Las cuentas por cobrar y su incidencia en la liquidez del centro educativo privado “LUIS E. GALVÁN” E.I.R.L.

El presente trabajo de investigación tiene como finalidad revisar las cuentas por cobrar y su incidencia en la liquidez del centro educativo privado “LUIS E. GALVAN” E.I.R.L. lo cual nos permitirá llevar un control de las cuentas por cobrar y ver de qué manera eso repercute en la liquides de la empresa ya que la empresa no lleva un adecuado control de las cuentas por cobrar. Estas cuentas por cobrar nos permitirán llevan un mejor control de los pagos de los alumnos de sus pensiones, así como los diferentes pagos que nuestros clientes hacen a la empresa y lo cual se ve reflejada en la liquides de la empresa. El trabajo de investigación contiene la documentación de todas las cuentas por cobrar que lleva la empresa a tomar decisiones a la gerencia sobre la rentabilidad y liquides de la empresaThe purpose of this research work is to review the accounts receivable and their impact on the liquidity of the private educational center "LUIS E. GALVAN" E.I.R.L. This will allow us to keep track of accounts receivable and see how this affects the company's liquidation since the company does not have adequate control of accounts receivable. These accounts receivable will allow us to have a better control of the payments of the students of their pensions, as well as the different payments that our clients make to the company and which is reflected in the liquids of the company. The research work contains the documentation of all accounts receivable that leads the company to make decisions to management on the profitability and liquids of the companyTrabajo de investigació

Efficacy, safety and pharmacokinetic of once-daily boosted saquinavir (1500/100 mg) together with 2 nucleos(t)ide reverse transcriptase inhibitors in real life: a multicentre prospective study

<p>Abstract</p> <p>Background</p> <p>Ritonavir-boosted saquinavir (SQVr) is nowadays regarded as an alternative antiretroviral drug probably due to several drawbacks, such as its high pill burden, twice daily dosing and the requirement of 200 mg ritonavir when given at the current standard 1000/100 mg bid dosing. Several once-daily SQVr dosing schemes have been studied with the 200 mg SQV old formulations, trying to overcome some of these disadvantages. SQV 500 mg strength tablets became available at the end of 2005, thus facilitating a once-daily regimen with fewer pills, although there is very limited experience with this formulation yet.</p> <p>Methods</p> <p>Prospective, multicentre study in which efficacy, safety and pharmacokinetics of a regimen of once-daily SQVr 1500/100 mg plus 2 NRTIs were evaluated under routine clinical care conditions in either antiretroviral-naïve patients or in those with no previous history of antiretroviral treatments and/or genotypic resistance tests suggesting SQV resistance. Plasma SQV trough levels were measured by HPLV-UV.</p> <p>Results</p> <p>Five hundred and fourteen caucasian patients were included (47.2% coinfected with hepatitis C and/or B virus; 7.8% with cirrhosis). Efficacy at 52 weeks (plasma RNA-HIV <50 copies/ml) was 67.7% (CI₉₅: 63.6 - 71.7%) by intention-to-treat, and 92.2% (CI₉₅: 89.8 - 94.6%) by on-treatment analysis. The reasons for failure were: dropout or loss to follow-up (18.4%), virological failure (7.8%), adverse events (3.1%), and other reasons (4.6%). The high rate of dropout may be explained by an enrollement and follow-up under routine clinical care condition, and a population with a significant number of drug users. The median SQV Cmin (n = 49) was 295 ng/ml (range, 53-2172). The only variable associated with virological failure in the multivariate analysis was adherence (OR: 3.36; CI95, 1.51-7.46, p = 0.003).</p> <p>Conclusions</p> <p>Our results suggests that SQVr (1500/100 mg) once-daily plus 2 NRTIs is an effective regimen, without severe clinical adverse events or hepatotoxicity, scarce lipid changes, and no interactions with methadone. All these factors and its once-daily administration suggest this regimen as an appropriate option in patients with no SQV resistance-associated mutations.</p

Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) for Shoulder Mobility Improvement in Women with Upper Limb Lymphedema Secondary to Breast Cancer: A Multicenter Controlled Clinical Trial

Lymphedema, secondary to breast cancer (BCRL), is the abnormal accumulation of protein-rich fluid in the interstitium caused by a malfunction of the lymphatic system. It causes swelling, deficiencies in upper limb functions and structures, sensory pain and emotional alterations, which have a chronic course and affect the upper limb’s functionality. This study aims to verify the efficacy and efficiency in the upper limb´s functionality of a protocolized experimental approach based on occupational therapy, TAPA (activity-oriented proprioceptive antiedema therapy), in the rehabilitation of BCRL in stages I and II, comparing it with the conservative treatment considered as the standard, complex decongestive therapy (CDT), through a multicenter randomized clinical trial.The study has been financed in the call for competitive competition of research and innovation projects in the field of Primary Care, Regional Hospitals and High Resolution Hospital Centers of the Public Health System of Andalusia for the year 2021, of the Andalusian Public Foundation Progress and Health, according to the definitive list of funded projects, published on 23 December 2021, with EXP. No.: AP-0160-2021-C2-F2, also in the call for “Grants for research projects in Occupational Therapy. Call 2020”, granted by the Professional Association of Occupational Therapists of Extremadura (COPTOEX), Spain and, in 2020, received an economic contribution from the Research Group in Primary Health Care of Aragon (GAIAP-B21-17R group)

Impact of Activity-Oriented Propioceptive Antiedema Therapy on the Health-Related Quality of Life of Women with Upper-Limb Lymphedema Secondary to Breast Cancer—A Randomized Clinical Trial

Alterations derived from lymphedema in the upper-limb secondary to breast cancer-related lymphedema (BCRL) decrease the health-related quality of life (HRQoL), but there is limited evidence of the impact of the different interventions on it. The aim of this research was to compare the effect of conventional treatment with another treatment based on Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) on HRQoL in women diagnosed with BCRL.This research was funded by the Call for research and innovation projects in the field of primary care, regional hospitals and high-resolution hospital centres of the Public Health System of Andalusia in 2021 by the Progreso y Salud Foundation, of the Ministry of Health and Families of the Junta de Andalucía, with EXP. No.: AP-0160-2021-C2-F2. He has also been awarded a scholarship by the Professional Association of Occupational Therapists of Extremadura (COPTOEX) (Spain) call 2020 and awarded a financial contribution from the Research Group in Primary Health Care of Aragon (GAIAP-B21-17R group), recognized and financed by the Government of Aragón (Spain) and by Feder Funds “Another way of making Europe”

Strengthening pro-environmental behavior in IED Luz Marina Caballero

La relación del hombre con el ambiente, es inherente a la existencia, por tal motivo la promoción de conductas pro-ambientales se ha convertido en foco atencional en los últimos años, buscando fortalecer acciones sustentables, dentro de los márgenes de la responsabilidad ambiental y social. A continuación, el presente estudio buscó entonces Identificar los componentes pro-ambientales que se pueden fortalecer a través de la investigación para la Formación de Cultura Ciudadana, la Conservación del Medio y el Desarrollo Sostenible en la Comunidad Educativa de la IED Luz Marina Caballero. La investigación fue abordada desde la mirada cuantitativa, con alcance descriptivo. La población abordada fue la comunidad educativa de la IED Luz Marina Caballero. Los resultados permiten ver como las conductas pro-ambientales, se orienta al mantenimiento óptimo de los recursos naturales, al equilibrio del ecosistema y a su vez responde a las necesidades sociales e individuales.The relationship of man with the environment is inherent to existence, for this reason the promotion of pro-environmental behavior has become an attention focus in recent years, seeking to strengthen sustainable actions, within the margins of environmental and social responsibility. Next, the present study seeks to identify the pro-environmental components that can be strengthened through research for Citizen Culture Training, Environmental Conservation and Sustainable Development in the IED Luz Marina Caballero Educational Community. The research will be approached from the quantitative perspective, with descriptive scope. The target population was the educational community of the IED Luz Marina Caballero. The results allow us to see how pro-environmental behaviors are oriented towards the optimal maintenance of natural resources, the balance of the ecosystem and, at the same time, responding to social and individual needs

Effectiveness and Safety of the Sequential Use of a Second and Third Anti-TNF Agent in Patients With Inflammatory Bowel Disease: Results From the Eneida Registry

Background: The effectiveness of the switch to another anti-tumor necrosis factor (anti-TNF) agent is not known. The aim of this study was to analyze the effectiveness and safety of treatment with a second and third anti-TNF drug after intolerance to or failure of a previous anti-TNF agent in inflammatory bowel disease (IBD) patients. Methods: We included patients diagnosed with IBD from the ENEIDA registry who received another anti-TNF after intolerance to or failure of a prior anti-TNF agent. Results: A total of 1122 patients were included. In the short term, remission was achieved in 55% of the patients with the second anti-TNF. The incidence of loss of response was 19% per patient-year with the second anti-TNF. Combination therapy (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.8-3; P < 0.0001) and ulcerative colitis vs Crohn's disease (HR, 1.6; 95% CI, 1.1-2.1; P = 0.005) were associated with a higher probability of loss of response. Fifteen percent of the patients had adverse events, and 10% had to discontinue the second anti-TNF. Of the 71 patients who received a third anti-TNF, 55% achieved remission. The incidence of loss of response was 22% per patient-year with a third anti-TNF. Adverse events occurred in 7 patients (11%), but only 1 stopped the drug. Conclusions: Approximately half of the patients who received a second anti-TNF achieved remission; nevertheless, a significant proportion of them subsequently lost response. Combination therapy and type of IBD were associated with loss of response. Remission was achieved in almost 50% of patients who received a third anti-TNF; nevertheless, a significant proportion of them subsequently lost response

MEGARA, the new intermediate-resolution optical IFU and MOS for GTC: getting ready for the telescope

MEGARA (Multi-Espectrógrafo en GTC de Alta Resolución para Astronomía) is an optical Integral-Field Unit (IFU) and Multi-Object Spectrograph (MOS) designed for the GTC 10.4m telescope in La Palma that is being built by a Consortium led by UCM (Spain) that also includes INAOE (Mexico), IAA-CSIC (Spain), and UPM (Spain). The instrument is currently finishing AIV and will be sent to GTC on November 2016 for its on-sky commissioning on April 2017. The MEGARA IFU fiber bundle (LCB) covers 12.5x11.3 arcsec2 with a spaxel size of 0.62 arcsec while the MEGARA MOS mode allows observing up to 92 objects in a region of 3.5x3.5 arcmin2 around the IFU. The IFU and MOS modes of MEGARA will provide identical intermediate-to-high spectral resolutions (RFWHM~6,000, 12,000 and 18,700, respectively for the low-, mid- and high-resolution Volume Phase Holographic gratings) in the range 3700-9800ÅÅ. An x-y mechanism placed at the pseudo-slit position allows (1) exchanging between the two observing modes and (2) focusing the spectrograph for each VPH setup. The spectrograph is a collimator-camera system that has a total of 11 VPHs simultaneously available (out of the 18 VPHs designed and being built) that are placed in the pupil by means of a wheel and an insertion mechanism. The custom-made cryostat hosts a 4kx4k 15-μm CCD. The unique characteristics of MEGARA in terms of throughput and versatility and the unsurpassed collecting are of GTC make of this instrument the most efficient tool to date to analyze astrophysical objects at intermediate spectral resolutions. In these proceedings we present a summary of the instrument characteristics and the results from the AIV phase. All subsystems have been successfully integrated and the system-level AIV phase is progressing as expected