Los sellos in planta pedis de las ánforas olearias béticas Dressel 23 (primera mitad siglo V d.C.)

Despite the numerous literature on the production and consumption of Baetican olive-oil during the Principate, little is known about the survival of the Baetican amphorae in the Late Roman Empire. We present an epigraphic and economic study on a particular production of Dressel 23 amphorae, welldated in the first half of the Vth century A.D. It is a high value documental source, because it confirms objectively that a vivid trade continued under the political and religious rule of the primitive Christianism.Mucho se ha escrito sobre la producción y consumo de aceite bético en el marco histórico del Alto Imperio romano, pero muy poco se sabe sobre la pervivencia de las ánforas olearias béticas durante el Bajo Imperio. Presentamos el estudio epigráfico y económico de una producción particular de ánforas Dressel 23, bien datada y contextualizada en la primera mitad del siglo V d.C. Se trata de una fuente documental de gran valor para la investigación, porque gracias a ella podemos afirmar, con datos objetivos, que este comercio continuó ejerciendo un liderazgo significativo en una época de gran vitalidad comercial bajo la esfera política y religiosa del cristianismo primitivo

The ecology of Roman trade. Reconstructing provincial connectivity with similarity measures

The creation of the Roman Empire promoted the connectivity of a vast area around the Mediterranean sea. Mobility and trade flourished over the Roman provinces as massive amounts of goods were shipped over thousands of kilometres through sea, rivers and road networks. Several works have explored these dynamics of interaction in specific case studies but there is still no consensus on the intensity of this connectivity beyond local trade. We argue here that the debate on the degree of large-scale connectivity across the empire is caused by a lack of appropriate methods and proxies of economic activity. The last years have seen an improvement on the availability of evidence as a growing amount of datasets is collected and published. However, data does not equal knowledge and the methods used to analyse this evidence have not advanced at the same pace. A new framework of connectivity analysis has been applied here to reveal the existence of distinctive trade routes through the provinces of the Western region of Rome. The amphora stamps collected over more than a thousand sites have been analysed using quantitative measures of similarity. The patterns that emerge from the analysis highlight the intense connectivity derived from factors such as the spatial closeness, presence of military units and the relevance of the Atlantic sea as a main shipping route

Depresión, ansiedad y estrés en sujetos con Diabetes Mellitus Tipo II mayores de 45 años residentes de la ciudad de Barranquilla - Atlántico, 2020 – 2021

La diabetes mellitus es una enfermedad crónica que se ha convertido en una pandemia constituyendo un problema de salud pública en el mundo. Se ha logrado estimar que la frecuencia de los trastornos psiquiátricos en sujetos con diabetes mellitus tipo II aun cuando es variable son un factor de riesgo para desarrollar complicaciones asociadas. Este proyecto determina la depresión, ansiedad y estrés en sujetos con Diabetes Mellitus tipo II mayores de 45 años y su relación con factores de riesgo en la ciudad de Barranquilla, Atlántico. Llevando a cabo para tal fin un estudio observacional descriptivo transversal, utilizando una encuesta estructurada obteniendo los datos pertinentes a partir sujetos con diagnóstico de diabetes mellitus tipo II asistentes a una IPS de primer nivel en la ciudad de Barranquilla. El proyecto permitió identificar que de los 251 sujetos de investigación con diagnósticos de diabetes mellitus tipo II encuestados, al menos un 30% padecía de depresión, ansiedad o estrés. Adicionalmente, al momento de relacionar estas enfermedades con factores sociodemográficos, de tratamiento, antropométricos y conductuales se observó de manera especial que, con respecto a sus factores sociodemográficos, un porcentaje de la población cercano al 45% no contaba con un apoyo social máximo, presentando el 19% (n. 47) depresión (p <0,01), 15% (n. 39) ansiedad (p <0,01) y el 17% (n. 43) estrés igualmente con un valor de p <0,01. Y que los sujetos sin adherencia al tratamiento o consumo no diario de frutas y verduras presentaban estas enfermedades.PregradoMedic

Innocampus Explora: Nuevas formas de comunicar ciencia

[EN] Innocampus Explora aims to show the students of the Burjassot-Paterna campus of the Universitat de València how the different scientific degrees are interrelated. To do this we propose activities in which students and teachers work together to cover the interdisciplinary nature of science, both in everyday and professional issues. Throughout this course the activities developed relate to new ways to communicate science. With the development of this project we contribute to a transversal quality education for all the participating students.[ES] Innocampus Explora tiene por objetivo mostrar a los estudiantes del campus de Burjassot-Paterna de la Universitat de València cómo los diferentes grados científicos están interrelacionados. Para ello proponemos actividades en las que estudiantes y profesores trabajen conjuntamente para abarcar la interdisciplinariedad de la ciencia, tanto en temas cotidianos como profesionales. A lo largo de este curso las actividades desarrolladas se relacionan con las nuevas formas de comunicar ciencia. Con el desarrollo de este proyecto contribuimos a una formación transversal de calidad para todos los estudiantes participantes.Moros Gregorio, J.; Rodrigo Martínez, P.; Torres Piedras, C.; Montoya Martínez, L.; Peña Peña, J.; Pla Díaz, M.; Galarza Jiménez, P.... (2019). Innocampus Explora: Nuevas formas de comunicar ciencia. En IN-RED 2019. V Congreso de Innovación Educativa y Docencia en Red. Editorial Universitat Politècnica de València. 814-823. https://doi.org/10.4995/INRED2019.2019.10449OCS81482

L’atelier de production d’amphores et de céramiques d’époque romaine d’El Vila-sec (Alcover, Tarragona, Catalunya)

La fouille archéologique réalisée à Vila-sec a permis d’identifier un centre de production potier couvrant une surface totale de 2 300 m² et présentant quatre phases chronologiques distinctes, entre les règnes de Tibère et Claude et la fin du IIer s./début du IIIe s. ap. J.-C. Cette opération a permis de mettre au jour un total de douze fours de différents types, six bassins de décantation d’argile, une fosse pour travailler l’argile, des canalisations de tegulae et quatre bâtiments destinés à la production des amphores et des céramiques. Le matériel céramique exhumé a permis de montrer que l’atelier de Vilasec a produit des matériaux de construction, des pondera, de la céramique commune, des lampes à huile, des imitations de sigillée hispanique, des céramiques à paroi fine, ainsi que des amphores Dr. 2 et Dr. 2 évoluées.A pottery production centre, covering an area of 2300m2, has been discovered at Vila-sec (Tarragona). The excavation revealed four distinct successive phases, starting between the reigns of Tiberius and Claudius and ending at to the end of the 2nd/beginning of 3rd century AD. A total of twelve kilns of different types, six tanks for clay decantation, a pit used to work the clay, pipelines made of tegulae, and four buildings used for amphorae and pottery production were found on site. The recovered finds shows that the workshop of Vila-sec produced building materials, pondera, coarse wares, oil lamps, Spanish samian imitation ware, fine wares, and Dressel 2 amphorae (including evolved Dressel 2 types)

Crossed mixture process design approach to model nanofiltration rejection for non-dilute multi-ionic solutions in a given range of solution compositions

The goal of the present work is to illustrate the applicability of crossed mixture-process design to predict the rejection of the nanofiltration membranes when treating non-dilute solutions. The method used in this work is based on the use of mixture factors derived from the fractions of equivalents of the major ions present in solution combined with the total concentration as a process variable. In this way, polynomial models for permselectivity properties can be obtained.Model accuracy is improved by using pseudo-components to restrict the range of the composition variables to that expected for the feed water compositions. The experimental plan uses the D-optimal criterion. As an application example, the procedurewas used to model the performance of the nanofiltration membrane NF270 (Dow-Filmtec) with ionicmixtures containing chloride, nitrate, sulfate, sodium and calcium. The experimentswere carried out in a pilot plantwith solutions of total concentration ranging from 2480 to 4050 mg/L. The obtained polynomialmodels could satisfactorily describe individual ion rejection despite the solutions not being dilute. The polynomial models can be useful for design and operation purposes as an alternative to physical-based nanofiltration models.The Spanish Ministry for Science and Innovation (Project OPTIMEM CTM2010-20248) and the Universitat Politecnica de Valencia (PAID-06-08-3287) are kindly acknowledged.Gozálvez Zafrilla, JM.; Santafé Moros, MA.; García Díaz, JC. (2013). Crossed mixture process design approach to model nanofiltration rejection for non-dilute multi-ionic solutions in a given range of solution compositions. Desalination. 315:61-69. https://doi.org/10.1016/j.desal.2012.08.009S616931

The ecology of Roman trade. Reconstructing provincial connectivity with similarity measures

The creation of the Roman Empire promoted the connectivity of a vast area around the Mediterranean sea. Mobility and trade flourished over the Roman provinces as massive amounts of goods were shipped over thousands of kilometres through sea, rivers and road networks. Several works have explored these dynamics of interaction in specific case studies but there is still no consensus on the intensity of this connectivity beyond local trade. We argue here that the debate on the degree of large-scale connectivity across the empire is caused by a lack of appropriate methods and proxies of economic activity. The last years have seen an improvement on the availability of evidence as a growing amount of datasets is collected and published. However, data does not equal knowledge and the methods used to analyse this evidence have not advanced at the same pace. A new framework of connectivity analysis has been applied here to reveal the existence of distinctive trade routes through the provinces of the Western region of Rome. The amphora stamps collected over more than a thousand sites have been analysed using quantitative measures of similarity. The patterns that emerge from the analysis highlight the intense connectivity derived from factors such as the spatial closeness, presence of military units and the relevance of the Atlantic sea as a main shipping route

Design and testing of a colorimetric immunoassay for the measurement of phenylalanine blood levels in patients with phenylketonuria

Resumen del trabajo presentado a la IX International Conference BIFI: New Challenges in Molecular Biotechnology, celebrada en Zaragoza del 3 al 5 de febrero 2020Peer reviewe

Design and synthesis of FMN derivatives for covalent binding to Anabaena apoflavodoxin

Resumen del trabajo presentado a la XI National Conference BIFI, celebrada del 25 al 27 de enero de 2023 en el Campus Río Ebro, Zaragoza (España).Many flavoproteins are involved in vital metabolic transformations, which are of high biotechnological relevance and play essential biological roles in small organisms and humans. Flavodoxins are electron- transfer flavoproteins that contain one molecule of non-covalently bound flavin mononucleotide as the redox component. This flavoprotein is subject to dissociation equilibrium and influenced by solution conditions, which may result in cofactor dissociation, leading to destabilization of the protein moiety and to irreversible loss of its catalytic activity. In order to develop a new strategy for the rational increase of flavoproteins conformational stability, we have been focused on getting variants of the Anabaena flavodoxin bearing covalently bound catalytically active FMN; for which we have synthesized two FMN derivatives which contain electrophilic and reactive groups. Suitable flavodoxin variants have also been designed, expressed and purified. We have performed a brief computational study to confirm that these compounds are suitable to establish covalent links with new flavodoxin mutants and that the links are compatible with maintaining the native orientation of the isoalloxacin moiety relative to the apoprotein. Currently, we are carrying out experiments to find the best conditions to achieve such covalent binding of FMN derivatives through nucleophilic residues strategically located near the active center.Peer reviewe