Análise comparativa de custo de materiais entre uma estrutura em concreto armado e metálica: estudo de caso na cidade de Palmas/TO

There are constantly advances in technology, and with that, several segments of the industrial market are benefited. In this context, one area that is gaining influence is that of civil construction. New technologies that can be applied, innovative materials, increasingly useful tools, all directly influence civil construction today. This range of action possibilities raises questions about the efficiency and effectiveness of these technological variability in the field of engineering and it is in this context that this work is supported. This research proposes a comparison of material costs considering two different construction systems (reinforced concrete structure and metallic structure), in which a building located in the city of Palmas / TO is based on the study. Starting from an existing structure in reinforced concrete, with the purpose of proposing a metallic structure, the CYPE 3D software was used, in addition to catalogs of companies that operate in the supply of the necessary materials. For the survey of costs, the compositions and inputs of the National System of Research on Costs and Indices of Civil Construction (SINAPI) were considered, in addition to surveying the market. In this context, it was found that the costs of the metallic structure were approximately 61% higher than the costs of reinforced concrete, since the precision of production of the metallic parts, associated with the agility of construction and the specialized labor directly influence the cost of the construction. constructions.Constantemente há avanços na tecnologia, e com isso, diversos segmentos do mercado industrial são beneficiados. Nesse contexto, uma área que obtém influência é a da construção civil. Novidades em tecnologias que podem ser aplicadas, materiais inovadores, ferramentas cada vez mais úteis, tudo influencia diretamente na construção civil atualmente. Essa gama de possibilidade de atuação, levanta o questionamento a respeito da eficiência e eficácia dessas variabilidades tecnológicas no âmbito da engenharia e é neste contexto que este trabalho se apoia. A presente pesquisa propos uma comparação de custos de materiais considerando dois sistemas construtivos distintos (estrutura em concreto armado e estrutura metálica), em que se tem como base de estudo um edifício localizado na cidade de Palmas/TO. Partindo de uma estrutura já existente em concreto armado, com a finalidade de propor uma estrutura metálica, foi utilizado o software CYPE 3D, além de catálogos de empresas que atuam no fornecimento dos materiais necessários. Para o levantamento de custos, considerou-se as composições e insumos do Sistema Nacional de Pesquisas de Custos e Índices da Construção Civil (SINAPI) além de levantamento no mercado. Nesse contexto contatou-se que os custos da estrutura metálica foram superiores em aproximadamente 61% em relação aos custos do concreto armado, pois a precisão de produção das peças metálicas, associadas a agilidade de construção e da mão de obra especializada podem influenciar diretamente no custo da obra

Concomitant infection of Haemogregarina sp. and Staphylococcus aureus in free-living yellow-spotted river turtle (Podocnemis unifilis): case report.

A male adult yellow-spotted river turtle Podocnemis unifilis (Chordata: Testudines: Podocnemididae) was captured during field collections. Blood sample was collected for haemoparasite screening by conventional light microscopy. Morphometric and morphological analyzes of the parasite developmental stages were performed in the blood extensions, as well as the parasitemia intensity. Gametocytes of hemogregarines and innumerable bacterial cells were observed. To identify the bacteria present, a culture was performed and the presence of Staphylococcus aureus was observed. It was concluded that a co-infection of Staphylococcus aureus (Firmicutes: Bacillales: Staphylococcaceae) and Haemogregarina sp. (Apicomplexa: Adeleina: Haemogregarinidae) was observed in this free-living yellow-spotted river turtle Podocnemis unifilis.

A case report of papular-purpuric gloves and socks syndrome: A manifestation of the parvovirus B19

Introduction: The majority of parvovirus B19 infections are asymptomatic. In childhood, however, they may present as the fifth disease and in adults their manifestations can vary from mild, non-specific, cold-like symptoms to other forms of presentations. Papular-purpuric gloves and socks syndrome (PPGSS) is an uncommon form of parvovirus B19 infection, characterized by symmetric, pruriginous and painful erythema and edema of feet and hands. Generally, systemic symptoms are usually mild and dissemination to other body regions occurs in only 50% of the cases. The rash gradually progresses to petechiae and purpura delineating well demarcated "socks" and "gloves" on both feet and hands. The diagnosis is predominantly based on the clinical features. Serologic conversion is not considered as evidence of parvovirus B19 infection and histopathological findings from lesional skin are not specific. There are no definite antiviral drugs or vaccines against parvovirus. Patients with PPGSS require only symptomatic therapy. Case Report: We report the case of a 30-year-old female with this characteristic erythema caused by the parvovirus B19. Nevertheless, this case is remarkable because the patient had significant systemic manifestations and an exuberant perineal and oropharyngeal involvement. Further, the erythema assumed a bullous expression that has not been so commonly reported. A biopsy was performed which was unspecific and the diagnosis was confirmed with the serology and molecular detection of the virus in blood sample as well as on mouth swab. Our patient needed treatment to control pain and pruritus, fever was self-limited. Conclusion: A high index of suspicion is essential to diagnose patients with this syndrome. Early recognition can prevent unproductive measures and the good management of this infection.info:eu-repo/semantics/publishedVersio

Acute HIV-1 and SARS-CoV-2 infections Share Slan+ Monocyte Depletion - evidence from an hyperacute HIV-1 case report

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Monocytes are key modulators in acute viral infections, determining both inflammation and development of specific B- and T-cell responses. Recently, these cells were shown to be associated to different SARS-CoV-2 infection outcome. However, their role in acute HIV-1 infection remains unclear. We had the opportunity to evaluate the mononuclear cell compartment in an early hyper-acute HIV-1 patient in comparison with an untreated chronic HIV-1 and a cohort of SARS-CoV-2 infected patients, by high dimensional flow cytometry using an unsupervised approach. A distinct polarization of the monocyte phenotype was observed in the two viral infections, with maintenance of pro-inflammatory M1-like profile in HIV-1, in contrast to the M2-like immunosuppressive shift in SARS-CoV-2. Noticeably, both acute infections had reduced CD14low/-CD16+ non-classical monocytes, with depletion of the population expressing Slan (6-sulfo LacNac), which is thought to contribute to immune surveillance through pro-inflammatory properties. This depletion indicates a potential role of these cells in acute viral infection, which has not previously been explored. The inflammatory state accompanied by the depletion of Slan+ monocytes may provide new insights on the critical events that determine the rate of viral set-point in acute HIV-1 infection and subsequent impact on transmission and reservoir establishment.This work was funded by the following grants from Fundação para a Ciência e a Tecnologia (FCT), Portugal, through “Apoio Especial Research4COVID-19”, project numbers 125 to S.M.F. and 803 to A.C.T. Fellowships funded by FCT (Doctorates4COVID-19, 2020.10202.BD), and Janssen-Cilag Farmacêutica were received by A.M.C.G. and G.B.F., respectively.info:eu-repo/semantics/publishedVersio

Influência da localização do núcleo rígido de edificios de múltiplos pavimentos de concreto armado na estabilidade global das estruturas / Influence of the location of the hard core of buildings of multiple armed concrete floors on the global stability of structures

A análise da estabilidade global das estruturas tem elevada importância no ramo da construção civil pois a tendência para a construção de edifícios cada vez mais altos e esbeltos só tem aumentado no pais. Este trabalho retrata um estudo, sobre a estabilidade global, realizado em uma edificação de múltiplos pavimentos de concreto armado considerando o núcleo rígido como sistema de contraventamento. Para viabilizar o estudo, foram realizados três dimensões com diferentes posições do núcleo rígido: centrado na edificação, excêntrico ao maior lado da edificação e excêntrico ao menor lado da edificação. A análise da estabilidade global foi realizada através do coeficiente de qualidade, também, classificar uma estrutura quanto aos tipos de nós.Também foram encontrados quanto ao consumo de materiais como aço, concreto e formas dos edifícios estudados. Esta pesquisa concluiu que o núcleo rígido localizado no centro da edificação apresentou melhores resultados que as outras relacionadas com a relação à estabilidade global. O estudo do consumo de material realizado não viabilizou determinar com precisão qual projeto apresenta o melhor custo benefício devido à alteração do núcleo rígido, pelo que se faz necessário um estudo mais detalhado

Severe COVID-19 recovery is associated with timely acquisition of a myeloid cell immune-regulatory phenotype

Copyright © 2021 Trombetta, Farias, Gomes, Godinho-Santos, Rosmaninho, Conceição, Laia, Santos, Almeida, Mota, Gomes, Serrano, Veldhoen, Sousa and Fernandes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.After more than one year since the COVID-19 outbreak, patients with severe disease still constitute the bottleneck of the pandemic management. Aberrant inflammatory responses, ranging from cytokine storm to immune-suppression, were described in COVID-19 and no treatment was demonstrated to change the prognosis significantly. Therefore, there is an urgent need for understanding the underlying pathogenic mechanisms to guide therapeutic interventions. This study was designed to assess myeloid cell activation and phenotype leading to recovery in patients surviving severe COVID-19. We evaluated longitudinally patients with COVID-19 related respiratory insufficiency, stratified according to the need of intensive care unit admission (ICU, n = 11, and No-ICU, n = 9), and age and sex matched healthy controls (HCs, n = 11), by flow cytometry and a wide array of serum inflammatory/immune-regulatory mediators. All patients featured systemic immune-regulatory myeloid cell phenotype as assessed by both unsupervised and supervised analysis of circulating monocyte and dendritic cell subsets. Specifically, we observed a reduction of CD14lowCD16+ monocytes, and reduced expression of CD80, CD86, and Slan. Moreover, mDCs, pDCs, and basophils were significantly reduced, in comparison to healthy subjects. Contemporaneously, both monocytes and DCs showed increased expression of CD163, CD204, CD206, and PD-L1 immune-regulatory markers. The expansion of M2-like monocytes was significantly higher at admission in patients featuring detectable SARS-CoV-2 plasma viral load and it was positively correlated with the levels of specific antibodies. In No-ICU patients, we observed a peak of the alterations at admission and a progressive regression to a phenotype similar to HCs at discharge. Interestingly, in ICU patients, the expression of immuno-suppressive markers progressively increased until discharge. Notably, an increase of M2-like HLA-DRhighPD-L1+ cells in CD14++CD16- monocytes and in dendritic cell subsets was observed at ICU discharge. Furthermore, IFN-γ and IL-12p40 showed a decline over time in ICU patients, while high values of IL1RA and IL-10 were maintained. In conclusion, these results support that timely acquisition of a myeloid cell immune-regulatory phenotype might contribute to recovery in severe systemic SARS-CoV-2 infection and suggest that therapeutic agents favoring an innate immune system regulatory shift may represent the best strategy to be implemented at this stage.The Research was funded by Fundação para a Ciência e Tecnologia (FCT), “APOIO ESPECIAL RESEARCH 4COVID-19” projects 803, 125, 231_596873172, and 729. AMCG and GF received fellowships funded by FCT (DOCTORATES4COVID-19, 2020.10202.BD), and JANSSEN- CILAG FARMACÊUTICA, respectively. The funder was not involved in the study design, collection, analysis, interpretation of data, writing of the article or decision to submit it for publication. MV was supported by the European Union H2020 ERA project (No 667824 – EXCELLtoINNOV). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 667824.info:eu-repo/semantics/publishedVersio

SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10

© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of circulating ILCs at hospital admission, in agreement with overall lymphocyte depletion. However, ILCs recovered in direct correlation with lung function improvement as measured by oxygenation index and in negative association with inflammatory and lung/endothelial damage markers like RAGE. While both ILC1 and ILC2 expanded, ILC2 showed the most striking phenotype changes, with CCR10 upregulation in strong correlation with these parameters. Overall, CCR10+ ILC2 emerge as relevant contributors to SARS-CoV-2 pneumonia recovery.This work was funded by the following grants from Fundação para a Ciência e a Tecnologia (FCT), Portugal, through “APOIO ESPECIAL RESEARCH4COVID-19,” project numbers 125 to SMF and 803 to ACT. AMCG and GBF received fellowships funded by FCT (DOCTORATES4COVID-19, 2020.10202.BD) and JANSSEN- CILAG FARMACÊUTICA, respectively.info:eu-repo/semantics/publishedVersio

Salmonella spp. em Cebus spp. mantidos em Centros de Triagem de Animais Silvestres no Nordeste do Brasil

Objetivou-se com esse estudo isolar e identificar os sorovares de Salmonella spp. em Cebus spp. mantidos em cativeiro. Foram investigados 28 animais mantidos em Centros de Triagem de Animais Silvestres (CETAS) do Nordeste do Brasil. Foram realizados suabes retais que foram processados para o isolamento da bactéria em meios seletivos seguido da identificação dos sorovares por meio de provas bioquímicas. Das 28 amostras analisadas, cinco (17,9%) foram positivas para Salmonella spp. e os sorovares identificados foram Infantis (40%), Panama (40%) e Newport (20%). Ocorreu associação significativa (p<0.05) para as variáveis: instituição (p=0,026), armazenamento de frutas, verduras e hortaliças (p=0,026), fornecimento de carne crua (p=0,026), tipo de bebedouro (p=0,026) e higienização diária de bebedouros (p=0,026). Esse estudo demonstrou que infecções por Salmonella spp. ocorrem em populações de Cebus mantidos em cativeiro e apontou para a necessidade de se realizar investigações periódicas em todo o plantel, assim como implantar medidas de controle para evitar riscos à saúde dos animas e pública

Prevention of hypertension in patients with pre-hypertension: protocol for the PREVER-prevention trial

<p>Abstract</p> <p>Background</p> <p>Blood pressure (BP) within pre-hypertensive levels confers higher cardiovascular risk and is an intermediate stage for full hypertension, which develops in an annual rate of 7 out of 100 individuals with 40 to 50 years of age. Non-drug interventions to prevent hypertension have had low effectiveness. In individuals with previous cardiovascular disease or diabetes, the use of BP-lowering agents reduces the incidence of major cardiovascular events. In the absence of higher baseline risk, the use of BP agents reduces the incidence of hypertension. The PREVER-prevention trial aims to investigate the efficacy, safety and feasibility of a population-based intervention to prevent the incidence of hypertension and the development of target-organ damage.</p> <p>Methods</p> <p>This is a randomized, double-blind, placebo-controlled clinical trial, with participants aged 30 to 70 years, with pre-hypertension. The trial arms will be chlorthalidone 12.5 mg plus amiloride 2.5 mg or identical placebo. The primary outcomes will be the incidence of hypertension, adverse events and development or worsening of microalbuminuria and of left ventricular hypertrophy in the EKG. The secondary outcomes will be fatal or non-fatal cardiovascular events: myocardial infarction, stroke, heart failure, evidence of new sub-clinical atherosclerosis, and sudden death. The study will last 18 months. The sample size was calculated on the basis of an incidence of hypertension of 14% in the control group, a size effect of 40%, power of 85% and P alpha of 5%, resulting in 625 participants per group. The project was approved by the Ethics committee of each participating institution.</p> <p>Discussion</p> <p>The early use of blood pressure-lowering drugs, particularly diuretics, which act on the main mechanism of blood pressure rising with age, may prevent cardiovascular events and the incidence of hypertension in individuals with hypertension. If this intervention shows to be effective and safe in a population-based perspective, it could be the basis for an innovative public health program to prevent hypertension in Brazil.</p> <p>Trial Registration</p> <p>Clinical Trials <a href="http://www.clinicaltrials.gov/ct2/show/NCT00970931">NCT00970931</a>.</p