Accelerator Testing of the General Antiparticle Spectrometer, a Novel Approach to Indirect Dark Matter Detection

We report on recent accelerator testing of a prototype general antiparticle spectrometer (GAPS). GAPS is a novel approach for indirect dark matter searches that exploits the antideuterons produced in neutralino-neutralino annihilations. GAPS captures these antideuterons into a target with the subsequent formation of exotic atoms. These exotic atoms decay with the emission of X-rays of precisely defined energy and a correlated pion signature from nuclear annihilation. This signature uniquely characterizes the antideuterons. Preliminary analysis of data from a prototype GAPS in an antiproton beam at the KEK accelerator in Japan has confirmed the multi-X-ray/pion star topology and indicated X-ray yields consistent with prior expectations. Moreover our success in utilizing solid rather than gas targets represents a significant simplification over our original approach and offers potential gains in sensitivity through reduced dead mass in the target area.Comment: 18 pages, 9 figures, submitted to JCA

Direct, Indirect and Collider Detection of Neutralino Dark Matter In SUSY Models with Non-universal Higgs Masses

In supersymmetric models with gravity-mediated SUSY breaking, universality of soft SUSY breaking sfermion masses m_0 is motivated by the need to suppress unwanted flavor changing processes. The same motivation, however, does not apply to soft breaking Higgs masses, which may in general have independent masses from matter scalars at the GUT scale. We explore phenomenological implications of both the one-parameter and two-parameter non-universal Higgs mass models (NUHM1 and NUHM2), and examine the parameter ranges compatible with Omega_CDM h^2, BF(b --> s,gamma) and (g-2)_mu constraints. In contrast to the mSUGRA model, in both NUHM1 and NUHM2 models, the dark matter A-annihilation funnel can be reached at low values of tan(beta), while the higgsino dark matter annihilation regions can be reached for low values of m_0. We show that there may be observable rates for indirect and direct detection of neutralino cold dark matter in phenomenologically aceptable ranges of parameter space. We also examine implications of the NUHM models for the Fermilab Tevatron, the CERN LHC and a Sqrt(s)=0.5-1 TeV e+e- linear collider. Novel possibilities include: very light s-top_R, s-charm_R squark and slepton_L masses as well as light charginos and neutralinos and H, A and H^+/- Higgs bosons.Comment: LaTeX, 48pages, 26 Figures. The version with high resolution Figures is available at http://hep.pa.msu.edu/belyaev/public/projects/nuhm/nuhm.p

Religiousness as a Predictor of Suicide: An Analysis of 162 European Regions

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149318/1/sltb12435.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149318/2/sltb12435_am.pd

Advanced multimodal laser imaging tool for urothelial carcinoma diagnosis (AMPLITUDE)

Bladder cancer (BC) is the eleventh most diagnosed cancer worldwide. The age-standardized incidence rate (per 100 000 person/years) is 9.0 for men and 2.2 for women [1]. Urothelial carcinoma (UC) represents about 90% of all bladder tumors, thus carrying an enormous social and economic burden [2]. UCs are classified in different stages and grades, depending on their invasiveness and on their degree of cytological abnormalities. The key aspect for a positive prognosis is the early and accurate diagnosis of the lesion stage, in order to identify the most aggressive disease forms and treat them promptly. It is well known that tissue metabolism constitutes a basic mechanism, which is at the base of many pathologies, especially BC. Being able to detect and characterize tissue metabolism and molecular fingerprints at the cellular level could be a key aspect in characterizing the pathology and enabling both early detection and therapy monitoring. The new European Union Horizon 2020 project called AMPLITUDE, the ‘Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy’, starting in January 2020, proposes the development of an advanced multi-modal imaging tool exploiting new laser technologies in an approach combining confocal and non-linear imaging to fulfil unmet clinical needs in terms of the specificity and accuracy of urothelial cancer diagnosis and therapy monitoring. The project is coordinated by Tampere University (Finland) and carried out in cooperation with leading European research organizations including Aston Insitute of Photonic Technologies—AIPT (UK), Consiglio Nazionale delle Ricerche—CNR (Italy), Institute of Photonic Sciences—ICFO (Spain), University of Milan-Bicocca, Modus Research and Innovation Ltd. (UK) and University of Florence (Italy), as well as industrial partners: Ampliconyx Oy (Finland), Femtonics Ltd. (Hungary), HC Photonics (Taiwan), and LEONI Fiber Optics GmbH (Germany)

Non-syndromic cleft palate: Association analysis on three gene polymorphisms of the folate pathway in Asian and Italian populations

Periconceptional folic acid supplementation can reduce the risk of inborn malformations, including orofacial clefts. Polymorphisms of MTHFR, TCN2, and CBS folate-related genes seem to modulate the risk of cleft lip with or without cleft palate (CL/P) in some populations. CL/P and cleft palate only (CPO) are different malformations that share several features and possibly etiological causes. In the present investigation, we conducted a family-based, candidate gene association study of non-syndromic CPO. Three single nucleotide polymorphisms, namely, rs1801133 of MTHFR, rs1801198 of TCN2, and rs4920037 of CBS, were investigated in a sample that included 129 Italian and 65 Asian families. No evidence of association between the three genotyped polymorphisms and CPO was found in the Italian and Asian cases, indeed the transmission disequilibrium test did not detect any asymmetry of transmission of alleles. This investigation, although with some limitation, further supports that CL/P and CPO diverge in their genetic background

High-Energy gamma-ray Astronomy and String Theory

There have been observations, first from the MAGIC Telescope (July 2005) and quite recently (September 2008) from the FERMI Satellite Telescope, on non-simultaneous arrival of high-energy photons from distant celestial sources. In each case, the highest energy photons were delayed, as compared to their lower-energy counterparts. Although the astrophysics at the source of these energetic photons is still not understood, and such non simultaneous arrival might be due to non simultaneous emission as a result of conventional physics effects, nevertheless, rather surprisingly, the observed time delays can also fit excellently some scenarios in quantum gravity, predicting Lorentz violating space-time "foam" backgrounds with a non-trivial subluminal vacuum refractive index suppressed linearly by a quantum gravity scale of the order of the reduced Planck mass. In this pedagogical talk, I discuss the MAGIC and FERMI findings in this context and I argue on a theoretical model of space-time foam in string/brane theory that can accommodate the findings of those experiments in agreement with all other stringent tests of Lorentz invariance. However, I stress the current ambiguities/uncertainties on the source mechanisms, which need to be resolved first before definite conclusions are reached regarding quantum gravity foam scenarios.Comment: 34 pages latex, 12 eps figures incorporated, uses special macros. Based on invited plenary talk at DICE 2008 Conference (Castiglioncello, Italy), September 22-26 200

Measuring Future Time Perspective across Adulthood: Development and Evaluation of a Brief Multidimensional Questionnaire.

PURPOSE OF THE STUDY: Despite calls for the consideration of future time perspective (FTP) as a multidimensional construct, mostly unidimensional measurement instruments have been used. This study had two objectives: (a) to develop a brief multidimensional questionnaire for assessing FTP in adulthood and evaluate its psychometric properties; and (b) to examine age associations and age-group differences of the dimensions of FTP. DESIGN AND METHODS: Data were collected from 625 community-residing adults between the ages of 18 and 93, representing young, middle-aged, and older adults. The psychometric evaluation involved exploratory factor analyses (EFA) and confirmatory FA (CFA), reliability and validity analyses, and measurement invariance testing. Zero-order and partial correlations were used to examine the association of the dimensions of FTP with age, and multivariate analysis of variance was used to examine age-group differences. RESULTS: EFA and CFA supported a three-factor solution: Future as Open, Future as Limited, and Future as Ambiguous. Metric measurement invariance for this factor structure was confirmed across the three age groups. Reliability and validity analyses provided evidence of sound psychometric properties of the brief questionnaire. Age was negatively associated with Future as Open and positively associated with Future as Limited. Young adults exhibited significantly greater ambiguity toward the future than middle-aged or older adults. IMPLICATIONS: This study provides evidence in support of the psychometric properties of a new brief multidimensional FTP scale. It also provides evidence for a pattern of age associations and age-group differences consistent with life-span developmental theory

Identification of Single Spectral Lines through Supervised Machine Learning in a Large HST Survey (WISP): A Pilot Study for Euclid and WFIRST

Future surveys focusing on understanding the nature of dark energy (e.g., Euclid and WFIRST) will cover large fractions of the extragalactic sky in near-IR slitless spectroscopy. These surveys will detect a large number of galaxies that will have only one emission line in the covered spectral range. In order to maximize the scientific return of these missions, it is imperative that single emission lines are correctly identified. Using a supervised machine-learning approach, we classified a sample of single emission lines extracted from the WFC3 IR Spectroscopic Parallel survey, one of the closest existing analogs to future slitless surveys. Our automatic software integrates a spectral energy distribution (SED)-fitting strategy with additional independent sources of information. We calibrated it and tested it on a "gold" sample of securely identified objects with multiple lines detected. The algorithm correctly classifies real emission lines with an accuracy of 82.6%, whereas the accuracy of the SED-fitting technique alone is low (~50%) due to the limited amount of photometric data available (≤6 bands). While not specifically designed for the Euclid and WFIRST surveys, the algorithm represents an important precursor of similar algorithms to be used in these future missions

Identification of single spectral lines through supervised machine learning in a large HST survey (WISP): a pilot study for Euclid and WFIRST

Future surveys focusing on understanding the nature of dark energy (e.g., Euclid and WFIRST) will cover large fractions of the extragalactic sky in near-IR slitless spectroscopy. These surveys will detect a large number of galaxies that will have only one emission line in the covered spectral range. In order to maximize the scientific return of these missions, it is imperative that single emission lines are correctly identified. Using a supervised machine-learning approach, we classified a sample of single emission lines extracted from the WFC3 IR Spectroscopic Parallel survey (WISP), one of the closest existing analogs to future slitless surveys. Our automatic software integrates a SED fitting strategy with additional independent sources of information. We calibrated it and tested it on a "gold" sample of securely identified objects with multiple lines detected. The algorithm correctly classifies real emission lines with an accuracy of 82.6%, whereas the accuracy of the SED fitting technique alone is low (~50%) due to the limited amount of photometric data available (<=6 bands). While not specifically designed for the Euclid and WFIRST surveys, the algorithm represents an important precursor of similar algorithms to be used in these future missions