An evaluation of thematic mapper simulator data for the geobotanical discrimination of rock types in Southwest Oregon

Rock type identification may be assisted by the use of remote sensing of associated vegetation, particularly in areas of dense vegetative cover where surface materials are not imaged directly by the sensor. The geobotanical discrimination of ultramafic parent materials was investigated and analytical techniques for lithologic mapping and mineral exploration were developed. The utility of remotely sensed data to discriminate vegetation types associated with ultramafic parent materials in a study area in southwest Oregon were evaluated. A number of specific objectives were identified, which include: (1) establishment of the association between vegetation and rock types; (2) examination of the spectral separability of vegetation types associated with rock types; (3) determination of the contribution of each TMS band for discriminating vegetation associated with rock types and (4) comparison of analytical techniques for spectrally classifying vegetation

Exposure to indoor mouldy odour increases the risk of asthma in older adults living in social housing

This is the author accepted manuscript. The final version is available from MDPI via the DOI in this record Background: Indoor dampness is thought to affect around 16% of European homes. It is generally accepted that increased exposure to indoor dampness and mould contamination (e.g., spores and hyphae) increases the risk of developing and/or exacerbating asthma. Around 30% of people in theWestern world have an allergic disease (e.g., allergy, wheeze and asthma). The role of indoor mould contamination in the risk of allergic diseases in older adults is yet to be fully explored. This is of interest because older people spend more time indoors, as well as facing health issues due to the ageing process, and may be at greater risk of developing and/or exacerbating asthma as a result of indoor dampness. Methods: Face-to-face questionnaires were carried out with 302 participants residing in social housing properties located in South West England. Self-reported demographic, mould contamination (i.e., presence of mould growth and mouldy odour) and health information was linked with the asset management records (e.g., building type, age and levels of maintenance). Multivariate logistic regression was used to calculate the odd ratios and confidence intervals of developing and/or exacerbating asthma, wheeze and allergy with exposure to reported indoor mould contamination. We adjusted for a range of factors that may affect asthma outcomes, which include age, sex, current smoking, presence of pets, education, and building type and age. To assess the role of mould contamination in older adults, we compared younger adults to those aged over 50 years. Results: Doctor-diagnosed adult asthma was reported by 26% of respondents, 34% had current wheeze while 18% had allergies. Asthma was common among subjects exposed to reported visible mould (32%) and reported mouldy odour (42%). Exposure to visible mould growth and mouldy odour were risk factors for asthma, but not for wheeze or allergy. Exposure to mouldy odour increased the risk of asthma in adults over the age of 50 years (odds ratio (OR) 2.4, 95% confidence interval (CI) 1.10–5.34) and the risk was higher for females than for males (OR 3.5, 95% CI 1.37–9.08). These associations were modified by a range of built environment characteristics. Conclusions: We found that older adults living in social (public) housing properties, specifically women, may be at higher risk of asthma when exposed to mouldy odour, which has a number of implications for policy makers and practitioners working in the health and housing sector. Additional measures should be put in place to protect older people living in social housing against indoor damp and mould contamination.European Regional Development Fund (ERDF

Exercise therapy for the treatment of tendinopathies: a scoping review.

Purpose: Tendinopathy is a common condition leading to pain, disability and reduced quality of life/participation. Due to many tendinopathies having a chronic or recurrent course, there is a need to identify effective, evidence based practice for this condition. Exercise is the mainstay of conservative management for tendinopathy however, due to the heterogeneity of tendinopathy, populations affected and variation in exercise approaches a mapping of this area is required to inform future research, both primary and secondary and ultimately practice. The aim of this scoping review was therefore to map the existing evidence on exercise interventions and outcomes for the treatment of any tendinopathy. Methods: JBI Scoping Review methodology and an apriori protocol guided this review. Inclusion criteria included i). Participants - studies including any age or gender with any tendinopathy, ii). Concept – Exercise therapy (any type or format) intervention, delivered in any setting by any professional with any outcomes related to evaluating exercise interventions for tendinopathy, iii). Context – any setting in any developed nation listed as having very high human development. Nine databases, five clinical trial registries and six grey literature sources were searched. Results were uploaded to Covidence for screening. All screening (title/abstract and full text) were conducted by two reviewers independently with conflicts resolved by a third reviewer. A data extraction tool was iteratively developed and piloted by the review team prior to data extraction. As per scoping review methodology, no critical appraisal was conducted. Data was synthesised to present a map of tendinopathy exercise interventions and outcomes (related to ICON health related domains) alongside an accompanying narrative. Results: 22,547 studies were identified and after de-duplication and screening 554 studies were included in the review representing 25,687 participants. Studies were predominantly randomised controlled trials or systematic reviews conducted in the UK, Turkey, USA & Australia. The main tendinopathies reported were rotator cuff, achilles, lateral elbow and patellar. The majority of studies included a range of strength training approaches followed by flexibility and motor re-training /proprioception exercise. There was a range in quality of reporting of exercise across tendinopathies, assessed using the TIDieR checklist with 65.8% partially reproducible and 28% not reproducible. There was variation across tendinopathies in domains (disability, pain and physical function capacity) reported with corresponding variation in primary outcome measures related to these. Conclusion(s): This scoping review has mapped the evidence on exercise for tendinopathies. There is a range of exercise approaches across different tendinopathies and a need for future research to strictly adhere to reporting guidelines. There are a range of outcomes and domains reported across tendinopathies and future research would benefit from the development of core outcome sets for each tendinopathy. Impact: This scoping review adds to the body of evidence on tendinopathy rehabilitation. The results have informed systematic reviews currently being conducted on effectiveness of exercise for tendinopathies and the acceptability and feasibility of exercise interventions for tendinopathies. These reviews will provide guidance on exercise for tendinopathy rehabilitation, which can be adopted internationally. Funding acknowledgements: This project is funded by the National Institute for Health Research (NIHR) [Health Technology Assessment (HTA) 129388 Exercise therapy for the treatment of tendinopathies]. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care

Trends in multimorbidity, complex multimorbidity and multiple functional limitations in the ageing population of England, 2002–2015

This is the final version. Available from SAGE via the DOI in this record.This study aimed to estimate the prevalence of three measures of multimorbidity among people aged 50 years or older in England. Beside the basic measure of two or more diseases within a person, we added a measure of three or more affected body systems (complex multimorbidity) and a measure of 10 or more functional limitations. We found that the three health outcomes became more prevalent between 2002 and 2015. They were more common among females than males and were becoming more common among younger age groups. While in 2002, the prevalence of basic multimorbidity overcame 50% from the 70–74 age group upwards, in 2015 it crossed the same threshold in the 65–69 age group. The distribution of multimorbidity and multiple functional limitations were stratified by the amount of household wealth. Multiple functional limitations reflected the largest differences between the most and the least affluent groups (5.9-fold in 2014/2015), followed by the measure of complex multimorbidity (2.8-fold in 2014/2015) and basic multimorbidity (1.9-fold) in 2014/2015.While age acted as a levelling factor for the wealth differences in basic multimorbidity, it had no such effect on the two other outcomes. Our study observed social polarization among multimorbid ageing population in England where complex multimorbidity and multiple functional limitations increase faster and reflect stronger inequality than basic multimorbidity

Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research

Animals studies have made significant contribution to expanding our knowledge of breast cancer. Often material is leftover and archived. SEARCHBreast provides a platform for collaborative sharing of archived material via a dedicated on-line database whereby users can both share and search available tissue. The SEARCHBreast database has information on over 50 different mouse models, including tissue from PDX models, available to share. With thousands of samples freely available, SEARCHBreast should be the first point of call for any researcher looking for animal material to aid their breast cancer research

SEARCHBreast: A new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers

No abstract available

SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs

Animal models have contributed to our understanding of breast cancer, with publication of results in high-impact journals almost invariably requiring extensive in vivo experimentation. As such, many laboratories hold large collections of surplus animal material, with only a fraction being used in publications relating to the original projects. Despite being developed at considerable cost, this material is an invisible and hence an underutilised resource, which often ends up being discarded. Within the breast cancer research community there is both a need and desire to make this valuable material available for researchers. Lack of a coordinated system for visualisation and localisation of this has prevented progress. To fulfil this unmet need, we have developed a novel initiative called Sharing Experimental Animal Resources: Coordinating Holdings—Breast (SEARCHBreast) which facilitates sharing of archival tissue between researchers on a collaborative basis and, de facto will reduce overall usage of animal models in breast cancer research. A secure searchable database has been developed where researchers can find, share, or upload materials related to animal models of breast cancer, including genetic and transplant models. SEARCHBreast is a virtual compendium where the physical material remains with the original laboratory. A bioanalysis pipeline is being developed for the analysis of transcriptomics data associated with mouse models, allowing comparative study with human and cell line data. Additionally, SEARCHBreast is committed to promoting the use of humanised breast tissue models as replacement alternatives to animals. Access to this unique resource is freely available to all academic researchers following registration at https://searchbreast.org

SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals

No abstract available

The SEARCHBreast portal: A virtual bioresource to facilitate the sharing of surplus animal materials derived from breast cancer studies

The SEARCHBreast portal (https://searchbreast.org/) provides access to a virtual bioresource enabling researchers to access and share material derived from breast cancer related animal studies on a collaborative basis. By registering as members of SEARCHBreast, researchers can browse the SEARCHBreast platform for relevant tissue and models, and request access to these to help answer their specific biological question(s). SEARCHBreast mediates the collaborations formed from requests for these materials. As of July 2016, the virtual bioresource has received 8 requests for tissue and has sent hundreds of tissue samples saving approximately 400 animals. SEARCHBreast is currently developing a bioinformatics pipeline, enabling users to access and mine published data on animal models of breast cancer, potentially helping to reduce experimental redundancy further, prioritising new relevant research

Stellar Activity in the Broad-Band Ultraviolet

The completion of the GALEX All-Sky Survey in the ultraviolet allows activity measurements to be acquired for many more stars than is possible with the limited sensitivity of ROSAT or the limited sky coverage of Chandra, XMM, or spectroscopic surveys for line emission in the optical or ultraviolet. We have explored the use of GALEX photometry as an activity indicator, using as a calibration sample stars within 50 pc, representing the field, and in selected nearby associations, representing the youngest stages of stellar evolution. We present preliminary relations between UV flux and the optical activity indicator R'_HK and between UV flux and age. We demonstrate that far-UV (FUV, 1350-1780{\AA}) excess flux is roughly proportional to R'_HK. We also detect a correlation between near-UV (NUV, 1780-2830{\AA}) flux and activity or age, but the effect is much more subtle, particularly for stars older than than ~0.5-1 Gyr. Both the FUV and NUV relations show large scatter, ~0.2 mag when predicting UV flux, ~0.18 dex when predicting R'_HK, and ~0.4 dex when predicting age. This scatter appears to be evenly split between observational errors in current state-of-the-art data and long-term activity variability in the sample stars.Comment: 37 pages, 12 figures. To appear in the Astronomical Journa