Problems of bridging plate fixation for the treatment of forearm shaft fractures with the locking compression plate

Introduction: Treatment of diaphyseal forearm fractures by open reduction and internal plate fixation is a well-accepted strategy. In a variety of fracture localizations, the use of bridging plate fixation with locking compression plates (LCP) has been shown to improve biomechanical and biological characteristics. Only very limited clinical data are available on bridging plate fixation using LCPs for the treatment of diaphyseal forearm fractures. The aims of this study were to assess both clinical outcomes of LCP fracture treatments, and the implant-specific advantages and disadvantages. Method: The study consisted of 53 patients. All relevant data were extracted from the medical reports and radiographs. Of the 53 patients, 39 completed the disabilities of the arm, shoulder and hand (DASH) questionnaire and 35 patients were available for clinical examination. The mean time of follow-up was 23.3months. Results: Thirty-nine fractures of the radius and 45 fractures of the ulna were treated with 3.5mm LCPs. Due to a fracture non-union, four patients underwent a second operation. In 13 patients, hardware had already been removed at the time of follow-up. Complete documentation of the removal operation was available for ten patients; in seven of these, procedures difficulties occurred. Mean ranges of motion were 138°, 141° and 162° for elbow flexion-extension, wrist flexion-extension and pronation-supination, respectively. The mean DASH score was calculated at 14.9. Conclusion: In conclusion, our data show that clinical and functional outcomes of LCP plating of diaphyseal forearm fractures are comparable to the use of conventional implants. However, implant-specific problems during hardware removal must be considere

Brownie: A Platform for Conducting NeuroIS Experiments

In the NeuroIS field, experimental software needs to simultaneously present experimental stimuli to participants while recording, analyzing, or displaying neurophysiological measures. For example, a researcher might record a user’s heart beat (neurophysiological measure) as the user interacts with an e-commerce website (stimulus) to track changes in user arousal or show a user’s changing arousal levels during an exciting game. In this paper, we identify requirements for a NeuroIS experimental platform that we call Brownie and present its architecture and functionality. We then evaluate Brownie via a literature review and a case study that demonstrates Brownie’s capability to meet the requirements in a complex research context. We also verify Brownie’s usability via a quantitative study with prospective experimenters who implemented a test experiment in Brownie and an alternative software. We summarize the salient features of Brownie as follows: 1) it integrates neurophysiological measurements, 2) it incorporates real-time processing of neurophysiological data, 3) it facilitates research on individual and group behavior in the lab, 4) it offers a large variety of options for presenting experimental stimuli, and 5) it is open source and easily extensible with open source libraries. In summary, we conclude that Brownie is innovative in its potential to reduce barriers for IS researchers by fostering replicability and research collaboration and to support NeuroIS and interdisciplinary research in cognate areas, such as management, economics, or human-computer interaction

Submarine mass movements and their consequences

This sixth edition of the Submarine Mass Movements and Their Consequences volume, coincident with the seventh eponymous conference includes 61 papers that span a variety of topics and are organized into nine parts as follows: (1) Submarine mass movement in margin construction and economic significance; (2) Failure dynamics from landslide geomorphology; (3) Geotechnical aspects of mass movement; (4) Multidisciplinary case studies; (5) Tectonics and mass move- ment processes; (6) Fluid flow and gas hydrates, (7) Mass transport deposits in modern and outcrop sedimentology; (8) Numerical and statistical analysis; and, (9) Tsunami generation from slope failure. The breath and quality of this body of work underpins a positive outlook and our enthusiasm for the future direction of research in this area of science as it moves towards ever more detailed analysis and monitoring. We also emphasize in this volume the need to look at mountain-scale outcrops to better understand our seismic imaging, to carry out statistical studies that draw on global data sets to better constrain broad behavioural characteristics, and to undertake numerical modelling to understand the sensitivity of a range of natural slopes.peer-reviewe

Fused Deposition Modeling of ABS-Barium Titanate Composites: A Simple Route towards Tailored Dielectric Devices

A process for the development, characterization and correlation of composite materials for 3D printing is presented, alongside the processing of a polymer-ceramic functional composite using fused deposition modeling (FDM). The composite was developed using acrylonitrile butadiene styrene (ABS) as the matrix material filled with barium titanate (BT) micro-powder up to 35 vol % (74.2 wt %). The ABS-BT composites exhibited a shear thinning behavior with increasing ceramic content. The composite was 3D printed into structural and functional test samples using FDM by adapting and optimizing the print parameters. Structural characterization revealed increasingly brittle behavior at higher filler ratios, with the ultimate tensile strength falling from 25.5 MPa for pure ABS to 13.7 MPa for the ABS-35 vol % BT composite. Four-point flexural tests showed a similar decrease in flexural strength with increasing ceramic content. Functional characterization revealed an increase in the relative permittivity at 200 kHz from 3.08 for pure ABS to 11.5 for the composite with 35 vol % BT. These results were correlated with the Maxwell-Garnett and Jayasundere-Smith effective medium models. The process described in this work can be used for other 3D printing processes and provides a framework for the rapid prototyping of functional composites into functional parts with reliable properties. The ABS-BT composite shows promise as a functional dielectric material, with potential applications as capacitors and light-weight passive antennas

Voyage Report RV Tangaroa Voyage TAN1703, 5 April – 1 May 2017

Meteoric recharge and topographically-driven flow are the most important sources of groundwater recharge in terrestrial settings. In passive continental margins, topographically driven meteoric (TDM) groundwater is only one of a range of drivers of offshore groundwater flow. Other drivers include seawater recirculation, sediment loading, geothermal convection, and diagenesis. Sea level has been much lower than today for 80% of the Quaternary, resulting in the emergence of extensive sections of continental shelf, a reduction of pressure exerted by the sea water column, as well as steepening of the hydraulic gradient and an increase in hydraulic head. The potential of TDM recharge to establish extensive water tables, create massive groundwater fluxes, and generate pore overpressures and discharges across the continental shelf and upper continental slope must have been significantly higher during the majority of the last 2.6 Ma than it is today. Considering that geothermal convection is strongest beneath the continental slope and tends to be dominated by TDM flow during sea level lowstands, whereas sediment loading is most important during rapid deglaciations in high sedimentation zones, TDM recharge is a likely very important driver of offshore groundwater systems in continental shelves and upper slopes globally.peer-reviewe

Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases

Background: Recently published results of quality of life (QoL) studies indicated different outcomes of palliative radiotherapy for brain metastases. This prospective multi-center QoL study of patients with brain metastases was designed to investigate which QoL domains improve or worsen after palliative radiotherapy and which might provide prognostic information. Methods: From 01/2007-01/2009, n=151 patients with previously untreated brain metastases were recruited at 14 centers in Germany and Austria. Most patients (82 %) received whole-brain radiotherapy. QoL was measured with the EORTC-QLQ-C15-PAL and brain module BN20 before the start of radiotherapy and after 3 months. Results: At 3 months, 88/142 (62 %) survived. Nine patients were not able to be followed up. 62 patients (70.5 % of 3-month survivors) completed the second set of questionnaires. Three months after the start of radiotherapy QoL deteriorated significantly in the areas of global QoL, physical function, fatigue, nausea, pain, appetite loss, hair loss, drowsiness, motor dysfunction, communication deficit and weakness of legs. Although the use of corticosteroid at 3 months could be reduced compared to pre-treatment (63 % vs. 37 %), the score for headaches remained stable. Initial QoL at the start of treatment was better in those alive than in those deceased at 3 months, significantly for physical function, motor dysfunction and the symptom scales fatigue, pain, appetite loss and weakness of legs. In a multivariate model, lower Karnofsky performance score, higher age and higher pain ratings before radiotherapy were prognostic of 3-month survival. Conclusions: Moderate deterioration in several QoL domains was predominantly observed three months after start of palliative radiotherapy for brain metastases. Future studies will need to address the individual subjective benefit or burden from such treatment. Baseline QoL scores before palliative radiotherapy for brain metastases may contain prognostic information

DNA methylation-based classification of central nervous system tumours.

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology

Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2).

Extension of the COVERALL (COrona VaccinE tRiAL pLatform) randomized trial showed noninferiority in antibody response of the third dose of Moderna mRNA-1273 vaccine (95.3% [95% confidence interval {CI}, 91.9%-98.7%]) compared to Pfizer-BioNTech BNT162b2 vaccine (98.1% [95% CI, 95.9%-100.0%]) in individuals with different levels of immunosuppression (difference, -2.8% [95% CI, -6.8% to 1.3%])