Review of the book “Extreme Temperatures and Health: How Heat Waves and Cold Snaps Affect Us”

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Revisão do livro “Temperaturas extremas e saúde. Como nos afetam as ondas de calor e de frio”

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Treatment and Interpretation of Physical Education during the Francoism legislative approach (1939-1970)

El estudio describe el tratamiento de la Educación Física bajo las leyes franquistas aprobadas tras 1939, para concluir el importante efecto de la orientación política de esta disciplina escolar hasta su progresiva modernización en los 70s. El trabajo parte de los estudios realizados sobre historia de la Educación Física en España durante el franquismo (1936-1975) que han versado sobre dos ejes: el ideal moralizador de la Educación Física acorde con el contexto político-social del momento y los estudios que han analizado los hábitos de práctica física y gimnástica de organizaciones políticas dependientes al régimen, como «Frente de Juventudes» o la «Sección Femenina». Como conclusión se aportan aspectos relevantes sobre la interpretación de la Educación Física desde las diferentes referencias legislativas y otros documentos durante la dictadura que podrían ayudar a entender diversas perspectivas de esta área.The present study describes the treatment and interpretation of Physical Education under Franco’s laws passed after 1939, so to discuss the important effect of the political orientation of this school subject until its progressive modernization in the 70’s. History of Physical Education in Spain during the dictatorship of Franco (1936-1975) has dealt with two basic axes: the moralizing ideal of Physical Education according to the political-social context of the moment, and the studies that have analysed the habits of Physical and gymnastic practice of political organizations subject to the regime, such as «Frente de Juventudes» or «Sección Femenina». In conclusion, relevant aspects are presented on the interpretation of Physical Education from different legislative references and other documents during the dictatorship that could help understand diverse perspectives of this area, according to the examined Education Law

Treatment and Interpretation of Physical Education during the Francoism legislative approach (1939-1970)

El estudio describe el tratamiento de la Educación Física bajo las leyes franquistas aprobadas tras 1939, para concluir el importante efecto de la orientación política de esta disciplina escolar hasta su progresiva modernización en los 70s. El trabajo parte de los estudios realizados sobre historia de la Educación Física en España durante el franquismo (1936-1975) que han versado sobre dos ejes: el ideal moralizador de la Educación Física acorde con el contexto político-social del momento y los estudios que han analizado los hábitos de práctica física y gimnástica de organizaciones políticas dependientes al régimen, como «Frente de Juventudes» o la «Sección Femenina». Como conclusión se aportan aspectos relevantes sobre la interpretación de la Educación Física desde las diferentes referencias legislativas y otros documentos durante la dictadura que podrían ayudar a entender diversas perspectivas de esta área.The present study describes the treatment and interpretation of Physical Education under Franco’s laws passed after 1939, so to discuss the important effect of the political orientation of this school subject until its progressive modernization in the 70’s. History of Physical Education in Spain during the dictatorship of Franco (1936-1975) has dealt with two basic axes: the moralizing ideal of Physical Education according to the political-social context of the moment, and the studies that have analysed the habits of Physical and gymnastic practice of political organizations subject to the regime, such as «Frente de Juventudes» or «Sección Femenina». In conclusion, relevant aspects are presented on the interpretation of Physical Education from different legislative references and other documents during the dictatorship that could help understand diverse perspectives of this area, according to the examined Education Law

Posibilidades de mejora en los planes de prevención frente al exceso de temperaturas

En el verano de 2003 las temperaturas alcanzadas fueron responsables de un gran número de muertes en el continente europeo. Un año después muchos países habían implantado algún tipo de plan de prevención frente al exceso de temperaturas. Planes que ya habían mostrado su capacidad de prevenir una buena parte de la mortalidad evitable en otras latitudes. Desde entonces, son numerosos los estudios publicados ofreciendo nuevos datos sobre los efectos en salud pública de una ola de calor, que pueden contribuir a aumentar la eficiencia de estos planes de prevención. Conocer las situaciones meteorológicas de mayor riesgo, definir ola de calor o tener en cuenta el tiempo que el plan debe estar activo a partir del estudio de la relación entre la temperatura y sus efectos en salud, identificar las características meteorológicas que modulan la relación entre la temperatura y la mortalidad, localizar el perfil de las personas de mayor riesgo o diseñar protocolos de actuación con la mayor precisión posible y basado en el conocimiento científico son elementos extraídos de numerosos trabajos realizados en los últimos años que deben ser tenidos en cuenta.S

Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients

Las estanniocalcinas se expresan en el tejido del páncreas, y se sugirió una correlación directa entre la insulina circulante y las concentraciones de STC2 en el ser humano. Aquí, mostramos una correlación significativa entre STC1 y tanto la glucemia como la hemoglobina glicosilada entre los pacientes con DM2, mientras que los pacientes con DM2 que presentan los mayores valores de hemoglobina glicosilada exhibieron la menor expresión de STC2. Sin embargo, el tratamiento de los pacientes con fármacos antiglicémicos no modifica significativamente la expresión de ambas STC. Por otra parte, los ratones STC2-/- que mostraron sobrepeso neonatal y adulto presentaron además una glucemia desregulada cuando fueron alimentados con una dieta hipercalórica (pellet de cría, BP). Esta alteración es más evidente en las primeras etapas de la vida animal. La glucemia desregulada en estos ratones se confirmó mediante una prueba oral de glucosa. Además, los ratones STC2-/- presentan un aumento del tamaño del páncreas; así, el análisis histológico revela que los ratones WT responden a la dieta BP aumentando el tamaño de los islotes pancreáticos a través de la inducción de la división celular, y los ratones STC2-/- carecen de este mecanismo compensatorio. Contrariamente, los ratones alimentados con STC2-/- muestran un mayor número de islotes pero de tamaño similar a los alimentados con el pellet regular. El análisis histopatológico demuestra la alteración de la estructura de los tejidos y las infiltraciones de eritrocitos en los ratones STC2-/-, posiblemente debido al estrés evocado por la dieta BP. Por último, se observó una mayor inmunotinción de glucagón en el islote de los ratones STC2-/-, y el ensayo ELISA de glucagón confirmó el aumento del glucagón circulante. En resumen, presentamos pruebas del papel de los STC, principalmente el STC2, como posible marcador temprano durante el desarrollo de la diabetes mellitus.Stanniocalcins are expressed in the pancreas tissue, and it was suggested a direct correlation between circulating insulin and STC2 concentrations in human. Here, we show a significant correlation between STC1 and both glycaemia and glycosylated haemoglobin among DM2 patients, while DM2 patients who present the greatest glycosylated haemoglobin values exhibited the lowest STC2 expression. However, treatment of patients with antiglycaemic drugs does not significantly modify the expression of both STCs. On the other hand, STC2-/- mice that exhibited neonatal and adult overweight further presented deregulated glycaemia when they were feed with a hypercaloric diet (breeding pellet, BP). This alteration is more evident at the early stages of the animal life. Deregulated glycaemia in these mice was confirmed using glucose oral test. In addition, STC2-/- mice present enhanced pancreas size; thus, the histological analysis reveals that WT mice respond to BP diet by increasing the size of the pancreatic islets through inducing cell division, and STC2-/- mice lack this compensatory mechanism. Contrary, BP fed STC2-/- mice show enhanced number of islets but of similar size than those fed with regular pellet. Histopathological analysis demonstrates tissue structure disruption and erythrocytes infiltrations in STC2-/- mice, possibly due to the stress evoked by the BP diet. Finally, enhanced glucagon immunostaining was observed in the islet of STC2-/- mice, and the glucagon ELISA assay confirmed the increase in the circulating glucagon. Summarizing, we present evidence of the role of STCs, mainly STC2, as a possible early marker during development of diabetes mellitus.• Ministerio de Economía y Competitividad. Becas 2013‐45564C2‐1‐P, BFU‐2016‐74932‐C2‐1‐P • Programa Juan de la Cierva. Becas IJCI‐2015‐25665, JC‐2012‐ 2934 • Junta de Extremadura. Beca PRIIB16046peerReviewe

Autoimmune Diseases and COVID-19 as Risk Factors for Poor Outcomes: Data on 13,940 Hospitalized Patients from the Spanish Nationwide SEMI-COVID-19 Registry

(1) Objectives: To describe the clinical characteristics and clinical course of hospitalized patients with COVID-19 and autoimmune diseases (ADs) compared to the general population. (2) Methods: We used information available in the nationwide Spanish SEMI-COVID-19 Registry, which retrospectively compiles data from the first admission of adult patients with COVID-19. We selected all patients with ADs included in the registry and compared them to the remaining patients. The primary outcome was all-cause mortality during admission, readmission, and subsequent admissions, and secondary outcomes were a composite outcome including the need for intensive care unit (ICU) admission, invasive and non-invasive mechanical ventilation (MV), or death, as well as in-hospital complications. (3) Results: A total of 13,940 patients diagnosed with COVID-19 were included, of which 362 (2.6%) had an AD. Patients with ADs were older, more likely to be female, and had greater comorbidity. On the multivariate logistic regression analysis, which involved the inverse propensity score weighting method, AD as a whole was not associated with an increased risk of any of the outcome variables. Habitual treatment with corticosteroids (CSs), age, Barthel Index score, and comorbidity were associated with poor outcomes. Biological disease-modifying anti-rheumatic drugs (bDMARDs) were associated with a decrease in mortality in patients with AD. (4) Conclusions: The analysis of the SEMI-COVID-19 Registry shows that ADs do not lead to a different prognosis, measured by mortality, complications, or the composite outcome. Considered individually, it seems that some diseases entail a different prognosis than that of the general population. Immunosuppressive/immunoregulatory treatments (IST) prior to admission had variable effects

Association between perceived level of stress, clinical characteristics and psychopathological symptoms in women with systemic lupus erythematosus

Objective: To evaluate psychopathological status and stress level from a sample with SLE; compare mental functioning and stress levels between women with SLE and healthy women; determine whether disease duration, disease activity, cumulative organ damage and stress have an influence on psychopathological symptoms in SLE patients; and evaluate whether perception of stress is related to SLE severity. Methods: We conducted a cross-sectional study of 425 participants; 202 women with SLE, with an average age (SD) of 36.61 (10.15), and 223 healthy women, with age-matched controls. The assessment included the clinical characteristics (disease duration, SLE activity, cumulative organ damage, pharmacotherapy), the Symptom Checklist-90-Revised (SCL-90-R) and the Perceived Stress Scale. Descriptive, comparative, univariate and multivariate analysis were performed. Results: SLE patients showed psychopathological alterations in the somatisation, obsessive-compulsive and positive discomfort subscales of SCL-90-R. Women with SLE reported significantly higher scores on the psychopathological dimensions and perceived stress compared to healthy women, except for paranoid ideation. Disease duration, SLE activity, cumulative organ damage, and perceived stress were shown to be significant predictors of psychopathological manifestations, explaining a range, between 20 and 43%, of variance across SCL-90-R dimensions. Moreover, perceived stress was related to SLE activity, after controlling for psychopathological dimensions. Conclusion: The psychopathological manifestations in SLE appeared to be influenced by perceived stress, disease duration, disease activity and cumulative organ damage. In turn, perceived stress was associated with disease severity. This knowledge may contribute to a more comprehensive perspective of these manifestations in the SLE population in the clinical setting.This research was developed in the framework of the I+D Project “SEJ2007-61857” and the I+D Project ‘‘PSI2010- 15780’’, funded by the Spanish Ministry of Education and Science. In addition, this study was supported by the Andalusian Health Service (grant no. PI-0059/2007)