2,262 research outputs found
Changing times in England: the influence on geography teachersâ professional practice
School geography in England has been characterised as a pendulum swinging between policies that emphasise curriculum and pedagogy alternately. In this paper, I illustrate the influence of these shifts on geography teacher's professional practice, by drawing on three âmomentsâ from my experience as a student, teacher and teacher educator. Barnett's description of teacher professionalism as a continuous project of âbeingâ illuminates how geography teachers can adapt to competing influences. It reflects teacher professionalism as an unfinished project, which is responsive, but not beholden, to shifting trends, and is informed by how teachers frame and enact policies. I argue that recognising these contextual factors is key to supporting geography teachers in âbeingâ geography education professionals. As education becomes increasingly competitive on a global scale, individual governments are looking internationally for âsolutionsâ to improve educational rankings. In this climate, the future of geography education will rest on how teachers react locally to international trends. Geography teacher educators can support this process by continuing to inform the field through meaningful geography education research, in particular in making the contextual factors of their research explicit. This can be supported through continued successful international collaboration in geography education research
Artificial Neural Network Inference (ANNI): A Study on Gene-Gene Interaction for Biomarkers in Childhood Sarcomas
Objective: To model the potential interaction between previously identified biomarkers in children sarcomas using artificial neural network inference (ANNI).
Method: To concisely demonstrate the biological interactions between correlated genes in an interaction network map, only 2 types of sarcomas in the children small round blue cell tumors (SRBCTs) dataset are discussed in this paper. A backpropagation neural network was used to model the potential interaction between genes. The prediction weights and signal directions were used to model the strengths of the interaction signals and the direction of the interaction link between genes. The ANN model was validated using Monte Carlo cross-validation to minimize the risk of over-fitting and to optimize generalization ability of the model.
Results: Strong connection links on certain genes (TNNT1 and FNDC5 in rhabdomyosarcoma (RMS); FCGRT and OLFM1 in Ewingâs sarcoma (EWS)) suggested their potency as central hubs in the interconnection of genes with different functionalities. The results showed that the RMS patients in this dataset are likely to be congenital and at low risk of cardiomyopathy development. The EWS patients are likely to be complicated by EWS-FLI fusion and deficiency in various signaling pathways, including Wnt, Fas/Rho and intracellular oxygen.
Conclusions: The ANN network inference approach and the examination of identified genes in the published literature within the context of the disease highlights the substantial influence of certain genes in sarcomas
Evaluation of the relative potential for contact and doffing transmission of SARS-CoV-2 by a range of personal protective equipment materials
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)âthe causative agent of coronavirus disease 2019 (COVID-19)âhas caused a global public health emergency. Personal protective equipment (PPE) is the primary defence against viral exposure in healthcare and community settings. However, the surfaces of PPE materials may trap virus for contact transmission or through laden aerosols generated during removal of PPE, through cleaning or during movement. In this study, the relative efficacy of current PPE materials in terms of virion adsorption to materials and their antiviral potency, has been evaluated on a wide range of PPE for the first time, including four polymer glove types, two types of scrubs, apron material, a mask, visor and a selection of other commercial polymers and products. Although differences in virion adsorption to the test materials were observed, none of the existing polymer-based PPE resulted in more than tenfold reduction in the SARS-CoV-2 titre within either 10min or 30min contact period. The wettability and surface chemistry of the test materials were analysed to investigate any correlations with their surface physicochemical properties. While no correlation was found between wettability and viral retention under air flow challenge, one secondary ion of m/z 101.03 (+) and three secondary ions of m/z 31.98 (â), 196.93 (â) and 394.33 (+) in ToFâSIMS data of the test materials showed positive and negative correlations with the viral retention, respectively, which was identified by PLS regression model, suggesting that the surface chemistry plays a role in determining the extent of virion adsorption. Our findings outline the material aspects that influence the efficacy of current PPE against SARS-CoV-2 transmission and give suggestions on the development of novel simple polymer-based PPE for better infection protection
Soft Openings: The psycho-technological expertise of third sector curriculum reform
Since the late 1990s the "third sector" has become active in generating new curriculum programmes in England. Based on tracing third sector participation in public education during the New Labour years, the article explores a documentary archive of third sector curriculum texts and argues that the programmes, strategies and techniques of the third sector have sought to pursue a new form of governmentality. The type of governmentality pursued by the third sector takes form as a "soft" style of curriculum reform derived from assembling together cybernetic and psychological forms of expertise, interactionist and constructivist pedagogies, and an emerging "psycho-technology" of subjectivity. The third sector fabricates reform proposals for a curriculum of the future in which governance is done by cross-sectoral networking, epistemological categories are blurred, and student subjectivities are made up to be malleable, soft-skilled and psychologically self-shaping. The article examines how third sector texts have assembled this new psycho-technological expertise of curriculum reform through both cybernetic and psychological styles of thinking
Statistical analysis plan for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice: identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i)
\ua9 2024, The Author(s).Background: The Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i) trial is being conducted to establish whether âscreening and interventionâ, consisting of usual school practice plus a pathway comprising screening, feedback and a brief parent-led online intervention (OSI: Online Support and Intervention for child anxiety), bring clinical and health economic benefits compared to usual school practice and assessment only â âusual school practiceâ, for children aged 8â9 years in the following: (1) the âtarget populationâ, who initially screen positive for anxiety problems according to a two-item parent-report child anxiety questionnaire â iCATS-2, and (2) the âtotal populationâ, comprising all children in participating classes. This article describes the detailed statistical analysis plan for the trial. Methods and design: iCATS-i2i is a definitive, superiority, pragmatic, school-based cluster randomised controlled trial (with internal pilot), with two parallel groups. Schools are randomised 1:1 to receive either screening and intervention or usual school practice. This article describes the following: trial objectives and outcomes; statistical analysis principles, including detailed estimand information necessary for aligning trial objectives, conduct, analyses and interpretation when there are different analysis populations and outcome measures to be considered; and planned main analyses, sensitivity and additional analyses. Trial registration: ClinicalTrials.gov ISRCTN76119074. Registered on 4 January 202
Photoproduction of neutral pion pairs in the Coulomb field of the nucleus
The total cross section for Coulomb photoproduction of neutral pion pairs in
the reaction gamma A --> pi0 pi0 A is estimated within the effective chiral
lagrangian approach.
The amplitude of gamma gamma* --> pi0 pi0 with one off-shell photon is
calculated at O(p^6) in the momentum expansion; in addition, nuclear absorption
is taken into account.
Besides its experimental feasibility, the results of the calculation
demonstrate that the reaction gamma A --> pi0 pi0 A is a powerful source of
information on the process gamma gamma --> pi0 pi0 close to threshold.Comment: 18 pages, 6 figures, uses epsf, ioplppt.sty, iopl12.sty (included);
Added a discussion of main background from double pion photoproduction on
nucleon gamma N --> 2pi0 N via baryon resonance exchange mechanis
Prescribing the Jacobian in critical spaces
International audienceWe consider the Sobolev space . We prove the existence of a robust distributional Jacobian for provided . This generalizes a result of Bourgain, Brezis and the second author (Comm. Pure Appl. Math. 2005), where the case is considered. In the critical case where , we identify the image of the map . This extends a result of Alberti, Baldo and Orlandi (J. Eur. Math. Soc. 2003) for and . We also present a new, analytical, dipole construction method
Analysis of Charged-Particle/Photon Observables in Hadronic Multiparticle Production
In order to analyze data on joint charged-particle/photon distributions from
an experimental search (T-864, MiniMax) for disoriented chiral condensate (DCC)
at the Fermilab Tevatron collider, we have identified robust observables,
ratios of normalized bivariate factorial moments, with many desirable
properties. These include insensitivity to many efficiency corrections and the
details of the modeling of the primary pion production, and sensitivity to the
production of DCC, as opposed to the generic, binomial-distribution partition
of pions into charged and neutral species. The relevant formalism is developed
and tested in Monte-Carlo simulations of the MiniMax experimental conditions.Comment: Latex, 35 pages, no figures. Submitted to Physical Review D.
PostScript file at http://fnmine.fnal.gov:80
Recommended reporting items for epidemic forecasting and prediction research : the EPIFORGE 2020 guidelines
Funding: MIDAS Coordination Center and the National Institutes of General Medical Sciences (NIGMS 1U24GM132013) for supporting travel to the face-to-face consensus meeting by members of the Working Group. NGR was supported by the National Institutes of General Medical Sciences (R35GM119582). Travel for SV was supported by the National Institutes of General Medical Sciences (1U24GM132013-01). BMA was supported by Bill & Melinda Gates through the Global Good Fund. RL was funded by a Royal Society Dorothy Hodgkin Fellowship.Background The importance of infectious disease epidemic forecasting and prediction research is underscored by decades of communicable disease outbreaks, including COVID-19. Unlike other fields of medical research, such as clinical trials and systematic reviews, no reporting guidelines exist for reporting epidemic forecasting and prediction research despite their utility. We therefore developed the EPIFORGE checklist, a guideline for standardized reporting of epidemic forecasting research. Methods and findings We developed this checklist using a best-practice process for development of reporting guidelines, involving a Delphi process and broad consultation with an international panel of infectious disease modelers and model end users. The objectives of these guidelines are to improve the consistency, reproducibility, comparability, and quality of epidemic forecasting reporting. The guidelines are not designed to advise scientists on how to perform epidemic forecasting and prediction research, but rather to serve as a standard for reporting critical methodological details of such studies. Conclusions These guidelines have been submitted to the EQUATOR network, in addition to hosting by other dedicated webpages to facilitate feedback and journal endorsement.Publisher PDFNon peer reviewe
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