A novel magnetostrictive curvature sensor employing flexible, figure-of-eight sensing coils

The demand for accurate angle measurements in a form that is robust and small is high, due to the advances in virtual reality applications, primarily the virtual reality headsets. The peripheral devices are required to completely immerse the user in a virtual reality setting, and for this purpose, a robust sensor has been developed. The angle measurements can also be used in motion sensing applications for medical purposes, allowing monitoring of a patient’s condition. This paper presents the development of a planar figure-of-eight coil sensor, which has been designed for the purpose of curvature sensing. The copper-plated polyimide material, FR4 FLEX, was used for the fabrication of the planar figure-of-eight coil. A curvature sensor was designed and consists of the figure-of-eight coil along with the magnetostrictive material Metglas 2605SA1. The sensor was incorporated in an oscillator circuit, where curvature-induced stress within the material changes the amplitude and the frequency of the output signal of the circuit

Using finite element modelling and experimental methods to investigate planar coil sensor topologies for inductive measurement of displacement

The usage of planar sensors is widespread due to their non-contact nature and small size profiles, however only a few basic design types are generally considered. In order to develop planar coil designs we have performed extensive finite element modelling (FEM) and experimentation to understand the performance of different planar sensor topologies when used in inductive sensing. We have applied this approach to develop a novel displacement sensor. Models of different topologies with varying pitch values have been analysed using the ANSYS Maxwell FEM package, furthermore the models incorporated a movable soft magnetic amorphous ribbon element. The different models used in the FEM were then constructed and experimentally tested with topologies that included mesh, meander, square coil, and circular coil configurations. The sensors were used to detect the displacement of the amorphous ribbon. A LabView program controlled both the displacement stage and the impedance analyser, the latter capturing the varying inductance values with ribbon displacement. There was good correlation between the FEM models and the experimental data confirming that the methodology described here offers an effective way for developing planar coil based sensors with improved performance

The feasibility of biomass CHP as an energy and CO2 source for commercial glasshouses

A techno-economic modelling tool has been developed to examine the feasibility of biomass combined heat and power (CHP) technologies to provide the energy and CO2 demands of commercial horticultural glasshouses. Using the UK as a case study, energy and CO2 demands of candidate glasshouse installations on an hourly basis are established using both measured and benchmark datasets. Modelled electrical and thermal generation profiles for a number of commercially available small-scale biomass CHP systems of rated outputs of 0.1–5 MWe are also derived, and the results of their application within the modelling tool to carry out multi-parametric techno-economic analyses for various operational scenarios are presented. The impacts of both capital grant and generation tariff-based support mechanisms upon economic feasibility are investigated, along with that of variations in feedstock fuel prices. Net CO2 reductions accruing from the implementation of biomass CHP are also assessed. Finally, technical options, marginal costs and sale tariffs for CO2 recovery and supply are evaluated for specific scenarios. The results indicate that feasibility is very sensitive to the relationship between specific biomass CHP power:heat ratios and their match with glasshouse temporal electrical and thermal energy demand profiles, along with economic factors such as specific levels of capital and tariff-based support. With the utilisation of currently available financial support mechanisms, biomass CHP offers significant promise for realising economically viable significant CO2 emission reductions in this sector

Comparison between modelled and measured magnetic field scans of different planar coil topologies for stress sensor applications

The investigation of planar coils of differing topologies, when combined with a magnetostrictive amorphous ribbon to form a stress-sensitive self-inductor, is an active research area for applications as stress or pressure sensors. Four topologies of planar coil (Circular, Mesh, Meander, and Square) have been constructed using copper track on 30 mm wide PCB substrate. The coils are energized to draw 0.4 A and the resulting magnetic field distribution is observed with a newly developed three-dimensional magnetic field scanner. The system is based on a variably angled Micromagnetics® STJ-020 tunneling magneto-resistance sensor with a spatial resolution of 5–10 µm and sensitivity to fields of less than 10 A/m. These experimental results are compared with the fields computed by ANSYS Maxwell® finite element modelling of the same topologies. Measured field shape and strength correspond well with the results of modelling, including direct observation of corner and edge effects. Three-dimensional analysis of the field shape produced by the square coil, isolating the components H(x) and H(z), is compared with the three-dimensional field solutions from modelling. The finite element modelling is validated and the accuracy and utility of the new system for three-dimensional scanning of general stray fields is confirmed

At risk of exclusion? : a study of the experiences of and support provided for ten young people aged 14-16 in two large, urban secondary schools

This study explored how and why some young people are considered “at-risk” of school exclusion, focusing on the implications for a cohort in the latter stages of compulsory education in two large urban secondary schools in the Midlands. Interviews, undertaken with students at four points during one academic year and with staff, alongside detailed data from records and files, were analysed with the interpretivist techniques of Constructivism and Document Analysis to identify the characteristics that influenced the students’ status, their schools’ provision and policy response processes and their experiences in the school environment and wider. A review of existing literature showed that whilst those “at-risk” share common characteristics, especially low socioeconomic status, the combination, extent and even timing of their influence is difficult to assess, such that response and intervention panaceas are unlikely to be found. This research showed that whilst the cohort completed their compulsory schooling, they were, perhaps, less successful in core academic outcomes and were also subject to variability and inconsistency in school responses and interventions, related to the influences of interpretation and dispositions on staff roles and policy implementation. The study concludes that deeper understanding of needs, staff training, a more relevant curriculum and greater involvement of young people “at-risk” and their parents/carers, in school life and decisions directly affecting them, could improve outcomes. The ramifications are potentially significant, suggesting that schools and policymakers can and should do more to avoid marginalising young people, with improvements that need not involve structural change, new schools, or extensive costs. The suggestions also implicitly challenge the mantra of recent national policy and developments in secondary education, that raising young peoples’ aspirations and diversifying provision are preconditions for improved social mobility

Minimal residual disease is an independent predictor for 10-year survival in CLL

Minimal residual disease (MRD) negativity, defined as <1 chronic lymphocytic leukemia (CLL) cell detectable per 10 000 leukocytes, has been shown to independently predict for clinical outcome in patients receiving combination chemoimmunotherapy in the frontline setting. However, the long-term prognostic value of MRD status in other therapeutic settings remains unclear. Here, we retrospectively analyzed, with up to 18 years follow-up, all patients at our institution who achieved at least a partial response (PR) with various therapies between 1996 and 2007, and received a bone marrow MRD assessment at the end of treatment according to the international harmonized approach. MRD negativity correlated with both progression-free survival (PFS) and overall survival (OS) independent of the type and line of treatment, as well as known prognostic factors including adverse cytogenetics. The greatest impact of achieving MRD negativity was seen in patients receiving frontline treatment, with 10-year PFS of 65% vs 10% and 10-year OS of 70% vs 30% for MRD-negative vs MRD-positive patients, respectively. Our results demonstrate the long-term benefit of achieving MRD negativity, regardless of the therapeutic setting and treatment modality, and support its use as a prognostic marker for long-term PFS and as a potential therapeutic goal in CLL

ER stress and Rho kinase activation underlie the vasculopathy of CADASIL

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) leads to premature stroke and vascular dementia. Mechanism-specific therapies for this aggressive cerebral small vessel disease are lacking. CADASIL is caused by NOTCH3 mutations that influence vascular smooth muscle cell (VSMC) function through unknown processes. We investigated molecular mechanisms underlying the vasculopathy in CADASIL focusing on endoplasmic reticulum (ER) stress and RhoA/Rho kinase (ROCK). Peripheral small arteries and VSMCs were isolated from gluteal biopsies of CADASIL patients and mesentery of TgNotch3R169C mice (CADASIL model). CADASIL vessels exhibited impaired vasorelaxation, blunted vasoconstriction, and hypertrophic remodeling. Expression of NOTCH3 and ER stress target genes was amplified and ER stress response, Rho kinase activity, superoxide production, and cytoskeleton-associated protein phosphorylation were increased in CADASIL, processes associated with Nox5 upregulation. Aberrant vascular responses and signaling in CADASIL were ameliorated by inhibitors of Notch3 (γ-secretase inhibitor), Nox5 (mellitin), ER stress (4-phenylbutyric acid), and ROCK (fasudil). Observations in human CADASIL were recapitulated in TgNotch3R169C mice. These findings indicate that vascular dysfunction in CADASIL involves ER stress/ROCK interplay driven by Notch3-induced Nox5 activation and that NOTCH3 mutation–associated vascular pathology, typical in cerebral vessels, also manifests peripherally. We define Notch3-Nox5/ER stress/ROCK signaling as a putative mechanism-specific target and suggest that peripheral artery responses may be an accessible biomarker in CADASIL

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial

Background: Knee replacement surgery reduces pain for many people with osteoarthritis (OA). However, surgical outcomes are partly dependent on patients’ moods, and those with depression or anxiety have worse outcomes. Approximately one-third of people with OA have mood problems. Cognitive behavioural therapy (CBT), a psychological therapy, is recommended by the National Institute for Health and Care Excellence for improving mood. However, evidence for the effectiveness of CBT before knee surgery in improving pain, mood, and quality of life following this surgery for people with knee OA is lacking. Methods/Design: This is a multi-centre, mixed-methods feasibility randomised controlled trial to compare treatment as usual (TAU) plus a brief CBT-based intervention with a TAU-only control, for people with knee OA. We will recruit 50 patients with knee OA, listed for knee replacement surgery, with high levels of distress (assessed using a mood questionnaire), and who consent to take part. Participants will be randomly allocated to receive TAU plus intervention or TAU. Up to 10 sessions of CBT will be offered on an individual basis by a psychologist. The assessments and interventions will be completed before surgery. Repeat assessments at 4 and 6 months after randomisation will be sent and received by post. Two patient-partners will conduct feedback interviews with some participants to assess what aspects of the intervention were helpful or unhelpful, the acceptability of randomisation, the experience of being in a control group, and the appropriateness of the measures used. Interviews will be audio-recorded, transcribed, and analysed using the framework approach. We will examine the feasibility and acceptability of patient-partners conducting the interviews by also interviewing the patient-partners. Discussion: Findings from this study will be used to design a definitive study that will examine the clinical and cost-effectiveness of the CBT intervention in improving patient outcomes following knee surgery