RXJ0256.5+0006: a merging cluster of galaxies at z=0.36 observed with XMM-Newton

(abridged) We present a study based on XMM data of RX J0256.5+0006, a medium distant (z=0.36) galaxy cluster found in the Bright SHARC catalog. The intracluster medium shows a bimodal structure: one main cluster component and a substructure in the west. Despite the indication of interaction we do not find any sign of temperature gradients. Due to the non-symmetric form of the main cluster we extract surface brightness profiles in different sectors around its centre. We see large variations between the profiles, which we quantify by beta-model fitting. The corresponding r_c's vary between 0.1-0.5Mpc and the beta's between 0.5-1.2. The variations of the beta-model parameters indicate that the main cluster is not entirely relaxed. This hypothesis is strengthened by the fact that the cluster is over-luminous with respect to the (z-evolving) L_x-T relation found for nearby clusters. Comparing our profiles to the reference emission measure profile of Arnaud et al., we find that only the profile extracted north-east (NE) of the main cluster centre is similar to this reference profile. This indicates that only the NE profile is representative for the relaxed part of this cluster component. Using this profile and the spectroscopically fitted temperature of T=4.9^+0.5_-0.4keV we find M_500~4 10^14 solar masses. This value is in agreement with the value obtained using the z-evolving M_500-T relation from the HIFLUGCS sample. For the gas mass fraction we find f_g~18-20% which is in good agreement with other work. We also develop a simple on-axis merger model for the cluster. Together with a simple ram pressure model we find that the most likely physical distance of the subcluster to the main cluster lies between 0.6<d<1.0Mpc. We find for the ratio of subcluster to main cluster mass values between 20-30%.Comment: 19 pages including 19 figures (including 4 figures in jpg and png format), accepted for publication in A&

Gravitational effects on the high energy emission of accreting black holes

We extend the investigation of general relativistic effects on the observed X-ray continuum of Kerr black holes in the context of the light bending model (Miniutti & Fabian, 2004). Assuming a ring-like illuminating source, co-rotating with the underlying accretion disk, we study the shape and normalisation of the primary and disc reflected continuum as well as the dependence of the observed spectrum on the line of sight for various source heights and radii. These calculations are performed using Monte-Carlo methods to compute the angle dependent reflection spectrum from the disc. The effects of general relativity are illustrated by a comparison with Newtonian and Special Relativity calculations. We find that relativistic distortions can strongly affect the shape of the reflected spectrum. Light bending can dramatically increase the observable reflected flux and reduce the primary emission. In addition, multiple reflections due to the reflected photons deflected toward the disc can alter significantly the shape of the spectrum above 10 keV. Large variations of the ring radius at constant height can lead to an (unobserved) anti-correlation between primary and reflected flux. In another side, the variability behaviour of several sources can be reproduced if the ring source radius is small (<5 r_g), and its height varies by a large factor. In particular, a non-linear flux-flux relation, similar to that observed in several sources, can be produced. We compare our model with the flux-flux plot of NGC4051, and find an agreement for low inclination angles (<20 deg.), ring source radius <3 r_g and a height varying between 0.5 to 10 r_g.Comment: 13 pages, 18 figures. Accepted for publication in A&

Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies

<p>Abstract</p> <p>Background</p> <p>Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood.</p> <p>Case presentation</p> <p>We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection.</p> <p>Conclusions</p> <p>Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.</p

The relationship between maternal education and mortality among women giving birth in health care institutions: Analysis of the cross sectional WHO Global Survey on Maternal and Perinatal Health

Background: Approximately one-third of a million women die each year from pregnancy-related conditions. Three-quarters of these deaths are considered avoidable. Millennium Development Goal five calls for a reduction in maternal mortality and the establishment of universal access to high quality reproductive health care. There is evidence of a relationship between lower levels of maternal education and higher maternal mortality. This study examines the relationship between maternal education and maternal mortality among women giving birth in health care institutions and investigates the association of maternal age, marital status, parity, institutional capacity and state-level investment in health care with these relationships.Methods: Cross-sectional information was collected on 287,035 inpatients giving birth in 373 health care institutions in 24 countries in Africa, Asia and Latin America, between 2004-2005 (in Africa and Latin America) and 2007-2008 (in Asia) as part of the WHO Global Survey on Maternal and Perinatal Health. Analyses investigated associations between indicators measured at the individual, institutional and country level and maternal mortality during the intrapartum period: from admission to, until discharge from, the institution where women gave birth. There were 363 maternal deaths.Results: In the adjusted models, women with no education had 2.7 times and those with between one and six years of education had twice the risk of maternal mortality of women with more than 12 years of education. Institutional capacity was not associated with maternal mortality in the adjusted model. Those not married or cohabiting had almost twice the risk of death of those who were. There was a significantly higher risk of death among those aged over 35 (compared with those aged between 20 and 25 years), those with higher numbers of previous births and lower levels of state investment in health care. There were also additional effects relating to country of residence which were not explained in the model.Conclusions: Lower levels of maternal education were associated with higher maternal mortality even amongst women able to access facilities providing intrapartum care. More attention should be given to the wider social determinants of health when devising strategies to reduce maternal mortality and to achieve the increasingly elusive MDG for maternal mortality

Entanglement entropy of non-unitary integrable quantum field theory

In this paper we study the simplest massive 1+1 dimensional integrable quantum field theory which can be described as a perturbation of a non-unitary minimal conformal field theory: the Lee–Yang model. We are particularly interested in the features of the bi-partite entanglement entropy for this model and on building blocks thereof, namely twist field form factors. Non-unitarity selects out a new type of twist field as the operator whose two-point function (appropriately normalized) yields the entanglement entropy. We compute this two-point function both from a form factor expansion and by means of perturbed conformal field theory. We find good agreement with CFT predictions put forward in a recent work involving the present authors. In particular, our results are consistent with a scaling of the entanglement entropy given by ceff/3 log⁡ℓ where ceff is the effective central charge of the theory (a positive number related to the central charge) and ℓ is the size of the region. Furthermore the form factor expansion of twist fields allows us to explore the large region limit of the entanglement entropy and find the next-to-leading order correction to saturation. We find that this correction is very different from its counterpart in unitary models. Whereas in the latter case, it had a form depending only on few parameters of the model (the particle spectrum), it appears to be much more model-dependent for non-unitary models

Introduction—Food Security and Food Waste Reduction: A Social Innovation Approach to Current Social, Environmental, and Political Concerns

This chapter presents the research rationale underpinning the book. It addresses the intertwining challenges of food security and surplus food management, discussing recent data and literature. It also presents how social innovation is conceptualized in the book as the theoretical framework to analyse partnerships between business and non-profit organisations in managing food surplus. The methodology of the research is also detailed, along with the book structure

Cell Type–Specific Transcriptome Analysis Reveals a Major Role for Zeb1 and miR-200b in Mouse Inner Ear Morphogenesis

Cellular heterogeneity hinders the extraction of functionally significant results and inference of regulatory networks from wide-scale expression profiles of complex mammalian organs. The mammalian inner ear consists of the auditory and vestibular systems that are each composed of hair cells, supporting cells, neurons, mesenchymal cells, other epithelial cells, and blood vessels. We developed a novel protocol to sort auditory and vestibular tissues of newborn mouse inner ears into their major cellular components. Transcriptome profiling of the sorted cells identified cell type–specific expression clusters. Computational analysis detected transcription factors and microRNAs that play key roles in determining cell identity in the inner ear. Specifically, our analysis revealed the role of the Zeb1/miR-200b pathway in establishing epithelial and mesenchymal identity in the inner ear. Furthermore, we detected a misregulation of the ZEB1 pathway in the inner ear of Twirler mice, which manifest, among other phenotypes, malformations of the auditory and vestibular labyrinth. The association of misregulation of the ZEB1/miR-200b pathway with auditory and vestibular defects in the Twirler mutant mice uncovers a novel mechanism underlying deafness and balance disorders. Our approach can be employed to decipher additional complex regulatory networks underlying other hearing and balance mouse mutants