1,297 research outputs found
Naturally Occurring Radioelements in the Ground Waters of Iowa
Reconnaissance studies of radioelements in the ground waters of Iowa indicate that, where radium is present, it is Ra226, the biologically significant isotope. Its distribution varies, but it appears that (1) waters from consolidated sandstones in areas distant from recharge points may contain up to 8 μ,μc/L Ra226; (2) waters from limestone aquifers vary but, in general, are likely to contain appreciable amounts, up to 3 μμc/L Ra226; and (3) waters from glacial aquifers contain little, if any, Ra226
Probing the isovector transition strength of the low-lying nuclear excitations induced by inverse kinematics proton scattering
A compact approach based on the folding model is suggested for the
determination of the isoscalar and isovector transition strengths of the
low-lying () excitations induced by inelastic proton
scattering measured with exotic beams. Our analysis of the recently measured
inelastic O+p scattering data at and 43 MeV/nucleon
has given for the first time an accurate estimate of the isoscalar
and isovector deformation parameters (which cannot be determined from
the (p,p') data alone by standard methods) for 2 and excited
states in O. Quite strong isovector mixing was found in the 2
inelastic O+p scattering channel, where the strength of the isovector
form factor (prototype of the Lane potential) corresponds to a
value almost 3 times larger than and a ratio of nuclear transition
matrix elements .Comment: 5 pages, 3 figure
A Study of the -component of the wave-function in light nuclei
We have measured cross sections for the reactions on
, , and in quasi-free
kinematics at incident pion beam energy 500 MeV. An enhancement of the
cross section in this kinematics is observed. If this is
interpreted as due to quasi-free scattering from pre-existing
components of the nuclear wave function, the extracted probabilities are in
agreement with theoretical expectations.Comment: 3 pages, 3 figures, 1 tabl
Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities
Kras-driven non–small-cell lung cancers (NSCLCs) are a leading cause of death with limited therapeutic options. Many NSCLCs exhibit high levels of Ezh2, the enzymatic subunit of polycomb repressive complex 2 (PRC2). We tested Ezh2 inhibitors as single agents or before chemotherapy in mice with orthotopic Kras-driven NSCLC grafts, which homogeneously express Ezh2. These tumors display sensitivity to EZH2 inhibition by GSK126 but also amplify an inflammatory program involving signaling through NF-κB and genes residing in PRC2-regulated chromatin. During this process, tumor cells overcome GSK126 antiproliferative effects. We identified oncogenes that may mediate progression through an in vivo RNAi screen aimed at targets of PRC2/NF-κB. An in vitro compound screening linked GSK126-driven inflammation and therapeutic vulnerability in human cells to regulation of RNA synthesis and proteostasis. Interestingly, GSK126-treated NSCLCs in vivo also showed an enhanced response to a combination of nimesulide and bortezomib. Thus, Ezh2 inhibition may restrict cell proliferation and promote defined adaptive responses. Targeting these responses potentially improves outcomes in Kras-driven NSCLCs
The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes
Integrin-mediated cell adhesion, or cross-linking of integrins using antibodies, often results in the enhanced tyrosine phosphorylation of certain intracellular proteins, suggesting that integrins may play a role in signal transduction processes. In fibroblasts, platelets, and carcinoma cells, a novel tyrosine kinase termed pp125FAK has been implicated in integrin-mediated tyrosine phosphorylation. In some cell types, integrin ligation or cell adhesion has also been shown to result in the increased expression of certain genes. Although it seems reasonable to hypothesize that integrin-mediated tyrosine phosphorylation and integrin-mediated gene induction are related, until now, there has been no direct evidence supporting this hypothesis. In the current report, we explore the relationship between integrin- mediated tyrosine phosphorylation and gene induction in human monocytes. We demonstrate that monocyte adherence to tissue culture dishes or to extracellular matrix proteins is followed by a rapid and profound increase in tyrosine phosphorylation, with the predominant phosphorylated component being a protein of 76 kD (pp76). Tyrosine phosphorylation of pp76 and other monocyte proteins can also be triggered by incubation of monocytes with antibodies to the integrin beta 1 subunit, or by F(ab')2 fragments of such antibodies, but not by F(ab) fragments. The ligation of beta 1 integrins with antibodies or F(ab')2 fragments also induces the expression of immediate-early (IE) genes such as IL-1 beta. When adhering monocytes are treated with the tyrosine kinase inhibitors genistein or herbimycin, both phosphorylation of pp76 and induction of IL-1 beta message are blocked in a dose-dependent fashion. Similarly, treatment with genistein or herbimycin can block tyrosine phosphorylation of pp76 and IL-1 beta message induction mediated by ligation of beta 1 integrin with antibodies. These observations suggest that protein tyrosine phosphorylation is an important aspect of integrin-mediated IE gene induction in monocytes. The cytoplasmic tyrosine kinase pp125FAK, although important in integrin signaling in other cell types, seems not to play a role in monocytes because this protein could not be detected in these cells
Tree method for quantum vortex dynamics
We present a numerical method to compute the evolution of vortex filaments in
superfluid helium. The method is based on a tree algorithm which considerably
speeds up the calculation of Biot-Savart integrals. We show that the
computational cost scales as Nlog{(N) rather than N squared, where is the
number of discretization points. We test the method and its properties for a
variety of vortex configurations, ranging from simple vortex rings to a
counterflow vortex tangle, and compare results against the Local Induction
Approximation and the exact Biot-Savart law.Comment: 12 pages, 10 figure
Rotating Black Branes in the presence of nonlinear electromagnetic field
In this paper, we consider a class of gravity whose action represents itself
as a sum of the usual Einstein-Hilbert action with cosmological constant and an
gauge field for which the action is given by a power of the Maxwell
invariant. We present a class of the rotating black branes with Ricci flat
horizon and show that the presented solutions may be interpreted as black brane
solutions with two event horizons, extreme black hole and naked singularity
provided the parameters of the solutions are chosen suitably. We investigate
the properties of the solutions and find that for the special values of the
nonlinear parameter, the solutions are not asymptotically anti-deSitter. At
last, we obtain the conserved quantities of the rotating black branes and find
that the nonlinear source effects on the electric field, the behavior of
spacetime, type of singularity and other quantities.Comment: 7 pages, 5 figures, to appear in EPJ
Accurate fundamental parameters and detailed abundance patterns from spectroscopy of 93 solar-type Kepler targets
We present a detailed spectroscopic study of 93 solar-type stars that are
targets of the NASA/Kepler mission and provide detailed chemical composition of
each target. We find that the overall metallicity is well-represented by Fe
lines. Relative abundances of light elements (CNO) and alpha-elements are
generally higher for low-metallicity stars. Our spectroscopic analysis benefits
from the accurately measured surface gravity from the asteroseismic analysis of
the Kepler light curves. The log g parameter is known to better than 0.03 dex
and is held fixed in the analysis. We compare our Teff determination with a
recent colour calibration of V-K (TYCHO V magnitude minus 2MASS Ks magnitude)
and find very good agreement and a scatter of only 80 K, showing that for other
nearby Kepler targets this index can be used. The asteroseismic log g values
agree very well with the classical determination using Fe1-Fe2 balance,
although we find a small systematic offset of 0.08 dex (asteroseismic log g
values are lower). The abundance patterns of metals, alpha elements, and the
light elements (CNO) show that a simple scaling by [Fe/H] is adequate to
represent the metallicity of the stars, except for the stars with metallicity
below -0.3, where alpha-enhancement becomes important. However, this is only
important for a very small fraction of the Kepler sample. We therefore
recommend that a simple scaling with [Fe/H] be employed in the asteroseismic
analyses of large ensembles of solar-type stars.Comment: MNRAS, in press, 12 page
Asteroseismic diagrams from a survey of solar-like oscillations with Kepler
Photometric observations made by the NASA Kepler Mission have led to a
dramatic increase in the number of main-sequence and subgiant stars with
detected solar-like oscillations. We present an ensemble asteroseismic analysis
of 76 solar-type stars. Using frequencies determined from the Kepler
time-series photometry, we have measured three asteroseismic parameters that
characterize the oscillations: the large frequency separation (\Delta \nu), the
small frequency separation between modes of l=0 and l=2 (\delta \nu_02), and
the dimensionless offset (\epsilon). These measurements allow us to construct
asteroseismic diagrams, namely the so-called C-D diagram of \delta \nu_02
versus \Delta \nu, and the recently re-introduced {\epsilon} diagram. We
compare the Kepler results with previously observed solar-type stars and with
theoretical models. The positions of stars in these diagrams places constraints
on their masses and ages. Additionally, we confirm the observational
relationship between {\epsilon} and T_eff that allows for the unambiguous
determination of radial order and should help resolve the problem of mode
identification in F stars.Comment: 6 pages, 5 figures, accepted for publication in The Astrophysical
Journal Letter
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