Propuesta de prevención del cyberbullying a través de la educación emocional

Hasta hace unos años el acoso escolar se limitaba a los centros escolares mientras que actualmente, gracias al auge de las Tecnologías de la Información y la Comunicación (TIC) en la vida de los adolescentes, se ha generado una nueva forma de acoso denominada cyberbullying el cual logra traspasar los muros de las aulas. El presente proyecto pretende crear un espacio educativo que gire en torno a las emociones y al inicio del aprendizaje de las nuevas tecnologías. Así pues, el proyecto consta de dos partes claramente diferenciadas: por una lado, una aproximación teórica al acoso escolar y cyberbullying para conocer sus características, tipos, perfiles así como sus consecuencias emocionales y académicas, y por otro lado, el desarrollo de un programa educativo dirigido al desarrollo de competencias emocionales y personales básicas para la prevención de este fenómeno. Resumen disponible también en inglés. El proyecto cuenta con materiales adicionales los cuales serán entregados al tribunal el día de la exposición. Dichos materiales son un cuadernillo y un cd con material didáctico para el desarrollo del programa que se propone en el proyecto. El cuadernillo consta de un pequeño resumen de la parte teórica del proyecto y el desarrollo de las sesiones también desarrolladas en el proyecto. El cd incluye aquel material necesario para el desarrollo de las sesiones planteadas en el proyecto: vídeos, imágenes..

Estudi sobre el ritme de restauració de les activitats extractives de Catalunya

L'objecte d'aquest projecte és determinar si el ritme restaurador de les activitats extractives és el mateix que el de l'extracció del mineral. Per avaluar-ho s'ha analitzat la dinàmica de les explotacions mineres que exploten els quatre tipus principals de recursos a Catalunya, en el període de 10 anys (1993-2003), amb l'ajuda de Sistemes d'Informació Geogràfica (SIG). Per dur a terme aquest estudi s'ha emprat bases cartogràfiques diferents: els Mapes de cobertes del Sòl de Catalunya (MCSC) i el de les activitats extractives (EXTCATA). A partir de l'anàlisi dels resultats, es determina que si bé, en general, el procés de restauració dels espais afectats per les activitats extractives està sent molt important des de l'entrada en vigor de la Llei 12/1981, no es pot afirmar que aquests treballs es realitzin de forma compaginada amb els d'explotació.El objeto de este proyecto es determinar si el ritmo restaurador de las actividades extractivas es el mismo que el de la extracción del mineral. Para evaluarlo se ha analizado la dinámica de las explotaciones mineras que explotan los cuatro tipos principales de recursos en Cataluña, en el periodo de 10 años (1993-2003), con la ayuda de Sistemas de Información Geográfica (SIG). Para llevar a cabo este estudio se ha empleado bases cartográficas diferentes: los Mapas de cubiertas del Suelo de Cataluña (MCSC) y el de las actividades extractivas (EXTCATA). A partir del análisis de los resultados, se determina que si bien, en general, el proceso de restauración de los espacios afectados por las actividades extractivas está siendo muy importante desde la entrada en vigor de la Ley 12/1981, no se puede afirmar que estos trabajos se realicen de forma compaginada con los de explotación.The main aim of this research is to determine whether the restoring rate of the extractive activities is the same as the one from mineral extraction. In order to evaluate that, the dynamics of the mining have been analysed. The four main sorts of resources in Catalonia were studied during 10 years (from 1993 to 2003) using the Geographic Information System (GIS). Different cartographic bases were used to carry out this study: maps on the layers of the Catalan soil and maps on extractive activities (EXTCATA). From the analyses of the results, it is determined that the process of restoration of the affected areas is being very important since the law 12/1981 came to force. However, it cannot be claimed that these works are arranged together with those of the mining

Case report : Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) haploinsufficiency is a T-cell hyperactivation disorder that can manifest with both immunodeficiency and immune dysregulation. Approximately one-third of patients may present mild symptoms and remain stable under supportive care. The remaining patients may develop severe multiorgan autoimmunity requiring lifelong immunosuppressive treatment. Hematopoietic stem cell transplantation (HSCT) is potentially curable for patients with treatment-resistant immune dysregulation. Nevertheless, little experience is reported regarding the management of complications post-HSCT. We present case 1 (CTLA-4 haploinsufficiency) and case 2 (CTLA-4 insufficiency-like phenotype) manifesting with severe autoimmunity including cytopenia and involvement of the central nervous system (CNS), lung, and gut and variable impairment of humoral responses. Both patients underwent HSCT for which the main complications were persistent mixed chimerism, infections, and immune-mediated complications [graft-versus-host disease (GVHD) and nodular lung disease]. Detailed management and outcomes of therapeutic interventions post-HSCT are discussed. Concretely, post-HSCT abatacept and human leukocyte antigen (HLA)-matched sibling donor lymphocyte infusions may be used to increase T-cell donor chimerism with the aim of correcting the immune phenotype of CTLA-4 haploinsufficiency

Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project

Background Plasma concentrations of lipoprotein (a) (Lp(a)), a lipoprotein with atherogenic and thrombogenic properties, have a strong genetic basis, although high concentrations of Lp(a) have also been reported in the context of inflammation, as in rheumatoid arthritis (RA). Few studies evaluate the impact of biologic therapies (BT) on Lp(a) in RA, taking into account that with these new therapies a better control of inflammation is achieved. Objective The aim of the study was to evaluate the plasma concentrations of Lp(a) in Spanish RA patients on BT attending rheumatology outpatient clinics. Methods Baseline analysis of the CARdiovascular in rheuMAtology project, a 10-year prospective study, evaluating the risk of cardiovascular events in RA and other forms of inflammatory arthritis. RA patients were classified according to treatment: no biologic, anti-tumor necrosis factor, anti-interleukin-6 receptor tocilizumab (TCZ), and other biologic (rituximab or abatacept). A model of linear multivariate regression was built in which the dependent variable was Lp(a) concentration and the explanatory variable was BT. The model was adjusted for confounding factors. Results Seven hundred and seventy-five RA patients were analyzed. Plasma concentrations of total cholesterol and triglyceride were significantly higher in TCZ-treated patients. Nevertheless, no significant difference in the atherogenic index between TCZ-treated patients and patients without BT was found. After adjusting for confounding factors, patients with BT had lower concentrations of Lp(a) than those without BT; however, only TCZ-treated patients achieved statistically significant differences (?: ?0.303, 95% confidence interval: ?0.558 to ?0.047; P = .02). Conclusions RA patients treated with TCZ show lower plasma concentrations of Lp(a) compared with patients without BT.This project has been supported by an unrestricted grant from Abbvie, Spain. The design, analysis, interpretation of results, and preparation of the article have been done independently of Abbvie. Dr González-Gay's studies have been supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII) (Spain)

Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial

Background: Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment. Methods: This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal. Results: Enrolment began in 2016, and the study is expected to end in 2020. Conclusions: This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission. Clinical trial reference number: EudraCT 2015-001410-1

Peri-operative red blood cell transfusion in neonates and infants: NEonate and Children audiT of Anaesthesia pRactice IN Europe: A prospective European multicentre observational study

BACKGROUND: Little is known about current clinical practice concerning peri-operative red blood cell transfusion in neonates and small infants. Guidelines suggest transfusions based on haemoglobin thresholds ranging from 8.5 to 12 g dl-1, distinguishing between children from birth to day 7 (week 1), from day 8 to day 14 (week 2) or from day 15 (≥week 3) onwards. OBJECTIVE: To observe peri-operative red blood cell transfusion practice according to guidelines in relation to patient outcome. DESIGN: A multicentre observational study. SETTING: The NEonate-Children sTudy of Anaesthesia pRactice IN Europe (NECTARINE) trial recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. PATIENTS: The data included 5609 patients undergoing 6542 procedures. Inclusion criteria was a peri-operative red blood cell transfusion. MAIN OUTCOME MEASURES: The primary endpoint was the haemoglobin level triggering a transfusion for neonates in week 1, week 2 and week 3. Secondary endpoints were transfusion volumes, 'delta haemoglobin' (preprocedure - transfusion-triggering) and 30-day and 90-day morbidity and mortality. RESULTS: Peri-operative red blood cell transfusions were recorded during 447 procedures (6.9%). The median haemoglobin levels triggering a transfusion were 9.6 [IQR 8.7 to 10.9] g dl-1 for neonates in week 1, 9.6 [7.7 to 10.4] g dl-1 in week 2 and 8.0 [7.3 to 9.0] g dl-1 in week 3. The median transfusion volume was 17.1 [11.1 to 26.4] ml kg-1 with a median delta haemoglobin of 1.8 [0.0 to 3.6] g dl-1. Thirty-day morbidity was 47.8% with an overall mortality of 11.3%. CONCLUSIONS: Results indicate lower transfusion-triggering haemoglobin thresholds in clinical practice than suggested by current guidelines. The high morbidity and mortality of this NECTARINE sub-cohort calls for investigative action and evidence-based guidelines addressing peri-operative red blood cell transfusions strategies. TRIAL REGISTRATION: ClinicalTrials.gov, identifier: NCT02350348

Estudi sobre el ritme de restauració de les activitats extractives de Catalunya

L’objecte d’aquest projecte és determinar si el ritme restaurador de les activitats extractives és el mateix que el de l’extracció del mineral. Per avaluar-ho s’ha analitzat la dinàmica de les explotacions mineres que exploten els quatre tipus principals de recursos a Catalunya, en el període de 10 anys (1993-2003), amb l’ajuda de Sistemes d’Informació Geogràfica (SIG). Per dur a terme aquest estudi s’ha emprat bases cartogràfiques diferents: els Mapes de cobertes del Sòl de Catalunya (MCSC) i el de les activitats extractives (EXTCATA). A partir de l’anàlisi dels resultats, es determina que si bé, en general, el procés de restauració dels espais afectats per les activitats extractives està sent molt important des de l’entrada en vigor de la Llei 12/1981, no es pot afirmar que aquests treballs es realitzin de forma compaginada amb els d’explotació.El objeto de este proyecto es determinar si el ritmo restaurador de las actividades extractivas es el mismo que el de la extracción del mineral. Para evaluarlo se ha analizado la dinámica de las explotaciones mineras que explotan los cuatro tipos principales de recursos en Cataluña, en el periodo de 10 años (1993-2003), con la ayuda de Sistemas de Información Geográfica (SIG). Para llevar a cabo este estudio se ha empleado bases cartográficas diferentes: los Mapas de cubiertas del Suelo de Cataluña (MCSC) y el de las actividades extractivas (EXTCATA). A partir del análisis de los resultados, se determina que si bien, en general, el proceso de restauración de los espacios afectados por las actividades extractivas está siendo muy importante desde la entrada en vigor de la Ley 12/1981, no se puede afirmar que estos trabajos se realicen de forma compaginada con los de explotación.The main aim of this research is to determine whether the restoring rate of the extractive activities is the same as the one from mineral extraction. In order to evaluate that, the dynamics of the mining have been analysed. The four main sorts of resources in Catalonia were studied during 10 years (from 1993 to 2003) using the Geographic Information System (GIS). Different cartographic bases were used to carry out this study: maps on the layers of the Catalan soil and maps on extractive activities (EXTCATA). From the analyses of the results, it is determined that the process of restoration of the affected areas is being very important since the law 12/1981 came to force. However, it cannot be claimed that these works are arranged together with those of the mining