722 research outputs found
A hybrid strain and thermal energy harvester based on an infra-red sensitive Er3+ modified poly(vinylidene fluoride) ferroelectret structure
In this paper, a novel infra-red (IR) sensitive Er3+ modified poly(vinylidene fluoride) (PVDF) (Er-PVDF) film is developed for converting both mechanical and thermal energies into useful electrical power. The addition of Er3+ to PVDF is shown to improve piezoelectric properties due to the formation of a self-polarized ferroelectric β-phase and the creation of an electret-like porous structure. In addition, we demonstrate that Er3+ acts to enhance heat transfer into the Er-PVDF film due to its excellent infrared absorbance, which, leads to rapid and large temperature fluctuations and improved pyroelectric energy transformation. We demonstrate the potential of this novel material for mechanical energy harvesting by creating a durable ferroelectret energy harvester/nanogenerator (FTNG). The high thermal stability of the β-phase enables the FTNG to harvest large temperature fluctuations (ΔT ~ 24 K). Moreover, the superior mechanosensitivity, SM ~ 3.4 VPa−1 of the FTNG enables the design of a wearable self-powered health-care monitoring system by human-machine integration. The combination of rare-earth ion, Er3+ with the ferroelectricity of PVDF provides a new and robust approach for delivering smart materials and structures for self-powered wireless technologies, sensors and Internet of Things (IoT) devices
Thermomechanical deformation behavior and mechanisms in transition metal carbides
Mechanical testing over 2000oC is arduous because of the required heating, compliance in components, and potential specimen reactions to name a few. In this talk, the use of a non-contact means of thermomechanical loading, initially demonstrated by Gangireddy and Halloran, is applied to TaC and HfC. By passing a current through the carbide, it is resistively heated and, in the presence of a magnetic field, the specimen bends under the Lorentz force. Using a variety of loads and temperatures up to 3000oC, the thermomechanical behavior is quantified for a series of tantalum and hafnium carbides. Findings include more deflection in TaC than HfC at equivalent load/temperatures which is contributed to TaC’s ease of {111} slip. At failure, TaC exhibited abnormal grain growth with multiple slip band formations on the fractured surface. In contrast, HfC exhibited minimal grain growth and substantially less slip band formations. Additional studies determining the relationship between load at failure as a function of temperature were determined. The collective results will be discussed in terms of TEM and DFT analysis of slip mechanisms in transition metal carbides
Zero retinal vein pulsation amplitude extrapolated model in non-invasive intracranial pressure estimation
Intracranial pressure (ICP) includes the brain, optic nerve, and spinal cord pressures; it influences blood flow to those structures. Pathological elevation in ICP results in structural damage through various mechanisms, which adversely affects outcomes in traumatic brain injury and stroke. Currently, invasive procedures which tap directly into the cerebrospinal fluid are required to measure this pressure. Recent fluidic engineering modelling analogous to the ocular vascular flow suggests that retinal venous pulse amplitudes are predictably influenced by downstream pressures, suggesting that ICP could be estimated by analysing this pulse signal. We used this modelling theory and our photoplethysmographic (PPG) retinal venous pulse amplitude measurement system to measure amplitudes in 30 subjects undergoing invasive ICP measurements by lumbar puncture (LP) or external ventricular drain (EVD). We estimated ICP from these amplitudes using this modelling and found it to be accurate with a mean absolute error of 3.0 mmHg and a slope of 1.00 (r = 0.91). Ninety-four percent of differences between the PPG and invasive method were between − 5.5 and + 4.0 mmHg, which compares favourably to comparisons between LP and EVD. This type of modelling may be useful for understanding retinal vessel pulsatile fluid dynamics and may provide a method for non-invasive ICP measurement
1999 Quadrantids and the lunar Na atmosphere
Enhancements of the Na emission and temperature from the lunar atmosphere
were reported during the Leonids meteor showers of 1995, 1997 and 1998. Here we
report a search for similar enhancement during the 1999 Quadrantids, which have
the highest mass flux of any of the major streams. No enhancements were
detected. We suggest that different chemical-physical properties of the Leonid
and Quadrantid streams may be responsible for the difference.Comment: 5 pages, 1 figure, accepted for publication in MNRA
Scalar Mesons in a Relativistic Quark Model with Instanton-Induced Forces
In a relativistic quark model with linear confinement and an
instanton-induced interaction which solves the - puzzle, scalar
mesons are found as almost pure SU(3) flavor states. This suggests a new
interpretation of the scalar nonet: We propose that the recently discovered
is not a glueball but the scalar (mainly)--octet meson for which
the decay mode is suppressed. The mainly--singlet state is
tentatively identified with the . The isovector and isodoublet states
correspond to the and , respectively.Comment: 10 pages including 2 uuencoded figures, RevTe
Recognising barriers to implementation of Blue-Green infrastructure: a Newcastle case study
There is a recognised need for a fundamental change in how the UK manages urban water and flood risk in response to increasingly frequent rainfall events coupled with planned urban expansion. Approaches centred on ‘living with and making space for water’ are increasingly adopted internationally. Nonetheless, widespread implementation of Blue-Green infrastructure (BGI) is currently hampered by barriers that impede uptake and innovation. We investigate the barriers to implementation of BGI in Newcastle, UK, through a series of semi-structured interviews with professional stakeholders. We identify and categorise 17 types of barrier and identify targeted strategies to overcome the dominant barriers. We recommend promotion of BGI’s capacity to meet the objectives of multiple organisations and Local Authority departments, in addition to managing urban water. We conclude that strong business cases, supported by monetised evidence of benefits, and collaborative, inter-agency working could advance implementation of BGI within the current flood risk management legislation
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML
The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer including myelodysplatic syndromes (MDS) and acute myeloid leukemia (AML). Here, using genetic dependency screens of STAG2-mutant AML, we identified DNA damage repair and replication as genetic dependencies in cohesin-mutant cells. We demonstrated increased levels of DNA damage and sensitivity of cohesin-mutant cells to PARP inhibition. We developed a mouse model of MDS in which Stag2 mutations arise as clonal secondary lesions in the background of clonal hematopoiesis driven by Tet2 mutations, and demonstrated selective depletion of cohesin-mutant cells with PARP inhibition in vivo. Finally, we demonstrated a shift from STAG2- to STAG1-containing cohesin complexes in cohesin-mutant cells, which is associated with longer DNA loop extrusion, more intermixing of chromatin compartments, and increased interaction with PARP and RPA proteins. Our findings inform the biology and therapeutic opportunities for cohesin-mutant malignancies
British Association of Dermatologists' guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018
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