Театральний фестиваль аматорських колективів «Блакитна троянда»

3-4 квітня 2009 року в Луцьку відбувся театральний фестиваль аматорських колективів «Блакитна троянда». Організатори – Луцька міська рада, Волинський національний університет імені Лесі Українки та театр-студія «Гармидер»

Employees’ emotional, cognitive, and behavioral responses to increasing statutory retirement ages

Increasing statutory retirement ages around the world are forcing employees to prolong their working lives. We study the different ways in which mid- and late-career workers respond to such changes. We distinguish between negative emotions about working longer, cognitive engagement with prolonged employment, and proactive behavior to facilitate longer working lives. We analyze data from 1,351 employees aged 40-66 from the Netherlands. We estimate a structural equation model to identify in which ways experiences of age discrimination, accessibility of accommodative HR facilities, and social norms in the workers’ social networks are related to the three different types of responses. Results show that when employees do not experience age discrimination, when their employer offers easily accessible accommodative HR facilities, and the social norms support prolonged employment, employees have fewer negative emotional reactions and are more likely to behaviorally respond to facilitate longer working lives. When these contexts are misaligned, the reverse is generally found. We also find socioeconomic differences in the ways employees respond to the prospect of prolonged employment. This study shows the importance of supportive contexts at different levels—societally, in organizations, and in individuals’ own lives—for policy changes such as increasing statutory retirement ages to be effective. Different responses between different socioeconomic groups may lead to growing long-term inequalit

A comparative study of three indices of umbilical blood flow in relation to prediction of growth retardation

Peer Reviewe

Targeted Therapies for Renal Cell Carcinoma: Review of Adverse Event Management Strategies

With the advent of targeted agents for the treatment of renal cell carcinoma (RCC), overall survival has improved, and patients are being treated continuously for increasingly long periods of time. This has raised challenges in the management of adverse events (AEs) associated with the six targeted agents approved in RCC—sorafenib, sunitinib, pazopanib, bevacizumab (in combination with interferon alpha), temsirolimus, and everolimus. Suggestions for monitoring and managing AEs have been published, but there are few consensus recommendations. In addition, there is a risk that patients will be subjected to multiple unnecessary investigations. In this review, we aimed to identify the level of supporting evidence for suggested AE management strategies to provide practical guidance on essential monitoring and management that should be undertaken when using targeted agents. Five databases were systematically searched for relevant English language articles (including American Society of Clinical Oncology abstracts) published between January 2007 and March 2011; European Society of Medical Oncology congress abstracts were hand searched. Strategies for AE management were summarized and categorized according to the level of recommendation. A total of 107 articles were identified that describe a large number of different investigations for monitoring AEs and interventions for AE management. We identify and summarize clear recommendations for the management of dermatologic, gastrointestinal, thyroid, cardiovascular, and other AEs, based predominantly on expert opinion. However, because the evidence for the suggested management strategies is largely anecdotal, there is a need for further systematic investigation of management strategies for AEs related to targeted therapies for RC

De steun voor een ‘zwareberoepenregeling’ ontleed:Hoe kijkt de Nederlandse bevolking aan tegen lagere pensioenleeftijden voor mensen in zware beroepen?

Het pensioenakkoord biedt mogelijkheden om afspraken te maken over lagere pensioenleeftijden voor mensen in zware beroepen. Onderzoek wijst uit dat burgers vinden dat voor fysiek zware beroepen lagere pensioenleeftijden moeten gelden dan de officiële AOW-leeftijd. Voor sommige zware beroepen kan dit oplopen tot anderhalf jaar. Voor een aantal lichte beroepen zou een beperkt hogere AOW- leeftijd moeten gelden (van een half jaar). Chronische gezondheidsklachten vormen de belangrijkste reden om mensen vervroegd (een jaar eerder) te laten uittreden

Wanneer ben je te oud om te werken?

Oudere werkzoekenden hebben het moeilijk op de arbeidsmarkt. Helpen verschuivende sociale normen over wie (te) oud is om de kansen van ouderen op de arbeidsmarkt te vergroten

Trichinella pseudospiralis in a wolverine (Gulo gulo) from the Canadian North

Species of Trichinella are a globally distributed assemblage of nematodes, often with distinct host ranges, which include people, domestic, and wild animals. Trichinella spp. are important in northern Canada, where dietary habits of people and methods of meat preparation (drying, smoking, fermenting as well as raw) increase the risk posed by these foodborne zoonotic parasites. Outbreaks in the arctic and subarctic regions of Canada and the United States are generally attributed to T. nativa (T2) or the T6 genotype, when genetic characterization is performed. We report the discovery of Trichinella pseudospiralis (T4), a non-encapsulated species, in a wolverine (Gulo gulo) from the Northwest Territories of Canada. This parasite has been previously reported elsewhere from both mammals and carnivorous birds, but our findings represent new host and geographic records for T. pseu- dospiralis. Multiplex PCR and sequencing of fragments of Cytochrome Oxidase Subunit I (COI) and D3 rDNA confirmed the identification. Phylogenetically, Canadian isolates linked with each other and others derived from Palearctic or Neotropical regions, but not elsewhere in the Nearctic (continental USA). We suggest that mi- gratory birds might have played a role in the dispersal of this pathogen 1000\u27s of km to northwestern Canada. Wolverines are not typically consumed by humans, and thus should not pose a direct food safety risk for tri- chinellosis. However, the current finding suggests that they may serve as an indicator of a broader distribution for T. pseudospiralis. Along with infection risk already recognized for T. nativa and Trichinella T6, our observa- tions emphasize the need for further studies using molecular diagnostics and alternative methods to clarify if this is a solitary case, or if T. pseudospiralis and other freeze susceptible species of Trichinella (such as T. spiralis) circulate more broadly in wildlife in Canada, and elsewhere

Reliability and Efficiency of the CAPRI-3 Metastatic Prostate Cancer Registry Driven by Artificial Intelligence

Background: Manual data collection is still the gold standard for disease-specific patient registries. However, CAPRI-3 uses text mining (an artificial intelligence (AI) technology) for patient identification and data collection. The aim of this study is to demonstrate the reliability and efficiency of this AI-driven approach. Methods: CAPRI-3 is an observational retrospective multicenter cohort registry on metastatic prostate cancer. We tested the patient-identification algorithm and automated data extraction through manual validation of the same patients in two pilots in 2019 and 2022. Results: Pilot one identified 2030 patients and pilot two 9464 patients. The negative predictive value of the algorithm was maximized to prevent false exclusions and reached 94.8%. The completeness and accuracy of the automated data extraction were 92.3% or higher, except for date fields and inaccessible data (images/pdf) (10–88.9%). Additional manual quality control took over 3 h less time per patient than the original fully manual CAPRI registry (105 vs. 300 min). Conclusions: The CAPRI-3 patient-identification algorithm is a sound replacement for excluding ineligible candidates. The AI-driven data extraction is largely accurate and complete, but manual quality control is needed for less reliable and inaccessible data. Overall, the AI-driven approach of the CAPRI-3 registry is reliable and timesaving.</p

Production of cascade hypernuclei via the (K-,K+) reaction within a quark-meson coupling model

We study the production of bound cascade hypernuclei via the (K-,K+) reaction on 12C and 28Si targets within a covariant effective Lagrangian model, employing the cascade bound state spinors derived from the latest quark-meson coupling model as well as Dirac single particle wave functions. The K+-cascade production vertex is described by excitation, propagation and decay of Lambda and Sigma resonance states in the initial collision of a K- meson with a target proton in the incident channel. The parameters of the resonance vertices are fixed by describing the available data on total and differential cross sections for the cascade production in elementary (K-,K+) reaction. We find that both the elementary and hypernuclear production cross sections are dominated by the contributions from the Lambda(1520) intermediate resonant state. The 0 degree differential cross sections for the formation of simple s-state cascade particle-hole states peak at a beam momentum around 1.0 GeV/c, with a value in excess of 1 mub.Comment: 17 pages, 8 figures, version accepted for publication in Nucl. Phys.