An investigation of functional MRI activation reproducibility

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Electroencephalographic correlates of spatial attention index the degree of online control in goal-directed reaching

Goal-directed reaches performed with limb vision (i.e., closed-loop: CL) are more accurate than their limb occluded (i.e., open-loop: OL) counterparts. This finding is frequently attributed to the use of online limb vision to effect trajectory amendments. Notably, however, the central planning of CL and OL reaches may also influence trajectory control. To that end, I examined the behavioural and event-related brain potentials (ERP) of reaches in a target perturbation paradigm wherein information regarding the nature of response (CL or OL) was provided prior to response cuing. CL reaches exhibited earlier and more effective trajectory amendments than OL reaches. Moreover, CL and OL reaches differed with regard to ERP components related to the allocation of visuospatial attention (i.e., the N1) and visuomotor integration (i.e., the P2). These results suggest that advanced knowledge related to the availability of online limb vision increases the visuospatial processing of the reaching limb and optimizes trajectory amendments

A case of Familial Mediterranean fever with vascular involvement

Introduction. Familial Mediterranean fever (FMF) is the most frequent autoinflammatory disease caused by mutations of MEFV gene encoding pyrin. Aim. To describe the evolution of FMF with a particular vascular involvement. Materials and methods. A case a patient of Druze descent. Results. A 17 y.o. male patient presents with pain and hemorrhagic rash of the left lower limb. The patient is considered to be sick from the age of 11: after playing football the child started developing pain in the left leg (soft tissue) and abdominal pain, fever (38-39°C), malaise for 1 month. The leg was inflamed for 3 months. X-ray showed bony abscess, for which the patient was given Amoxicillin for 3 months. After 5 months, the opposite leg got involved. In 2 weeks petechia developed on the lower limbs. The rash started on ankles and progressed upwards. Consequently, the child was diagnosed with small vessel vasculitis (IgA). The child was hospitalized and given corticosteroids 60 mg for 3 months. Genetic testing for FMF showed 2 mutations (FMF-V726A and FMF-E148Q). The child developed obesity, growth retardation from corticosteroid use. He continued having abdominal pain and fever twice a month while he was on colchicine 0.5 mg daily. The patient stopped having FMF attacks once he started canakinumab (a human antiIL-1β monoclonal antibody neutralizing IL-1β signaling – therefore preventing the acute inflammatory response following aberrant inflammasome assembly in pyrin mutations). Conclusions. FMF patients may develop vasculitis, IgA deposit being the most frequent one. FMF is a potentially debilitating disease with a poor response to conventionally used colchicine and corticosteroids. High doses of corticosteroids should be avoided in pediatric population. Biologic therapy should be prompted in severe cases as early as possible in the course of disease

ATOPİK DERMATİTLİ KÖPEKLERDE DERİNİN BİYOFİZİKSEL PARAMETRELERİNİN DEĞERLENDİRİLMESİ

Bu çalışmada atopik dermatitli köpeklerde meydana gelen deri lezyonlarının korneometri cihazı ile pH, hidrasyon, deri sıcaklığı, elastikiyet melanin profillerinin değerlendirilmesi amaçlandı. Araştırmamızın hayvan materyalini Adnan Menderes Üniversitesi Veteriner Fakültesi İç Hastalıkları Küçük Hayvan Kliniği’ne gelen 19’u atopik dermatitli, 10’u sağlıklı olmak üzere toplam 29 köpek oluşturdu. Deri lezyonları ile kliniğe getirilen köpeklerden Favrot Kriterlerinden 3 ya da daha fazlasına sahip olanlar atopik dermatit grubuna dahil edilerek, invitro alerji testi ile korneometrik analiz metodları uygulandı. Yapılan korneometrik analizlere göre atopili köpeklerde pH ölçümü (p=0,001), elastikiyet (p=0,003), deri sıcaklığı (p=0,031) ve melanin ölçümlerinin (p=0,014) sağlıklı kontrol grubuna göre istatistiksel açıdan önemli olduğu fark edildi. Yapılan korneometrik ve in-vitro alerji testlerinin gerek tanı gerek sağaltım metodlarının seçimi konusunda ileride yapılacak çalışmalara yol gösterebileceği düşünüldü.KABUL VE ONAY SAYFASI ................................................................................................... i TEŞEKKÜR ............................................................................................................................... ii İÇİNDEKİLER .......................................................................................................................... iii SİMGELER VE KISALTMALAR DİZİNİ .............................................................................. vi ŞEKİLLER DİZİNİ .................................................................................................................. vii RESİMLER DİZİNİ ................................................................................................................ viii TABLOLAR DİZİNİ ................................................................................................................. ix ÖZET .......................................................................................................................................... x ABSTRACT .............................................................................................................................. xi 1. GİRİŞ ...................................................................................................................................... 1 2. GENEL BİLGİLER ................................................................................................................ 3 2.1. Atopik Dermatit .................................................................................................................. 3 2.1.1.Genetik Yatkınlık .............................................................................................................. 4 2.1.2. Çevresel Şartlar ................................................................................................................. 6 2.3.2.Epidermal bariyer nedir? ................................................................................................... 7 2.3.3.Peki yanlış giden ne? ......................................................................................................... 8 2.3.4. Epidermal bariyer fonksiyonu .......................................................................................... 9 2.3.5. Cilt Bariyeri Anormallikleri ........................................................................................... 10 2.2. Atopik Dermatitin Patogenezisi ......................................................................................... 10 2.2.1. Alerjenlere Karşı IgE Oluşumu ...................................................................................... 11 2.2.2.Derinin İmmun Yanıtı ..................................................................................................... 13 2.2.3.Mikrobiyal kolonizasyonun rolü ..................................................................................... 15 2.3.Klinik Belirtiler ve Diagnoz ............................................................................................... 16 2.4.Tedavi ................................................................................................................................. 20 2.4.1.Akut Atopik Dermatit İçin Tedavi Seçenekleri ............................................................... 20 2.4.2. Kronik Atopik Dermatit İçin Tedavi Seçenekleri ........................................................... 26 2.5. Derinin Tanımı .................................................................................................................. 44 2.5.1. Derinin Yapısı ................................................................................................................. 44 2.5.2.Derinin fonksiyonları ....................................................................................................... 48 3. GEREÇ VE YÖNTEM ......................................................................................................... 49 3.1.Gereç ................................................................................................................................... 49 3.1.1.Hayvan Materyali ............................................................................................................ 49 3.2.Yöntem ............................................................................................................................... 49 3.2.1. Klinik tanıyı takiben yapılacak işlemler ......................................................................... 50 3.2.2. İstatistiksel Analizler ...................................................................................................... 50 3.2.3.Callegari Soft Plus Korneometrik Ölçüm Cihazı ............................................................ 51 3.2.3.1. Hidrasyon Analizi ve Ölçüm Prensibi ......................................................................... 52 3.2.3.2. Elastisite Analizi ve Ölçüm Prensibi ............................................................................. 53 3.2.3.3. Melanin Analizi ve Ölçüm Prensibi ............................................................................ 54 3.2.3.4. Sıcaklık Analizi ve Ölçüm Prensibi ............................................................................. 55 3.2.3.5. pH Analizi ve Ölçüm Prensibi ...................................................................................... 56 3.2.4. Hill’s Atopy İndeks ........................................................................................................ 57 3.2.5. CADESI 4 Şiddet Skalası ............................................................................................... 58 3.2.6. Polycheck Alerji Testi .................................................................................................... 63 4. BULGULAR ........................................................................................................................ 65 4.1. Demografik veriler ............................................................................................................ 65 4.2. Korneometrik analiz bulguları ........................................................................................... 80 5. TARTIŞMA .......................................................................................................................... 84 6. SONUÇ VE ÖNERİLER ...................................................................................................... 89 KAYNAKLAR ......................................................................................................................... 90 EK-1 ........................................................................................................................................ 112 ÖZGEÇMİŞ ............................................................................................................................ 11

Electrochemical study of modified glassy carbon electrode with polyaniline nanoparticles using cyclic voltammetry

ABSTRACT. The mechanical attachment method was used to modify the glass carbon electrode (GCE) with polyaniline nanoparticles (PANI NPs) to produce a new nanosensor (PAN NPs/GCE). Electrochemical properties was studied by a new nano working electrode using cyclic voltammetric (CV) technique to develop the oxidation – reduction reaction. K4[Fe(CN)6] solution is one of the standard solutions for CV titration by redox peak current of FeII/FeIII in KCl solution as electrolyte, which can be used to study different concentrations, scan rates, pH, diffusion coefficient (Df) and reliability and stability PAN NPs/GCE modified electrode. The CV results of the new PANI NPs/GCE nanosensor have two peaks at 400 and 200 mV for oxidation-reduction FeII/FeIII, respectively. The current ratio value of the new PAN NPs/GCE was found to be Ipa/Ipc ≈ 1 with a separation peak of ∆Epa-pc = 200 mV. From these results, the nanosensor acts as an irreversible and heterogeneous reaction. Other electrochemical properties of the new sensor have a low detection limit of K4[Fe(CN)6]. In addition to the highly enhancement of the redox peak current in acidic pH, it was obtained good stability of nanomaterial on the electrode.   KEY WORDS: Polyaniline nanoparticles, GCE, K4[Fe(CN)6], Redox process, Cyclic voltammetry Bull. Chem. Soc. Ethiop. 2022, 36(3), 687-696.                                                                DOI: https://dx.doi.org/10.4314/bcse.v36i3.17                                                   &nbsp

Dynamic Co-movement and Integration of Stock Markets Between Hong Kong and Its Top Trading Partners

本文主要研究动态运动建模和香港股市及其主要贸易伙伴之间的相互依存性（中国大陆地区，德国，印度，日本，韩国，新加坡，台湾和美国）。采用月度数据股票的市场价格从1992年12月至2013年1月。总共分为四个阶段：亚洲金融危机前夕，亚洲金融危机期间，介于亚洲金融危机期间之后和全球金融危机之前，全球金融危机。实施的研究方法包括Johansen协整检验，Granger因果关系测试和随时间变化的系数回归分析。该方法分为两部分，第一部分是股票的市场价格，而第二部分是股票的市场回报。 在第一部分中，我们将探讨香港股票的市场价格和其主要贸易伙伴之间的联系和相互依存。在亚洲金融危机之前，香港及其他股市之间的相关...This paper investigates the dynamic co-movement and interdependency between Hong Kong stock markets and its top trading partners (Main land China, Germany, India, Japan, Korea, Singapore, Taiwan and USA). Monthly data on stock market price from December 1992 through January 2013 are employed. The aggregate period is divided into four sub-periods; before the Asian financial crisis, during Asian fin...学位：经济学硕士院系专业：王亚南经济研究院_金融学(含保险学)学号：2772011115438

Assessment of water pollution by a rapid microbiological test

No abstract available

MAJOR COMPONENTS OF “TYPICAL VILLA” IN SAUDI ARABIA FOR PRICE/COST INDEX DEVELOPMENT

In spite of being the second largest industry after oil industry, the Saudi construction industry lacks the availability of proper information about its products and operations. One of the missing crucial information is this related to construction price and cost indexes for the different construction products (housing, highway, school, etc). The development of such indexes necessitates the identification of basic elements or components that need to be included in the index basket. Ingredients of villas as housing units are the elements needed for developing a housing index. This study identifies and defines the components of “The Typical Villa.” The files of 200 villas that were built in the Dhahran area in the last five years were obtained from the archives of the Dhahran Municipality. These files were inspected to determine the most common building systems used in villas. This study was able to identify and define the major components of “The Typical Villa”. The findings of this study set the first stone for developing a housing (residential villa) price/cost index. In addition, the study results will be of great interest to many architects, contractors, and suppliers. This work belongs to the Engineering Profession and its Practice in Saudi Arabia: Role of professional societies; local and international societies; challenges and problems; codes and ethics

Comparative Study Between Air-Cooled and Water-Cooled Condensers of the Air-Conditioning Systems

The weather in Kuwait is very dry where the dry-bulb temperature exceeds the wet-bulb temperature more than 20oC in most of the summer months. Thus, the air-conditioning (A/C) system with the water-cooled (WC) condensers is expected to perform more efficiently than with the air-cooled (AC) condensers. This fact was behind the idea of a field study conducted in one of the major hospital in Kuwait during a summer season to investigate the performance of WC and AC systems in terms of peak power and energy consumptions. The cooling capacities for WC and AC systems were 373 and 278 tons-of- refrigeration, respectively. It was found that for the same cooling production, the peak power demand and the daily energy consumption of the WC system were 45 and 32% less than that of the AC system, respectively. The maximum reduction in the power demand coincided with the peak power demand period of the utilities i.e. between 14:00 and 17:00 hr, thereby offering a maximum advantage of peak power saving