1,308 research outputs found
HEMODINĂMICA PERIFĂRICA E CENTRAL DE PRATICANTES DE TREINAMENTO RESISTIDO OU AERĂBICO
Objetivos: O presente estudo visou comparar a hemodinùmica central e periférica de
indivĂduos treinados com exercĂcios resistidos intensos e corredores de endurance.
Métodos: Tonometria de aplanação da artéria radial, velocidade de onda de pulso e
medidas ecocardiogrĂĄficas foram realizadas em 19 indivĂduos treinados em
exercĂcios resistidos, 21 corredores de endurance e 29 controles saudĂĄveis
destreinados, todos homens, pareados por idade (25 a 50 anos). ANOVA de uma via
ou Kruskall Wallis foram usados para a anålise dos dados. O teste de comparaçÔes
mĂșltiplas de Tukey foi utilizado como post-hoc apĂłs a ANOVA e o mĂ©todo de Dunn
após Kruskall Wallis. Dados expressos como média ± desvio padrão (mediana).
Resultados: O Ăndice de incremento corrigido por 75 batimentos por minuto
(AIx@75%) foi menor nos indivĂduos treinados em exercĂcios resistidos intensos do
que nos corredores de endurance e controles respectivamente [-10,8 ± 10,0 (-15.0)]
vs. [-0,6 ± 13,2 (-1.0)] vs. [1,2 ± 12,9 (1.0)], com valor de P <0.001. Corredores de
endurance por sua vez apresentaram maior razĂŁo de viabilidade subendocĂĄrdica
(SEVR%) [225 ± 32 (223)] que indivĂduos treinados em exercĂcios resistidos intensos
[186 ± 35 (185)] e controles saudåveis [173 ± 27 (174)], com valor de P <0,001. Além
disso, corredores de endurance mostraram menor Ăndice de duração de ejeção
(ED%) [28 ± 3 (27)] do que indivĂduos treinados em exercĂcios resistidos intensos [32
± 4 (31)] e controles saudåveis [33 ± 3 (33)], com valor de P <0,001. A velocidade de
onda de pulso foi semelhante entre os grupos (P=0,08). Os grupos treinados
apresentaram maior massa ventricular esquerda indexada pela superfĂcie corporal
(P <0,001). ConclusĂ”es: IndivĂduos treinados em exercĂcios resistidos intensos
mostraram melhor amortecimento das ondas de pressĂŁo enquanto corredores de
endurance apresentaram melhor perfusão miocårdica e contração ventricular mais
eficiente
Cr[CH(SiMe3)2]3/SiO2 catalysts for ethene polymerization: The correlation at a molecular level between the chromium loading and the microstructure of the produced polymer
Effect of stocking density and protein/fat ratio of the diet on growth of Dover sole (Solea solea)
250 soles (30g initial weight) were randomly placed in 12 experimental tanks at the Discizia's aquaculture marine station. They were reared at 2 different stocking densities (2.3 and 1.3kg/m2 corresponding to 40% and 25% of the bottom surface area covered by fish) and fed on 2 diets with different protein/fat ratio (50% and 54% crude protein and 21% and 18% total lipid, respectively for diets A and B) with triplicate tanks per treatment. The trial lasted 120 days. Fish stocked at the lower density resulted in significantly higher weight gain than fish reared at 2.3 kg/m2 (29.0±7.3 g vs 20.3±8.0g; P<0.01) with a specific growth rate (SGR) of 0.54±0.09 and 0.42±0.13, respectively. Feed conversion rate (FCR) was improved at the lower density (1.8 vs 2.4, P<0.01). The chemical composition of the test diets significantly affected the growth performance of sole. Diet B led to a higher final weight (59.7 vs 50.8g; P<0.01) and better feed utilisation (FCR: 1.8 vs 2.4, P<0.01). These results confirm the necessity to ensure an adequate space for the growing sole and suggest the need for high protein diets to meet sole's requirements
Autotrophic vs. Heterotrophic cultivation of the marine diatom cyclotella cryptica for epa production
Recently, the marketable value of Ï-3 fatty acid, particularly eicosapentaenoic acid (EPA), increased considering their health effects for human consumption. Microalgae are considered a valuable and âgreenâ source of EPA alternative to fish oils, but considerable efforts are necessary for their exploitation at an industrial level. Due to the high operation costs of photoautotrophic microalgae cultivation, heterotrophic growth represents a promising economic solution. Marine diatoms are the major ecological producers of Ï-3 fatty acids. Few species of diatoms are capable to grow in the dark using organic carbon sources. The marine diatom Cyclotella cryptica was cultivated for 14 days under photoautotrophic and heterotrophic conditions to define the effects on growth parameters, lipid production, total fatty acids and EPA content. Photoautotrophic conditions led to a total EPA production of 1.6% of dry weight, 12.2 mg Lâ1 culture and productivity of 0.9 mg Lâ1 dayâ1 . The heterotrophy cultures reported a total EPA production of 2.7% of dry cell weight, 18 mg Lâ1 culture, a productivity of 1.3 mg Lâ1 dayâ1, which are promising values in the prospective of improving culture parameters for the biotechnological exploitation of dark cultivation. C. cryptica could be a potential candidate for the heterotrophic production of EPA, also considering its robustness, capacity to resist to bacterial contaminations and plasticity of lipid metabolism
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Editorial: Computational drug discovery for targeting of protein-protein interfacesâVolume II
An experimental measurement of the staggered magnetization curve for a Haldane spin chain
Long-range magnetic ordering in R_2 Ba Ni O_5 (R=magnetic rare earth)
quasi-1-dimensional mixed-spin antiferromagnets is described by a simple
mean-field model that is based on the intrinsic staggered magnetization
function of isolated Haldane spin chains for the Ni-subsystem, and single-ion
magnetization functions for the rare earth ions. The model is applied to new
experimental results obtained in powder diffraction experiments on Nd_2 Ba Ni
O_5 and Nd Y Ba Ni O_5, and to previously published diffraction data for Er_2
Ba Ni O_5. From this analysis we extract the bare staggered magnetization curve
for Haldane spin chains in these compounds.Comment: some revisions in text and figures 5 pages, 2 figures, PRL accepted
for publicatio
Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities
Mesoporous bioactive glass nanoparticles (MBGNs) are emerging biomaterials for bone repair/regeneration, considering their favorable pro-osteogenic and proangiogenic activities. To further improve their therapeutic effects, the endowment of MBGNs with additional antioxidant properties is of particular interest to target oxidative stress related to bone remodeling and diseases. To this end, we developed antioxidant cerium-containing MBGNs (Ce-MBGNs) (particle size of 100â300 ânm) by using a postimpregnation strategy to incorporate Ce, through which the shape, pore structure, and dispersity of the nanoparticles were preserved. The incorporated amount of Ce could be tailored by adjusting the concentration of the Ce precursor solution. When impregnated at a relatively low temperature (20 â°C), Ce-MBGNs containing either 1.8 or 2.8 âmol% of Ce were produced, while the formation of by-product cerium oxide nanoparticles (nanoceria) could be avoided. In both developed Ce-MBGNs, the concentration of Ce4+ was higher than that of Ce3+, while the relative molar percentage of Ce4+ was similar (âŒ74%) in both Ce-MBGNs. The obtained Ce-MBGNs were evidenced to be non-cytotoxic against fibroblasts at the concentration of 1 âmg/mL. Moreover, the incorporation of Ce into MBGNs significantly reduced the expression of oxidative stressârelated genes in macrophages (J774a.1). Particularly in the presence of pro-oxidation agents, Ce-MBGNs could downregulate the expression of oxidative stressârelated genes in comparsion with the polystyrene plates (control). When cultured with Ce-MBGNs, the expression of proinflammatory-related genes in macrophages could also be downregulated in comparsion with MBGNs and the control. Ce-MBGNs also exhibited pro-osteogenic activities through suppressing pro-osteoclastogenic responses. The obtained results highlight the great potential of the developed Ce-MBGNs in a variety of biomedical applications, particularly in treating bone defects under inflammatory conditions, considering their antioxidant, anti-inflammatory, and pro-osteogenesis activities
Consensus conference on the management of tumor lysis syndrome.
Tumor lysis syndrome is a potentially life threatening complication of massive cellular lysis in cancers. Identification of high-risk patients and early recognition of the syndrome is crucial in the institution of appropriate treatments. Drugs that act on the metabolic pathway of uric acid to allantoin, like allopurinol or rasburicase, are effective for prophylaxis and treatment of tumor lysis syndrome. Sound recommendations should regulate diagnosis and drug application in the clinical setting. The current article reports the recommendations on the management of tumor lysis syndrome that were issued during a Consensus Conference project, and which were endorsed by the Italian Society of Hematology (SIE), the Italian Association of Pediatric Oncologists (AIEOP) and the Italian Society of Medical Oncology (AIOM). Current concepts on the pathophysiology, clinical features, and therapy of tumor lysis syndrome were evaluated by a Panel of 8 experts. A consensus was then developed for statements regarding key questions on tumor lysis syndrome management selected according to the criterion of relevance by group discussion. Hydration and rasburicase should be administered to adult cancer patients who are candidates for tumor-specific therapy and who carry a high risk of tumor lysis syndrome. Cancer patients with a low-risk of tumor lysis syndrome should instead receive hydration along with oral allopurinol. Hydration and rasburicase should also be administered to patients with clinical tumor lysis syndrome and to adults and high-risk children who develop laboratory tumor lysis syndrome. In conclusion, the Panel recommended rasburicase for tumor lysis syndrome prophylaxis in selected patients based on the drug efficacy profile. Methodologically rigorous studies are needed to clarify its cost-effectiveness profile
Low density polyethylene functionalized with antibiofilm compounds inhibits Escherichia coli cell adhesion
The present work concerns an efficient strategy to obtain novel medical devices materials able to inhibit biofilm formation. The new materials were achieved by covalent grafting of p-aminocinnamic or p-aminosalicylic acids on low density polyethylene coupons. The polyethylene surface, previously activated by oxygen plasma treatment, was functionalized using 2-hydroxymethylmetacrylate as linker. The latter was reacted with succinic anhydride affording the carboxylic end useful for the immobilization of the antibiofilm molecules. The modified surface was characterized by scanning electron microscope, X-ray photoelectron spectroscopy, attenuated total reflectance Fourier transform infrared and fluorescence analyses. The antibiofilm activity of the modified materials were tested against Escherichia coli biofilm grown in the Center of Disease Control biofilm reactor. The results revealed that the grafted cinnamic and salicylic acid derivatives reduced biofilm biomass, in comparison with the control, by 73.7\u2009\ub1\u200910.7% and 63.4\u2009\ub1\u20097.1%, respectively
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