Naturally Occurring Radioelements in the Ground Waters of Iowa

Reconnaissance studies of radioelements in the ground waters of Iowa indicate that, where radium is present, it is Ra226, the biologically significant isotope. Its distribution varies, but it appears that (1) waters from consolidated sandstones in areas distant from recharge points may contain up to 8 μ,μc/L Ra226; (2) waters from limestone aquifers vary but, in general, are likely to contain appreciable amounts, up to 3 μμc/L Ra226; and (3) waters from glacial aquifers contain little, if any, Ra226

Probing the isovector transition strength of the low-lying nuclear excitations induced by inverse kinematics proton scattering

A compact approach based on the folding model is suggested for the determination of the isoscalar and isovector transition strengths of the low-lying ($\Delta S=\Delta T=0$) excitations induced by inelastic proton scattering measured with exotic beams. Our analysis of the recently measured inelastic $^{18,20}$O+p scattering data at $E_{\rm lab}=30$ and 43 MeV/nucleon has given for the first time an accurate estimate of the isoscalar $\beta_0$ and isovector $\beta_1$ deformation parameters (which cannot be determined from the (p,p') data alone by standard methods) for 2$^+_1$ and $3^-_1$ excited states in $^{18,20}$O. Quite strong isovector mixing was found in the 2$^+_1$ inelastic $^{20}$O+p scattering channel, where the strength of the isovector form factor $F_1$ (prototype of the Lane potential) corresponds to a $\beta_1$ value almost 3 times larger than $\beta_0$ and a ratio of nuclear transition matrix elements $M_n/M_p\simeq 4.2$.Comment: 5 pages, 3 figure

A Study of the Δ−\Delta^--component of the wave-function in light nuclei

We have measured cross sections for the $(\pi^+,\pi^\pm p)$ reactions on ${\rm ^3H}$, ${\rm ^4He}$, ${\rm ^6Li}$ and ${\rm ^7Li}$ in quasi-free kinematics at incident pion beam energy 500 MeV. An enhancement of the $(\pi^+,\pi^- p)$ cross section in this kinematics is observed. If this is interpreted as due to quasi-free scattering from pre-existing $\Delta$ components of the nuclear wave function, the extracted probabilities are in agreement with theoretical expectations.Comment: 3 pages, 3 figures, 1 tabl

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities

Kras-driven non–small-cell lung cancers (NSCLCs) are a leading cause of death with limited therapeutic options. Many NSCLCs exhibit high levels of Ezh2, the enzymatic subunit of polycomb repressive complex 2 (PRC2). We tested Ezh2 inhibitors as single agents or before chemotherapy in mice with orthotopic Kras-driven NSCLC grafts, which homogeneously express Ezh2. These tumors display sensitivity to EZH2 inhibition by GSK126 but also amplify an inflammatory program involving signaling through NF-κB and genes residing in PRC2-regulated chromatin. During this process, tumor cells overcome GSK126 antiproliferative effects. We identified oncogenes that may mediate progression through an in vivo RNAi screen aimed at targets of PRC2/NF-κB. An in vitro compound screening linked GSK126-driven inflammation and therapeutic vulnerability in human cells to regulation of RNA synthesis and proteostasis. Interestingly, GSK126-treated NSCLCs in vivo also showed an enhanced response to a combination of nimesulide and bortezomib. Thus, Ezh2 inhibition may restrict cell proliferation and promote defined adaptive responses. Targeting these responses potentially improves outcomes in Kras-driven NSCLCs

The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes

Integrin-mediated cell adhesion, or cross-linking of integrins using antibodies, often results in the enhanced tyrosine phosphorylation of certain intracellular proteins, suggesting that integrins may play a role in signal transduction processes. In fibroblasts, platelets, and carcinoma cells, a novel tyrosine kinase termed pp125FAK has been implicated in integrin-mediated tyrosine phosphorylation. In some cell types, integrin ligation or cell adhesion has also been shown to result in the increased expression of certain genes. Although it seems reasonable to hypothesize that integrin-mediated tyrosine phosphorylation and integrin-mediated gene induction are related, until now, there has been no direct evidence supporting this hypothesis. In the current report, we explore the relationship between integrin- mediated tyrosine phosphorylation and gene induction in human monocytes. We demonstrate that monocyte adherence to tissue culture dishes or to extracellular matrix proteins is followed by a rapid and profound increase in tyrosine phosphorylation, with the predominant phosphorylated component being a protein of 76 kD (pp76). Tyrosine phosphorylation of pp76 and other monocyte proteins can also be triggered by incubation of monocytes with antibodies to the integrin beta 1 subunit, or by F(ab')2 fragments of such antibodies, but not by F(ab) fragments. The ligation of beta 1 integrins with antibodies or F(ab')2 fragments also induces the expression of immediate-early (IE) genes such as IL-1 beta. When adhering monocytes are treated with the tyrosine kinase inhibitors genistein or herbimycin, both phosphorylation of pp76 and induction of IL-1 beta message are blocked in a dose-dependent fashion. Similarly, treatment with genistein or herbimycin can block tyrosine phosphorylation of pp76 and IL-1 beta message induction mediated by ligation of beta 1 integrin with antibodies. These observations suggest that protein tyrosine phosphorylation is an important aspect of integrin-mediated IE gene induction in monocytes. The cytoplasmic tyrosine kinase pp125FAK, although important in integrin signaling in other cell types, seems not to play a role in monocytes because this protein could not be detected in these cells

Tree method for quantum vortex dynamics

We present a numerical method to compute the evolution of vortex filaments in superfluid helium. The method is based on a tree algorithm which considerably speeds up the calculation of Biot-Savart integrals. We show that the computational cost scales as Nlog{(N) rather than N squared, where $N$ is the number of discretization points. We test the method and its properties for a variety of vortex configurations, ranging from simple vortex rings to a counterflow vortex tangle, and compare results against the Local Induction Approximation and the exact Biot-Savart law.Comment: 12 pages, 10 figure

Rotating Black Branes in the presence of nonlinear electromagnetic field

In this paper, we consider a class of gravity whose action represents itself as a sum of the usual Einstein-Hilbert action with cosmological constant and an $U(1)$ gauge field for which the action is given by a power of the Maxwell invariant. We present a class of the rotating black branes with Ricci flat horizon and show that the presented solutions may be interpreted as black brane solutions with two event horizons, extreme black hole and naked singularity provided the parameters of the solutions are chosen suitably. We investigate the properties of the solutions and find that for the special values of the nonlinear parameter, the solutions are not asymptotically anti-deSitter. At last, we obtain the conserved quantities of the rotating black branes and find that the nonlinear source effects on the electric field, the behavior of spacetime, type of singularity and other quantities.Comment: 7 pages, 5 figures, to appear in EPJ

Accurate fundamental parameters and detailed abundance patterns from spectroscopy of 93 solar-type Kepler targets

We present a detailed spectroscopic study of 93 solar-type stars that are targets of the NASA/Kepler mission and provide detailed chemical composition of each target. We find that the overall metallicity is well-represented by Fe lines. Relative abundances of light elements (CNO) and alpha-elements are generally higher for low-metallicity stars. Our spectroscopic analysis benefits from the accurately measured surface gravity from the asteroseismic analysis of the Kepler light curves. The log g parameter is known to better than 0.03 dex and is held fixed in the analysis. We compare our Teff determination with a recent colour calibration of V-K (TYCHO V magnitude minus 2MASS Ks magnitude) and find very good agreement and a scatter of only 80 K, showing that for other nearby Kepler targets this index can be used. The asteroseismic log g values agree very well with the classical determination using Fe1-Fe2 balance, although we find a small systematic offset of 0.08 dex (asteroseismic log g values are lower). The abundance patterns of metals, alpha elements, and the light elements (CNO) show that a simple scaling by [Fe/H] is adequate to represent the metallicity of the stars, except for the stars with metallicity below -0.3, where alpha-enhancement becomes important. However, this is only important for a very small fraction of the Kepler sample. We therefore recommend that a simple scaling with [Fe/H] be employed in the asteroseismic analyses of large ensembles of solar-type stars.Comment: MNRAS, in press, 12 page

Asteroseismic diagrams from a survey of solar-like oscillations with Kepler

Photometric observations made by the NASA Kepler Mission have led to a dramatic increase in the number of main-sequence and subgiant stars with detected solar-like oscillations. We present an ensemble asteroseismic analysis of 76 solar-type stars. Using frequencies determined from the Kepler time-series photometry, we have measured three asteroseismic parameters that characterize the oscillations: the large frequency separation (\Delta \nu), the small frequency separation between modes of l=0 and l=2 (\delta \nu_02), and the dimensionless offset (\epsilon). These measurements allow us to construct asteroseismic diagrams, namely the so-called C-D diagram of \delta \nu_02 versus \Delta \nu, and the recently re-introduced {\epsilon} diagram. We compare the Kepler results with previously observed solar-type stars and with theoretical models. The positions of stars in these diagrams places constraints on their masses and ages. Additionally, we confirm the observational relationship between {\epsilon} and T_eff that allows for the unambiguous determination of radial order and should help resolve the problem of mode identification in F stars.Comment: 6 pages, 5 figures, accepted for publication in The Astrophysical Journal Letter