El grafismo en los festivales de animación

En el siguiente trabajo de investigación trato la evolución de los títulos de crédito cinematográficos y cómo su estilo narrativo ha influido en los openings de los principales festivales de animación y artes visuales del mundo. Se pretende descubrir las claves de su estilo a través de las hipótesis que he creado debido a la repercusión que los títulos de crédito de las películas llevan teniendo desde hace más de cincuenta años y los cuales han influido también, en la forma de realizar y crear las openings de los festivales de animación, donde, de una forma breve y muy cuidada, se sintetiza todo lo que se va a mostrar en los días del festival. A partir de los openings del Animac Lleida, Festival International du film d’animation d’Annecy, Cortoons Festival, Ottawa International Animation Festival, FITC Toronto, F5 Festival, OFFF Festival, Toca Me Workshops y Art Futura, crearé un modelo de análisis propio para identificar cada tipo de opening a lo largo de las diferentes ediciones de los festivales. Veremos así si se han seguido diferentes tendencias, modas o patrones a la hora de crear los openings durante años, para poder sostener la hipótesis inicial.The following research work studies the evolution and analysis of the openings of the most important animation and graphical arts festivals around the globe. I have described and formulated a series of hypothesis that I have postulated due to the notoriety that film credits have had in the last 50 years. The language of credit rolls has an informative narrative. Nevertheless, some of them have evolved in such a way that they present a classical narrative structure, with a presentation, a body and an ending; they act as a preface to the story that will be presented and introduce the viewer to what is going to take place during the actual film. Starting from the openings from Animac Lleida, Festival International du film d'animation d'Annecy, Cortoons Festival, Ottawa International Animation Festival, FITC Toronto, F5 Festival, OFFF Festival, Toca Me Workshops and Art Futura, an analytical model will be created to identify each type of openings throughout the different editions of the festivals. It will be then possible to observe if different trends, styles or patterns have been followed when creating openings throughout the years, in order to support the initial hypothesisMoreno Martínez, P. (2016). El grafismo en los festivales de animación. Universitat Politècnica de València. http://hdl.handle.net/10251/7491

Child-to-parent violence, peer victimization and cybervictimization in spanish adolescents.

The aim of this study was to analyse the relationship between child-to-parent violence (CPV) (high, moderate and low), peer victimization (PV) (relational and overt, both physical and verbal) and cybervictimization (CV) (relational and overt), taking into account the role of sex. 1304 adolescents (53.14% girls) between the ages of 11 and 18 enrolled at secondary schools in the Autonomous Communities of Valencia, Aragón and Andalusia participated in the study. Adolescents with high CPV scores obtained higher scores for all types of PV and CV compared to the other CPV groups. Boys scored higher than girls in overt physical PV and in overt CV and girls obtained higher scores in relational PV. A statistically significant interaction effect was observed; boys with high CPV scores reported greater overt CV. The results suggest the importance of CPV in relation to specific forms of PV and CV and highlight the need to take into account the different processes of family socialization between boys and girls to reduce the likelihood of adolescents being victimized

Parenting dimensions and adolescent peer aggression: a gendered analysis.

Thepresent studyhadtwomaingoals. The firstwas to analyze thedifferences between parenting dimensions¿strictness/imposition and involvement/acceptance¿in adolescents' engagement in peer aggression as aggressors, victims, aggressive victims, and non-involved. The second goal was to examine diferences between parenting dimensions and peer-aggression roles by gender of both parents and adolescents. Participants were 779 adolescents (49.16% boys and 50.84% girls), aged between 12 and 16 years old (M = 14.21; SD = 1.35), enrolled in schools in Andalusia (Spain). Findings showed significant diferences in parenting dimensions depending on gender of both adolescents (boy or girl) and parents (mother and father). For sons, non-involved adolescents scored higher in mother and father involvement than aggressors and aggressive victims. For daughters, non-involved scored higher in mother involvement than aggressors. Furthermore, girl aggressors and aggressive victims reported higher levels of mother imposition than non-involved. Results and their implications for sustainable development in adolescence are discussed

The role of parental communication and emotional intelligence in child-to-parent violence.

In recent years, cases of child-to-parent violence (CPV) have increased significantly, prompting greater scientific interest in clarifying its causes. The aim of this research was to study the relationship between styles of family communication (open, offensive and avoidant), emotional intelligence or EI (attention, repair and perceived emotional clarity) and CPV, taking into account the gender of the aggressors. The participants of the study were 1200 adolescents (46.86% boys) between the ages of 12 and 18 enrolled at secondary schools in the Autonomous Communities of Andalusia and Valencia (M = 13.88, SD = 1.32). A Multivariate Analysis of Variance (MANOVA, 3 × 2) was performed with CPV and gender as independent variables and family communication styles and EI as dependent variables. The results showed that the adolescents with low CPV obtained lower scores for offensive and avoidant family communication and higher scores for both positive family communication and emotional repair. The girls scored higher than the boys in both offensive communication and perceived emotional attention. The results highlight the importance of encouraging positive communication, as well as the need to strengthen perceived emotional repair to prevent future cases of CPV

Mechanisms involved in the remyelinating effect of sildenafil

Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease. Sildenafil, a cyclic GMP (cGMP)-specific phosphodiesterase 5 inhibitor (PDE5-I), is an oral vasodilator drug extensively used in humans for treatment of erectile dysfunction and pulmonary arterial hypertension. PDE5 is expressed in central nervous system (CNS) neuronal and glial populations and in endothelial cells and numerous studies in rodent models of neurological disease have evidenced the neuroprotective potential of PDE5-Is. Using myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) as a MS model, we previously showed that daily administration of sildenafil starting at peak disease rapidly ameliorates clinical symptoms while administration at symptoms onset prevents disease progression. These beneficial effects of the drug involved down-regulation of adaptive and innate immune responses, protection of axons and oligodendrocytes (OLs) and promotion of remyelination. In this work we have investigated mechanisms involved in the remyelinating effect of sildenafil. Using demyelinated organotypic cerebellar slice cultures we demonstrate that sildenafil stimulates remyelination by direct effects on CNS cells in a nitric oxide (NO)-cGMP-protein kinase G (PKG)-dependent manner. We also show that sildenafil treatment enhances OL maturation and induces expression of the promyelinating factor ciliary neurotrophic factor (CNTF) in spinal cord of EAE mice and in cerebellar slice cultures. Furthermore, we demonstrate that sildenafil promotes a M2 phenotype in bone marrow derived macrophages (BMDM) and increases myelin phagocytosis in these cells and in M2 microglia/macrophages in the spinal cord of EAE mice. Taken together these data indicate that promotion of OL maturation directly or through induction of growth factor expression, regulation of microglia/macrophage inflammatory phenotype and clearance of myelin debris may be relevant mechanisms involved in sildenafil enhancement of remyelination in demyelinated tissue and further support the contention that this well tolerated drug could be useful for ameliorating MS pathology

The mediating role of classroom climate on school violence.

Mediation analysis has been confirmed as a very useful statistical tool in the social sciences, especially in school-related studies. This type of analysis was used in the present study to examine the mediating role of classroom climate (measured with the classroom environmental scale), categorized into three dimensions, namely involvement, affiliation, and teacher support, on the relationship between peer victimization and peer aggression. The participants consisted of 2011 adolescents (50.67% boys and 49.32% girls), aged between 12 and 18 years old (M = 14.17; SD = 1.47), enrolled in schools in Andalusia (Spain). Findings revealed a significant direct relationship of all the dimensions. They also revealed that teacher support was the only dimension that mediates in the relationship between peer violence and peer aggression. The results and their implications for improving classroom climate and school violence are discussed

Construcción de una lógica trinaria con la hoja de cálculo de excel

Nuestro trabajo está basado en el proyecto realizado por los estudiantes de la promoción 2010 del Instituto Pedagógico Nacional del énfasis de matemáticas, que consistió en analizar los 16 conectores lógicos generados a partir de la disyunción (V) y la negación (¬). Este trabajo dio las herramientas para dar inicio a nuestro proyecto, que radica en generar un sistema “trinario”, investigando el comportamiento y propiedades de cada uno de los conectores lógicos resultantes de tres valores de verdad y sus negaciones existentes. Buscamos cuál de las posibles negaciones mantiene las mismas propiedades en el sistema trinario con respecto al binario

Mechanisms Involved in the Remyelinating Effect of Sildenafil

Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease. Sildenafil, a cyclic GMP (cGMP)-specific phosphodiesterase 5 inhibitor (PDE5-I), is an oral vasodilator drug extensively used in humans for treatment of erectile dysfunction and pulmonary arterial hypertension. PDE5 is expressed in central nervous system (CNS) neuronal and glial populations and in endothelial cells and numerous studies in rodent models of neurological disease have evidenced the neuroprotective potential of PDE5-Is. Using myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) as a MS model, we previously showed that daily administration of sildenafil starting at peak disease rapidly ameliorates clinical symptoms while administration at symptoms onset prevents disease progression. These beneficial effects of the drug involved down-regulation of adaptive and innate immune responses, protection of axons and oligodendrocytes (OLs) and promotion of remyelination. In this work we have investigated mechanisms involved in the remyelinating effect of sildenafil. Using demyelinated organotypic cerebellar slice cultures we demonstrate that sildenafil stimulates remyelination by direct effects on CNS cells in a nitric oxide (NO)-cGMP-protein kinase G (PKG)-dependent manner. We also show that sildenafil treatment enhances OL maturation and induces expression of the promyelinating factor ciliary neurotrophic factor (CNTF) in spinal cord of EAE mice and in cerebellar slice cultures. Furthermore, we demonstrate that sildenafil promotes a M2 phenotype in bone marrow derived macrophages (BMDM) and increases myelin phagocytosis in these cells and in M2 microglia/macrophages in the spinal cord of EAE mice. Taken together these data indicate that promotion of OL maturation directly or through induction of growth factor expression, regulation of microglia/macrophage inflammatory phenotype and clearance of myelin debris may be relevant mechanisms involved in sildenafil enhancement of remyelination in demyelinated tissue and further support the contention that this well tolerated drug could be useful for ameliorating MS pathology

Stenotrophomonas maltophilia responds to exogenous AHL signals through the LuxR solo SmoR (Smlt1839)

Quorum Sensing (QS) mediated by Acyl Homoserine Lactone (AHL) molecules are probably the most widespread and studied among Gram-negative bacteria. Canonical AHL systems are composed by a synthase (LuxI family) and a regulator element (LuxR family), whose genes are usually adjacent in the genome. However, incomplete AHL-QS machinery lacking the synthase LuxI is frequently observed in Proteobacteria, and the regulator element is then referred as LuxR solo. It has been shown that certain LuxR solos participate in interspecific communication by detecting signals produced by different organisms. In the case of Stenotrophomonas maltophilia, a preliminary genome sequence analysis revealed numerous putative luxR genes, none of them associated to a luxI gene. From these, the hypothetical LuxR solo Smlt1839, here designated SmoR, presents a conserved AHL binding domain and a helix-turn-helix DNA binding motif. Its genomic organization-adjacent to hchA gene-indicate that SmoR belongs to the new family "LuxR regulator chaperone HchA-associated." AHL-binding assays revealed that SmoR binds to AHLs in-vitro, at least to oxo-C8-homoserine lactone, and it regulates operon transcription, likely by recognizing a conserved palindromic regulatory box in the hchA upstream region. Supplementation with concentrated supernatants from Pseudomonas aeruginosa, which contain significant amounts of AHLs, promoted swarming motility in S. maltophilia. Contrarily, no swarming stimulation was observed when the P. aeruginosa supernatant was treated with the lactonase AiiA from Bacillus subtilis, confirming that AHL contributes to enhance the swarming ability of S. maltophilia. Finally, mutation of smoR resulted in a swarming alteration and an apparent insensitivity to the exogenous AHLs provided by P. aeruginosa. In conclusion, our results demonstrate that S. maltophilia senses AHLs produced by neighboring bacteria through the LuxR solo SmoR, regulating population behaviors such as swarming motility

Bioaccessible peptides released by in vitro gastrointestinal digestion of fermented goat milks

In this study, ultrafiltered goat milks fermented with the classical starter bacteria Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus salivarus subsp. thermophilus or with the classical starter plus the Lactobacillus plantarum C4 probiotic strain were analyzed using ultra-high performance liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) and/or liquid chromatography-ion trap (LC-IT-MS/MS). Partial overlapping of the identified sequences with regard to fermentation culture was observed. Evaluation of the cleavage specificity suggested a lower proteolytic activity of the probiotic strain. Some of the potentially identified peptides had been previously reported as angiotensin converting enzyme (ACE)-inhibitory, antioxidant and antibacterial and might account for the in vitro activity previously reported for these fermented milks. Simulated digestion of the products was conducted in presence of a dialysis membrane to retrieve the bioaccessible peptide fraction. Some sequences with reported physiological activity resisted digestion but were found in the non-dialyzable fraction. However, non-previously detected sequences such as the antioxidant αs1-casein 144YFYPQL149, the antihypertensive αs2-casein 90YQKFPQY96 and the antibacterial αs2-casein 165LKKISQ170 were found in the dialyzable fraction of both fermented milks. Moreover, in the fermented milk including the probiotic strain, the k-casein dipeptidyl peptidase IV inhibitor (DPP-IV) 51INNQFLPYPY60 as well as additional ACE-inhibitory or antioxidant sequences could be identified. With the aim to anticipate further biological outcomes, quantitative structure activity relationship (QSAR) analysis was applied to the bioaccessible fragments and led to propose potential ACE inhibitory sequences