The rare case of positive FDG-positron emission tomography for giant cavernous hemangioma of the liver

Hemangioma is the most common benign liver tumor and the second most common liver tumor after metastases. Large hemangiomas are often heterogeneous. When they exceed 4 cm in diameter, they are termed giant hemangiomas. These giant hemangiomas often present heterogeneous patterns. These heterogeneous appearances are shown because of intratumoral changes due to several degenerative phenomena. PET/CT is reported to be useful for the differentiation of benign from malignant liver lesions. We report the case of a large hepatic hemangioma characterized by high FDG uptake

Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases

The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a critical player in gut homeostasis maintenance as it ensures the complex crosstalk between gut microbes (both commensals and pathogens) and the host immune system. Highly specialized epithelial cells constantly cope with several protective and harmful agents to maintain the multiple physiological functions of the barrier as well as its integrity. However, both genetic defects and environmental factors can break such equilibrium, thus promoting gut dysbiosis, dysregulated immune-inflammatory responses, and even the development of chronic pathological conditions. Here, we review and discuss the molecular and cellular pathways underlying intestinal barrier structural and functional homeostasis, focusing on potential alterations that may undermine this fine balance

Aerosol optical properties at Lampedusa (Central Mediterranean) ? 2. Determination of single scattering albedo at two wavelengths for different aerosol types

International audienceAerosol optical properties were retrieved from direct and diffuse spectral irradiance measurements made by a multi-filter rotating shadowband radiometer (MFRSR) at the island of Lampedusa (35.5° N, 12.6° E), in the Central Mediterranean, in the period July 2001?September 2003. In a companion paper (Pace et al., 2005) the aerosol optical depth (AOD) and Ångström exponent were used together with airmass backward trajectories to identify and classify different aerosol types. The MFRSR diffuse-to-direct ratio (DDR) at 415.6 nm and 868.7 nm for aerosol classified as biomass burning-urban/industrial, originating primarily from the European continent, and desert dust, originating from the Sahara, is used in this study to estimate the aerosol single scattering albedo (SSA). A detailed radiative transfer model is initialized with the measured aerosol optical depth; calculations are performed at the two wavelengths varying the SSA values until the modelled DDR matches the MFRSR observations. Sensitivity studies are performed to estimate how uncertainties on AOD, DDR, asymmetry factor (g), and surface albedo influence the retrieved SSA values. The results show that a 3% variation of AOD or DDR produce a change of about 0.02 in the retrieved SSA value at 415.6 and 868.7 nm; a ±0.06 variation of the asymmetry factor g produces a change of the estimated SSA of <0.04 at 415.6 nm, and <0.06 at 868.7 nm; finally, an increase of the assumed surface albedo of 0.05 gives very small changes (0.01?0.02) in the retrieved SSA. The calculations show that the SSA of desert dust (DD) increases with wavelength, from 0.81±0.05 at 415.6 nm to 0.94±0.05 at 868.7 nm; on the contrary, the SSA of urban/industrial (UN) aerosols decreases from 0.96±0.02 at 415.6 nm to 0.87±0.07 at 868.7 nm; the SSA of biomass burning (BB) particles is 0.82±0.04 at 415.6 nm and 0.80±0.05 at 868.7 nm. Episodes of UN aerosols occur usually in June and July; BB aerosol episodes with large AOD and long duration are observed mainly in July and August, the driest months of the year, when the development of fires is favoured

Prioritising CAP intervention needs: An improved cumulative voting approach

The process to define the 2023–2027 Common Agricultural Policy (CAP) is underway. The implementation model governing the process requires each EU Member State to design a National Strategic Plan to deliver operational actions exploiting the synergies under the two pillars of the policy. Each Plan must be built from an evidence-based needs assessment that undergoes rigorous prioritisation and planning to create comprehensive, integrated, and achievable interventions. In Italy, the success of this planning process requires all interested stakeholders to generate options for the regional authorities who plan, manage, and legislate agricultural activities. This research proposes a decision-making technique, based on the cumulative voting approach, that can be used effectively when multiple persons from different backgrounds and perspectives are engaged in problem-solving and needs prioritisation. The results indicate that the model can be applied both theoretically and practically to prioritise Strategic Plan needs that involve national and regional authorities. Validation of the model allows it to be used in the next consultative processes and for expansion to socioeconomic stakeholders

Mind the gap: IR and the challenge of international politics

The discipline of International Relations (IR) for a long time of its history has developed in the form of Great Debates that involved competing paradigms and schools. More recently, it has been described as a cacophony of voices unable to communicate among themselves, but also incapable to provide keys to understand an ever more complex reality. This collection aims at evaluating the heuristic value of a selection of traditional paradigmsrealism and liberalism), schools (constructivism), and subdisciplines (security studies and international political economy) so as to assess the challenges before IR theory today and the ability of the discipline to provide tools to make the changed world still intelligible

Artichoke biorefinery: From food to advanced technological applications

A sequential extraction process has been designed for valorizing globe artichoke plant residues and waste (heads, leaves, stalks, and roots left in the field) by means of green extraction techniques according to a biorefinery approach. We investigated two cascading extractions based on microwave-assisted extractions (MAE) and green solvents (water and ethanol) that have been optimized for varying temperature, solvent and extraction time. In the first step, phenols were extracted with yields that ranged between 6.94 mg g−1 dw (in leaves) and 3.28 mg g−1 dw (in roots), and a phenols productivity of 175.74 kg Ha−1. In the second step, inulin was extracted with impressive yields (42% dw), higher than other conventional inulin sources, corresponding to an inulin productivity of 4883.58 kg Ha−1. The remaining residues were found to be valuable feedstocks both for bioenergy production and green manure (back to the field), closing the loop according to the Circular Economy paradigm

In search of knowledge: text mining dedicated to technical translation

Articolo pubblicato su CD e commercializzato direttamente dall'ASLIB (http://shop.emeraldinsight.com/product_info.htm/cPath/56_59/products_id/431). Programma del convegno su http://aslib.co.uk/conferences/tc_2011/programme.htm

Biomechanics of anterior cruciate ligament reconstruction using twisted doubled hamstring tendons

We studied the biomechanical properties of a twisted doubled semitendinosus and gracilis graft. We applied an un-axial load in order to reproduce the kinematics of a reconstructed anterior cruciate ligament (ACL). A modified cryo-jaw clamp system was used to minimize soft tissue slippage. The lower grip, after fixation of the free ends of the tendons, was rotated 45degrees, translated 1 cm, and bent 40degrees, simulating a knee sprain. The graft was tested to failure using a servohydraulic machine. The specimen from one knee of seven unembalmed cadavers was assigned to the untwisted (parallel) bundles group, while its pair was assigned to the twisted group. For the parallel bundles group, the mean maximum load was 1709.3+/-581.9 N, for the twisted group 2428.3+/-475.4 N (P<0.05). The mean stiffness was respectively 213.6+/-72.4 N/mm and 310.3+/-97.3 N/mm (P=0.08). Although caution should be used in extrapolating the results to clinical estimates of the strength of hamstring grafts, the results of the present study could justify the use of twisted semitendinosus and gracilis bundles in ACL reconstruction

Comparison of ground‐based and Total Ozone Mapping Spectrometer erythemal UV doses at the island of Lampedusa in the period 1998–2003: Role of tropospheric aerosols

The Total Ozone Mapping Spectrometer (TOMS) has the longest time series of globally distributed estimates of UV irradiance at the Earth's surface. The proper interpretation of TOMS estimated irradiances relies on well‐calibrated and well‐maintained spectrometers at the Earth's surface. In this study, daily erythemal irradiances measured by a Brewer spectrophotometer at the island of Lampedusa (35.5°N, 12.6°E), in the Mediterranean are compared with TOMS observations in the period January 1998 to August 2003. The comparison, also because of the peculiar conditions at Lampedusa, a very good site for ground‐based validation of satellite observations, allows us to recognize how the space‐borne observations are influenced by the presence of atmospheric aerosols. Two TOMS data sets, derived applying different algorithms to retrieve ozone and UV irradiance from the backscattered radiance, are used in this study: Version 7 (V7) and the recently developed version 8 (V8), which uses new climatologies for ozone and temperature profiles and accounts for the attenuation by tropospheric aerosols through the aerosol index (AI). As shown in previous studies performed with V7 TOMS data, satellite‐derived erythemal doses systematically overestimate ground‐based measurements, mainly because of uncorrected absorption by aerosols in the troposphere. The bias between the TOMS and Brewer doses for all‐sky conditions is (9.4 ± 19.8)% for V7 and (7.3 ± 20.0)% for V8 and decreases to (5.6 ± 8.0)% for V7 and (3.4 ± 8.4)% for V8 for the cloud‐free cases. The large standard deviations for all‐sky conditions are due to nonhomogeneity in the cloud cover within the sensor field of view, while those for cloud‐free days are caused by the large aerosol variability occurring at Lampedusa. The biases for cloud‐free days have been related to differences in the TOMS AI UV attenuation algorithm and to the aerosol optical depth (AOD) at 415.6 nm measured with a Sun photometer at Lampedusa since 2001. The mean bias between the V7 TOMS and Brewer doses progressively increases with AI and AOD at 415.6 nm, from ± 3% for low AI and AOD up to 21% for 1.5 ≤ AI < 2.5 and 0.5 ≤ AOD < 0.6. The bias calculated with V8 data set varies between +6% for 0 ≤ AI < 1 and about −8% for 4 ≤ AI < 5, well within the respective uncertainties of the Brewer and TOMS measurements. TOMS V8 data show a smaller dependency on the aerosol absorption, indicating that the implemented corrections produce more reliable estimated doses. For very low aerosol loading (AOD at 415.6 nm below 0.2), the TOMS‐to‐Brewer erythemal dose ratio, both for V7 and V8, is approximately 1, indicating that the radiometric calibration of the Brewer instrument is consistent with the TOMS estimated irradiances from derived ozone and Rayleigh scattering attenuation