The Rings of Power Book Club (Part 1): Seduction, Knowledge, and Metallurgy in the Second Age of Middle-earth

The upcoming Amazon-produced streaming series The Rings of Power represents the most expensive adaptation of Tolkien’s Middle-earth to date, and will explore the Second Age, of which Tolkien wrote relatively little. This adaptation has generated massive buzz, both positive and negative, prior to its airing, often centered around issues of race, gender, and diversity. Over the past 5 months, a group of Mythies have gathered periodically on the Mythopoeic Society’s Discord server to pore over Tolkien’s meager writings about the Second Age, and how this material could be adapted into a live action streaming series. We will revisit some of the recurring themes from our book club meetings; Which Second Age elements and characters likely will/will not be portrayed, depictions of race/culture/religion, origins of histories, descriptions of Sauron’s influence in Numenor, and more

Towards the identification of the soil fungal microbiome community associated with Longleaf Pine

This project is part of a larger study looking at the restoration of the Longleaf Pine (LLP) ecosystem in certain Wildlife Management Areas (WMA) in Northwest Georgia. Our long-term aim is to look for potential associations between the aboveground and belowground community structures as the complex system of feedback mechanisms between the soil microbiome, the rhizosphere, and the plant communities is not yet understood. Soil samples were collected from a total of six plots in the Sheffield WMA located in Paulding County. The samples were collected from north or south facing hillside plots except for in the savanna sites (an area actively being restored for longleaf pine), where samples were collected on east or west facing slopes. Soil was sampled at three locations per plot (at the center, and 10 m below and above the center of each plot). A total of 18 soil samples were collected, each in sterile tubes with screw tops. DNA was extracted from five subsamples per tube using a commercially available kit. We hypothesized that the soil microbiome would differ significantly in north versus south facing areas, as well as between the savanna LLP and other plots due to the difference in aboveground plant communities. Analysis shows that the fungal phyla of Ascomycota and Basidiomycota are predominant in all plots of sampled. Basidiomycota shows its greatest predominance in the center of each plot. The most diverse results were found in the savanna plots showing a significant amount of unclassified fungi present as well as Zygomycota

Out-of-frame T cell receptor beta transcripts are eliminated by multiple pathways In Vivo

Non-productive antigen receptor genes with frame shifts generated during the assembly of these genes are found in many mature lymphocytes. Transcripts from these genes have premature termination codons (PTCs) and could encode truncated proteins if they are not either inactivated or destroyed by nonsense-mediated decay (NMD). In mammalian cells, NMD can be activated by pathways that rely on the presence of an intron downstream of the PTC; however, NMD can also be activated by pathways that do not rely on these downstream introns, and pathways independent of NMD can inactivate PTC-containing transcripts. Here, through the generation and analysis of mice with gene-targeted modifications of the endogenous T cell receptor beta (Tcrb) locus, we demonstrate that in T cells in vivo, optimal clearance of PTC-containing Tcrb transcripts depends on the presence of an intron downstream of the PTC

New Mexico Speculative Fiction Authors

New Mexico is not only a place of many enchanting sunsets and landscapes, but also home to many authors of speculative fiction. Join us in this roundtable as we discuss and introduce a few works of fantasy and science fiction by New Mexico-linked writers that our roundtable members have found particularly interesting, enjoyable, or mythopoeic. Just a few New Mexico speculative fiction writers you may have heard of are Roger Zelazny, George R. R. Martin, Diana Gabaldon, Suzy McKee Charnas, James S. A. Corey, Stephen R. Donaldson, Rebecca Roanhorse, Daniel Abraham, Fred Saberhagen, Walter Jon Williams, Melinda Snodgrass, S. M. Sterling, Jane Lindskold, Sheri S. Tepper, and of course Rivera Sun (our Mythcon Guest of Honor). While we will not have time to discuss all those listed, we will lead what we expect to be a lively, interactive discussion with attendees about the mythopoeic riches New Mexico authors offer

COVID-19 Perception, Knowledge, and Preventive Practice: Comparison between South Korea, Ethiopia, and Democratic Republic of Congo

In Africa, the first confirmed case of COVID-19 was reported in Egypt on February 14, 2020. Since then, the number of cases has continued to  increase with Ethiopia, the Democratic Republic of Congo (DRC), Nigeria, Sudan, Angola, Tanzania, Ghana, and Kenya identified as vulnerable  countries. The present study aimed to: 1) identify differences in trust level of COVID-19 diagnosis, recent healthcare utilization experiences, and COVID-19-related knowledge, information, and prevention practices in South Korea, Ethiopia, and DRC; and 2) identify factors influencing trust level in healthcare facilities regarding COVID-19 diagnosis. The present study was cross-sectional. The questionnaire survey was conducted between May 1–14, 2020 using Google forms, and 748 respondents were included in the final analysis. The data collected were analyzed using ANOVA, post - hoc test, and binary logistic regression analysis. South Korea showed higher rate of practice for COVID-19 prevention such as hand washing, mask wearing, and etc. than Ethiopia and DRC. The results showed significant differences with the trust level being 3.129 times higher in respondents from DRC than those from Ethiopia (aOR=3.129, 95% CI: [1.884-5.196], p<.000) and 29.137 times higher in respondents from South Korean than those from Ethiopia (aOR=29.137, 95% CI: [13.869-61.210], p<.000). Gender, age, number of family members, healthcare utilization experience, information, and practice were significant variables. Health education expansion for information and practice about COVID-19 in Ethiopia and DRC is necessary. Keywords: COVID-19, Pandemic, Ethiopia, DRC, South Korea, Online Survey En Afrique, le premier cas confirmé de COVID-19 a été signalé en Égypte le 14 février 2020. Depuis, le nombre de cas n'a cessé d'augmenter avec l'Éthiopie, la République démocratique du Congo (RDC), le Nigéria, le Soudan, l'Angola, La Tanzanie, le Ghana et le Kenya ont été identifiés comme pays vulnérables. La présente étude visait à: 1) identifier les différences de niveau de confiance dans le diagnostic du COVID-19, les expériences récentes d'utilisation des soins de santé et les connaissances, informations et pratiques de prévention liées au COVID-19 en Corée du Sud, en Éthiopie et en RDC; et 2) identifier les facteurs influençant le niveau de confiance dans les établissements de santé concernant le diagnostic du COVID-19. La présente étude était transversale. L'enquête par questionnaire a été menée du 1er au 14 mai 2020 à l'aide de formulaires Google, et 748 répondants ont été inclus dans l'analyse finale. Les données collectées ont été analysées en utilisant une analyse ANOVA, un test post-hoc et une analyse de régression logistique binaire. La Corée du Sud a montré un taux de pratique plus élevé pour la prévention du COVID-19, comme le lavage des mains, le port d'un masque, etc. que l'Éthiopie et la RDC. Les résultats ont montré des différences significatives, le niveau de confiance étant 3,129 fois plus élevé chez les répondants de RDC que chez ceux d'Éthiopie (aOR = 3,129, IC à 95%: [1,884-5,196], p <.000) et 29,137 fois plus élevé chez les répondants sud-coréens que ceux d'Éthiopie (aOR = 29,137, IC à 95%: [13,869-61,210], p <.000). Le sexe, l'âge, le nombre de membres de la famille, l'expérience d'utilisation des soins de santé, l'information et la pratique étaient des variables importantes. L'élargissement de l'éducation sanitaire pour l'information et la pratique du COVID-19 en Éthiopie et en RDC est nécessaire. Mots-clés: COVID-19, Pandémie, Éthiopie, RDC, Corée du Sud, Enquête en lign

NF-κB Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress

Activation of NF-κB, pivotal for immunity and oncogenesis, is tightly controlled by multiple feedback mechanisms. In response to DNA damage, SUMOylation of NEMO (NF-κB essential modulator) is critical for NF-κB activation, however SUMO proteases and feedback mechanisms involved remain unknown. Here we show that among the six known SENPs (Sentrin/SUMO-specific proteases) only SENP2 can efficiently associate with NEMO, deSUMOylate NEMO and inhibit NF-κB activation induced by DNA damage. We further show that NF-κB induces SENP2 (and SENP1) transcription selectively in response to genotoxic stimuli, which involves ATM (ataxia telangiectasia mutated)-dependent histone methylation of SENP2 promoter κB regions and NF-κB recruitment. SENP2-null cells display biphasic NEMO SUMOylation and activation of IKK and NF-κB, and higher resistance to DNA damage-induced cell death. Our study establishes a self-attenuating feedback mechanism selective to DNA damage induced signaling to limit NF-κB-dependent cell survival responses

Religions and Social Progress:Critical Assessments and Creative Partnerships

This chapter engages with three important themes of the larger report: the meaning of progress, its uneven nature, and obstacles to future progress. It also considers a number of political and economic alternatives aimed to overcome these obstacles, emphasizing the need for diverse strategies, open-minded experimentation, and scientific assessment. While it may be impossible to ever reach agreement, the effort to calibrate different interpretations of progress remains an important exercise for political deliberation about how to make the world a better place. The very hope of moving forward implies some agreement on a destination. All of us must take responsibility for the future. Our discussion emphasizes the complexity and multidimensionality of the interpretive debate, but also calls attention to its ideological character. Social actors-individuals, groups, and even academic disciplines-tend to define progress in ways that serve their own interests. In a way, distributional conflict undermines our very efforts to better understand and mediate such conflict. The uneven character of progress is manifest in many different domains. Increases in the global reach of formally democratic institutions have been accompanied by growing concerns about their stability, efficacy, and consistency with democratic ideals

Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entry

Lymphocytic choriomeningitis virus (LCMV) is an enveloped and segmented negative-sense RNA virus classified within th

Effect of Brachionus rubens on the growth characteristics of various species of microalgae

Background: Cultivation of algae for conversion to biofuels has gained global interest. Outdoor raceway cultivation is preferred because of its lower capital and operating costs. A major disadvantage of outdoor cultivation is susceptibility of algal crops to attack by predatory rotifers. In order to quantify the impact of rotifer attack on different species of algae, we evaluated the growth of eleven microalgal species over a 21-d period after being infected by the predatory rotifer Brachionus rubens. Results: Of the eleven species, Chlorella sorokiniana was the most susceptible with rapid decline in algal growth concomitant with increase in rotifer population growth (3.82/d). In contrast, Synechococcus elongatus and Scenedesmus dimorphus were both resistant to the rotifer and suppressed rotifer growth (-0.06/d). An index of algal species susceptibility to be consumed by the rotifer was generated with C. sorokiniana as the baseline (index = 1.000) indicating most susceptible among species tested. Other species' susceptibilities are indicated in parenthesis as follows: Monoraphidium spp. (0.997), Chlamydomonas globosa (0.827), Botryococcus braunii (0.740), Chlorella minutissima (0.570), Chlamydomonas augustae (0.530), Chlamydomonas yellowstonensis (0.500), Scenedesmus bijuga (0.420), and Haematococcus pluvialis (0.360). Two species, namely, S. dimorphus and S. elongatus were unique in that they exhibited an ability to suppress the growth of the rotifer as indicated by the decline in rotifer populations in their presence. Conclusions: Variations in susceptibility of algal species to rotifer predation could be a result of their individual morphology, cell walls structure, or the biochemical composition of individual species