Exploring the relativistic regime with Newtonian hydrodynamics: II. An effective gravitational potential for rapid rotation

We present the generalization of a recently introduced modified gravitational potential for self-gravitating fluids. The use of this potential allows for an accurate approximation of general relativistic effects in an otherwise Newtonian hydrodynamics code also in cases of rapid rotation. We test this approach in numerical simulations of astrophysical scenarios related to compact stars, like supernova core collapse with both a simplified and detailed microphysical description of matter, and rotating neutron stars in equilibrium. We assess the quality of the new potential, and demonstrate that it provides a significant improvement compared to previous formulations for such potentials. Newtonian simulations of compact objects employing such an effective relativistic potential predict inaccurate pulsation frequencies despite the excellent agreement of the collapse dynamics and structure of the compact objects with general relativistic results. We analyze and discuss the reason for this behavior.Comment: 15 pages, 12 figures, minor modification

"Mariage des Maillages": A new numerical approach for 3D relativistic core collapse simulations

We present a new 3D general relativistic hydrodynamics code for simulations of stellar core collapse to a neutron star, as well as pulsations and instabilities of rotating relativistic stars. It uses spectral methods for solving the metric equations, assuming the conformal flatness approximation for the three-metric. The matter equations are solved by high-resolution shock-capturing schemes. We demonstrate that the combination of a finite difference grid and a spectral grid can be successfully accomplished. This "Mariage des Maillages" (French for grid wedding) approach results in high accuracy of the metric solver and allows for fully 3D applications using computationally affordable resources, and ensures long term numerical stability of the evolution. We compare our new approach to two other, finite difference based, methods to solve the metric equations. A variety of tests in 2D and 3D is presented, involving highly perturbed neutron star spacetimes and (axisymmetric) stellar core collapse, demonstrating the ability to handle spacetimes with and without symmetries in strong gravity. These tests are also employed to assess gravitational waveform extraction, which is based on the quadrupole formula.Comment: 29 pages, 16 figures; added more information about convergence tests and grid setu

COSTEP: A comprehensive suprathermal and energetic particle analyzer for SOHO

The group of instruments involved in the COSTEP (comprehensive suprathermal and energetic particle analyzer) project are described. Three sensors, the LION (low energy ion and electron) instrument, the MEICA (medium energy ion composition analyzer) and the EPHIN (electron proton helium instrument) are described. They are designed to analyze particle emissions from the sun over a wide range of species (electrons through iron) and energies (60 KeV/particle to 500 MeV/nucleon). The data collected is used in studying solar and space plasma physics

Fatalism, Climate Resiliency Training and Farmers’ Adaptation Responses: Implications for Sustainable Rainfed-Wheat Production in Pakistan

Climate change is a severe threat to the agricultural sector in general and to rainfed farming in particular. The aim of this study was to investigate the factors that can potentially affect the adaptation process against climate change. This study focused on wheat farmers and farming systems in the rainfed agroecological zone of Pakistan. Farmers’ data related to climate change fatalism, the availability of climate-specific extension services, socioeconomic and institutional variables, and farm characteristics were collected. A logit model to assess farmers’ decisions to adopt an adaptation measure and a multinomial logit model to assess their choice of various adaptation measures were used. The results showed that fatalistic farmers were unlikely to implement climate change adaptation measures. The variables related to the climate-specific extension services, including farmers’ participation in training on climate-resilient crop farming and the availability of mobile communication-based advisory services, had highly significant and positive impacts on farmers’ decisions and their choice of adaptation measures. Input market access and tractor ownership also had positive and significant impacts on farmers’ decisions to adapt and their choice of adaptation measures. This study highlights the need to improve rainfed-wheat farmers’ education levels to change their fatalistic attitudes towards climate change. Furthermore, government action is needed to provide climate-specific extension services to ensure sustainable production levels that will ultimately lead to food and livelihood security under a changing climate.Fritz Thyssen StiftungStiftung fiat panisPeer Reviewe

Neurocysticercosis with a single brain lesion in Germany: a case report

Neurocysticercosis is rare in Western Europe and a high degree of physician awareness is necessary for diagnosis. We describe a case of Neurocysticercosis with a single brain lesion acquired in Germany in which only surgical removal and subsequent histological examination allowed diagnosis whereas diagnostic investigation yielded no pathological findings

Combined Evaluation of FDG-PET and MRI Improves Detection and Differentiation of Dementia

INTRODUCTION: Various biomarkers have been reported in recent literature regarding imaging abnormalities in different types of dementia. These biomarkers have helped to significantly improve early detection and also differentiation of various dementia syndromes. In this study, we systematically applied whole-brain and region-of-interest (ROI) based support vector machine classification separately and on combined information from different imaging modalities to improve the detection and differentiation of different types of dementia. METHODS: Patients with clinically diagnosed Alzheimer's disease (AD: n = 21), with frontotemporal lobar degeneration (FTLD: n = 14) and control subjects (n = 13) underwent both [F18]fluorodeoxyglucose positron emission tomography (FDG-PET) scanning and magnetic resonance imaging (MRI), together with clinical and behavioral assessment. FDG-PET and MRI data were commonly processed to get a precise overlap of all regions in both modalities. Support vector machine classification was applied with varying parameters separately for both modalities and to combined information obtained from MR and FDG-PET images. ROIs were extracted from comprehensive systematic and quantitative meta-analyses investigating both disorders. RESULTS: Using single-modality whole-brain and ROI information FDG-PET provided highest accuracy rates for both, detection and differentiation of AD and FTLD compared to structural information from MRI. The ROI-based multimodal classification, combining FDG-PET and MRI information, was highly superior to the unimodal approach and to the whole-brain pattern classification. With this method, accuracy rate of up to 92% for the differentiation of the three groups and an accuracy of 94% for the differentiation of AD and FTLD patients was obtained. CONCLUSION: Accuracy rate obtained using combined information from both imaging modalities is the highest reported up to now for differentiation of both types of dementia. Our results indicate a substantial gain in accuracy using combined FDG-PET and MRI information and suggest the incorporation of such approaches to clinical diagnosis and to differential diagnostic procedures of neurodegenerative disorders

Renal Perfusion in Scleroderma Patients Assessed by Microbubble-Based Contrast-Enhanced Ultrasound

OBJECTIVES: Renal damage is common in scleroderma. It can occur acutely or chronically. Renal reserve might already be impaired before it can be detected by laboratory findings. Microbubble-based contrast-enhanced ultrasound has been demonstrated to improve blood perfusion imaging in organs. Therefore, we conducted a study to assess renal perfusion in scleroderma patients utilizing this novel technique. MATERIALS AND METHODOLOGY: Microbubble-based contrast agent was infused and destroyed by using high mechanical index by Siemens Sequoia (curved array, 4.5 MHz). Replenishment was recorded for 8 seconds. Regions of interests (ROI) were analyzed in renal parenchyma, interlobular artery and renal pyramid with quantitative contrast software (CUSQ 1.4, Siemens Acuson, Mountain View, California). Time to maximal Enhancement (TmE), maximal enhancement (mE) and maximal enhancement relative to maximal enhancement of the interlobular artery (mE%A) were calculated for different ROIs. RESULTS: There was a linear correlation between the time to maximal enhancement in the parenchyma and the glomerular filtration rate. However, the other parameters did not reveal significant differences between scleroderma patients and healthy controls. CONCLUSION: Renal perfusion of scleroderma patients including the glomerular filtration rate can be assessed using microbubble-based contrast media

Circular RNAs in urine of kidney transplant patients with acute T Cell-mediated allograft rejection

BACKGROUND: Circular RNAs (circRNAs) have recently been described as novel noncoding regulators of gene expression. They are detectable in the blood of patients with acute kidney injury. We tested whether circRNAs were present in urine and could serve as new predictors of outcome in renal transplant patients with acute rejection. METHODS: A global circRNA expression analysis using RNA from urine of patients with acute T cell-mediated renal allograft rejection and control transplant patients was performed. Dysregulated circRNAs were confirmed in a cohort of 62 patients with acute rejection, 10 patients after successful antirejection therapy, 18 control transplant patients without rejection, and 13 stable transplant patients with urinary tract infection. RESULTS: A global screen revealed several circRNAs to be altered in urine of patients with acute rejection. Concentrations of 2 circRNAs including hsa_circ_0001334 and hsa_circ_0071475 were significantly increased. These were validated in the whole cohort of patients. hsa_circ_0001334 was upregulated in patients with acute rejection compared with controls. Concentrations of hsa_circ_0001334 normalized in patients with acute rejection following successful antirejection therapy. hsa_circ_0001334 was associated with higher decline in glomerular filtration rate 1 year after transplantation. CONCLUSIONS: CircRNA concentrations are significantly dysregulated in patients with acute rejection at subclinical time points. Urinary hsa_circ_0001334 is a novel biomarker of acute kidney rejection, identifying patients with acute rejection and predicting loss of kidney function