant throughout, so that the peripheral processes remained the same. The results show that
the lightness of the target depends on both variables. As the retinal stimulation was kept constant, we
conclude that central mechanisms are involved in both lightness contrast and lightness assimilation
Telomerase activity in melanoma and non-melanoma skin cancer
Telomeres are specialized structures consisting of repeat arrays of TTAGGGn located at the ends of chromosomes. They are essential for chromosome stability and, in the majority of normal somatic cells, telomeres shorten with each cell division. Most immortalized cell lines and tumours reactivate telomerase to stabilize the shortening chromosomes. Telomerase activation is regarded as a central step in carcinogenesis and, here, we demonstrate telomerase activation in premalignant skin lesions and also in all forms of skin cancer. Telomerase activation in normal skin was a rare event, and among 16 samples of normal skin (one with a history of chronic sun exposure) 12.5% (2 out of 16) exhibited telomerase activity. One out of 16 (6.25%) benign proliferative lesions, including viral and seborrhoeic wart samples, had telomerase activity. In premalignant actinic keratoses and Bowen's disease, 42% (11 out of 26) of samples exhibited telomerase activity. In the basal cell carcinoma and cutaneous malignant melanoma (CMM) lesions, telomerase was activated in 77% (10 out of 13) and 69% (22 out of 32) respectively. However, only 25% (3 out of 12) of squamous cell carcinomas (SCC) had telomerase activity. With the exception of one SCC sample, telomerase activity in a positive control cell line derived from a fibrosarcoma (HT1080) was not inhibited when mixed with the telomerase-negative SCC or CMM extracts, indicating that, overall, Taq polymerase and telomerase inhibitors were not responsible for the negative results. Mean telomere hybridizing restriction fragment (TRF) analysis was performed in a number of telomerase-positive and -negative samples and, although a broad range of TRF sizes ranging from 3.6 to 17 kb was observed, a relationship between telomerase status and TRF size was not found
Multi-detector row computed tomography (MDCT) and magnetic resonance imaging (MRI) in the evaluation of the mandibular invasion by squamous cell carcinomas (SCC) of the oral cavity. Correlation with pathological data
<p>Abstract</p> <p>Background</p> <p>To retrospectively compare the diagnostic accuracy of magnetic resonance imaging (MRI) and multidetector-row computed tomography (MDCT) in the assessment of the mandibular invasion by squamous cell carcinoma (SCC) having histopathological exams as standard of reference.</p> <p>Materials and methods</p> <p>Institutional review board approval with a waiver of informed patient consent was obtained. Of the 147 patients selected from our database who underwent surgical excision of a tumour arising into the oral cavity, thirty-six patients (26 men, 10 women; mean age, 56 years; range, 30-75 years) with hystologically proven SCC who performed both a preoperative MRI and MDCT, composed our final study population.</p> <p>Images were qualitatively analyzed in consensus by two expert radiologist in head and neck imaging. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were assessed for both MRI and MDCT.</p> <p>Differences in sensitivity, specificity, positive and negative predictive values were calculated at a statistical significance of p < .05.</p> <p>Results</p> <p>The sensitivity, the specificity and the accuracy of MRI and MDCT in the detection of the mandibular involvement were respectively 93%, 82%, 86% and 79%, 82%, 81%, while the positive predictive value (PPV) and negative predictive value (NPV) were respectively 76%, 95% and 73%, 86%. There wasn't any statistically significant difference in overall diagnostic accuracy between MRI and MDCT in the evaluation of mandibular tumour invasion (p > .05).</p> <p>Conclusion</p> <p>MRI showed to have a higher sensitivity compare to MDCT in the assessment of mandibular involvement from SCC arising in the oral cavity although none statistically significant differences were noted.</p
Recovery and resilience of tropical forests after disturbance
The time taken for forested tropical ecosystems to re-establish post-disturbance is of widespread interest. Yet to date there has been no comparative study across tropical biomes to determine rates of forest re-growth, and how they vary through space and time. Here we present results from a meta-analysis of palaeoecological records that use fossil pollen as a proxy for vegetation change over the past 20,000 years. A total of 283 forest disturbance and recovery events, reported in 71 studies, are identified across four tropical regions. Results indicate that forests in Central America and Africa generally recover faster from past disturbances than those in South America and Asia, as do forests exposed to natural large infrequent disturbances compared with post-climatic and human impacts. Results also demonstrate that increasing frequency of disturbance events at a site through time elevates recovery rates, indicating a degree of resilience in forests exposed to recurrent past disturbance
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