Developing a cultural competence assessment tool for people in recovery from racial, ethnic and cultural backgrounds: the journey, challenges and lessons learned.

In 1997, Maryland implemented a new managed care mental health system. Consumer satisfaction, evaluation and cultural competency were considered high priorities for the new system. While standardized tools for measuring consumer satisfaction were readily available, no validated, reliable and standardized tool existed to measure the perception of people from minority groups receiving mental health services. The MHA*/MHP* Cultural Competency Advisory Group (CCAG) accepted the challenge of developing a consumer assessment tool for cultural competency. The CCAG, composed of people in recovery, clinicians and administrators used their collective knowledge and experiences to develop a 52-item tool that met standards for validity and reliability. Consultation from a researcher helped to further develop the tool into one possessing tremendous potential for statewide implementation within Maryland's Public Mental Health System. Recognizing the limitations of the study and the need for further research, this instrument is a work in progress. Strategies to improve the instrument are currently underway with the Mental Hygiene Administration's Systems Evaluation Center of the University of Maryland and several national researchers

MH-60 Seahawk / MQ-8 Fire Scout interoperability

Approved for public release; distribution is unlimitedAs part of a Naval Postgraduate School's capstone project in Systems Engineering, a project team from Cohort 311-0911 performed a Systems Engineering analysis. This Project focused on defining alternatives for enhanced Anti-Surface Warfare (ASUW) mission effectiveness through increased interoperability and integration for the Fire Scout Unmanned Air Vehicle and Seahawk helicopter. Specifically, the Project explored the available trade space for enhancing communications back to the ship for analysis and decision-making. Modeling and Simulation (MandS) was used to assess the impact of enhanced communication on specific Key performance Parameters (KPPs) and Measures of Effectiveness (MOEs) associated with the ASUW mission. Once the trade space was defined, alternatives were analyzed and a recommendation provided that supports near-, mid-, and long-term mission enhancement

Guidelines for Verification Strategies to Minimize RISK Based on Mission Environment, -Application and -Lifetime (MEAL)

There is a trend of compromising verification testing to address the cost and schedule constraints, which poses a high-risk posture for programs/projects. Current and emerging aerospace scientific and/or human exploration programs continue to pose new technological challenges. These technological challenges combined with finite budgets and truncated schedules are forcing designers, scientists, engineers, and managers to push technologies to their physical limits. In addition, budget and schedule pressures challenge how those technologies/missions are verified. A clear understanding of the different verification processes is needed to ensure the proper verification of the technology within the mission (i.e., capabilities, advantages, and limitations). The goal of verification is to prove through test, analysis, inspection, and/or demonstration that a product provides its required function while meeting the performance requirements. It is important that verification yield understanding of representative performance under worst-case conditions so that margins to failure can be evaluated for proposed applications. The capabilities, advantages, and limitations of the testing and inspection performed at each level are different, and the risk incurred by omitting a verification step depends on the level of integration as well as Mission, Environment, Application and Lifetime (MEAL). This paper focuses on verification processes. The goal of the verification process is to ensure the given avionics technology could be safely implemented on the given MEAL consistent with the program/project risk posture

Peanuts and Pigs.

18 p

Anti-Neoplastic Activity of Two Flavone Isomers Derived From Gnaphalium Elegans and Achyrocline Bogotensis

Over 4000 flavonoids have been identified so far and among these, many are known to have antitumor activities. The basis of the relationships between chemical structures, type and position of substituent groups and the effects these compounds exert specifically on cancer cells are not completely elucidated. Here we report the differential cytotoxic effects of two flavone isomers on human cancer cells from breast (MCF7, SK-BR-3), colon (Caco-2, HCT116), pancreas (MIA PaCa, Panc 28), and prostate (PC3, LNCaP) that vary in differentiation status and tumorigenic potential. These flavones are derived from plants of the family Asteraceae, genera Gnaphalium and Achyrocline reputed to have anti-cancer properties. Our studies indicate that 5,7-dihydroxy-3,6,8-trimethoxy-2-phenyl-4H-chromen-4-one (5,7-dihydroxy-3,6,8-trimethoxy flavone) displays potent activity against more differentiated carcinomas of the colon (Caco-2), and pancreas (Panc28), whereas 3,5-dihydroxy-6,7,8-trimethoxy-2-phenyl-4H-chromen-4-one (3,5-dihydroxy-6,7,8-trimethoxy flavone) cytototoxic action is observed on poorly differentiated carcinomas of the colon (HCT116), pancreas (Mia PaCa), and breast (SK-BR3). Both flavones induced cell death (\u3e50%) as proven by MTT cell viability assay in these cancer cell lines, all of which are regarded as highly tumorigenic. At the concentrations studied (5-80 μM), neither flavone demonstrated activity against the less tumorigenic cell lines, breast cancer MCF-7 cells, androgen-responsive LNCaP human prostate cancer line, and androgen-unresponsive PC3 prostate cancer cells. 5,7-dihydroxy-3,6,8-trimethoxy-2-phenyl-4H-chromen-4-one (5,7-dihydroxy-3,6,8-trimethoxy flavone) displays activity against more differentiated carcinomas of the colon and pancreas, but minimal cytotoxicity on poorly differentiated carcinomas of these organs. On the contrary, 3,5-dihydroxy-6,7,8-trimethoxy-2-phenyl-4H-chromen-4-one (3,5-dihydroxy-6,7,8-trimethoxy flavone) is highly cytotoxic to poorly differentiated carcinomas of the colon, pancreas, and breast with minimal activity against more differentiated carcinomas of the same organs. These differential effects suggest activation of distinct apoptotic pathways. In conclusion, the specific chemical properties of these two flavone isomers dictate mechanistic properties which may be relevant when evaluating biological responses to flavones

Peas and Peanuts.

31 p

Anti-Neoplastic Activity of Two Flavone Isomers Derived from Gnaphalium elegans and Achyrocline bogotensis

Over 4000 flavonoids have been identified so far and among these, many are known to have antitumor activities. The basis of the relationships between chemical structures, type and position of substituent groups and the effects these compounds exert specifically on cancer cells are not completely elucidated. Here we report the differential cytotoxic effects of two flavone isomers on human cancer cells from breast (MCF7, SK-BR-3), colon (Caco-2, HCT116), pancreas (MIA PaCa, Panc 28), and prostate (PC3, LNCaP) that vary in differentiation status and tumorigenic potential. These flavones are derived from plants of the family Asteraceae, genera Gnaphalium and Achyrocline reputed to have anti-cancer properties. Our studies indicate that 5,7-dihydroxy-3,6,8-trimethoxy-2-phenyl-4H-chromen-4-one (5,7-dihydroxy-3,6,8-trimethoxy flavone) displays potent activity against more differentiated carcinomas of the colon (Caco-2), and pancreas (Panc28), whereas 3,5-dihydroxy-6,7,8-trimethoxy-2-phenyl-4H-chromen-4-one (3,5-dihydroxy-6,7,8-trimethoxy flavone) cytototoxic action is observed on poorly differentiated carcinomas of the colon (HCT116), pancreas (Mia PaCa), and breast (SK-BR3). Both flavones induced cell death (\u3e50%) as proven by MTT cell viability assay in these cancer cell lines, all of which are regarded as highly tumorigenic. At the concentrations studied (5–80 µM), neither flavone demonstrated activity against the less tumorigenic cell lines, breast cancer MCF-7 cells, androgen-responsive LNCaP human prostate cancer line, and androgen-unresponsive PC3 prostate cancer cells. 5,7-dihydroxy-3,6,8-trimethoxy-2-phenyl-4H-chromen-4-one (5,7-dihydroxy-3,6,8-trimethoxy flavone) displays activity against more differentiated carcinomas of the colon and pancreas, but minimal cytotoxicity on poorly differentiated carcinomas of these organs. On the contrary, 3,5-dihydroxy-6,7,8-trimethoxy-2-phenyl-4H-chromen-4-one (3,5-dihydroxy-6,7,8-trimethoxy flavone) is highly cytotoxic to poorly differentiated carcinomas of the colon, pancreas, and breast with minimal activity against more differentiated carcinomas of the same organs. These differential effects suggest activation of distinct apoptotic pathways. In conclusion, the specific chemical properties of these two flavone isomers dictate mechanistic properties which may be relevant when evaluating biological responses to flavones

Aerodynamic model comparison for an X-shaped vertical-axis wind turbine

This article presents a comparison study of different aerodynamic models for an X-shaped vertical-axis wind turbine and offers insight into the 3D aerodynamics of this rotor at fixed pitch offsets. The study compares six different numerical models: a double-multiple streamtube (DMS) model, a 2D actuator cylinder (2DAC) model, an inviscid free vortex wake model (from CACTUS), a free vortex wake model with turbulent vorticity (from QBlade), a blade-resolved unsteady Reynolds-averaged Navier–Stokes (URANS) model, and a lattice Boltzmann method (from PowerFLOW). All models, except URANS and PowerFLOW use the same blade element characteristics other than the number of blade elements. This comparison covers the present rotor configuration for several tip-speed ratios and fixed blade pitch offsets without unsteady corrections, except for the URANS and PowerFLOW which cover a single case. The results show that DMS and 2DAC models are inaccurate – especially at highly loaded conditions, are unable to predict the downwind blade vortex interaction, and do not capture the vertical/axial induction this rotor exhibits. The vortex models are consistent with each other, and the differences when compared against the URANS and PowerFLOW mostly arise due to the unsteady and flow curvature effects. Furthermore, the influence of vertical induction is very prominent for this rotor, and this effect becomes more significant with fixed pitch offsets where the flow at the blade root is considerably altered

Motivações e satisfação dos consumidores: o caso das Células de Consumidores Responsáveis (CCR) em Florianópolis-SC

Existe uma crescente preocupação por parte dos consumidores com a busca por alimentos bons, limpos e justos, além do interesse emergente em construir relações de proximidade aqueles que os produzem. Nesse contexto, este trabalho buscou identificar as motivações dos consumidores ao integrar uma iniciativa de compra direta de alimentos em Florianópolis-SC e avaliar a satisfação dos mesmos após um ano de participação, através de questionários online aplicados em diferentes etapas. Observou-se que a iniciativa possibilitou aos consumidores uma maior valorização da agricultura familiar, havendo um alto índice de satisfação para com a iniciativa principalmente no que se refere à relação preço-qualidade dos produtos. Conclui-se que há necessidade de uma maior aproximação entre produtores e consumidores e de estreitamento das relações, fato que pode vir a despertar um consumo mais ético e responsável

Elaboración de madera plástica, como material para la construcción de obras civiles

La mayoría de materiales constituido estructuralmente por macromoléculas de polímero, tiene la gran capacidad de poder ser reutilizados según Zambrano (2007), este nuevo uso se puede lograr a través del reciclaje de los distintos elementos que lo conforman, llevando así todo este compuesto a sus características iniciales. De igual forma, si sigue esta línea y dicho material, se mezcla con un segundo o tercer agregado, se pueden mejorar significativamente las características físicas y químicas con las que este contaba. La madera plástica, es un conglomerado constituido por polímeros PP, HDPE, (polipropileno y polietileno de alta densidad, respectivamente) y algún tipo de fibra de origen orgánico, en este caso bagazo de caña, con la unión de   estos  dos agregados, se  busca obtener un componente  superior, según Proaño, Bonilla y Aidas (2015), el cual posea unas muy buenas  propiedades mecánicas, las cuales permitan emplear este derivado, como pieza  para la construcción de obras  civiles, o  como   alguna herramienta para el desarrollo de las mismas. La elaboración de la madera plástica, conlleva una serie de procedimientos , los cuales van desde la recolección  limpieza, clasificación, mezclado de los agregados sintéticos y orgánicos hasta pasar por la sección de extrusión, en la cual la unión de los compuestos da como resultado un  elemento sólido, este es  sometido a una serie de ensayos, de resistencia  enmarcados en la norma ASTMD-143, con la finalidad de desarrollar, dicho producto cumpliendo con los estándares y normativas que rigen su uso