Epilepsy and Psychiatric Comorbidities: Drug Selection.

Purpose of review The pharmacological treatment of patients with epilepsy and psychiatric comorbidities may sometimes represent a therapeutic challenge. This review is focused on the pharmacological management of patients with epilepsy and psychiatric problems in terms of rationalization of the antiepileptic drug (AED) treatment and the pharmacological management of the most clinically relevant psychiatric comorbidities, namely mood and anxiety disorders, psychoses, and attention deficit hyperactivity disorder (ADHD). Recent findings Up to 8% of patients with drug-resistant epilepsy develop treatment-emergent psychiatric adverse events of AED regardless of the mechanism of action of the drug and this is usually related to an underlying predisposition given by the previous psychiatric history and the involvement of mesolimbic structures. Careful history taking, periodic screening for mood and anxiety disorders, low starting doses, and slow titration schedules can reduce the possibility of AED-related problems. A pragmatic checklist for the pharmacological management of patients with epilepsy and psychiatric disorders is presented. Summary patients should be informed of potential behavioral effects of AEDs but no drugs should be excluded a priori. Any psychiatric comorbidity should be addressed in the appropriate setting and full remission and recovery should always represent the first goal of any therapeutic intervention. Neurologists should be aware of the side effects of major psychotropic drug classes in order to fully counsel their patients and other health professionals involved

Frecuencia cardiaca, formas de organización y situaciones de juego en baloncesto

Introduction: The purpose of this study was to find out the effect of task organization and different game situations on intensity and of repetitions in basketball. Method: A quasi-experimental design with twelve players group of 12, 4 ± 0, 7 years-old average was done. Three training sessions about lay-up was realized. The independent variables were task organization and different game situations. The dependent variables were heart rate and number of repetitions, and player´s perception about intensity and work. Results: a) statistically significant differences in heart rate between the status of 1x0 and 2x2 (p =. 014), and trends towards significance between the situation of game 1x0 and 3x3 (p =. 065), b) were statistically significant differences in heart rate between the situation frequents gaming 1x0 circuit on the rows (p =. 027) and forms involving simultaneous moves (p =. 000), and the game situation 1x1 between rows with respect to the ways games with simultaneous participation (p =. 014); c) The effect of the interaction between the game situation factor and type of organization was statistically significant (F6, 42 = 9,256, p =. 000 ). Are statistically significant differences in the number of operations performed by the players on the combination of the four game situations and the three types of organization. Conclusions: a) The groups in circuits had a greater number of repetitions and intensity perceived, b) the groups in games through forms showed greater heart rate and more repetitions, and c) the group in rows presented no value to excel regard to the task structure. From the collected data, it is deduced that depending on which are the objectives of the sports abilities, will be more useful adapted to use a type of organization or another one.Introducción: El presente trabajo analiza la influencia de diferentes formas de organización y situaciones de juego sobre la intensidad y el número de intervenciones en baloncesto. Método: Se realizó un diseño cuasi-experimental, con 12 jugadores de edad 12,4 ± 0,7, años. Se realizaron tres sesiones de intervención sobre el lanzamiento a canasta en carrera (entrada a canasta). Las variables independientes fueron la forma de organización y las diferentes situaciones de juego. Las variables dependientes fueron la frecuencia cardiaca media, el número de intervenciones de lanzamientos, y la percepción de la intensidad de trabajo de los jugadores. Resultados: a) se observan diferencias estadísticamente significativas en frecuencia cardiaca entre la situación de 1x0 y la de 2x2 (p=.014), y tendencias a la significación entre la situación de juego de 1x0 y la de 3x3 (p=.065), b) Se aprecian diferencias estadísticamente significativas en frecuenta cardiaca entre la situación de juego de 1x0 en circuito con respecto a las filas (p=.027) y las formas jugadas con participación simultanea (p=.000), y en la situación de juego de 1x1 entre filas con respecto a las formas jugadas con participación simultanea (p=.014); c) El efecto de la interacción entre el factor situación de juego y tipo de organización fue estadísticamente significativo (F6,42 = 9.256, p=.000). Se aprecian diferencias estadísticamente significativas en el número de intervenciones realizadas por los jugadores en la combinación de las cuatro situaciones de juego y los tres tipos de organización. Conclusiones: a) La organización grupal con participación simultánea mediante circuitos presentó mayor número de intervenciones e intensidad percibida; b) la organización grupal con participación simultánea mediante formas jugadas con participación simultanea mostró mayor frecuencia cardiaca y más intervenciones; y c) la organización grupal con participación alternativa mediante filas no presentó ningún valor que sobresalga respecto a las formas de organización. A partir de los datos obtenidos, se deduce que dependiendo de cuáles sean los objetivos de la habilidad deportiva, será más adecuado utilizar un tipo de organización u otro

The Mediational Role of Desire for Cultural Tightness on Concern With COVID-19 and Perceived Self-Control

When ecological threats are more severe or prevalent, societies are more likely to tighten their social norms and punishments. Moreover, when people follow clear and tight rules, they are more prone to regulate their behavior (i.e., self-control) in order to avoid punishment. Therefore, we examined the mediating role of people’s endorsement of cultural tightness (i.e., support and desire) on the relationship between concern with COVID-19 threat and personal self-control. Our hypothesis was tested through a mediation model in two studies with a sample of (N=315, 77.1% females, Mage=23.71) university students (Study 1) and with a heterogeneous sample of (N=239, 65.7% females, Mage=36.55) participants (Study 2). Empirical support for the proposed model was found in both studies. Implications of this research will be discussed. The main implication is related to the possibility that people’s desire for strong norms to cope with the COVID-19 threat could promote greater self-regulated preventive behavior in order to protect their health

Accounting Information Systems [1st Australasian edition]

At last – the Australasian edition of Romney and Steinbart's respected AIS text! Accounting Information Systems first Australasian edition offers the most comprehensive and student-friendly coverage of Accounting Information Systems in Australia, New Zealand and Asia. Accounting Information Systems has been extensively revised and updated to incorporate local laws, standards and business practices. The text has a new and flexible structure developed especially for Australasian AIS courses, while also retaining the features that make the US edition easy to use. Important concepts such as systems cycles, controls, auditing, fraud and cybercrime, ethics and the REA data model are brought to life by a wide variety of Australasian case studies and examples. With a learning and teaching resource package second to none, this is the perfect resource for one-semester undergraduate and graduate courses in Accounting Information Systems

A reference architecture for the collaborative planning modelling process in multi-tier supply chain networks: a Zachman-based approach

A prominent and contemporary challenge for supply chain (SC) managers concerns the coordination of the efforts of the nodes of the SC in order to mitigate unpredictable market behaviour and satisfy variable customer demand. A productive response to this challenge is to share pertinent market-related information, on a timely basis, in order to effectively manage the decision-making associated with the SC production and transportation planning processes. This paper analyses the most well-known reference modelling languages and frameworks in the collaborative SC field and proposes a novel reference architecture, based upon the Zachman Framework (ZF), for supporting collaborative plan- ning (CP) in multi-level, SC networks. The architecture is applied to an automotive supply chain configuration, where, under a collaborative and decentralised approach, improvements in the service levels for each node were observed. The architecture was shown to provide the base discipline for the organisation of the processes required to manage the CP activity.The authors thanks the support from the project 'Operations Design and Management in Global Supply Chains (GLOBOP)' (Ref. DPI2012-38061-C02-01), funded by the Ministry of Science and Education of Spain, for the supply chain environment research contribution.Hernández Hormazábal, JE.; Lyons, AC.; Poler, R.; Mula, J.; Goncalves, R. (2014). A reference architecture for the collaborative planning modelling process in multi-tier supply chain networks: a Zachman-based approach. Production Planning and Control. 25(13-14):1118-1134. https://doi.org/10.1080/09537287.2013.808842S111811342513-14Al-Mutawah, K., Lee, V., & Cheung, Y. (2008). A new multi-agent system framework for tacit knowledge management in manufacturing supply chains. Journal of Intelligent Manufacturing, 20(5), 593-610. doi:10.1007/s10845-008-0142-0Baïna, S., Panetto, H., & Morel, G. (2009). New paradigms for a product oriented modelling: Case study for traceability. Computers in Industry, 60(3), 172-183. doi:10.1016/j.compind.2008.12.004Berasategi, L., Arana, J., & Castellano, E. (2011). A comprehensive framework for collaborative networked innovation. Production Planning & Control, 22(5-6), 581-593. doi:10.1080/09537287.2010.536628Chan, H. K., & Chan, F. T. S. (2009). A review of coordination studies in the context of supply chain dynamics. International Journal of Production Research, 48(10), 2793-2819. doi:10.1080/00207540902791843Chen, D., Doumeingts, G., & Vernadat, F. (2008). Architectures for enterprise integration and interoperability: Past, present and future. Computers in Industry, 59(7), 647-659. doi:10.1016/j.compind.2007.12.016Choi, Y., Kang, D., Chae, H., & Kim, K. (2006). An enterprise architecture framework for collaboration of virtual enterprise chains. The International Journal of Advanced Manufacturing Technology, 35(11-12), 1065-1078. doi:10.1007/s00170-006-0789-7Choi, Y., Kim, K., & Kim, C. (2005). A design chain collaboration framework using reference models. The International Journal of Advanced Manufacturing Technology, 26(1-2), 183-190. doi:10.1007/s00170-004-2262-9COLQUHOUN, G. J., BAINES, R. W., & CROSSLEY, R. (1993). A state of the art review of IDEFO. International Journal of Computer Integrated Manufacturing, 6(4), 252-264. doi:10.1080/09511929308944576Danilovic, M., & Winroth, M. (2005). A tentative framework for analyzing integration in collaborative manufacturing network settings: a case study. Journal of Engineering and Technology Management, 22(1-2), 141-158. doi:10.1016/j.jengtecman.2004.11.008Derrouiche, R., Neubert, G., Bouras, A., & Savino, M. (2010). B2B relationship management: a framework to explore the impact of collaboration. Production Planning & Control, 21(6), 528-546. doi:10.1080/09537287.2010.488932Dudek, G., & Stadtler, H. (2005). Negotiation-based collaborative planning between supply chains partners. European Journal of Operational Research, 163(3), 668-687. doi:10.1016/j.ejor.2004.01.014Gruat La Forme, F.-A., Genoulaz, V. B., & Campagne, J.-P. (2007). A framework to analyse collaborative performance. Computers in Industry, 58(7), 687-697. doi:10.1016/j.compind.2007.05.007Gutiérrez Vela, F. L., Isla Montes, J. L., Paderewski Rodríguez, P., Sánchez Román, M., & Jiménez Valverde, B. (2007). An architecture for access control management in collaborative enterprise systems based on organization models. Science of Computer Programming, 66(1), 44-59. doi:10.1016/j.scico.2006.10.005Hernández, J. E., Poler, R., Mula, J., & Lario, F. C. (2010). The Reverse Logistic Process of an Automobile Supply Chain Network Supported by a Collaborative Decision-Making Model. Group Decision and Negotiation, 20(1), 79-114. doi:10.1007/s10726-010-9205-7Hernández, J. E., J. Mula, R. Poler, and A. C. Lyons. 2013. “Collaborative Planning in Multi-Tier Supply Chains Supported by a Negotiation-Based Mechanism and Multi-Agent System.”Group Decision and Negotiation Journal. doi:10.1007/s10726-013-9358-2.Jardim-Goncalves, R., Grilo, A., Agostinho, C., Lampathaki, F., & Charalabidis, Y. (2013). Systematisation of Interoperability Body of Knowledge: the foundation for Enterprise Interoperability as a science. Enterprise Information Systems, 7(1), 7-32. doi:10.1080/17517575.2012.684401Kampstra, R. P., Ashayeri, J., & Gattorna, J. L. (2006). Realities of supply chain collaboration. The International Journal of Logistics Management, 17(3), 312-330. doi:10.1108/09574090610717509Kim, W., Chung, M. J., Qureshi, K., & Choi, Y. K. (2006). WSCPC: An architecture using semantic web services for collaborative product commerce. Computers in Industry, 57(8-9), 787-796. doi:10.1016/j.compind.2006.04.007Ku, K.-C., Kao, H.-P., & Gurumurthy, C. K. (2007). Virtual inter-firm collaborative framework—An IC foundry merger/acquisition project. Technovation, 27(6-7), 388-401. doi:10.1016/j.technovation.2007.02.010LEE, J., GRUNINGER, M., JIN, Y., MALONE, T., TATE, A., YOST, G., & OTHER MEMBERS OF THE PIF WORKING GROUP. (1998). The Process Interchange Format and Framework. The Knowledge Engineering Review, 13(1), 91-120. doi:10.1017/s0269888998001015Lee, J., Chae, H., Kim, C.-H., & Kim, K. (2009). Design of product ontology architecture for collaborative enterprises. Expert Systems with Applications, 36(2), 2300-2309. doi:10.1016/j.eswa.2007.12.042Liu, J., Zhang, S., & Hu, J. (2005). A case study of an inter-enterprise workflow-supported supply chain management system. Information & Management, 42(3), 441-454. doi:10.1016/j.im.2004.01.010Marques, D. M. N., & Guerrini, F. M. (2011). Reference model for implementing an MRP system in a highly diverse component and seasonal lean production environment. Production Planning & Control, 23(8), 609-623. doi:10.1080/09537287.2011.572469Mula, J., Peidro, D., & Poler, R. (2010). The effectiveness of a fuzzy mathematical programming approach for supply chain production planning with fuzzy demand. International Journal of Production Economics, 128(1), 136-143. doi:10.1016/j.ijpe.2010.06.007Murata, T. (1989). Petri nets: Properties, analysis and applications. Proceedings of the IEEE, 77(4), 541-580. doi:10.1109/5.24143Noran, O. (2003). An analysis of the Zachman framework for enterprise architecture from the GERAM perspective. Annual Reviews in Control, 27(2), 163-183. doi:10.1016/j.arcontrol.2003.09.002Olorunniwo, F. O., & Li, X. (2010). Information sharing and collaboration practices in reverse logistics. Supply Chain Management: An International Journal, 15(6), 454-462. doi:10.1108/13598541011080437Recker, J., Rosemann, M., Indulska, M., … Green, P. (2009). Business Process Modeling- A Comparative Analysis. Journal of the Association for Information Systems, 10(04), 333-363. doi:10.17705/1jais.00193Rodriguez, K., & Al-Ashaab, A. (2005). Knowledge web-based system architecture for collaborative product development. Computers in Industry, 56(1), 125-140. doi:10.1016/j.compind.2004.07.004Romero, F., Company, P., Agost, M.-J., & Vila, C. (2008). Activity modelling in a collaborative ceramic tile design chain: an enhanced IDEF0 approach. Research in Engineering Design, 19(1), 1-20. doi:10.1007/s00163-007-0040-zSandberg, E. (2007). Logistics collaboration in supply chains: practice vs. theory. The International Journal of Logistics Management, 18(2), 274-293. doi:10.1108/09574090710816977Spekman, R. E., & Carraway, R. (2006). Making the transition to collaborative buyer–seller relationships: An emerging framework. Industrial Marketing Management, 35(1), 10-19. doi:10.1016/j.indmarman.2005.07.002Stevens, W. P., Myers, G. J., & Constantine, L. L. (1974). Structured design. IBM Systems Journal, 13(2), 115-139. doi:10.1147/sj.132.0115Ulieru, M. (2000). A multi-resolution collaborative architecture for web-centric global manufacturing. Information Sciences, 127(1-2), 3-21. doi:10.1016/s0020-0255(00)00026-8Van der Aalst, W. M. P. (1999). Formalization and verification of event-driven process chains. Information and Software Technology, 41(10), 639-650. doi:10.1016/s0950-5849(99)00016-6Zachman, J. A. (1987). A framework for information systems architecture. IBM Systems Journal, 26(3), 276-292. doi:10.1147/sj.263.0276Zapp, M., Forster, C., Verl, A., & Bauernhansl, T. (2012). A Reference Model for Collaborative Capacity Planning Between Automotive and Semiconductor Industry. Procedia CIRP, 3, 155-160. doi:10.1016/j.procir.2012.07.028Zeng, Y., Wang, L., Deng, X., Cao, X., & Khundker, N. (2012). Secure collaboration in global design and supply chain environment: Problem analysis and literature review. Computers in Industry, 63(6), 545-556. doi:10.1016/j.compind.2012.05.00

Ergotropy and entanglement in critical spin chains

A subsystem of an entangled ground state is in a mixed state. Thus, if we isolate this subsystem from its surroundings we may be able to extract work applying unitary transformations, up to a maximal amount which is called ergotropy. Once this work has been extracted, the subsystem will still contain some bound energy above its local ground state, which can provide valuable information about the entanglement structure. We show that the bound energy for half a free fermionic chain decays as the square of the entanglement entropy divided by the chain length, thus approaching zero for large system sizes, and we conjecture that this relation holds for all 1D critical states

Chickpea (Garbanzos): An emerging crop for the rainfed and dryland areas of the Philippines.Information Bulletin No. 88

This information bulletin contains brief information on the characteristic, cultural management, and market requirements of the crop. The science-based knowledge highlighted in this publication speaks of the bright prospect and great potential of chickpea as a climate-change ready, profitable and nutritious crop in the country. The bulletin also outlines the way forward for the promotion as well as for the eventual commercial production of chickpea in the Philippines. We hope you find this publication useful and meaningful in boosting chickpea production in the country

Pearl millet as a postrainy cool season crop: case studies from Gujarat and Maharashtra, India

Case studies of winter season (rabi) pearl millet cultivation conducted in 2007–09 in Junagadh, Gujarat, and Jalgaon, Maharashtra states of India showed increasing interest of farmers in this cropping system because of the importance of the crop in sustaining farmers’ household requirements of nutritious food and fodder. A major constraint faced by farmers in these areas is the changing growing conditions such as low temperature of 10–15°C, which reduces plant growth, delays maturity, and leads to a reduced biomass yield. The existence of genetic variation for this trait can effectively address this issue. The farmers’ practice of adjusting sowing time largely overcomes the problem of poor seed setting at low temperature. However, genetic improvement of this trait is needed to allow flexible sowing time. Employing other cultural management practices, such as crop rotation juxtaposed with the adherence to a cropping calendar of pearl millet, yields economic benefits to farmers. Results showed that winter season pearl millet cultivation resulted in a benefit-cost ratio of 3.62 in Junagadh and 3.12 in Jalgaon. These attributes of pearl millet combined with high water-use efficiency under water limiting environments make it a potential replacement crop in the global scenario of climate change with bright prospect for developing hybrids suited to winter season environments

Seasonal variation of antiretroviral drug exposure during the year: The experience of 10 years of therapeutic drug monitoring

Although studies show an annual trend for immunosuppressive drugs, particularly during different seasons, no data are available for antiretroviral drugs exposures in different periods of the year. For this reason, the aim of this study was to investigate an association between seasonality and antiretroviral drugs plasma concentrations. Antiretroviral drugs exposures were measured with liquid chromatography validated methods. A total of 4148 human samples were analysed. Lopinavir, etravirine and maraviroc levels showed seasonal fluctuation. In detail, maraviroc and etravirine concentrations decreased further in summer than in winter. In contrast, lopinavir concentrations had an opposite trend, increasing more in summer than in winter. The etravirine efficacy cut-off value of 300 ng/mL seems to be affected by seasonality: 77.1% and 22.9% of samples achieved this therapeutic target, respectively, in winter and summer, whereas 30% in winter and 70% in summer did not reach this value. Finally, age over 50 years and summer remained in the final multivariate regression model as predictors of the etravirine efficacy cut-off. This study highlights the seasonal variation in antiretroviral drugs plasma concentrations during the year, leading to a better understanding of inter-individual variability in drug exposures. Studies are required in order to confirm these data, clarifying which aspects may be involved