A scientometric review of the synergetic effects of emotions on the travel motivation of senior tourists

This paper seeks to make three contributions to the senior tourism literature. The first apllies a scientometric review to analyse when, how and why the subject title has potential value in scientific domain; the second measure and validate senior tourists’ emotional experiences when vacationing in Lisbon, adapting Hosany and Gilbert Destination Emotion Scale (DES); and the third identifies the effect of positive emotions on push motivations. The scientometric review over 18479 bibliographical records published since 1900, were retrieved by terms from the Web-of-Science and exported to CiteSpace. A sample of 464 senior tourists vacationing in Lisbon was conducted to analyses the synergetic effect of emotions on the travel motivations of senior tourists, applying structural equations modeling (SEM). The results shows the association between positive emotions, place attachment and push motivations in seniors tourist experience, through the connection between ten areas of research in the knowledge domain: the first seven major clusters (#0 to #6), and three small clusters: #10 with the reference Jang, (2009); # 41, with the reference Sangpikul, (2008) and cluster #48 with the reference Pearce, (2005)

Measaurement of the intelectual contribution of the issue: Synergetic effect of emotions on the travel motivation of senior tourists

Detecting the signs of potential valuable ideas has theoretical and practical implications in order to safeguard the integrity of scientific knowledge. A critical part is to discern whether the study of a new idea is cognitively demanding. Not only do we need to have an up-do-date understanding of the scientific field’s intellectual structure as we must be able to identify exactly how the newly idea is connected to the intellectual structure as well. The perceived value of this paper is to provide specific trails of evidence to show why and how “The Synergetic Effect of Emotions on Travel Motivation of Senior Tourists” is novel in the scientific domain. The prediction of its potential value is going to be made in computational terms, using the program CiteSpace, showing the degree of changes introduced by it due to its connection with previously disparate patches of knowledge, creating a network of ideas. CiteSpace supports the modeling and visualization of our topic from bibliographical sources in terms of networks of several types of entities, including cited references, co-authors, co-occuring keywords and identify centrality between pivotal points as a measure of the importance of those nodes. This paper centered on document citations and co-citations networks in order to deliver accurate results for the knowledge of each domain. Individual nodes in the network can be aggregated into different thematic concentrations or clusters, based on their interconnectivity. Other points of interest include articles highly cited, strong bursts and hight frequency of occurance

Pancreatic cancer diagnosis and management: Has the time come to prick the bubble?

Pancreatic cancer (PC) is associated with poor prognosis and very dismal survival rates. The most effective possibility of cure is tumor resection, which is only possible in about 15% of patients diagnosed at early stages of disease progression. Recent whole-genome sequencing studies pointed genetic alterations in 12 core signaling pathways in PC. These observations hint at the possibility that the initial mutation in PC might appear nearly 20 years before any symptoms occur, suggesting that a large window of opportunity may exist for early detection. Biomarkers with the potential to identify pre-neoplastic disease or very early stages of cancer are of great promise to improve patient survival. The concept of liquid biopsy refers to a minimally invasive sampling and analysis of liquid biomarkers that can be isolated from body fluids, primarily blood, urine and saliva. A myriad of circulating molecules may be useful as tumor markers, including cell-free DNA (cfDNA), cell-free RNA (cfRNA), circulating tumor cells (CTC), circulating tumor proteins, and extracellular vesicles, more specifically exosomes. In this review, we discuss with more detail the potential role of exosomes in several aspects related to PC, from initiation to tumor progression and its applicability in early detection and treatment. Exosomes are small circulating extracellular vesicles of 50-150 nm in diameter released from the plasma membrane by almost all cells and exhibit some advantages over other biomarkers. Exosomes are central players of intercellular communication and they have been implicated in a series of biological process, including tumorigenesis, migration and metastasis. Several exosomal microRNAs and proteins have been observed to distinguish PC from benign pancreatic diseases and healthy controls. Besides their possible role in diagnosis, understanding exosomes functions in cancer has clarified the importance of microenvironment in PC progression as well as its influence in proliferation, metastasis and resistance to chemotherapy. Increasing knowledge on cancer exosomes provides valuable insights on new therapeutic targets and can potentially open new strategies to treat this disease. Continuous research is needed to ascertain the reliability of using exosomes and their content as potential biomarkers, so that, hopefully, in the near future, they will provide the opportunity for early diagnosis, treatment intervention and increase survival of PC patients.The Melo team is supported by the project NORTE-01-0145-FEDER-000029, Norte Portugal Regional Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and national funds through FCT—Foundation for Science and Technology IF/00543/2013/CP1184/CT0004, PTDC/BIM-ONC/2754/2014, POCI-01-0145-FEDER-32189 and Astrazeneca Foundation, FAZ Ciencia Award

Coaching in pharmaceutical sciences

Poster presented at the European Association of Faculties of Pharmacy Annual Conference. 15-17 May 2019, Krakow, PolandN/

Multispectral Indices for Wildfire Management

This paper highlights and summarizes the most important multispectral indices and associated methodologies for fire management. Various fields of study are examined where multispectral indices align with wildfire prevention and management, including vegetation and soil attribute extraction, water feature mapping, artificial structure identification, and post-fire burnt area estimation. The versatility and effectiveness of multispectral indices in addressing specific issues in wildfire management are emphasized. Fundamental insights for optimizing data extraction are presented. Concrete indices for each task, including the NDVI and the NDWI, are suggested. Moreover, to enhance accuracy and address inherent limitations of individual index applications, the integration of complementary processing solutions and additional data sources like high-resolution imagery and ground-based measurements is recommended. This paper aims to be an immediate and comprehensive reference for researchers and stakeholders working on multispectral indices related to the prevention and management of fires

Wood anatomical characterization and intraspecific variation in Protium apiculatum Swart at the second forest management cycle.

A Floresta Nacional do Tapajós teve seu primeiro ciclo de corte em 1979 e a área foi monitorada através de inventários florestais desde então. Neste período houve mudanças na composição florística, com Protium apiculatum Swart sendo uma das espécies mais abundantes e frequentes. No entanto, não existem estudos das suas características tecnológicas da madeira. Assim, o estudo teve como objetivo caracterizar anatomicamente cinco árvores dessa espécie. Discos de madeira de foram coletados a dois metros de altura de cada árvore, o material foi separado para análise macroscópica e microscópica. Através dos resultados obtidos, percebeu-se variação intraespecífica entre os caracteres anatômicos de Protium apiculatum em um mesmo local e similaridade com outros indivíduos de seu gênero

Low-Dissipation Data Bus via Coherent Quantum Dynamics

The transfer of information between two physical locations is an essential component of both classical and quantum computing. In quantum computing the transfer of information must be coherent to preserve quantum states and hence the quantum information. We establish a simple protocol for transferring one- and two-electron encoded logical qubits in quantum dot arrays. The theoretical energetic cost of this protocol is calculated - in particular, the cost of freezing and unfreezing tunnelling between quantum dots. Our results are compared with the energetic cost of shuttling qubits in quantum dot arrays and transferring classical information using classical information buses. Only our protocol can manage constant dissipation for any chain length. This protocol could reduce the cooling requirements and constraints on scalable architectures for quantum dot quantum computers.Comment: 10 pages, 6 figure

An Analysis of Phyllotoxins and Accompanying Bioactives

The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) for the grant 2022.00252.CEECIND to A.P.R., the grant 2022.11150.BD to I.M.C., the funding of the WormALL project (PTDC/BTA-BTA/28650/2017), and for supporting the Applied Molecular Biosciences Unit—UCIBIO (UIDP/04378/2020 and UIDB/04378/2020) and the Associate Laboratory Institute for Health and Bioeconomy—i4HB (LA/P/0140/2020). The authors also acknowledge Fundo Azul for co-financing the MARVEN project (FA_05_2017_007). Publisher Copyright: © 2024 by the authors.Proteinaceous toxins are peptides or proteins that hold great biotechnological value, evidenced by their ecological role, whether as defense or predation mechanisms. Bioprospecting using bioinformatics and omics may render screening for novel bioactives more expeditious, especially considering the immense diversity of toxin-secreting marine organisms. Eulalia sp. (Annelida: Phyllodocidae), a toxin bearing marine annelid, was recently shown to secrete cysteine-rich protein (Crisp) toxins (hitherto referred to as ‘phyllotoxins’) that can immobilize its prey. By analyzing and validating transcriptomic data, we narrowed the list of isolated full coding sequences of transcripts of the most abundant toxins or accompanying bioactives secreted by the species (the phyllotoxin Crisp, hyaluronidase, serine protease, and peptidases M12A, M13, and M12B). Through homology matching with human proteins, the biotechnological potential of the marine annelid’s toxins and related proteins was tentatively associated with coagulative and anti-inflammatory responses for the peptidases PepM12A, SePr, PepM12B, and PepM13, and with the neurotoxic activity of Crisp, and finally, hyaluronidase was inferred to bear properties of an permeabilizing agent. The in silico analysis succeeded by validation by PCR and Sanger sequencing enabled us to retrieve cDNAs can may be used for the heterologous expression of these toxins.publishersversionpublishe