Factors Affecting the Uptake of COVID-19 Vaccine amongDubai Airport's Professionals

Aim: Comprehending the elements that influence COVID-19 vaccination acceptability and recognizing expediters for vaccination decisions are critical components of developing effective ways to increase vaccine coverage in the general population. This study aims to investigate the main factors affecting COVID-19 vaccination uptake among Dubai 'Airport's employees. In addition, it seeks to explore the main signs and symptoms that appeared on vaccinated employees after taking the COVID-19 vaccination, hence, track the vaccine's safety. Methods: Employees at Dubai's airport in the United Arab Emirates (UAE), mainly in Dubai, provided data. To gather data online utilising the Google Forms platform, a questionnaire was used as the main quantitative tool. As 2000 questionnaires got distributed, 1007 employees participated in the survey, yielding a 50.4% response rate. Results: The results show that employees overwhelmingly agree with the assertion that the factors of accessibility and affordability have a significant effect on their decision to receive the COVID-19 vaccine, followed by a trust in vaccine, knowledge, vaccine safety, advice and information, and beliefs on the vaccine. In this study, the agreement level on factors affecting the COVID-19 vaccine uptake was found significantly to be higher in females (88.6%) who were married (91.6%) and those aged over 60 years (89.2%) at P <.05. In addition, the results show that 53.7% of vaccinated staff was found to have one or more side effects of the vaccine, where none of them was hospitalized after immunization. The binary logistic regression analysis in this study shows that females were two times more likely to have 'vaccine's symptoms after vaccination than males (Exp (B): 1.6; 95%CI: 1.127 - 2.351, P< .01). It further reveals that participants in the age group over 50 were three times more likely to have 'vaccine's symptoms after vaccination than participants in the age group 20-29 (Exp (B): 2.9; 95%CI: 2.497-9.681, P< .001). Finally, it indicates that individuals with previous SARS-CoV-2 infection were 2 times more likely to have 'vaccine's symptoms after vaccination than those without known past infection (Exp (B): 1.9; 95%CI: 1.272 - 2.542, P< .01). Conclusion: There are several factors that playing a significant role in population’s decision to receive the COVID-19 vaccine, where the accessibility and affordability factors were found to have the greatest effect on their decision to uptake the vaccine. The current study concluded that COVID-19 vaccination is safe and that adverse effects from a vaccine are usually modest and affected by several factors such as age, gender, and COVID-19 infection history. &nbsp

SemEval-2020 Task 12: Multilingual Offensive Language Identification in Social Media (OffensEval 2020)

We present the results and main findings of SemEval-2020 Task 12 on Multilingual Offensive Language Identification in Social Media (OffensEval 2020). The task involves three subtasks corresponding to the hierarchical taxonomy of the OLID schema (Zampieri et al., 2019a) from OffensEval 2019. The task featured five languages: English, Arabic, Danish, Greek, and Turkish for Subtask A. In addition, English also featured Subtasks B and C. OffensEval 2020 was one of the most popular tasks at SemEval-2020 attracting a large number of participants across all subtasks and also across all languages. A total of 528 teams signed up to participate in the task, 145 teams submitted systems during the evaluation period, and 70 submitted system description papers.Comment: Proceedings of the International Workshop on Semantic Evaluation (SemEval-2020

The Relationship Between Dieting and Levels of Perceived Psychological Stress in United Arab Emirates residents

Aim: The primary aim of this cross-sectional research study was to investigate the potential differences in perceived psychological stress level in those dieting compared to those not undertaking a diet. The secondary objective was to assess if stress levels in those dieting were correlated with the duration of the diet.Methods: We administered the previously validated Perceived Stress Scale (PSS) to 60 United Arab Emirates residents. Participants were also asked demographic questions concerning age and gender and were requested to indicate if they were currently undertaking a diet to achieve weight loss. Participants who were actively on a diet were also asked about the duration of the diet (days).Results: A total of 60 participants were recruited to the study, of which 71.7% were female. The majority (71.7%) of the sample were 18-25 years old and 58.3% indicated that they were undertaking a diet at the time of data acquisition. The median total score on the PSS was 19 (14 – 22). There was a significant difference in PSS total score between those on a diet and those not (p=0.021). A positive correlation was found between number of days on a diet and perceived stress level (r=0.147) but this was not statistically significant (p=0.406).Conclusions: Dieting behaviour was associated with higher levels of perceived psychological stress compared to those not undertaking a diet. Engaging in dieting behaviour is commonly driven by body dissatisfaction and may be linked to heightened stress due to social pressures or other factors.

High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines

Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via high–temporal resolution blood transcriptome profiling. The first vaccine dose elicited modest interferon and adaptive immune responses, which peaked on days 2 and 5, respectively. The second vaccine dose, in contrast, elicited sharp day 1 interferon, inflammation, and erythroid cell responses, followed by a day 5 plasmablast response. Both post-first and post-second dose interferon signatures were associated with the subsequent development of antibody responses. Yet, we observed distinct interferon response patterns after each of the doses that may reflect quantitative or qualitative differences in interferon induction. Distinct interferon response phenotypes were also observed in patients with COVID-19 and were associated with severity and differences in duration of intensive care. Together, this study also highlights the benefits of adopting high-frequency sampling protocols in profiling vaccine-elicited immune responses

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020

Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study)

Background: This study provides a global overview of the management of patients with acute cholecystitis during the initial phase of the COVID-19 pandemic. Methods: CHOLECOVID is an international, multicentre, observational comparative study of patients admitted to hospital with acute cholecystitis during the COVID-19 pandemic. Data on management were collected for a 2-month study interval coincident with the WHO declaration of the SARS-CoV-2 pandemic and compared with an equivalent pre-pandemic time interval. Mediation analysis examined the influence of SARS-COV-2 infection on 30-day mortality. Results: This study collected data on 9783 patients with acute cholecystitis admitted to 247 hospitals across the world. The pandemic was associated with reduced availability of surgical workforce and operating facilities globally, a significant shift to worse severity of disease, and increased use of conservative management. There was a reduction (both absolute and proportionate) in the number of patients undergoing cholecystectomy from 3095 patients (56.2 per cent) pre-pandemic to 1998 patients (46.2 per cent) during the pandemic but there was no difference in 30-day all-cause mortality after cholecystectomy comparing the pre-pandemic interval with the pandemic (13 patients (0.4 per cent) pre-pandemic to 13 patients (0.6 per cent) pandemic; P = 0.355). In mediation analysis, an admission with acute cholecystitis during the pandemic was associated with a non-significant increased risk of death (OR 1.29, 95 per cent c.i. 0.93 to 1.79, P = 0.121). Conclusion: CHOLECOVID provides a unique overview of the treatment of patients with cholecystitis across the globe during the first months of the SARS-CoV-2 pandemic. The study highlights the need for system resilience in retention of elective surgical activity. Cholecystectomy was associated with a low risk of mortality and deferral of treatment results in an increase in avoidable morbidity that represents the non-COVID cost of this pandemic

Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia

Multi-ancestry genome-wide association meta-analysis of Parkinson?s disease

Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations

Effects of thermal processing on physicochemical properties and oxidative stability of Balanities aegyptiaca kernels and extracted oil

Efecto de tratamientos térmicos sobre las propiedades fisicoquímicas y estabilidad oxidativa de semillas de Balanities aegyptiaca y de los aceites extraídos. En el presente estudio se investigaron los efectos del tostado y ebullición sobre la composición proximal de las semillas, así como las propiedades fisicoquímicas y estabilidad oxidativa de los aceites extraídos de Balanites aegyptiaca. La torrefacción se realizó a 180 ºC durante 15 minutos mientras que la ebullición de los granos se realizó en agua durante una hora. Los aceites de las muestras crudas y térmicamente procesadas se extrajeron utilizando n-hexano mediante Soxhlet y fueron caracterizados. La torrefacción influyó significativamente (p < 0,05) en el valor del peróxido y en la estabilidad oxidativa del aceite extraído, de manera positiva, mientras que la ebullición tiene el efecto opuesto. Los aceites contenían linoleico, oleico, esteárico y palmítico como principales ácidos grasos (96%) y contenían predominantemente α- y γ-tocoferoles (aprox. 400 mg/kg). El estudio sugiere que el aceite de granos tostados podría ser utilizado como un antioxidante natural para mejorar las características de otros aceites comestibles a través de la mezcla.In the present study, the effects of roasting and boiling on the proximate composition of the kernels as well as the physicochemical properties and oxidative stabilities of the extracted oils of Balanites aegyptiaca were investigated. Roasting was performed at 180 °C for 15 minutes, whereas boiling of the kernels was carried out in tap water for one hour. The oils from raw and thermally processed samples were extracted using n-hexane in a Soxhlet extraction apparatus and characterized. The roasting significantly (p < 0.05) influenced the peroxide value and the oxidative stability of the extracted oil in a positive way; whereas boiling had the opposite effect. The oils were composed of linoleic, oleic, stearic, and palmitic acids as the major fatty acids (96%) and contained predominantly α- and γ-tocopherols (ca. 400mg/kg). The study suggests that the oil from roasted kernels could be used as a natural antioxidant for enhancing the characteristics of other edible oils via blending