Revista do Museu Paulista e(m) capas: identidade e representação institucional em texto e imagem

Este artigo propõe reflexão sobre a escrita da história, a partir de estudo das capas da Revista do Museu Paulista, especialmente durante as gestões dos dois primeiros diretores da instituição, quando certa continuidade editorial foi preservada. Tomadas como "fontes", ou seja, objeto de trabalho do historiador, as capas revelam vestígios de processos que permitem reconstruir, em suas dimensões históricas, as complexas imbricações entre a produção da Revista, sua materialidade, e os atos de leitura e interpretação que condicionam e refletem relações entre produtores de textos e seus leitores nas primeiras décadas do século XX, a partir de São Paulo, onde era editada.This paper offers a reflection about the writing of History, based on the study of Revista do Museu Paulista's covers, noticeably during the term of its two first directors, when a certain editorial continuity was preserved. Taken as "sources", namely as historian subjects, those covers reveal evidences of practices that allow one to reconstitute, in its historic dimensions, the complex connection between the creation of the Revista, its materiality, and the reading and interpretation efforts that condition and reflect liaisons with writers and readers during the first decades of the XXth Century, from São Paulo, where it was published.

Decreto n. 248 de 26 de Julho de 1894 - Programa das Escolas Preliminares de São Paulo

Trecho do Decreto n. 248 de 26 de Julho de 1894 aprovado por Bernardino de Campos e assinado pelo Dr. Cesário Motta Junior.Este decreto apresenta o regimento interno das escolas públicas do Estado de São Paulo tendo em seu Annexo 1 os programas das Escolas Preliminares de São Paulo pertencentes aos Grupos Escolares. Documento retirado do site da Assembleia Legislativa do Estado de São Paulo: http://www.al.sp.gov.br/repositorio/legislacao/decreto/1894/decreto%20n.248,%20de%2026.07.1894.ht

Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway

This study presents data suggesting that both human mesothelioma (cell lines and human mesothelioma biopsies) and human normal mesothelial cells express receptors for acetylcholine and that stimulation of these receptors by nicotine prompted cell growth via activation of nicotinic cholinergic receptors. Thus, these data demonstrate that: (a) human mesothelioma cells and human biopsies of mesothelioma as well as of normal pleural mesothelial cells express functionally alpha-7 nicotinic acethlycholine receptors, evaluated by alpha-bungarotoxin-FITC binding, receptor binding assay, Western blot, and reverse transcription-PCR; (b) choline acetyltransferase immunostaining is present in mesothelioma cells; (c) mesothelioma cell growth is modulated by the cholinergic system in which agonists (i.e., nicotine) has a proliferative effect, and antagonists (i.e., curare) has an inhibitory effect, evaluated by cell cloning, DNA synthesis and cell cycle; (d) nicotine induces Ca(+2) influx, evaluated by [(45)Ca(2+)] uptake, and consequently activation of mitogen-activated protein kinase pathway (extracellular signal-regulated kinase and p90(RSK) phosphorylation), evaluated by Western blot; and (e) apoptosis mechanisms in mesothelioma cells are under the control of the cholinergic system (nicotine antiapoptotic via induction of nuclear factor-kappaB complexes and phosphorylation of Bad at Ser(112); curare proapoptotic via G(0)-G(1) arrest p21(waf-1) dependent but p53 independent). The involvement of the nonneuronal cholinergic system in mesothelioma appears reasonable and open up new therapeutic strategies

alfa7-Nicotinic Acetylcholine Receptors Affect Growth Regulation of Human Mesothelioma Cells: Role of Mitogen-Activated Protein Kinase Pathway

This study presents data suggesting that both human mesothelioma (cell lines and human mesothelioma biopsies) and human normal mesothelial cells express receptors for acetylcholine and that stimulation of these receptors by nicotine prompted cell growth via activation of nicotinic cholinergic receptors. Thus, these data demonstrate that: (a) human mesothelioma cells and human biopsies of mesothelioma as well as of normal pleural mesothelial cells express functionally alpha-7 nicotinic acethlycholine receptors, evaluated by alpha-bungarotoxin-FITC binding, receptor binding assay, Western blot, and reverse transcription-PCR; (b) choline acetyltransferase immunostaining is present in mesothelioma cells; (c) mesothelioma cell growth is modulated by the cholinergic system in which agonists (i.e., nicotine) has a proliferative effect, and antagonists (i.e., curare) has an inhibitory effect, evaluated by cell cloning, DNA synthesis and cell cycle; (d) nicotine induces Ca(+2) influx, evaluated by [(45)Ca(2+)] uptake, and consequently activation of mitogen-activated protein kinase pathway (extracellular signal-regulated kinase and p90(RSK) phosphorylation), evaluated by Western blot; and (e) apoptosis mechanisms in mesothelioma cells are under the control of the cholinergic system (nicotine antiapoptotic via induction of nuclear factor-kappaB complexes and phosphorylation of Bad at Ser(112); curare proapoptotic via G(0)-G(1) arrest p21(waf-1) dependent but p53 independent). The involvement of the nonneuronal cholinergic system in mesothelioma appears reasonable and open up new therapeutic strategies

Imigração e epidemias no estado de São Paulo Immigration and epidemics in the state of São Paulo

Esse artigo tem por objetivo apresentar e discutir aspectos de interesse sanitário no processo de imigração estrangeira para o estado de São Paulo, na primeira década após a proclamação da República. Objetiva também apresentar as relações da imigração com a formação dos serviços sanitários estaduais e com a elaboração do modelo tecno-assistencial por eles adotado a partir da década de 1890. Num momento em que a febre amarela era a mais freqüente e letal das epidemias que afetavam o estado, matando principalmente os estrangeiros, a defesa do fluxo migratório foi um dos fios condutores das ações em saúde pública. A combinação entre os interesses da cafeicultura, a expansão ferroviária, imigração e febre amarela definiu os rumos da ação sanitária promovida pelas oligarquias no poder nesse período em São Paulo. A organização autoritária do Estado brasileiro não dava espaço à implantação de ações individuais de assistência à saúde. Sempre reivindicada pela população urbana e rural, somente com o desenvolvimento da medicina previdenciária no país, na década de 1930, difundiram-se as ações de assistência individual à saúde.<br>The article discusses sanitation issues as aspects of the process of foreign immigration into São Paulo state during the first decade after the Proclamation of the Republic. The text also shows the relationships between this wave of immigration and the structuring of state sanitation services and the devising of the techno assistance model adopted by these services as of the 1890' s. At a time when yellow fever was the most common and lethal of the epidemics plaguing that state killing mainly foreigners one of the lodestars of public health actions was the defense of this inflow of immigrants. The interests of coffee growers, expansion of the railroads, immigration, and yellow fever all came into play when the oligarchies then in power in São Paulo defined what direction sanitation measures would take. The Brazilian government's authoritarian organization left no room for individual health assistance initiatives. Long a demand of both urban and rural populations, forms of individual health assistance became widespread only in the 1930' s, when Brazil developed its social health-care system