\u27Race, Racism, and American Law \u27: A Seminar From The Indigenous, Black, And Immigrant Legal Perspectives

The events of fall 2016 exploded the myth of a post-racial America that some believed had been ushered in by Barack Obama’s presidency.1With the U.S. presidential campaign in full swing, soon-to-be President Donald Trump disparaged Muslims as terrorists, Mexicans as rapists and murderers, and African Americans as poor.2 Trump’s racist demagoguery came amidst the momentum of the Black Lives Matter,Standing Rock, and Dreamer movements—mass mobilizations that sought to end the police killings of Black people, protect Native American treaty rights, and grant immigrant minors legal status.3 Once again, the racial divide that has defined this nation since its inception 2019] RACE,RACISM,ANDAMERICANLAW 3reemerged in the national discourse with an intensity that exposed the fallacy of post-racialism.4The national anger, confusion, and vulnerability sown by that fall’s campaign reflected and reverberated in our community in Montana. They fractured our law school, our university, our state, and our city along lines of difference, not the least of which was racial.5 We would not know until November that Trump would be elected president. We would not know until after his inauguration that he would harden and intensify his racist agenda.6 But we sensed a new era had dawned, and therefore, we and our students needed to understand the undercurrents and urgencies of the moment. In response, we sought to reaffirm an anti-racist agenda and harness the ferment by finding common ground in the legal treatments of Native Americans, African Americans, and immigrants. That is how our seminar, “Race, Racism, and American Law from the Native American, African American, and Immigrant Legal Perspectives,” came to be

Antiracism, Reflection, and Professional Identity

Intent on more systematically developing the emerging professional identities of law students, the professional identity formation movement is recasting how we think about legal education. Notably, however, the movement overlooks the structural racism imbedded in American law and legal education. While current models of professional development value diversity and cross-cultural competence, they do not adequately prepare the next generation of legal professionals to engage in the sustained work of interrupting and overthrowing race and racism in the legal profession and system. This article argues that antiracism is essential to the profession’s responsibility to serve justice and therefore key to legal professional identity. Fortunately, developing a legal antiracist identity does not require inventing a new approach. Rather, infusing reflective practice with critical race consciousness provides a sound basis from which to launch a new effort to develop the next generation of antiracist lawyers

Antiracism, Reflection, and Professional Identity

Intent on more systematically developing the emerging professional identities of law students, the professional identity formation movement is recasting how we think about legal education. Notably, however, the movement overlooks the structural racism imbedded in American law and legal education. While current models of professional development value diversity and cross-cultural competence, they do not adequately prepare the next generation of legal professionals to engage in the sustained work of interrupting and overthrowing race and racism in the legal profession and system. This article argues that antiracism is essential to the profession’s responsibility to serve justice and therefore key to legal professional identity. Fortunately, developing a legal antiracist identity does not require inventing a new approach. Rather, infusing reflective practice with critical race consciousness provides a sound basis from which to launch a new effort to develop the next generation of antiracist lawyers

Spatial construction for ideational meaning: An analysis of interior design students' multimodal projects

Multimodality is an inter-disciplinary approach that considers communication to be more than just language. Multimodal studies focus mostly on the analysis of two-dimensional printed, digital, and screen production. This paper explores a multimodal pedagogic approach used to teach students to create interior design projects as three-dimensional ensembles, which we reflect upon to contribute to the framework of multimodality. This qualitative research begins with a review of multimodal discourse establishing language as a system of choice, and a relationship between spatial design and language. A case-study of students' multimodal ensembles reveals how the design choices of mode, semiotic resource, modal affordance and inter-semiosis led to students producing rich and inclusive meaning, supporting a reproductive health mandate. An interpretive semiotic framework based on Hallidayan principles of Systemic-functional linguistics is developed for spatial meaning-making analysis for future projects. The findings offer a narrative metalanguage for spatial meaning-making, contributing to broader interior design discourse

Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 Through Poly-Ubiquitination

Hedgehog (Hh) signaling regulates multiple aspects of metazoan development and tissue homeostasis, and is constitutively active in numerous cancers. We identified Ubr3, an E3 ubiquitin ligase, as a novel, positive regulator of Hh signaling in Drosophila and vertebrates. Hh signaling regulates the Ubr3-mediated poly-ubiquitination and degradation of Cos2, a central component of Hh signaling. In developing Drosophila eye discs, loss of ubr3 leads to a delayed differentiation of photoreceptors and a reduction in Hh signaling. In zebrafish, loss of Ubr3 causes a decrease in Shh signaling in the developing eyes, somites, and sensory neurons. However, not all tissues that require Hh signaling are affected in zebrafish. Mouse UBR3 poly-ubiquitinates Kif7, the mammalian homologue of Cos2. Finally, loss of UBR3 up-regulates Kif7 protein levels and decreases Hh signaling in cultured cells. In summary, our work identifies Ubr3 as a novel, evolutionarily conserved modulator of Hh signaling that boosts Hh in some tissues

HIV Continuum of Care for Youth in the United States

BACKGROUND: Beneficial HIV treatment outcomes require success at multiple steps along the HIV Continuum of Care. Youth living with HIV are a key population, and sites in the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) are known for modeling optimum HIV adolescent care. METHODS: A longitudinal cohort study conducted at 14 network sites across the United States assessed how the later steps of the Continuum of Care were achieved among the youth: engagement, treatment, and viral load (VL) suppression. Youth aged 13-24 who were behaviorally infected with HIV and linked to care at an ATN-affiliated site were eligible to participate. RESULTS: A total of 467 youth were enrolled and had 1 year of available data. Most were aged 22-24 (57%), male (79%), and black/non-Hispanic (71%). Most used alcohol (81%) and marijuana (61%) in the 3 months before enrollment, and 40% had a history of incarceration. Among this cohort of youth, 86% met criteria for care engagement; among these, 98% were prescribed antiretroviral therapy and 89% achieved VL suppression. Sustained VL suppression at all measured time points was found among 59% with initial suppression. Site characteristics were notable for the prevalence of adherence counseling (100%), case management (100%), clinic-based mental health (93%), and substance use (64%) treatment. CONCLUSIONS: Youth living with HIV in the United States can be successfully treated at health care sites with experience, excellence, and important resources and services. Sustained VL suppression may be an important step to add to the Continuum of Care for youth

Role of chronic cannabis use: Cyclic vomiting syndrome vs cannabinoid hyperemesis syndrome

Cannabis is commonly used in cyclic vomiting syndrome (CVS) due to its antiemetic and anxiolytic properties. Paradoxically, chronic cannabis use in the context of cyclic vomiting has led to the recognition of a putative new disorder called cannabinoid hyperemesis syndrome (CHS). Since its first description in 2004, numerous case series and case reports have emerged describing this phenomenon. Although not pathognomonic, a patient behavior called “compulsive hot water bathing” has been associated with CHS. There is considerable controversy about how CHS is defined. Most of the data remain heterogenous with limited follow‐up, making it difficult to ascertain whether chronic cannabis use is causal, merely a clinical association with CVS, or unmasks or triggers symptoms in patients inherently predisposed to develop CVS. This article will discuss the role of cannabis in the regulation of nausea and vomiting, specifically focusing on both CVS and CHS, in order to address controversies in this context. To this objective, we have collated and analyzed published case series and case reports on CHS in order to determine the number of reported cases that meet current Rome IV criteria for CHS. We have also identified limitations in the existing diagnostic framework and propose revised criteria to diagnose CHS. Future research in this area should improve our understanding of the role of cannabis use in cyclic vomiting and help us better understand and manage this disorder.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149684/1/nmo13606_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149684/2/nmo13606.pd

AltitudeOmics: Red Blood Cell metabolic adaptation to high altitude hypoxia

Red blood cells (RBCs) are key players in systemic oxygen transport. RBCs respond to in vitro hypoxia  through  the so-called  oxygen-dependent  metabolic  regulation,  which  involves  the competitive  binding  of  deoxyhemoglobin  and  glycolytic  enzymes  to  the  N-terminal  cytosolic domain  of  band  3.  This  mechanism  promotes  the  accumulation  of  2,3-DPG,  stabilizing  the deoxygenated state of hemoglobin, and cytosol acidification, triggering oxygen off-loading through the  Bohr  effect.  Despite  in  vitro  studies,  in  vivo adaptations  to  hypoxia  have  not  yet  been completely elucidated. Within  the  framework  of  the AltitudeOmics  study,  erythrocytes  were  collected  from  21 healthy volunteers at sea level, after exposure to high altitude (5260m) for 1, 7 and 16days, and following  reascent  after  7days  at 1525m.  UHPLC-MS  metabolomics  results  were  correlated  to physiological and athletic performance parameters. Immediate  metabolic  adaptations  were  noted as early as a few hours from ascending  to >5000m, and maintained for 16 days at high altitude.  Consistent with the mechanisms elucidated in vitro, hypoxia promoted glycolysis and deregulated the pentose phosphate pathway, as well purine catabolism, glutathione homeostasis, arginine/nitric oxide and sulphur/H2S metabolism. Metabolic adaptations were preserved one week after descent, consistently with improved physical performances in comparison to the first ascendance, suggesting a mechanism of metabolic memory

Calibration of AGILE-GRID with In-Flight Data and Monte Carlo Simulations

Context: AGILE is a gamma-ray astrophysics mission which has been in orbit since 23 April 2007 and continues to operate reliably. The gamma-ray detector, AGILE-GRID, has observed Galactic and extragalactic sources, many of which were collected in the first AGILE Catalog. Aims: We present the calibration of the AGILE-GRID using in-flight data and Monte Carlo simulations, producing Instrument Response Functions (IRFs) for the effective area A_eff), Energy Dispersion Probability (EDP), and Point Spread Function (PSF), each as a function of incident direction in instrument coordinates and energy. Methods: We performed Monte Carlo simulations at different gamma-ray energies and incident angles, including background rejection filters and Kalman filter-based gamma-ray reconstruction. Long integrations of in-flight observations of the Vela, Crab and Geminga sources in broad and narrow energy bands were used to validate and improve the accuracy of the instrument response functions. Results: The weighted average PSFs as a function of spectra correspond well to the data for all sources and energy bands. Conclusions: Changes in the interpolation of the PSF from Monte Carlo data and in the procedure for construction of the energy-weighted effective areas have improved the correspondence between predicted and observed fluxes and spectra of celestial calibration sources, reducing false positives and obviating the need for post-hoc energy-dependent scaling factors. The new IRFs have been publicly available from the Agile Science Data Centre since November 25, 2011, while the changes in the analysis software will be distributed in an upcoming release