The 750 GeV Diphoton excess, Dark Matter and Constraints from the IceCube experiment

Recent LHC data show hints of a new resonance in the diphoton distribution at an invariant mass of 750 GeV. Interestingly, this new particle might be both CP odd and play the role of a portal into the dark matter sector. Under these assumptions and motivated by the fact that the requirement of $SU(2)_L$ invariance automatically implies the coupling of this alleged new resonance to $ZZ$ and $Z\gamma$, we investigate the current and future constraints coming from the indirect searches performed through the neutrino telescope IceCube. We show that these constraints can be stronger than the ones from direct detection experiments if the dark matter mass is larger than a few hundred GeV. Furthermore, in the scenario in which the dark matter is a scalar particle, the IceCube data limit the cross section between the DM and the proton to values close to the predicted ones for natural values of the parameters.Comment: 20 pages, 6 figures; v2: added references; v3: published version, with some minor edits and including the exclusion bounds from searches of gamma ray

BBBW on the spindle

We study the spindle compactification of families of AdS$_5$ consistent truncations corresponding to M5 branes wrapped on complex curves in Calabi-Yau three-folds. From the AdS/CFT correspondence these models are dual to $\mathcal{N}=1$ SCFTs obtained by gluing of $T_N$ blocks. The truncations considered here have both vector and hyper multiplets and the analysis of the BPS equations on the spindle allows to extract the central charges. Such analysis gives also consistency conditions for the existence of the solutions. The solutions are then found both analytically and numerically for opportune choices of the charges for some sub-families of truncations. We then compare our results with the one expected from the field theory side, by integrating the anomaly polynomial.Comment: 34 pages, 1 figur

Genomic tools for durum wheat breeding: de novo assembly of Svevo transcriptome and SNP discovery in elite germplasm

BACKGROUND: The tetraploid durum wheat (Triticum turgidum L. ssp. durum Desf. Husnot) is an important crop which provides the raw material for pasta production and a valuable source of genetic diversity for breeding hexaploid wheat (Triticum aestivum L.). Future breeding efforts to enhance yield potential and climate resilience will increasingly rely on genomics-based approaches to identify and select beneficial alleles. A deeper characterisation of the molecular and functional diversity of the durum wheat transcriptome will be instrumental to more effectively harness its genetic diversity. RESULTS: We report on the de novo transcriptome assembly of durum wheat cultivar 'Svevo'. The transcriptome of four tissues/organs (shoots and roots at the seedling stage, reproductive organs and developing grains) was assembled de novo, yielding 180,108 contigs, with a N50 length of 1121\u2009bp and mean contig length of 883\u2009bp. Alignment against the transcriptome of nine plant species identified 43% of transcripts with homology to at least one reference transcriptome. The functional annotation was completed by means of a combination of complementary software. The presence of differential expression between the A- and B-homoeolog copies of the durum wheat tetraploid genome was ascertained by phase reconstruction of polymorphic sites based on the T. urartu transcripts and inferring homoeolog-specific sequences. We observed greater expression divergence between A and B homoeologs in grains rather than in leaves and roots. The transcriptomes of 13 durum wheat cultivars spanning the breeding period from 1969 to 2005 were analysed for SNP diversity, leading to 95,358 non-rare, hemi-SNPs shared among two or more cultivars and 33,747 locus-specific (diploid inheritance) SNPs. CONCLUSIONS: Our study updates and expands the de novo transcriptome reference assembly available for durum wheat. Out of 180,108 assembled transcripts, 13,636 were specific to the Svevo cultivar as compared to the only other reference transcriptome available for durum, thus contributing to the identification of the tetraploid wheat pan-transcriptome. Additionally, the analysis of 13 historically relevant hallmark varieties produced a SNP dataset that could successfully validate the genotyping in tetraploid wheat and provide a valuable resource for genomics-assisted breeding of both tetraploid and hexaploid wheats

Preliminary evaluation of the impact of temperature fluctuations in the HFI 4K stage on LFI

In this technical note we provide a preliminary analysis of the effect of temperature fluctuations at the level of the HFI 4K stage on the scientific performances of the Planck-LFI instrument. The stability of this stage is of crucial importance for the LFI, as it impact directly the stability of the measured signal through its reference load. The availability of the first simulations of the 4K temperature stability from the HFI team has prompted a quick assessment of the expected effect, which is found to be large enough to require the application of software removal algorithms to maintain the residual effect in the final maps within the required levels. Clearly it is of crucial importance the availability in a short time of measurements from the HFI 4K cooler in order to be able to perform robust estimates of the final expected systematic effect

A single polyploidization event at the origin of the tetraploid genome of Coffea arabica is responsible for the extremely low genetic variation in wild and cultivated germplasm

The genome of the allotetraploid species Coffea arabica L. was sequenced to assemble independently the two component subgenomes (putatively deriving from C. canephora and C. eugenioides) and to perform a genome-wide analysis of the genetic diversity in cultivated coffee germplasm and in wild populations growing in the center of origin of the species. We assembled a total length of 1.536 Gbp, 444 Mb and 527 Mb of which were assigned to the canephora and eugenioides subgenomes, respectively, and predicted 46,562 gene models, 21,254 and 22,888 of which were assigned to the canephora and to the eugeniodes subgenome, respectively. Through a genome-wide SNP genotyping of 736 C. arabica accessions, we analyzed the genetic diversity in the species and its relationship with geographic distribution and historical records. We observed a weak population structure due to low-frequency derived alleles and highly negative values of Taijma's D, suggesting a recent and severe bottleneck, most likely resulting from a single event of polyploidization, not only for the cultivated germplasm but also for the entire species. This conclusion is strongly supported by forward simulations of mutation accumulation. However, PCA revealed a cline of genetic diversity reflecting a west-to-east geographical distribution from the center of origin in East Africa to the Arabian Peninsula. The extremely low levels of variation observed in the species, as a consequence of the polyploidization event, make the exploitation of diversity within the species for breeding purposes less interesting than in most crop species and stress the need for introgression of new variability from the diploid progenitors

The Pain in Dystonia Scale (PIDS)—Development and Validation in Cervical Dystonia

BACKGROUND: A better understanding of pain in adult-onset idiopathic dystonia (AOID) is needed to implement effective therapeutic strategies. OBJECTIVE: To develop a new rating instrument for pain in AOID and validate it in cervical dystonia (CD). METHODS: Development and validation of the Pain in Dystonia Scale (PIDS) comprised three phases. In phase 1, international experts and participants with AOID generated and evaluated the preliminary items for content validity. In phase 2, the PIDS was drafted and revised by the experts, followed by cognitive interviews to ensure self-administration suitability. In phase 3, the PIDS psychometric properties were assessed in 85 participants with CD and retested in 40 participants. RESULTS: The final version of PIDS evaluates pain severity (by body-part), functional impact, and external modulating factors. Test-retest reliability showed a high-correlation coefficient for the total score (0.9, P < 0.001), and intraclass correlation coefficients were 0.7 or higher for all items in all body-parts subscores. The overall PIDS severity score showed high internal consistency (Cronbach's α, 0.9). Convergent validity analysis revealed a strong correlation between the PIDS severity score and the Toronto Western Spasmodic Torticollis Rating Scale pain subscale (0.8, P < 0.001) and the Brief Pain Inventory-short form items related to pain at time of the assessment (0.7, P < 0.001) and impact of pain on daily functioning (0.7, P < 0.001). CONCLUSION: The PIDS is the first specific questionnaire developed to evaluate pain in all patients with AOID, here, demonstrating high-level psychometric properties in people with CD. Future work will validate PIDS in other forms of AOID. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

The STRIP instrument of the Large Scale Polarization Explorer: microwave eyes to map the Galactic polarized foregrounds

In this paper we discuss the latest developments of the STRIP instrument of the "Large Scale Polarization Explorer" (LSPE) experiment. LSPE is a novel project that combines ground-based (STRIP) and balloon-borne (SWIPE) polarization measurements of the microwave sky on large angular scales to attempt a detection of the "B-modes" of the Cosmic Microwave Background polarization. STRIP will observe approximately 25% of the Northern sky from the "Observatorio del Teide" in Tenerife, using an array of forty-nine coherent polarimeters at 43 GHz, coupled to a 1.5 m fully rotating crossed-Dragone telescope. A second frequency channel with six-elements at 95 GHz will be exploited as an atmospheric monitor. At present, most of the hardware of the STRIP instrument has been developed and tested at sub-system level. System-level characterization, starting in July 2018, will lead STRIP to be shipped and installed at the observation site within the end of the year. The on-site verification and calibration of the whole instrument will prepare STRIP for a 2-years campaign for the observation of the CMB polarization.Comment: 17 pages, 15 figures, proceedings of the SPIE Astronomical Telescopes + Instrumentation conference "Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy IX", on June 15th, 2018, Austin (TX

Genomic tools for durum wheat breeding: De novo assembly of Svevo transcriptome and SNP discovery in elite germplasm

Abstract Background The tetraploid durum wheat (Triticum turgidum L. ssp. durum Desf. Husnot) is an important crop which provides the raw material for pasta production and a valuable source of genetic diversity for breeding hexaploid wheat (Triticum aestivum L.). Future breeding efforts to enhance yield potential and climate resilience will increasingly rely on genomics-based approaches to identify and select beneficial alleles. A deeper characterisation of the molecular and functional diversity of the durum wheat transcriptome will be instrumental to more effectively harness its genetic diversity. Results We report on the de novo transcriptome assembly of durum wheat cultivar ‘Svevo’. The transcriptome of four tissues/organs (shoots and roots at the seedling stage, reproductive organs and developing grains) was assembled de novo, yielding 180,108 contigs, with a N50 length of 1121 bp and mean contig length of 883 bp. Alignment against the transcriptome of nine plant species identified 43% of transcripts with homology to at least one reference transcriptome. The functional annotation was completed by means of a combination of complementary software. The presence of differential expression between the A- and B-homoeolog copies of the durum wheat tetraploid genome was ascertained by phase reconstruction of polymorphic sites based on the T. urartu transcripts and inferring homoeolog-specific sequences. We observed greater expression divergence between A and B homoeologs in grains rather than in leaves and roots. The transcriptomes of 13 durum wheat cultivars spanning the breeding period from 1969 to 2005 were analysed for SNP diversity, leading to 95,358 non-rare, hemi-SNPs shared among two or more cultivars and 33,747 locus-specific (diploid inheritance) SNPs. Conclusions Our study updates and expands the de novo transcriptome reference assembly available for durum wheat. Out of 180,108 assembled transcripts, 13,636 were specific to the Svevo cultivar as compared to the only other reference transcriptome available for durum, thus contributing to the identification of the tetraploid wheat pan-transcriptome. Additionally, the analysis of 13 historically relevant hallmark varieties produced a SNP dataset that could successfully validate the genotyping in tetraploid wheat and provide a valuable resource for genomics-assisted breeding of both tetraploid and hexaploid wheats

PROBA-3 mission and the Shadow Position Sensors: Metrology measurement concept and budget

PROBA-3 is a space mission of the European Space Agency that will test, and validate metrology and control systems for autonomous formation flying of two independent satellites. PROBA-3 will operate in a High Elliptic Orbit and when approaching the apogee at 6·104 Km, the two spacecraft will align to realize a giant externally occulted coronagraph named ASPIICS, with the telescope on one satellite and the external occulter on the other one, at inter-satellite distance of 144.3 m. The formation will be maintained over 6 hrs across the apogee transit and during this time different validation operations will be performed to confirm the effectiveness of the formation flying metrology concept, the metrology control systems and algorithms, and the spacecraft manoeuvring. The observation of the Sun's Corona in the field of view [1.08;3.0]RSun will represent the scientific tool to confirm the formation flying alignment. In this paper, we review the mission concept and we describe the Shadow Position Sensors (SPS), one of the metrological systems designed to provide high accuracy (sub-millimetre level) absolute and relative alignment measurement of the formation flying. The metrology algorithm developed to convert the SPS measurements in lateral and longitudinal movement estimation is also described and the measurement budget summarized