Incidence, risk factors, and evolution of venous thromboembolic events in patients diagnosed with pancreatic carcinoma and treated with chemotherapy on an outpatient basis.

Background Pancreatic carcinoma is one of the tumors associated with a higher risk for thromboembolic events, with incidence rates ranging from 5% to 41% in previous retrospective series. Patients and methods We conducted a retrospective study in eleven Spanish hospitals that included 666 patients diagnosed with pancreatic carcinoma (any stage) between 2008 and 2011 and treated with chemotherapy. The main objective was to evaluate the incidence of venous thromboembolic events (VTE) in this population, as well as potential risk factors for thrombosis. The impact of VTE on mortality was also assessed. Results With a median follow-up of 9.3 months, the incidence of VTE was 22.1%; 52% were diagnosed incidentally. Our study was unable to confirm the ability of the Khorana score to discriminate between patients in the intermediate or high risk category for thrombosis. The presence of VTE proved to be an independent prognostic factor associated with increased risk of death (HR 2.39, 95% CI 1.96–2.92). Symptomatic events correlated with higher mortality than asymptomatic events (HR 1.72; 95% CI, 1.21–2.45; p = 0.002), but incidental VTE, including visceral vein thrombosis (VVT), negatively affected survival compared to patients without VTE. Subjects who developed VTE within the first 3 months of diagnosis of pancreatic carcinoma had lower survival rates than those with VTE after 3 months (HR 1.92, 95% CI 1.30–2.84; p<0.001). Conclusions Pancreatic carcinoma is associated with a high incidence of VTE, which, when present, correlates with worse survival, even when thrombosis is incidental. Early onset VTE has a particularly negative impact.post-print1290 K

Continental margin radiography from a potential field and sediment thickness standpoint: the Iberian Atlantic Margin

El presente estudio realiza una revisión del estado del conocimiento en el Margen Atlántico Ibérico atendiendo a las tres provincias en las que clásicamente se sub-divide éste: margen gallego, planicie abisal suribérica, y planicie abisal del Tagus, utilizando como fuente de información datos de campos potenciales e información derivada de espesor de sedimentos. Se estudian las características de su basamento, estableciendo límites para la extensión de la corteza continental, y la amplitud del dominio denominado transición océano-continente cuyo fin marca el inicio de la corteza oceánica. La corteza continental en el margen gallego ocupa aproximadamente 210 km, la mayor de las tres provincias, mientras que su zona de transición océano- continente varía ligeramente entre los 65 km en su zona sur y los 56 km más al norte, difiriendo de lo propuesto por otros autores que consideran ronda los 30 km. La situación en la planicie abisal sur-ibérica es aproximadamente la contraria. El dominio continental se extiende menos que en el gallego, aproximadamente unos 60 km, mientras que la zona de transición océano-continente lo hace unos 185 km. El estudio de la planicie abisal del Tagus muestra una evolución morfológica más rápida que las otras dos, registrando a partir del análisis de la variación del factor de adelgazamiento ß una zona de transición océano-continente de aproximadamente 100 km. Los resultados obtenidos apoyarían una naturaleza intermedia a la corteza en prácticamente todo el dominio del Tagus, en contra de lo establecido por otros autores.This study reviews the state of knowledge in the Iberian Atlantic margin. In order to do this, the margin has been divided into three provinces: the Galicia margin, the southern Iberian abyssal plain, and the Tagus abyssal plain. We have used potential field and sediment thickness data. This has allowed us to study the crust, setting limits for the continental crust domain, and the amplitude of the so-called ocean-continent transition, whose end marks the beginning of the oceanic crust. The study shows the continental crust in the Galician margin to be the widest, about 210 km in length, whilst the ocean-continent transition varies slightly in this province: between 65 km wide in the south and 56 km wide in the north. This result shows up some differences with the hypothesis of other authors. The situation in the southern Iberian abyssal plain is nearly the opposite. Its continental crust extends approximately 60 km, whilst the ocean-continent transition zone is 185 km long. The Tagus abyssal plain study shows a faster morphological evolution than the others, according with the amount of crustal thinning ß, the ocean-continent transition domain spanning 100 km. These results support a transitional intermediate character for almost the whole Tagus plain, in contrary to what other authors have stated.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEMinisterio de Economía y Competitividad (MINECO)pu

Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis

Anemia is a common condition in cancer patients and is associated with a wide variety of symptoms that impair quality of life (QoL). However, exactly how anemia affects QoL in cancer patients is unclear because of the inconsistencies in its definition in previous reports. We aimed to examine the clinical impact of anemia on the QoL of cancer patients using specific questionnaires. We performed a post-hoc analysis of a multicenter, prospective, case-control study. We included patients with cancer with (cases) or without (controls) anemia. Participants completed the European Organization for Research and Treatment of Cancer Quality of Life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ–5D–3L) questionnaire. Statistically significant and clinically relevant differences in the global health status were examined. From 2015 to 2018, 365 patients were included (90 cases and 275 controls). We found minimally important differences in global health status according to the EORTC QLQ-C30 questionnaire (case vs. controls: 45.6 vs. 58%, respectively; mean difference: −12.4, p < 0.001). Regarding symptoms, cancer patients with anemia had more pronounced symptoms in six out of nine scales in comparison with those without anemia. In conclusion, cancer patients with anemia had a worse QoL both clinically and statistically

Effects of Rho kinase inhibitors on grafts of dopaminergic cell precursors in a rat model of Parkinson's Disease

In models of Parkinson’s disease (PD), Rho kinase (ROCK) inhibitors have antiapoptotic and axonstabilizing effects on damaged neurons, decrease the neuroinflammatory response, and protect against dopaminergic neuron death and axonal retraction. ROCK inhibitors have also shown protective effects against apoptosis induced by handling and dissociation of several types of stem cells. However, the effect of ROCK inhibitors on dopaminergic cell grafts has not been investigated. In the present study, treatment of dopaminergic cell suspension with ROCK inhibitors yielded significant decreases in the number of surviving dopaminergic neurons, in the density of graft-derived dopaminergic fibers, and in graft vascularization. Dopaminergic neuron death also markedly increased in primary mesencephalic cultures when the cell suspension was treated with ROCK inhibitors before plating, which suggests that decreased angiogenesis is not the only factor leading to cell death in grafts. Interestingly, treatment of the host 6-hydroxydopamine-lesioned rats with ROCK inhibitors induced a slight, nonsignificant increase in the number of surviving neurons, as well as marked increases in the density of graft-derived dopaminergic fibers and the size of the striatal reinnervated area. The study findings discourage treatment of cell suspensions before grafting. However, treatment of the host induces a marked increase in graft-derived striatal reinnervation. Because ROCK inhibitors have also exerted neuroprotective effects in several models of PD, treatment of the host with ROCK inhibitors, currently used against vascular diseases in clinical practice, before and after grafting may be a useful adjuvant to cell therapy in PDThis work was supported by Spanish Ministry of Health (PI12/00798 and RD12/0019/0020) and Spanish Ministry of Economy and Competitiveness (BFU2012-3708)S

Clinical impact of the TPSAB1 genotype in mast cell diseases: A REMA study in a cohort of 959 individuals

[Background]: A close association between hereditary alpha-tryptasemia (HAT) and mast cell (MC) disorders has been previously reported. However, the relationship between HAT and the diagnostic subtypes and clinical features of MC disorders still remains to be established.[Objective]: To determine the prevalence of HAT in healthy donors (HD) vs patients with different diagnostic subtypes of MC activation syndromes (MCAS) and mastocytosis, and its relationship with the clinical behavior of the disease.[Methods]: A total of 959 subjects were studied including 346 healthy donors (HD), 464 mastocytosis, and 149 non-clonal MCAS patients. Molecular studies to assess the TPSAB1 genotype were performed, and data on serum baseline tryptase (sBT) and basal MC-mediator release episodes and triggers of anaphylaxis were collected.[Results]: HAT was detected in 15/346 (4%) HD versus 43/149 (29%) non-clonal MCAS and 84/464 (18%) mastocytosis cases. Among mastocytosis, HAT was more frequently found in patients with MC-restricted KITD816V (21% vs. 10% among multilineage KITD816V patients; p = .008). Overall, median sBT was higher in cases presenting with HAT (28.9 vs. 24.5 ng/mL; p = .008), while no significant differences in sBT were observed among HAT+ mastocytosis patients depending on the presence of 1 vs. ≥2 extra copies of the α-tryptase gene (44.1 vs. 35.2 ng/mL, p > .05). In turn, anaphylaxis was more frequently observed in HAT+ versus HAT− mastocytosis patients (76% vs. 65%; p = .018), while HAT+ and HAT− patients who did not refer anaphylaxis as the presenting symptom (n = 308) showed a similar prevalence of subsequent anaphylaxis (35% vs. 36%, respectively).[Conclusion]: The frequency of HAT in MC disorders varies according to the diagnostic subtype of the disease. HAT does not imply a higher risk (and severity) of anaphylaxis in mastocytosis patients in whom anaphylaxis is not part of the presenting symptoms of the disease.This work was supported by grants from the Fundación para la Investigación Biomédica del Hospital Ramón y Cajal IRYCIS (reference 2018/0250), Fundación Sociedad Española de Alergología e Inmunología Clínica 2018, Instituto de Salud Carlos III (reference PI22/01657) and Fundación Española de Mastocitosis (reference FEM-2021-SAM). PNN was supported by a grant of the Government of Castilla y León (Orden EDU 875 2021), Spain.Peer reviewe

Crustal structure of the Spanish Central System: Constraints from ambient noise autocorrelation and controlled source data

This presentation provides an image of the crustal structure underneath the Central System, in the Central Iberian Zone, by means of seismic noise autocorrelation and wide angle seismic dat

Long-term outcomes of high-risk HR-positive and HER2-negative early breast cancer patients from GEICAM adjuvant studies and El Álamo IV registry

Purpose The monarchE trial showed that the addition of abemaciclib improves efficacy in patients with high-risk early breast cancer (EBC). We analyzed the long-term outcomes of a population similar to the monarchE trial to put into context the potential benefit of abemaciclib. Methods HR-positive/HER2-negative EBC patients eligible for the monarchE study were selected from 3 adjuvant clinical trials and a breast cancer registry. Patients with ≥ 4 positive axillary lymph nodes (N +) or 1–3 N + with tumor size ≥ 5 cm and/or histologic grade 3 and/or Ki67 ≥ 20%, who had undergone surgery with curative intent and had received anthracyclines ± taxanes and endocrine therapy in the neoadjuvant and /or adjuvant setting were included. We performed analysis of Invasive Disease-Free Survival (iDFS), Distant Disease-Free Survival (dDFS) and Overall Survival (OS) at 5 and 10 years, as well as yearly (up to 10) of Invasive Relapse Rate (IRR), Distant Relapse Rate (DRR) and Death Rate (DR). Results A total of 1,617 patients were analyzed from the GEICAM-9906 (312), GEICAM-2003–10 (210), and GEICAM-2006–10 (160) trials plus 935 from El Álamo IV. With a median follow-up of 10.1 years, the 5 and 10 years iDFS rates were 75.2% and 57.0%, respectively. The dDFS and OS rates at 5 years were 77.4% and 88.8% and the respective figures at 10 years were 59.7% and 70.9%. Conclusions This data points out the need for new therapies for those patients. A longer follow-up of the monarchE study to see the real final benefit with abemaciclib is warranted

Segmentation and kinematics of the North America-Caribbean plate boundary offshore Hispaniola

We explored the submarine portions of the Enriquillo–Plantain Garden Fault zone (EPGFZ) and the Septentrional–Oriente Fault zone (SOFZ) along the Northern Caribbean plate boundary using high-resolution multibeam echo-sounding and shallow seismic reflection. The bathymetric data shed light on poorly documented or previously unknown submarine fault zones running over 200 km between Haiti and Jamaica (EPGFZ) and 300 km between the Dominican Republic and Cuba (SOFZ). The primary plate-boundary structures are a series of strike-slip fault segments associated with pressure ridges, restraining bends, step overs and dogleg offsets indicating very active tectonics. Several distinct segments 50–100 km long cut across pre-existing structures inherited from former tectonic regimes or bypass recent morphologies formed under the current strike-slip regime. Along the most recent trace of the SOFZ, we measured a strike-slip offset of 16.5 km, which indicates steady activity for the past ~1.8 Ma if its current GPS-derived motion of 9.8 ± 2 mm a−1 has remained stable during the entire Quaternary.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEpu

Elastic scattering and α -particle production in 6 He + 208 Pb collisions at 22 MeV

Experimental results of the elastic scattering of 6He on 208Pb at E LAB=22 MeV, measured at the CRC facility (Louvain-la-Neuve, Belgium), are presented, including results on the 4He production channel. These data were taken with full angular coverage and high angular resolution. Both experimental cross sections are compared with continuum discretized coupled channels and distorted-wave Born approximation calculations, where direct breakup and transfer to the continuum processes are considered. The elastic data confirm the absence of the Coulomb rainbow, while the distribution of α particles indicates that such production is mostly generated by transfer to the continuum.MICINN FPA2005-04460 FPA200502379 FPA2006-13807-c02-01 FPA2007-63074 FPA2009-07653 FPA2009-07387 FPA2010-22131-C02-01Junta de Andalucía FQM-4964Programa Consolider-Ingenio 2010 CSD2007-00042Comisión Europea HPRI-CT-1999-0011

Planck early results. V. The low frequency instrument data processing

We describe the processing of data from the Low Frequency Instrument (LFI) used in production of the Planck Early Release Compact Source Catalogue (ERCSC). In particular, we discuss the steps involved in reducing the data from telemetry packets to cleaned, calibrated, time-ordered data (TOD) and frequency maps. Data are continuously calibrated using the modulation of the temperature of the cosmic microwave background radiation induced by the motion of the spacecraft. Noise properties are estimated from TOD from which the sky signal has been removed using a generalized least square map-making algorithm. Measured 1/f noise knee-frequencies range from ~100 mHz at 30 GHz to a few tens of mHz at 70GHz. A destriping code (Madam) is employed to combine radiometric data and pointing information into sky maps, minimizing the variance of correlated noise. Noise covariance matrices required to compute statistical uncertainties on LFI and Planck products are also produced. Main beams are estimated down to the ??10dB level using Jupiter transits, which are also used for geometrical calibration of the focal plane.Planck is too large a project to allow full acknowledgement of all contributions by individuals, institutions, industries, and funding agencies. The main entities involved in the mission operations are as follows. The European Space Agency operates the satellite via its Mission Operations Centre located at ESOC (Darmstadt, Germany) and coordinates scientific operations via the Planck Science Office located at ESAC (Madrid, Spain). Two Consortia, comprising around 50 scientific institutes within Europe, the USA, and Canada, and funded by agencies from the participating countries, developed the scientific instruments LFI and HFI, and continue to operate them via Instrument Operations Teams located in Trieste (Italy) and Orsay (France). The Consortia are also responsible for scientific processing of the acquired data. The Consortia are led by the Principal Investigators: J.L. Puget in France for HFI (funded principally by CNES and CNRS/INSU-IN2P3) and N. Mandolesi in Italy for LFI(funded principally via ASI). NASA US Planck Project, based at J.P.L. and involving scientists at many US institutions, contributes significantly to the efforts of these two Consortia. The author list for this paper has been selected by the Planck Science Team, and is composed of individuals from all of the above entities who have made multi-year contributions to the development of the mission. It does not pretend to be inclusive of all contributions. The Planck-LFI project is developed by an International Consortium lead by Italy and involving Canada, Finland, Germany, Norway, Spain, Switzerland, UK, USA. The Italian contribution to Planck is supported by the Italian Space Agency (ASI) and INAF. This work was supported by the Academy of Finland grants 121703 and 121962. We thank the DEISA Consortium (http://www.deisa.eu), co-funded through the EU FP6 project RI-031513 and the FP7 project RI-222919, for support within the DEISA Virtual Community Support Initiative. We thank CSC – IT Center for Science Ltd (Finland) for computational resources. We acknowledge financial support provided by the Spanish Ministerio de Ciencia e Innovaciõn through the Plan Nacional del Espacio y Plan Nacional de Astronomia y Astrofisica. We acknowledge The Max Planck Institute for Astrophysics Planck Analysis Centre (MPAC) is funded by the Space Agency of the German Aerospace Center (DLR) under grant 50OP0901 with resources of the German Federal Ministry of Economics and Technology, and by the Max Planck Society. This work has made use of the Planck satellite simulation package (Level-S), which is assembled by the Max Planck Institute for Astrophysics Planck Analysis Centre (MPAC) Reinecke et al. (2006). We acknowledge financial support provided by the National Energy Research Scientific Computing Center, which is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. Some of the results in this paper have been derived using the HEALPix package Górski et al. (2005). A description of the Planck Collaboration and a list of its members, indicating which technical or scientific activities they have been involved in, can be found at http://www.rssd.esa.int/index.php?project=PLANCK&page=Planck_Collaboration