1,242 research outputs found
A Randomized Depression Prevention Trial Comparing Interpersonal Psychotherapy—Adolescent Skills Training To Group Counseling In Schools
Given the rise in depression disorders in adolescence, it is important to develop and study depression prevention programs for this age group. The current study examined the efficacy of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), a group prevention program for adolescent depression, in comparison to group programs that are typically delivered in school settings. In this indicated prevention trial, 186 adolescents with elevated depression symptoms were randomized to receive IPT-AST delivered by research staff or group counseling (GC) delivered by school counselors. Hierarchical linear modeling examined differences in rates of change in depressive symptoms and overall functioning from baseline to the 6-month follow-up assessment. Cox regression compared rates of depression diagnoses. Adolescents in IPT-AST showed significantly greater improvements in self-reported depressive symptoms and evaluator-rated overall functioning than GC adolescents from baseline to the 6-month follow-up. However, there were no significant differences between the two conditions in onset of depression diagnoses. Although both intervention conditions demonstrated significant improvements in depressive symptoms and overall functioning, results indicate that IPT-AST has modest benefits over groups run by school counselors which were matched on frequency and duration of sessions. In particular, IPT-AST outperformed GC in reduction of depressive symptoms and improvements in overall functioning. These findings point to the clinical utility of this depression prevention program, at least in the short-term. Additional follow-up is needed to determine the long-term effects of IPT-AST, relative to GC, particularly in preventing depression onset
A Novel Use of Light Guides and Wavelength Shifting Plates for the Detection of Scintillation Photons in Large Liquid Argon Detectors
Scintillation light generated as charged particles traverse large liquid
argon detectors adds valuable information to studies of weakly-interacting
particles. This paper uses both laboratory measurements and cosmic ray data
from the Blanche dewar facility at Fermilab to characterize the efficiency of
the photon detector technology developed at Indiana University for the single
phase far detector of DUNE. The efficiency of this technology was found to be
0.48% at the readout end when the detector components were characterized with
laboratory measurements. A second determination of the efficiency using cosmic
ray tracks is in reasonable agreement with the laboratory determination. The
agreement of these two efficiency determinations supports the result that
minimum ionizing muons generate photons/MeV as
they cross the LAr volume.Comment: Accepted version (without final editorial corrections
Metabolic reprogramming of the immune response in the tumor microenvironment
A Division of Cancer Biology, NCI sponsored workshop, Metabolic Reprogramming of the Immune Response in the Tumor Microenvironment, was held October 2nd in Bethesda, MD. The purpose of the workshop was to bring together cancer cell biologists and immunologists to explore the mechanistic relationships between the metabolic pathways used by cancer cells and anti-tumor immune cells and how this information could be used to improve cancer immunotherapy. At the conclusion of the workshop a general discussion focused on defining the major challenges and opportunities concerning the impact of metabolism on anti-tumor immunity and cancer immunotherapy as well as what tools, technologies, resources or community efforts are required to accelerate research in this area. Overall, future studies need to consider how cancer cell metabolic pathways differ from activated lymphocytes in order to define a therapeutic window for cancer therapy. Further, studies aimed at reprogramming the metabolic qualities of T cells with the goal of improving immunotherapy were considered a promising avenue
Time Domain Explorations With Digital Sky Surveys
One of the new frontiers of astronomical research is the exploration of time
variability on the sky at different wavelengths and flux levels. We have
carried out a pilot project using DPOSS data to study strong variables and
transients, and are now extending it to the new Palomar-QUEST synoptic sky
survey. We report on our early findings and outline the methodology to be
implemented in preparation for a real-time transient detection pipeline. In
addition to large numbers of known types of highly variable sources (e.g., SNe,
CVs, OVV QSOs, etc.), we expect to find numerous transients whose nature may be
established by a rapid follow-up. Whereas we will make all detected variables
publicly available through the web, we anticipate that email alerts would be
issued in the real time for a subset of events deemed to be the most
interesting. This real-time process entails many challenges, in an effort to
maintain a high completeness while keeping the contamination low. We will
utilize distributed Grid services developed by the GRIST project, and implement
a variety of advanced statistical and machine learning techniques.Comment: 5 pages, 2 postscript figures, uses adassconf.sty. To be published
in: "ADASS XIV (2004)", Eds. Patrick Shopbell, Matthew Britton and Rick
Ebert, ASP Conference Serie
Can charcoal improve outcomes in COVID-19 infections?
COVID-19 infection causes considerable morbidity and mortality, especially to those who are aged, have impaired renal function and are obese. We propose to examine the potential utility of oral activated charcoal with the hypothesis that such treatment would lower absorption of microbiome derived toxins and ameliorate systemic oxidant stress and inflammation
The QUEST RR Lyrae Survey: Confirmation of the Clump at 50 kpc and Other Over-Densities in the Outer Halo
We have measured the periods and light curves of 148 RR Lyrae variables from
V=13.5 to 19.7 from the first 100 sq. degrees of the QUEST RR Lyrae survey.
Approximately 55% of these stars belong to the clump of stars detected earlier
by the Sloan Digital Sky Survey. According to our measurements, this feature
has ~10 times the background density of halo stars, spans at least 37.5 deg by
3.5 deg in right ascension and declination (>=30 by >=3 kpc), lies ~50 kpc from
the Sun, and has a depth along the line of sight of ~5 kpc (1 sigma). These
properties are consistent with the recent models that suggest it is a tidal
stream from the Sgr dSph galaxy. The mean period of the type ab variables, 0.58
d, is also consistent. In addition, we have found two smaller over-densities in
the halo, one of which may be related to the globular cluster Pal 5.Comment: 12 pages (including 4 figures). Accepted for publication in the ApJ
Letter
Test of Antiproton Apparatus
This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440
Long-Term Effects From A School-Based Trial Comparing Interpersonal Psychotherapy-Adolescent Skills Training To Group Counseling
Adolescence represents a vulnerable developmental period for depression and an opportune time for prevention efforts. In this study, 186 adolescents with elevated depressive symptoms (M age = 14.01, SD = 1.22; 66.7% female; 32.2% racial minority) were randomized to receive either Interpersonal Psychotherapy–Adolescent Skills Training (IPT-AST; n = 95) delivered by research clinicians or group counseling (GC; n = 91) delivered by school counselors. We previously reported the short-term outcomes of this school-based randomized controlled trial: IPT-AST youth experienced significantly greater improvements in depressive symptoms and overall functioning through 6-month follow-up. Here, we present the long-term outcomes through 24 months postintervention. We examined differences in rates of change in depressive symptoms and overall functioning and differences in rates of depression diagnoses. Youth in both conditions showed significant improvements in depressive symptoms and overall functioning from baseline to 24-month follow-up, demonstrating the efficacy of school-based depression prevention programs. However, the two groups did not differ in overall rates of change or in rates of depression diagnoses from baseline to 24-month follow-up. Although IPT-AST demonstrated advantages over GC in the short term, these effects dissipated over long-term follow-up. Specifically, from 6- to 24-month follow-up, GC youth showed continued decreases in depressive symptoms, whereas IPT-AST youth showed a nonsignificant increase in symptoms. GC youth remained relatively stable in overall functioning, whereas IPT-AST youth experienced a small but statistically significant worsening in functioning. This study highlights the potential of school-based depression prevention efforts and the need for further research
Near infrared detectors for SNAP
Large format (1k x 1k and 2k x 2k) near infrared detectors manufactured by Rockwell Scientific Center and Raytheon Vision Systems are characterized as part of the near infrared R&D effort for SNAP (the Super-Nova/Acceleration Probe). These are hybridized HgCdTe focal plane arrays with a sharp high wavelength cut-off at 1.7 um. This cut-off provides a sufficiently deep reach in redshift while it allows at the same time low dark current operation of the passively cooled detectors at 140 K. Here the baseline SNAP near infrared system is briefly described and the science driven requirements for the near infrared detectors are summarized. A few results obtained during the testing of engineering grade near infrared devices procured for the SNAP project are highlighted. In particular some recent measurements that target correlated noise between adjacent detector pixels due to capacitive coupling and the response uniformity within individual detector pixels are discussed
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