Quantitative characterization of p-sites from the human t-lymphocyte phosphoproteome using isotopic labeling and mass spectrometry

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Classifying Four-Body Convex Central Configurations

We classify the full set of convex central configurations in the Newtonian four-body problem. Particular attention is given to configurations possessing some type of symmetry or defining geometric property. Special cases considered include kite, trapezoidal, co-circular, equidiagonal, orthodiagonal, and bisecting-diagonal configurations. Good coordinates for describing the set are established. We use them to prove that the set of four-body convex central configurations with positive masses is three-dimensional, a graph over a domain $D$ that is the union of elementary regions in $\mathbb{R}^{+^3}$.Comment: 28 pages, 14 figure

A four-body convex central configuration with perpendicular diagonals is necessarily a kite

This is a post-peer-review, pre-copyedit version of an article published in Qualitative Theory of Dynamical Systems. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12346-017-0238-z.We prove that any four-body convex central configuration with perpendicular diagonals must be a kite configuration. The result extends to general power-law potential functions, including the planar four-vortex problem.Peer ReviewedPostprint (author's final draft

Marine litter, the new plague of seas and oceans

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Differential expression analysis in spinal muscular atrophy patients

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Vigilance by Sentinels in a group of baboons (Papio hamadryas hamadryas) in a zoo setting

Vigilance by sentinels is an anti-predator strategy by which certain group members keep watch from strategic positions, while the group is involved in other activities. Many anti-predatory behavior patterns observed in natural habitats are also deployed similarly when provoked by human presence. This work is part of a study conducted with a group of hamadryas baboons (Papio h. hamadryas) in semi-freedom in a 15-hectare zoo complex with extensive human pressure. The animals make incursions into an adjoining high-risk area to access food resources, making use of vigilance with sentinels and other risk minimization strategies. Results reveal that human presence provokes similar reactions to natural predatory pressure, forcing them to select strategies to minimize the factors involved in risk perception, such as the degree of visibility of the surroundings, minimizing the length of the incursion and behavioral restrictions

Efecto de la activación linfocitaria sobre el fosfoproteoma del linfocito T primario humano: estudio mediante marcaje isotópico y espectrometría de masas

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Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells

During embryogenesis, the mammalian kidney arises because of reciprocal interactions between the ureteric bud (UB) and the metanephric mesenchyme (MM), driving UB branching and nephron induction. These morphogenetic processes involve a series of cellular rearrangements that are tightly controlled by gene regulatory networks and signaling cascades. Here, we discuss how kidney developmental studies have informed the definition of procedures to obtain kidney organoids from human pluripotent stem cells (hPSCs). Moreover, bioengineering techniques have emerged as potential solutions to externally impose controlled microenvironments for organoid generation from hPSCs. Next, we summarize some of these advances with major focus On recent works merging hPSC-derived kidney organoids (hPSC-kidney organoids) with organ-on-chip to develop robust models for drug discovery and disease modeling applications. We foresee that, in the near future, coupling of different organoid models through bioengineering approaches will help advancing to recreate organ-to-organ crosstalk to increase our understanding on kidney disease progression in the human context and search for new therapeutics