La maleta viatgera

Treball de l'alumnat del Grau d'Educació Primària de la Facultat d'Educació de la UB. Proposta d'activitat emmarcada al projecte de recerca EDU201S-69332-R "Desarrollo de las competencias para la educación multilingüe". Any: 2017. Tutors: Juli Palou i Margarida CambraLa següent activitat està plantejada com una capsa d'aprenentatge amb la qual es vol treballar diferents conceptes relacionats amb la multiculturalitat i el plurilingüisme dins d'una aula ordinària. Per aquest motiu, en aquesta activitat, a través d'un fil conductor, s'exposen diversos països dels diferents continents perquè els alumnes els coneguin i els investiguin com uns autèntics exploradors i, d'aquesta manera, descobreixin noves cultures que, possiblement i sense saber-ho, podrien estar molt arrelades a ells. Per dur a terme aquesta caixa, comptaran amb l'ajuda de la Tina, una viatgera molt divertida que els anirà donant indicacions per saber què han de fer en tot moment

Impact of Methylation on the Physical Properties of DNA

AbstractThere is increasing evidence for the presence of an alternative code imprinted in the genome that might contribute to gene expression regulation through an indirect reading mechanism. In mammals, components of this coarse-grained regulatory mechanism include chromatin structure and epigenetic signatures, where d(CpG) nucleotide steps are key players. We report a comprehensive experimental and theoretical study of d(CpG) steps that provides a detailed description of their physical characteristics and the impact of cytosine methylation on these properties. We observed that methylation changes the physical properties of d(CpG) steps, having a dramatic effect on enriched CpG segments, such as CpG islands. We demonstrate that methylation reduces the affinity of DNA to assemble into nucleosomes, and can affect nucleosome positioning around transcription start sites. Overall, our results suggest a mechanism by which the basic physical properties of the DNA fiber can explain parts of the cellular epigenetic regulatory mechanisms

Anthropogenic pollutants in Nephrops norvegicus (Linnaeus, 1758) from the NW Mediterranean Sea : Uptake assessment and potential impact on health

Altres ajuts: Generalitat de Catalunya. Departament d'Agricultura ARP059/19/00003 ; Unidad de excelencia María de Maeztu CEX2019-000940-MAltres ajuts: acord transformatiu CRUE-CSICAnthropogenic pollution is considered one of the main threats to the marine environment, and there is an imperious need to assess its potential impact on ecologically and economically relevant species. This study characterises plastic ingestion and tissue levels of potentially toxic metallic elements in Nephrops norvegicus and their simultaneous levels in abiotic compartments from three locations of the Catalan coast (NW Mediterranean Sea). A multidisciplinary assessment of the health condition of N. norvegicus through condition indices, enzymatic biomarkers and histological techniques is provided, and its relationship with anthropogenic pollutant levels explored. Plastic fibres were commonly found in stomachs of N. norvegicus (85% of the individuals), with higher abundances (13 ± 21 fibres · ind) in specimens captured close to Barcelona. The presence of long synthetic fibres in near-bottom waters, as well as the mirroring trends in abundance among locations for water and ingested plastics, suggest that uptake from water may be occurring potentially through suspension feeding. The spatial variability in the levels of metallic elements in N. norvegicus was poorly correlated to the variability in sediments. In any case, present levels in abdominal muscle are considered safe for human consumption. Levels of ingested plastics only showed significant, yet weak, correlations with glutathione S-transferase and catalase activities. However, no other health parameter analysed showed any trend potentially associated to anthropogenic pollutant levels. Neither the condition indices nor the histopathological assessment evidenced any signs of pathologic conditions affecting N. norvegicus. Thus, it was concluded that presently there is no evidence of a negative impact of the studied pollutants on the health condition of N. norvegicus in the studied grounds

Textos sobre Educación Universitaria: la Docencia de la Estadística (2014)

Esta publicación recoge diversas contribuciones del Grupo de Innovación Docente Consolidado “ANDES - Análisis de Datos en Economía y Empresa” que difunden los trabajos relacionados con la innovación docente en el amplio universo del análisis de datos. Se trata, pues, de un texto que pretende hacer llegar a docentes universitarios (o personas interesadas en la docencia universitaria) la investigación y la innovación que se producen en este ámbito. El Grupo de Innovación Docente Consolidado “ANDES” tiene como objetivos estudiar, analizar, ajustar y movilizar los recursos y acciones necesarias para mejorar la docencia de la Estadística y otras asignaturas de análisis de datos, que se dirigen a estudiantes de diferentes Grados, como Estadística, ADE, Economía, etc. Fundamentalmente, el trabajo de innovación docente se focaliza en asignaturas obligatorias y troncales de los Grados mencionados.Este texto ha sido llevado a cabo en el marco de los proyectos 2012PID-UB/094, 2013PID-UB/004, REDICE12-1623-02 y REDICE-ACCIÓ-13-01. Agradecemos a la Universitat de Barcelona su apoyo y financiación.Este texto ha sido llevado a cabo en el marco de los proyectos 2012PID-UB/094, 2013PID-UB/004, REDICE12-1623-02 y REDICE-ACCIÓ-13-01. Agradecemos a la Universitat de Barcelona su apoyo y financiació

Inventory and Analysis of Environmental Sustainability Education in the Degrees of the University of Alcalá (Spain)

In order to promote education in environmental sustainability at higher education institutions and establish action priorities, a detailed analysis of the initial situation is needed, both in terms of courses offered and teaching and assessment strategies implemented. This article presents a methodology that can be used to standardize the evaluation of teaching in environmental sustainability at different universities. We exemplify its application at the University of Alcalá, located in Central Spain. The inventory was conducted using in-house software development for the extraction of environmental sustainability concepts in the degree courses? syllabi, completed with a survey to faculty members and a manual review to confirm its adjustment to environmental issues. Those finally selected were analyzed in depth. The main results indicate that currently, only a small part of the courses (5.5%) offered at the University explicitly include environmental sustainability content. The grades that concentrate most of the courses are those of Environmental Sciences, Biology, Economics, Tourism and Pharmacy, with very low occurrence in the grades of Education and Health Sciences. It is concluded that further institutional commitment is needed in the definition of medium-term strategies to guide the training and dissemination efforts in order to promote sound environmental education in university courses

Obesity, knee osteoarthritis, and polypathology: factors favoring weight loss in older people

We aimed to explore the meaning of obesity in elderly persons with knee osteoarthritis (KO) and to determine the factors that encourage or discourage weight loss. Background: Various studies have demonstrated that body mass index is related to KO and that weight loss improves symptoms and functional capacity. However, dietary habits are difficult to modify and most education programs are ineffective. Design: A phenomenological qualitative study was conducted. Intentional sampling was performed in ten older persons with KO who had lost weight and improved their health-related quality of life after participating in a health education program. A thematic content analysis was conducted following the stages proposed by Miles and Huberman. Findings: Participants understood obesity as a risk factor for health problems and stigma. They believed that the cause of obesity was multifactorial and criticized health professionals for labeling them as 'obese' and for assigning a moral value to slimness and diet. The factors identified as contributing to the effectiveness of the program were a tolerant attitude among health professionals, group education that encouraged motivation, quantitative dietary recommendations, and a meaningful learning model based on social learning theories. Conclusion: Dietary self-management without prohibitions helped participants to make changes in the quantity and timing of some food intake and to lose weight without sacrificing some foods that were deeply rooted in their culture and preferences. Dietary education programs should focus on health-related quality of life and include scientific knowledge but should also consider affective factors and the problems perceived as priorities by patients. Keywords: obesity, elderly, polypathology, therapeutic education, diet, nursing, knee osteoarthriti

Las unidades del discurso oral. La propuesta Val.Es.Co. de segmentación de la conversación (coloquial)

El presente artículo resume y examina críticamente la propuesta de segmentación del discurso realizada en Briz y Grupo Val.Es.Co (2003). El modelo Val.Es.Co. consta de ocho unidades (discurso, diálogo, intercambio/ alternancia de turnos, intervención/turno, acto y subacto), tres órdenes (social, estructural e informativo) y cuatro posiciones (inicial, media, final e independiente); se caracteriza, además, por ser jerárquico y recursivo. La aplicación del modelo Val.Es.Co. permite la segmentación de una conversación coloquial sin residuos, así como un adecuado tratamiento de diversos fenómenos conversacionales (actos truncados, solapamientos, elementos suprasegmentales o marcadores discursivos)This paper summarizes and critically reviews the model of discourse segmentation made by Briz and Grupo Val.Es.Co (2003). This model is made up of eight units (discourse, dialogue, exchange/ turn taking, intervention/turn, act and subact), three orders (social, structural and informative) and four positions (initial, medial, final and independent). The Val.Es.Co model is also hyerarchical and recursive. By applying the Val.Es.Co model, a conversation can be divided into parts and subparts without any element remaining unanalyzed. Also, some specific features occurring in conversations such as false starts, overlappings, the segmentation value of prosodic features or discourse markers, can be successfully analyze

The coexistence of diabetic retinopathy and diabetic nephropathy is associated with worse kidney outcomes

Up to 50-60% of patients with diabetes have non-diabetic kidney disease (NDKD) on kidney biopsy. Diabetic retinopathy (DR) is a microvascular complication of diabetes frequently associated with diabetic nephropathy (DN). The objective of the current study was to investigate the kidney outcomes and survival in patients with biopsy diagnoses of DN and NDKD according to the presence of DR. We conducted an observational, multicentre and retrospective study of the pathological findings of renal biopsies from 832 consecutive patients with diabetes from 2002 to 2014 from 18 nephrology departments. The association of DR with kidney replacement therapy (KRT) or survival was assessed by Kaplan-Meier and Cox regression analyses. Of 832 patients with diabetes and renal biopsy, 768 had a retinal examination and 221/768 (22.6%) had DR. During a follow-up of 10 years, 288/760 (37.9%) patients with follow-up data needed KRT and 157/760 (20.7%) died. The incidence of KRT was higher among patients with DN (alone or with NDKD) and DR [103/175 (58.9%)] than among patients without DR [88/216 (40.7%), P <.0001]. The incidence of KRT was also higher among patients with only NDKD and DR than among those without DR [18/46 (39.1%) versus 79/331 (23.9%), P <.0001]. In multivariate analysis, DR or DN were independent risk factors for KRT {hazard ratio [HR] 2.48 [confidence interval (CI) 1.85-3.31], P <.001}. DN (with or without DR) was also identified as an independent risk factor for mortality [HR 1.81 (CI 1.26-2.62), P =.001]. DR is associated with a higher risk of progression to kidney failure in patients with histological DN and in patients with NDKD

Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study

Background Most children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention. However, a small proportion of pediatric patients develop a severe clinical condition, multisystem inflammatory syndrome in children (MIS-C). The involvement of epigenetics in the control of the immune response and viral activity prompted us to carry out an epigenomic study to uncover target loci regulated by DNA methylation that could be altered upon the appearance of MIS-C. Methods Peripheral blood samples were recruited from 43 confirmed MIS-C patients. 69 non-COVID-19 pediatric samples and 15 COVID-19 pediatric samples without MIS-C were used as controls. The cases in the two groups were mixed and divided into discovery (MIS-C= 29 and non-MIS-C= 56) and validation (MIS-C= 14 and non-MIS C = 28) cohorts, and balanced for age, gender and ethnic background. We interrogated 850,000 CpG sites of the human genome for DNA methylation variants. Findings The DNA methylation content of 33 CpG loci was linked with the presence of MIS-C. Of these sites, 18 (54.5%) were located in described genes. The top candidate gene was the immune T-cell mediator ZEB2; and others highly ranked candidates included the regulator of natural killer cell functional competence SH2D1B; VWA8, which contains a domain of the Von Willebrand factor A involved in the pediatric hemostasis disease; and human leukocyte antigen complex member HLA-DRB1; in addition to pro-inflammatory genes such as CUL2 and AIM2. The identified loci were used to construct a DNA methylation profile (EPIMISC) that was associated with MIS-C in both cohorts. The EPIMISC signature was also overrepresented in Kawasaki disease patients, a childhood pathology with a possible viral trigger, that shares many of the clinical features of MIS-C. Interpretation We have characterized DNA methylation loci that are associated with MIS-C diagnosis. The identified genes are likely contributors to the characteristic exaggerated host inflammatory response observed in these patients. The described epigenetic signature could also provide new targets for more specific therapies for the disorder.Copyright (c) 2022 The Author(s). Published by Elsevier Ltd

Nuevas miradas sobre el antiimperialismo y/o el antiamericanismo desde la Historia, la Literatura y el Arte

Esta publicación forma parte del Proyecto de cooperación interuniversitaria UAM-Banco Santander con EEUU titulado: De las palabras a los hechos: manifestaciones violentas del antiamericanismo desde la Guerra Fría hasta los albores de la Era Trump.Prólogo / Misael Arturo López Zapico, Aida Rodríguez Campesino y Gonzalo Vitón (pp. V-VI). -- Introducción / Montserrat Huguet Santos (pp. 7-10). -- Revisitar el pasado: el antiamericanismo de Guerra Fría a la sombra de la Segunda Guerra Mundial / Silvina Campo (pp. 11-27). -- Del anticolonialismo al "antiamericanismo" en Oriente Medio y el norte de África: reformulación de los movimientos de resistencia en el periodo de la Guerra Fría / Laura Sestafe Silvestre (pp. 28-47). -- The GI Movement: Veteranos de Vietnam y la configuración de nuevas conciencias antiimperialistas y antiamericanas en Estados Unidos (1966-1975) / Albert Soler Ruda (pp. 48-61). -- "Venir a España a aprender" España en el Antiamericanismo del Movimiento Conservador Norteamericano / David Sarias (pp. 62-72). -- "Pasándolo bomba con Haig": Protestas antiamericanas en la República Federal Alemana, 1981-1982 / Carolina Labarta Rodríguez-Maribona (pp. 73-88). -- ¿Antiamericanismo futuro? El interés de Estados Unidos por el Acuífero Guaraní en Paraguay / Eduardo Tamayo Belda (pp. 89-111). -- Hacia la consolidación de las identidades globales: Antiimperialismo y Sur Global / Diego Sebastián Crescentino (pp. 112-132). -- Antiamericanismo y antiimperialismo en el cómic de superhéroes: el caso de Mark Millar / Ignacio Cortiguera Sánchez (pp. 133-146). -- Zombis nada más: Juan de los muertos, iconoclasta y antiimperialista / Patricia Saldarriaga y Emy Manini (pp. 147-161). -- Encontrar el sur, pensar el norte. Subversión y resistencia en el audiovisual contemporáneo de artistas del sur del cono sur / Alejandra Crescentino (pp. 162-177)