The global, regional, and national burden of adult lip, oral, and pharyngeal cancer in 204 countries and territories:A systematic analysis for the Global Burden of Disease Study 2019

Importance Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning.Objective To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates.Evidence Review The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019.Findings In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia.Conclusions and Relevance In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts

Factors affecting the morphology of benzoyl peroxide microsponges

Benzoyl peroxide (BPO) is primarily used in the treatment of mild to moderate acne. However, its application is associated with skin irritation. It has been shown that encapsulation and controlled release of BPO could reduce the side effect while also reducing percutaneous absorption when administered to the skin. The aim of the present investigation was to design and formulate an appropriate encapsulated form of BPO, using microsponge technology, and explore the parameters affecting the morphology and other characteristics of the resultant products employing scanning electron microscopy (SEM). Benzoyl peroxide particles were prepared using an emulsion solvent diffusion method by adding an organic internal phase containing benzoyl peroxide, ethyl cellulose and dichloromethane into a stirred aqueous phase containing polyvinyl alcohol (PVA). Different concentrations of BPO microsponges were incorporated in lotion formulations and the drug release from these formulations were studied. The SEM micrographs of the BPO microsponges enabled measurement of their size and showed that they were spherical and porous. Results showed that the morphology and particle size of microsponges were affected by drug:polymer ratio, stirring rate and the amount of emulsifier used. The results obtained also showed that an increase in the ratio of drug:polymer resulted in a reduction in the release rate of BPO from the microsponges. The release data showed that the highest and the lowest release rates were obtained from lotions containing plain BPO particles and BPO microsponges with the drug:polymer ratio of 13:1, respectively. The kinetics of release study showed that the release data followed Peppas model and the main mechanism of drug release from BPO microsponges was diffusion

Mobile internet of things:can UAVs provide an energy-efficient mobile architecture?

Abstract In this paper, the optimal trajectory and deployment of multiple unmanned aerial vehicles (UAVs), used as aerial base stations to collect data from ground Internet of Things (IoT) devices, is investigated. In particular, to enable reliable uplink communications for IoT devices with a minimum energy consumption, a new approach for optimal mobility of the UAVs is proposed. First, given a fixed ground IoT network, the total transmit power of the devices is minimized by properly clustering the IoT devices with each cluster being served by one UAV. Next, to maintain energy-efficient communications in time-varying mobile IoT networks, the optimal trajectories of the UAVs are determined by exploiting the framework of optimal transport theory. Simulation results show that by using the proposed approach, the total transmit power of IoT devices for reliable uplink communications can be reduced by 56% compared to the fixed Voronoi deployment method. Moreover, our results yield the optimal paths that will be used by UAVs to serve the mobile IoT devices with a minimum energy consumption

Mobile unmanned aerial vehicles (UAVs) for energy-efficient internet of things communications

Abstract In this paper, the efficient deployment and mobility of multiple unmanned aerial vehicles (UAVs), used as aerial base stations to collect data from ground Internet of Things (IoT) devices, are investigated. In particular, to enable reliable uplink communications for the IoT devices with a minimum total transmit power, a novel framework is proposed for jointly optimizing the 3D placement and the mobility of the UAVs, device-UAV association, and uplink power control. First, given the locations of active IoT devices at each time instant, the optimal UAVs’ locations and associations are determined. Next, to dynamically serve the IoT devices in a time-varying network, the optimal mobility patterns of the UAVs are analyzed. To this end, based on the activation process of the IoT devices, the time instances at which the UAVs must update their locations are derived. Moreover, the optimal 3D trajectory of each UAV is obtained in a way that the total energy used for the mobility of the UAVs is minimized while serving the IoT devices. Simulation results show that, using the proposed approach, the total-transmit power of the IoT devices is reduced by 45% compared with a case, in which stationary aerial base stations are deployed. In addition, the proposed approach can yield a maximum of 28% enhanced system reliability compared with the stationary case. The results also reveal an inherent tradeoff between the number of update times, the mobility of the UAVs, and the transmit power of the IoT devices. In essence, a higher number of updates can lead to lower transmit powers for the IoT devices at the cost of an increased mobility for the UAVs

Drone-based antenna array for service time minimization in wireless networks

Abstract In this paper, the effective use of multiple drones as an aerial antenna array that provides wireless service to ground users is investigated. In particular, under the goal of minimizing the service time needed for servicing ground users, a novel framework for deploying a drone- based antenna array system whose elements are single-antenna drones is proposed. To this end, first, the antenna array gain is maximized by optimizing the drone spacing within the array. In this case, using perturbation techniques, the drone spacing optimization problem is addressed by solving successive, perturbed convex optimization problems. In the second step, the optimal locations of the drones around the array’s center are derived such that the service time for each ground user is minimized. Simulation results show that the proposed approach can significantly reduce the service time to ground users compared to a single drone that uses the same amount of power as the array. The results also show that the network’s spectral efficiency can be improved by 78% while leveraging the drone antenna array system

Factors affecting the morphology of benzoyl peroxide microsponges

Benzoyl peroxide (BPO) is primarily used in the treatment of mild to moderate acne. However, its application is associated with skin irritation. It has been shown that encapsulation and controlled release of BPO could reduce the side effect while also reducing percutaneous absorption when administered to the skin. The aim of the present investigation was to design and formulate an appropriate encapsulated form of BPO, using microsponge technology, and explore the parameters affecting the morphology and other characteristics of the resultant products employing scanning electron microscopy (SEM). Benzoyl peroxide particles were prepared using an emulsion solvent diffusion method by adding an organic internal phase containing benzoyl peroxide, ethyl cellulose and dichloromethane into a stirred aqueous phase containing polyvinyl alcohol (PVA). Different concentrations of BPO microsponges were incorporated in lotion formulations and the drug release from these formulations were studied. The SEM micrographs of the BPO microsponges enabled measurement of their size and showed that they were spherical and porous. Results showed that the morphology and particle size of microsponges were affected by drug:polymer ratio, stirring rate and the amount of emulsifier used. The results obtained also showed that an increase in the ratio of drug:polymer resulted in a reduction in the release rate of BPO from the microsponges. The release data showed that the highest and the lowest release rates were obtained from lotions containing plain BPO particles and BPO microsponges with the drug:polymer ratio of 13:1, respectively. The kinetics of release study showed that the release data followed Peppas model and the main mechanism of drug release from BPO microsponges was diffusion

Unmanned aerial vehicle with underlaid device-to-device communications:performance and tradeoffs

Abstract In this paper, the deployment of an unmanned aerial vehicle (UAV) as a flying base station used to provide the fly wireless communications to a given geographical area is analyzed. In particular, the coexistence between the UAV, that is transmitting data in the downlink, and an underlaid device-to-device (D2D) communication network is considered. For this model, a tractable analytical framework for the coverage and rate analysis is derived. Two scenarios are considered: a static UAV and a mobile UAV. In the first scenario, the average coverage probability and the system sum-rate for the users in the area are derived as a function of the UAV altitude and the number of D2D users. In the second scenario, using the disk covering problem, the minimum number of stop points that the UAV needs to visit in order to completely cover the area is computed. Furthermore, considering multiple retransmissions for the UAV and D2D users, the overall outage probability of the D2D users is derived. Simulation and analytical results show that, depending on the density of D2D users, the optimal values for the UAV altitude, which lead to the maximum system sum-rate and coverage probability, exist. Moreover, our results also show that, by enabling the UAV to intelligently move over the target area, the total required transmit power of UAV while covering the entire area, can be minimized. Finally, in order to provide full coverage for the area of interest, the tradeoff between the coverage and delay, in terms of the number of stop points, is discussed

Optimal transport theory for cell association in UAV-enabled cellular networks

Abstract In this letter, a novel framework for delay-optimal cell association in unmanned aerial vehicle (UAV)-enabled wireless cellular networks is proposed. In particular, to minimize the average network delay under any arbitrary spatial distribution of the ground users, the optimal cell partitions of the UAVs and terrestrial base stations are determined. To this end, using the powerful mathematical tools of optimal transport theory, the existence of the solution to the optimal cell association problem is proved and the solution space is completely characterized. The analytical and simulation results show that the proposed approach yields substantial improvements in terms of the average network delay

Performance optimization for UAV-enabled wireless communications under flight time constraints

Abstract In this paper, the effective use of unmanned aerial vehicles (UAVs) as flying base stations that can provide wireless service to ground users is investigated. In particular, a novel framework for optimizing the performance of such UAV-based wireless systems, in terms of the average number of bits (data service) transmitted to users under flight time constraints, is proposed. In the considered model, UAVs are deployed over a given geographical area to serve ground users that are distributed within a given area based on an arbitrary spatial distribution function. In this case, based on the maximum possible flight times of the UAVs, the average data service delivered to the users is maximized by finding the optimal cell partitions associated to the UAVs, under a fair resource allocation scheme. To this end, using the powerful mathematical framework of optimal transport theory, a gradient-based algorithm is proposed for optimally partitioning the geographical area based on the users’ distribution, flight times, and locations of the UAVs. Simulation results show that the proposed cell partitioning approach yields a significantly higher fairness among the users compared to the classical weighted Voronoi diagram. In particular, by using our approach, the Jain’s fairness index is improved by a factor of 2.6