Drone Flight Performance Evaluation Methodology Based on Data Science

Nowadays Unmanned Aerial Vehicle (UAV) consist of collaborators for hazardous jobs like deliveries, from commerce to clients, and emergency scenarios, like fire fighting and rescue humanitarian jobs. The pilot’s responsibility has increased as the new requirements settle for new applications, so in this way, they need to have enough capabilities to perform this valuable work. However, this required knowledge, skills, and attitudes not provided in a formal educational institute with an established process. Therefore, there is no method defined to know the level of performance of a Pilot, and this is essential before giving a duty as valuable of delivery. This thesis presents an effort to establish a detailed structured methodology for evaluating a pilot’s ability to coordinate psycho-motor and evaluate this determined pilot’s learning rate in a sequence of flights. Furthermore, to generate a predictive model representing this learning for a specific pilot and give formal evidence of the improvement in the near future and which orientation coordination ability can improve

The promoter effect of Nb species on the catalytic performance of Ir-based catalysts for VOCs total oxidation

12 figures, 2 tables.-- Supporting information available.Ir/TiO2 catalysts promoted by niobium have been synthesized, characterized by different complementary techniques and tested for the total oxidation of a set of alkanes and their mixtures. The addition of appropriate amounts of niobium to Ir/TiO2 catalysts resulted in a remarkable increase in the catalytic activity compared to the Nb-free Ir/TiO2 catalysts. The promotion caused by the presence of niobium has been related to the massive presence of isolated IrOx surface species which, interestingly, present remarkable reducibility and, consequently, excellent catalytic activity. Conversely, the IrOx species formed in the catalyst in the absence of niobium also include IrO2 clusters with lower intrinsic reactivity. Similarly, Nb-loadings exceeding the theoretical monolayer tends to the formation of bulk Nb2O5 species on the titania surface that provokes the formation of IrO2 nanoclusters. A positive influence on the reactivity of non-stoichiometric surface non- Ti3+ species that generates oxygen vacancies is also observed.This work was supported by the Regional Government of Aragon (DGA) under the research groups support programme. We also thank the MAT2017-84118-C2-1-R MCIN/AEI/10.13039/501100011033/ project and FEDER “Una manera de hacer Europa”. This research was also funded by MINECO-Spain, grant number PRE2018-085211.Peer reviewe

Cell-Mediated Immune Responses to in vivo -Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups

A quarter of the global human population is estimated to be latently infected by Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). TB remains the global leading cause of death by a single pathogen and ranks among the top-10 causes of overall global mortality. Current immunodiagnostic tests cannot discriminate between latent, active and past TB, nor predict progression of latent infection to active disease. The only registered TB vaccine, Bacillus Calmette-Guérin (BCG), does not adequately prevent pulmonary TB in adolescents and adults, thus permitting continued TB-transmission. Several Mtb proteins, mostly discovered through IFN-γ centered approaches, have been proposed as targets for new TB-diagnostic tests or -vaccines. Recently, however, we identified novel Mtb antigens capable of eliciting multiple cytokines, including antigens that did not induce IFN-γ but several other cytokines. These antigens had been selected based on high Mtb gene-expression in the lung in vivo, and have been termed in vivo expressed (IVE-TB) antigens. Here, we extend and validate our previous findings in an independent Southern European cohort, consisting of adults and adolescents with either LTBI or TB. Our results confirm that responses to IVE-TB antigens, and also DosR-regulon and Rpf stage-specific Mtb antigens are marked by multiple cytokines, including strong responses, such as for TNF-α, in the absence of detectable IFN-γ production. Except for TNF-α, the magnitude of those responses were significantly higher in LTBI subjects. Additional unbiased analyses of high dimensional flow-cytometry data revealed that TNF-α+ cells responding to Mtb antigens comprised 17 highly heterogeneous cell types. Among these 17 TNF-α+ cells clusters identified, those with CD8+TEMRA or CD8+CD4+ phenotypes, defined by the expression of multiple intracellular markers, were the most prominent in adult LTBI, while CD14+ TNF-α+ myeloid-like clusters were mostly abundant in adolescent LTBI. Our findings, although limited to a small cohort, stress the importance of assessing broader immune responses than IFN-γ alone in Mtb antigen discovery as well as the importance of screening individuals of different age groups. In addition, our results provide proof of concept showing how unbiased multidimensional multiparametric cell subset analysis can identify unanticipated blood cell subsets that could play a role in the immune response against Mtb

Clinical Presentation and Outcomes of Kawasaki Disease in Children from Latin America: A Multicenter Observational Study from the REKAMLATINA Network

Objetivos: Describir la presentación clínica, el manejo y los resultados de la enfermedad de Kawasaki (EK) en Latinoamérica y evaluar los indicadores pronósticos tempranos de aneurisma de la arteria coronaria (AAC). Diseño del estudio: Se realizó un estudio observacional basado en el registro de la EK en 64 centros pediátricos participantes de 19 países latinoamericanos de forma retrospectiva entre el 1 de enero de 2009 y el 31 de diciembre de 2013, y de forma prospectiva desde el 1 de junio de 2014 hasta el 31 de mayo de 2017. Se recopilaron datos demográficos, clínicos y de laboratorio iniciales. Se utilizó una regresión logística que incorporaba factores clínicos y la puntuación z máxima de la arteria coronaria en la presentación inicial (entre 10 días antes y 5 días después de la inmunoglobulina intravenosa [IGIV]) para desarrollar un modelo pronóstico de AAC durante el seguimiento (>5 días después de la IGIV). Resultados: De 1853 pacientes con EK, el ingreso tardío (>10 días tras el inicio de la fiebre) se produjo en el 16%, el 25% tuvo EK incompleta y el 11% fue resistente a la IGIV. Entre los 671 sujetos con puntuación z de la arteria coronaria notificada durante el seguimiento (mediana: 79 días; IQR: 36, 186), el 21% presentaba AAC, incluido un 4% con aneurismas gigantes. Un modelo pronóstico simple que utilizaba sólo una puntuación z de la arteria coronaria máxima ≥2,5 en la presentación inicial fue óptimo para predecir la AAC durante el seguimiento (área bajo la curva: 0,84; IC del 95%: 0,80, 0,88). Conclusiones: De nuestra población latinoamericana, la puntuación z de la arteria coronaria ≥2,5 en la presentación inicial fue el factor pronóstico más importante que precedió a la AAC durante el seguimiento. Estos resultados resaltan la importancia de la ecocardiografía temprana durante la presentación inicial de la EK. © 2023 Los autoresObjectives: To describe the clinical presentation, management, and outcomes of Kawasaki disease (KD) in Latin America and to evaluate early prognostic indicators of coronary artery aneurysm (CAA). Study design: An observational KD registry-based study was conducted in 64 participating pediatric centers across 19 Latin American countries retrospectively between January 1, 2009, and December 31, 2013, and prospectively from June 1, 2014, to May 31, 2017. Demographic and initial clinical and laboratory data were collected. Logistic regression incorporating clinical factors and maximum coronary artery z-score at initial presentation (between 10 days before and 5 days after intravenous immunoglobulin [IVIG]) was used to develop a prognostic model for CAA during follow-up (>5 days after IVIG). Results: Of 1853 patients with KD, delayed admission (>10 days after fever onset) occurred in 16%, 25% had incomplete KD, and 11% were resistant to IVIG. Among 671 subjects with reported coronary artery z-score during follow-up (median: 79 days; IQR: 36, 186), 21% had CAA, including 4% with giant aneurysms. A simple prognostic model utilizing only a maximum coronary artery z-score ≥2.5 at initial presentation was optimal to predict CAA during follow-up (area under the curve: 0.84; 95% CI: 0.80, 0.88). Conclusion: From our Latin American population, coronary artery z-score ≥2.5 at initial presentation was the most important prognostic factor preceding CAA during follow-up. These results highlight the importance of early echocardiography during the initial presentation of KD. © 2023 The Author(s

Highly active Co3O4-based catalysts for total oxidation of light C1-C3 alkanes prepared by a simple soft chemistry method: effect of the heat-treatment temperature and mixture of alkanes

9 figures, 2 tables.In the present work, a simple soft chemistry method was employed to prepare cobalt mixed oxide (Co3O4) materials, which have shown remarkably high activity in the heterogeneously catalyzed total oxidation of low reactive VOCs such as the light alkanes propane, ethane, and methane. The optimal heat-treatment temperature of the catalysts was shown to depend on the reactivity of the alkane studied. The catalytic activity of the Co3O4 catalysts was found to be as high as that of the most effective catalysts based on noble metals. The physicochemical properties, from either the bulk (using XRD, TPR, TPD-O2, and TEM) or the surface (using XPS), of the catalysts were investigated to correlate the properties with the catalytic performance in the total oxidation of VOCs. The presence of S1 low-coordinated oxygen species at the near surface of the Co3O4-based catalysts appeared to be linked with the higher reducibility of the catalysts and, consequently, with the higher catalytic activity, not only per mass of catalyst but also per surface area (enhanced areal rate). The co-presence of propane and methane in the feed at low reaction temperatures did not negatively affect the propane reactivity. However, the co-presence of propane and methane in the feed at higher reaction temperatures negatively affected the methane reactivity.This research was funded by MINECO-Spain, grant number PRE2018-085211. This work was also funded by the MAT2017-84118-C2-1-R MCIN/AEI/10.13039/501100011033/ project and FEDER Una manera de hacer Europa. Comunidad de Madrid, grant number 2017-T1/IND-6025, within the program “Atracción y Retención de Talento Investigador” of the V PRICIT.Peer reviewe

Prudentia Iuris, 1999, n° 50 (número completo)

Contenido: Editorial – Estudios para la reforma procesal plenal: Los distintos proyectos de reforma al Código Procesal Penal de la Nación, frente a la diferente problemática existente en la legislación actual / Raúl E. Granillo Ocampo – El Ministerio Público / Angela Ester Ledesma – El juez de garantías / Jorge Moreno – La policía judicial francesa / Alain Perez – Enfoque sobre policía judicial, preventiva y represiva / Adrián Juan Pelacchi – Perfil funcional del Ministerio Público Fiscal en la nueva legislación argentina / José I. Cafferata Nores – La acción penal : el Ministerio Público y los jueces / Luis E. Velasco – El principio de igualdad de armas y los nuevos requerimientos / Luis M. García – Procedimiento penal : de las nulidades en general y de las absolutas en particular / José Licinio Scelzi – Reflexiones sobre el juicio por jurados / Rodolfo Eduardo Madariaga – Acerca del juicio correccional en la actualidad / Roberto Calandra – El juicio con debate oral y los procesados menores / Miguel Julián del Castillo – Reforma del sistema de enjuiciamiento, Ministerio Público y relaciones entre juez y fiscal / Maximiliano Rusconi – Una visualización panorámica del fenómeno criminal / Jorge Kent – Los desafíos del Ministerio Público a partir del reconocimiento constitucional y la implementación de la reciente ley orgánica de la institución / Nicolás Becerra – Policía judicial y la función policial ante el delito / Hugo Antolin Almirón – Consideraciones en torno al imputado / Julio J. Martínez Vivot (h) – In Memoria

Prudentia Iuris, 1999, n° 50 (número completo)

Contenido: Editorial – Estudios para la reforma procesal plenal: Los distintos proyectos de reforma al Código Procesal Penal de la Nación, frente a la diferente problemática existente en la legislación actual / Raúl E. Granillo Ocampo – El Ministerio Público / Angela Ester Ledesma – El juez de garantías / Jorge Moreno – La policía judicial francesa / Alain Perez – Enfoque sobre policía judicial, preventiva y represiva / Adrián Juan Pelacchi – Perfil funcional del Ministerio Público Fiscal en la nueva legislación argentina / José I. Cafferata Nores – La acción penal : el Ministerio Público y los jueces / Luis E. Velasco – El principio de igualdad de armas y los nuevos requerimientos / Luis M. García – Procedimiento penal : de las nulidades en general y de las absolutas en particular / José Licinio Scelzi – Reflexiones sobre el juicio por jurados / Rodolfo Eduardo Madariaga – Acerca del juicio correccional en la actualidad / Roberto Calandra – El juicio con debate oral y los procesados menores / Miguel Julián del Castillo – Reforma del sistema de enjuiciamiento, Ministerio Público y relaciones entre juez y fiscal / Maximiliano Rusconi – Una visualización panorámica del fenómeno criminal / Jorge Kent – Los desafíos del Ministerio Público a partir del reconocimiento constitucional y la implementación de la reciente ley orgánica de la institución / Nicolás Becerra – Policía judicial y la función policial ante el delito / Hugo Antolin Almirón – Consideraciones en torno al imputado / Julio J. Martínez Vivot (h) – In Memoria

Discovering HIV related information by means of association rules and machine learning

Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorders associated with HIV/AIDS-so that they can be anticipated and possibly mitigated. We propose to achieve this by using Association Rules (ARs). They allow us to represent the dependencies between a number of diseases and other specific diseases. However, classical techniques systematically generate every AR meeting some minimal conditions on data frequency, hence generating a vast amount of uninteresting ARs, which need to be filtered out. The lack of manually annotated ARs has favored unsupervised filtering, even though they produce limited results. In this paper, we propose a semi-supervised system, able to identify relevant ARs among HIV-related diseases with a minimal amount of annotated training data. Our system has been able to extract a good number of relationships between HIV-related diseases that have been previously detected in the literature but are scattered and are often little known. Furthermore, a number of plausible new relationships have shown up which deserve further investigation by qualified medical experts

X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients

Rett syndrome (RTT) is a severe neurological disorder usually caused by mutations in the MECP2 gene. Since the MECP2 gene is located on the X chromosome, X chromosome inactivation (XCI) could play a role in the wide range of phenotypic variation of RTT patients; however, classical methylation-based protocols to evaluate XCI could not determine whether the preferentially inactivated X chromosome carried the mutant or the wild-type allele. Therefore, we developed an allele-specific methylation-based assay to evaluate methylation at the loci of several recurrent MECP2 mutations. We analyzed the XCI patterns in the blood of 174 RTT patients, but we did not find a clear correlation between XCI and the clinical presentation. We also compared XCI in blood and brain cortex samples of two patients and found differences between XCI patterns in these tissues. However, RTT mainly being a neurological disease complicates the establishment of a correlation between the XCI in blood and the clinical presentation of the patients. Furthermore, we analyzed MECP2 transcript levels and found differences from the expected levels according to XCI. Many factors other than XCI could affect the RTT phenotype, which in combination could influence the clinical presentation of RTT patients to a greater extent than slight variations in the XCI pattern