Using Gaussian Processes to detect AGN flares

A key feature of active galactic nuclei (AGN) is their variability across all wavelengths. Typically, AGN vary by a few tenths of a magnitude or more over periods lasting from hours to years. By contrast, extreme variability of AGN -- large luminosity changes that are a significant departure from the baseline variability -- are known as AGN flares. These events are rare and their timescales poorly constrained, with most of the literature focusing on individual events. It has been suggested that extreme AGN variability including flares can provide insights into the accretion processes in the disk. With surveys such as the Legacy Survey of Space and Time (LSST) promising millions of transient detections per night in the coming decade, there is a need for fast and efficient classification of AGN flares. The problem with the systematic detection of AGN flares is the requirement to detect them against a stochastically variable baseline; the ability to define a signal as a significant departure from the ever-present variability is a statistical challenge. Recently, Gaussian Processes (GPs) have revolutionised the analysis of time-series data in many areas of astronomical research. They have, however, seen limited uptake within the field of transient detection and classification. Here we investigate the efficacy of Gaussian Processes to detect AGN flares in both simulated and real optical light curves. We show that GP analysis can successfully detect AGN flares with a false-positive rate of less than seven per cent, and we present examples of AGN light curves that show extreme variability.Comment: 14 pages, 25 figures, accepted for publication in MNRA

The transcriptional response of Caenorhabditis elegans to ivermectin exposure identifies novel genes involved in the response to reduced food intake

We have examined the transcriptional response of Caenorhabditis elegans following exposure to the anthelmintic drug ivermectin (IVM) using whole genome microarrays and real-time QPCR. Our original aim was to identify candidate molecules involved in IVM metabolism and/or excretion. For this reason the IVM tolerant strain, DA1316, was used to minimise transcriptomic changes related to the phenotype of drug exposure. However, unlike equivalent work with benzimidazole drugs, very few of the induced genes were members of xenobiotic metabolising enzyme families. Instead, the transcriptional response was dominated by genes associated with fat mobilization and fatty acid metabolism including catalase, esterase, and fatty acid CoA synthetase genes. This is consistent with the reduction in pharyngeal pumping, and consequential reduction in food intake, upon exposure of DA1316 worms to IVM. Genes with the highest fold change in response to IVM exposure, cyp-37B1, mtl-1 and scl-2, were comparably up-regulated in response to short–term food withdrawal (4 hr) independent of IVM exposure, and GFP reporter constructs confirm their expression in tissues associated with fat storage (intestine and hypodermis). These experiments have serendipitously identified novel genes involved in an early response of C. elegans to reduced food intake and may provide insight into similar processes in higher organisms

X-UDS: The Chandra Legacy Survey of the UKIDSS Ultra Deep Survey Field

We present the X-UDS survey, a set of wide and deep Chandra observations of the Subaru-XMM Deep/UKIDSS Ultra Deep Survey (SXDS/UDS) field. The survey consists of 25 observations that cover a total area of 0.33 deg(2). The observations are combined to provide a nominal depth of similar to 600 ks in the central 100 arcmin(2) region of the field that has been imaged with Hubble/WFC3 by the CANDELS survey and similar to 200 ks in the remainder of the field. In this paper, we outline the survey's scientific goals, describe our observing strategy, and detail our data reduction and point source detection algorithms. Our analysis has resulted in a total of 868 band-merged point sources detected with a false-positive Poisson probability of <1 x 10(-4). In addition, we present the results of an X-ray spectral analysis and provide best-fitting neutral hydrogen column densities, N-H, as well as a sample of 51 Compton-thick active galactic nucleus candidates. Using this sample, we find the intrinsic Compton-thick fraction to be 30%-35% over a wide range in redshift (z = 0.1-3), suggesting the obscured fraction does not evolve very strongly with epoch. However, if we assume that the Compton-thick fraction is dependent on luminosity, as is seen for Compton-thin sources, then our results are consistent with a rise in the obscured fraction out to z similar to 3. Finally, an examination of the host morphologies of our Compton-thick candidates shows a high fraction of morphological disturbances, in agreement with our previous results. All data products described in this paper are made available via a public website

The XMM-SERVS Survey: XMM-Newton Point-source Catalogs for the W-CDF-S and ELAIS-S1 Fields

We present the X-ray point-source catalogs in two of the XMM-Spitzer Extragalactic Representative Volume Survey (XMM-SERVS) fields, W-CDF-S (4.6 deg2) and ELAIS-S1 (3.2 deg2), aiming to fill the gap between deep pencil-beam X-ray surveys and shallow X-ray surveys over large areas. The W-CDF-S and ELAIS-S1 regions were targeted with 2.3 and 1.0 Ms of XMM-Newton observations, respectively; 1.8 and 0.9 Ms exposures remain after flare filtering. The survey in W-CDF-S has a flux limit of 1.0 × 10−14 erg cm−2 s−1 over 90% of its area in the 0.5–10 keV band; 4053 sources are detected in total. The survey in ELAIS-S1 has a flux limit of 1.3 × 10−14 erg cm−2 s−1 over 90% of its area in the 0.5–10 keV band; 2630 sources are detected in total. Reliable optical-to-IR multiwavelength counterpart candidates are identified for ≈89% of the sources in W-CDF-S and ≈87% of the sources in ELAIS-S1. A total of 3129 sources in W-CDF-S and 1957 sources in ELAIS-S1 are classified as active galactic nuclei (AGNs). We also provide photometric redshifts for X-ray sources; ≈84% of the 3319/2001 sources in W-CDF-S/ELAIS-S1 with optical-to-near-IR forced photometry available have either spectroscopic redshifts or high-quality photometric redshifts. The completion of the XMM-Newton observations in the W-CDF-S and ELAIS-S1 fields marks the end of the XMM-SERVS survey data gathering. The ≈12,000 pointlike X-ray sources detected in the whole ≈13 deg2 XMM-SERVS survey will benefit future large-sample AGN studies

The Chandra Deep Wide-field Survey: A New Chandra Legacy Survey in the Boötes Field. I. X-Ray Point Source Catalog, Number Counts, and Multiwavelength Counterparts

We present a new, ambitious survey performed with the Chandra X-ray Observatory of the 9.3 deg2 Boötes field of the NOAO Deep Wide-Field Survey. The wide field probes a statistically representative volume of the universe at high redshift. The Chandra Deep Wide-field Survey exploits the excellent sensitivity and angular resolution of Chandra over a wide area, combining 281 observations spanning 15 yr, for a total exposure time of 3.4 Ms, and detects 6891 X-ray point sources down to limiting fluxes of 4.7 × 10−16, 1.5 × 10−16, and 9 ×10−16 erg cm−2 s−1 in the 0.5–7, 0.5–2, and 2–7 keV bands, respectively. The robustness and reliability of the detection strategy are validated through extensive, state-of-the-art simulations of the whole field. Accurate number counts, in good agreement with previous X-ray surveys, are derived thanks to the uniquely large number of point sources detected, which resolve 65.0% ± 12.8% of the cosmic X-ray background between 0.5 and 2 keV and 81.0% ± 11.5% between 2 and 7 keV. Exploiting the wealth of multiwavelength data available on the field, we assign redshifts to ~94% of the X-ray sources, estimate their obscuration, and derive absorption-corrected luminosities. We provide an electronic catalog containing all of the relevant quantities needed for future investigations

Researching underwater: a submerged study

This chapter explores the unknown territory of a lost project: an ethnography of a public swimming pool. The discussion is contextualised within my broader sociological theory of ‘nothing’, as a category of unmarked, negative social phenomena, including no-things, no-bodies, no-wheres, non-events and non-identities. These meaningful symbolic objects are constituted through social interaction, which can take two forms: acts of commission and acts of omission. I tell the story of how this project did not happen, through the things I did not do or that did not materialise, and how I consequently did not become a certain type of researcher. I identify three types of negative phenomena that I did not observe and document – invisible figures, silent voices and empty vessels – and, consequently, the knowledge I did not acquire. However, nothing is also productive, generating new symbolic objects as substitutes, alternatives and replacements: the somethings, somebodies and somewheres that are done or made instead. Thus finally, I reflect on how not doing this project led me to pursue others, cultivating a different research identity that would not otherwise have existed

Increasing capacity for the treatment of common musculoskeletal problems: A non-inferiority RCT and economic analysis of corticosteroid injection for shoulder pain comparing a physiotherapist and orthopaedic surgeon

Background Role substitution is a strategy employed to assist health services manage the growing demand for musculoskeletal care. Corticosteroid injection is a common treatment in this population but the efficacy of its prescription and delivery by physiotherapists has not been established against orthopaedic standards. This paper investigates whether corticosteroid injection given by a physiotherapist for shoulder pain is as clinically and cost effective as that from an orthopaedic surgeon. Methods A double blind non-inferiority randomized controlled trial was conducted in an Australian public hospital orthopaedic outpatient service, from January 2013 to June 2014. Adults with a General Practitioner referral to Orthopaedics for shoulder pain received subacromial corticosteroid and local anaesthetic injection prescribed and delivered independently by a physiotherapist or a consultant orthopaedic surgeon. The main outcome measure was total Shoulder Pain and Disability Index (SPADI) score at baseline, six and 12 weeks, applying a non-inferiority margin of 15 points. Secondary outcomes tested for superiority included pain, shoulder movement, perceived improvement, adverse events, satisfaction, quality of life and costs. Results 278 participants were independently assessed by the physiotherapist and the orthopaedic surgeon, with 64 randomised (physiotherapist 33, orthopaedic surgeon 31). There were no significant differences in baseline characteristics between groups. Non-inferiority of injection by the physiotherapist was declared from total SPADI scores at 6 and 12 weeks (upper limit of the 95% one-sided confidence interval 13.34 and 7.17 at 6 and 12 weeks, respectively). There were no statistically significant differences between groups on any outcome measures at 6 or 12 weeks. From the perspective of the health funder, the physiotherapist was less expensive. Conclusions Corticosteroid injection for shoulder pain, provided by a suitably qualified physiotherapist is at least as clinically effective, and less expensive, compared with similar care delivered by an orthopaedic surgeon. Policy makers and service providers should consider implementing this model of care

T2 R8 NWP [Township 2 Range 8]

Plan of Township 2 Range 8, (26,279 acres) in Penobscot County as surveyed by James Sewall. Now known as Seboeis Plantation. Scale of 2 inches to 1 mile.https://digitalmaine.com/maps_penobscot_county/1117/thumbnail.jp