Dissociative symptoms in female patients with mood and anxiety disorders: a psychopathological and temperamental investigation.

Abstract OBJECTIVE: Dissociative symptoms are frequent among psychiatric patients and may considerably affect patients' psychopathological condition and treatment outcomes. The objectives of the study are to assess the presence of dissociative symptoms in female patients with mood and anxiety disorders, to investigate their correlation with the clinical severity of the disorders and to investigate those personality traits that are more frequent in patients with high levels of dissociation. PATIENTS AND METHODS: 50 Caucasian females were enrolled in the study. Patients were assessed through the Self-Report Symptom Check-List, the Dissociative Experiences Scale (DES) and rating scales for Depression and Anxiety. RESULTS: The mean DES score in the overall sample was 16.6. 32% of patients had a DES score > 20. Depressive symptoms positively correlated with the DES total scores. Dissociator patients presented some significantly different temperamental characteristics in comparison with non dissociator patients. CONCLUSIONS: Dissociative symptoms are highly present in patients with mood and anxiety disorders and correlate with the severity of depressive symptoms. Specific personality traits more frequently observed in dissociator people may represent predisposing factors; their early identification could be clinically relevant

Memristive Bauelemente für neuronale Schaltungen

The present post-doctoral thesis covers 14 original publications, which result from my work as research assistant between 2011 and 2015 at the Institute of electrical engineering at the technical faculty of the Christian-Albrecht university at Kiel. During this time my research work was strongly guided by the question how to understand memory and learning in brains and how we can build up non-biological systems, which function similar to those. In particular, I focused on the usage of new non-volatile memory technologies and electronic circuits for neuromorphic systems. Thus, the development of non-volatile devices and electronic circuits as well as biological models based on those devices is at the heart of this post-doctoral thesis

Geothermal state of the deep Western Alpine Molasse Basin, France-Switzerland

Over the last few years the Western Alpine Molasse Basin (WAMB) has been attracting large institutional, industrial and scientific interest to evaluate the feasibility of geothermal energy production. However, the thermal state of the basin, which is instrumental to the development of such geothermal projects, has remained to date poorly known. Here, we compile and correct temperature measurements (mostly bottom hole temperature) from 26 existing well data mostly acquired during former hydrocarbon exploration in the basin. These data suggest that the average geothermal gradient of the WAMB is around 25–30 °C/km. We further use these data to build the first well data-driven 3D geostatistical temperature model of the whole basin and generate probabilistic maps of isotherms at 70 and 140 °C. This model highlights a number of positive and negative thermal anomalies that are interpreted in the context of heat advection caused by fluid circulation along faults and/or karst systems. This study confirms that the WAMB has a great potential for low-enthalpy geothermal resources and presents a typology of advection-dominated potential targets

tofacitinib treatment is associated with modest and reversible increases in serum lipids in patients with ulcerative colitis

Background & Aims Tofacitinib is an oral, small-molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). We analyzed inflammation, lipid concentrations, and incidence rates of major adverse cardiovascular (CV) events (MACEs) in patients who received tofacitinib in worldwide studies. Methods We collected data from 1157 patients who participated in 3 8-week induction studies (1 phase-2 study and 2 phase-3 studies; patients received tofacitinib 10 mg twice daily or placebo), a 52-week phase-3 maintenance study of responders (patients received tofacitinib 5 or 10 mg twice daily or placebo), and an ongoing long-term extension study of patients who did and did not respond to induction or maintenance therapy (patients received tofacitinib 5 or 10 mg twice daily). Lipid concentrations were assessed from induction baseline to week 61 (week 52 of maintenance therapy). We calculated MACE incidence rates (patients with ≥1 event per 100 patient-years of exposure) and Reynolds risk score (RRS; a composite score used to determine CV risk) for patients given tofacitinib vs placebo. Results The mean RRS was P Conclusions In an analysis of data from 5 trials of patients with UC who received tofacitinib, we found reversible increases in lipids with treatment and inverse correlations with reduced levels of high-sensitivity C-reactive protein. We did not find clinically meaningful changes in lipid ratios or RRS. MACEs were infrequent and not dose-related. Clinical trial registration Clinicaltrials.gov : A3921063 ( NCT00787202 ); OCTAVE Induction 1 ( NCT01465763 ); OCTAVE Induction 2 ( NCT01458951 ); OCTAVE Sustain ( NCT01458574 ); OCTAVE Open ( NCT01470612

Betti numbers for numerical semigroup rings

We survey results related to the magnitude of the Betti numbers of numerical semigroup rings and of their tangent cones.Comment: 22 pages; v2: updated references. To appear in Multigraded Algebra and Applications (V. Ene, E. Miller Eds.