Danish rocked my world

My life took an unexpected twist when I fell in love with a Dane and moved to Denmark. Faced with mastering the next to impossible Danish language, my modern day fairytale quickly turned into one of the most challenging epochs of my life

Portrait of a Contender: Corey Morris

“Language at Work – Bridging Theory and Practice” caught up with busy Corey Morris on a cold and rainy November day in Denmark. We had two main reasons for looking up Corey at his work. First, we knew that his work takes him to the four corners of the world of branding on a daily basis. Second, we were well aware that Corey would be the right person to ask questions as to where branding is going these days

Extended treatment with MY-NEOVAX, personalized neoantigen-enhanced oncolytic viruses, for two end-stage cancer patients.

Neoantigen vaccines involving multi-peptides and poly-epitope-encoding RNA or DNA have undergone early phase clinical testing with modest reported antitumor effects [ 1]. The less-than-expected activity of these neoantigenic vaccines may correspond with the development of immune escape mechanisms. One permutation on neoantigen vaccines, which may counter or prevent these adaptive immune escape mechanisms, are 'personalized' oncolytic viruses that encode one or more tumor-specific transgenes. Herein, positive therapeutic effects for MY-NEOVAX™, personalized neoantigen-enhanced oncolytic adenoviruses, are described for two heavily pretreated end-stage patients, one with high-grade metastatic neuroendocrine carcinoma of the pancreas and the other with colorectal cancer metastatic to the brain, liver and lungs. To date, treatment benefit has exceeded 12 months without dose-limiting toxicities or related serious adverse events and with documented radiologic stabilization and improved performance status

The Warty Dory, Allocyttus verrucosus, New to the Fish Fauna of Canada

In April 2010, a Warty Dory, Allocyttus verrucosus (Gilchrist, 1906), was captured during commercial fishing activities in the Labrador Sea. This is the first record for Canada and the northwest Atlantic Ocean

Sound exposure level as a metric for analyzing and managing underwater soundscapes

The auditory frequency weighted daily sound exposure level (SEL) is used in many jurisdictions to assess possible injury to the hearing of marine life. Therefore, using daily SEL to describe soundscapes would provide baseline information about the environment using the same tools used to measure injury. Here, the daily SEL from 12 recordings with durations of 18-97days are analyzed to: (1) identify natural soundscapes versus environments affected by human activity, (2) demonstrate how SEL accumulates from different types of sources, (3) show the effects of recorder duty cycling on daily SEL, (4) make recommendations on collecting data for daily SEL analysis, and (5) discuss the use of the daily SEL as an indicator of cumulative effects. The autocorrelation of the one-minute sound exposure is used to help identify soundscapes not affected by human activity. Human sound sources reduce the autocorrelation and add low-frequency energy to the soundscapes. To measure the daily SEL for all marine mammal auditory frequency weighting groups, data should be sampled at 64kHz or higher, for at least 1min out of every 30min. The daily autocorrelation of the one-minute SEL provides a confidence interval for the daily SEL computed with duty-cycled data. (C) 2019 Acoustical Society of America

NO DATASET TOO SMALL! ANIMATING 3D MOTION DATA TO ENLARGE 2D VIDEO DATABASES

This study outlines a technique to leverage the wide availability of high resolution three-dimensional (3D) motion capture data for the purpose of synthesising two-dimensional (2D) video camera views, thereby increasing the availability of 2D video image databases for training machine learning models requiring large datasets. We register 3D marker trajectories to generic 3D body-shapes (hulls) and use a 2D pose estimation algorithm to predict joint centre and anatomical landmark keypoints in the synthesised 2D video views – a novel approach that addresses the limited data available in elite sport settings. We use 3D long jump data as an exemplar use case and investigate the influence of; 1) varying anthropometrics, and 2) the 2D camera view, on keypoint estimation accuracy. The results indicated that 2D keypoint determination accuracy is affected by body-shape. Frontal plane camera views result in lower accuracy than sagittal plane camera views

PREDICTING 3D GROUND REACTION FORCE FROM 2D VIDEO VIA NEURAL NETWORKS IN SIDESTEPPING TASKS

Sports science practitioners often measure ground reaction forces (GRFs) to assess performance, rehabilitation and injury risk. However, recording of GRFs during dynamic tasks has historically been limited to lab settings. This work aims to use neural networks (NN) to predict three-dimensional (3D) GRF via pose estimation keypoints as inputs, determined from 2D video data. Two different NN were trained on a dataset containing 1474 samples from 14 participants and their prediction accuracy compared with ground truth force data. Results for both NN showed correlation coefficients ranging from 0.936 to 0.954 and normalised root mean square errors from 11.05% to 13.11% for anterior-posterior and vertical GRFs, with poorer results found in the medio-lateral direction. This study demonstrates the feasibility and utility of predicting GRFs from 2D video footage

The Polycomb protein, Bmi1, regulates insulin sensitivity

Objective: The Polycomb Repressive Complexes (PRC) 1 and 2 function to epigenetically repress target genes. The PRC1 component, Bmi1, plays a crucial role in maintenance of glucose homeostasis and beta cell mass through repression of the Ink4a/Arf locus. Here we have explored the role of Bmi1 in regulating glucose homeostasis in the adult animal, which had not been previously reported due to poor postnatal survival of Bmi1−/− mice. Methods: The metabolic phenotype of Bmi1+/− mice was characterized, both in vivo and ex vivo. Glucose and insulin tolerance tests and hyperinsulinemic-euglycemic clamps were performed. The insulin signaling pathway was assessed at the protein and transcript level. Results: Here we report a negative correlation between Bmi1 levels and insulin sensitivity in two models of insulin resistance, aging and liver-specific insulin receptor deficiency. Further, heterozygous loss of Bmi1 results in increased insulin sensitivity in adult mice, with no impact on body weight or composition. Hyperinsulinemic-euglycemic clamp reveals increased suppression of hepatic glucose production and increased glucose disposal rate, indicating elevated glucose uptake to peripheral tissues, in Bmi1+/− mice. Enhancement of insulin signaling, specifically an increase in Akt phosphorylation, in liver and, to a lesser extent, in muscle appears to contribute to this phenotype. Conclusions: Together, these data define a new role for Bmi1 in regulating insulin sensitivity via enhancement of Akt phosphorylation

Testing of a Wireless Sensor System for Instrumented Thermal Protection Systems

Funded by NASA's Constellation Universities Institutes Project (CUIP), we have been developing and testing a system to wirelessly power and collect data from sensors on space platforms in general and, in particular, the harsh environment of spacecraft re-entry. The elimination of wires and associated failures such as chafing, sparking, ageing, and connector issues can increase reliability and design flexibility while reducing costs. These factors present an appealing case for the pursuit of wireless solutions for harsh environments, particularly for their use in space and on spacecraft. We have designed and built a prototype wireless sensor system. The system, with capabilities similar to that of a wired sensor system, was tested in NASA Ames Research Center s Aerodynamic Heating Facility and Interaction Heating Facility. This paper discusses the overall development effort, testing results, as well as future directions