Efeitos de um jogo de futebol sobre marcadores fisiológicos, bioquímicos e de performance

Inclui apendicesOrientador : Raul OsieckiDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Biológicas, Programa de Pós-Graduação em Educação Física. Defesa: Curitiba, 31/03/2009Inclui bibliografiaÁrea de concentração: Exercício e esport

The role of the nurse in the neonatal intensive care unit: between the ideal, the real and the possible

The nurse is one of the professionals responsible for the care directed toward the physical, mental and social development of newborns in the Neonatal Intensive Care Unit. This study aimed to comprehend the experience of nurses working in a Neonatal Intensive Care Unit. Data collection was performed in 2008, through interviews with 12 nurses working in public and private hospitals of the city of São Paulo. The units of meaning identified were grouped into three categories: Developing actions; Perceiving their actions and Expectations. The analysis was based on social phenomenology. It was concluded that the overload of activities, the reduced number of staff, the lack of materials, equipment and the need for professional improvement are the reality of the work of the nurse in this sector. To supervise the care is the possible; integral care of the newborn, involving the parents, is the ideal desired.El enfermero es uno de los profesionales responsables por el cuidado dirigido al desarrollo físico, psíquico y social del recién nacido en la Unidad de Terapia Intensiva Neonatal. Este trabajo objetivó comprender la experiencia de enfermeras que actúan en una Unidad de Terapia Intensiva Neonatal. La recolección de datos fue realizada en 2.008, por medio de entrevistas con 12 enfermeras que actuaban en hospitales públicos y privados de la ciudad de Sao Paulo. Las unidades de significado identificadas fueron agrupadas en tres categorías: Desarrollando acciones, Percibiendo sus acciones y Expectativas. El análisis fue fundamentado en la fenomenología social. Se concluye que la sobrecarga de actividades, el reducido número de personal, la falta de materiales, equipamientos y la necesidad de perfeccionamiento profesional son la realidad del trabajo de la enfermera en ese sector. Supervisar los cuidados, es posible; cuidar integralmente del recién nacido, envolviendo sus padres, es el ideal deseado.O enfermeiro é um dos profissionais responsáveis pelo cuidado voltado ao desenvolvimento físico, psíquico e social do recém-nascido na unidade de terapia intensiva neonatal. Este trabalho objetivou compreender a experiência de enfermeiras que atuam em uma unidade de terapia intensiva neonatal. A coleta de dados foi realizada em 2008, por meio de entrevistas com 12 enfermeiras que atuavam em hospitais públicos e privados da cidade de São Paulo. As unidades de significado identificadas foram agrupadas em três categorias: desenvolvendo ações, percebendo suas ações e expectativas. A análise foi fundamentada na fenomenologia social. Conclui-se que a sobrecarga de atividades, o reduzido número de pessoal, a falta de materiais, equipamentos e a necessidade de aprimoramento profissional são a realidade do trabalho da enfermeira nesse setor. Supervisionar os cuidados é o possível; cuidar integralmente do recém-nascido, envolvendo seus pais, é o ideal almejado

Small intestine histomorphometry of beef cattle with divergent feed efficiency

BACKGROUND: The provision of feed is a major cost in beef production. Therefore, the improvement of feed efficiency is warranted. The direct assessment of feed efficiency has limitations and alternatives are needed. Small intestine micro-architecture is associated with function and may be related to feed efficiency. The objective was to verify the potential histomorphological differences in the small intestine of animals with divergent feed efficiency. METHODS: From a population of 45 feedlot steers, 12 were selected with low-RFI (superior feed efficiency) and 12 with high-RFI (inferior feed efficiency) at the end of the finishing period. The animals were processed at 13.79 ± 1.21 months of age. Within 1.5 h of slaughter the gastrointestinal tract was collected and segments from duodenum and ileum were harvested. Tissue fragments were processed, sectioned and stained with hematoxylin and eosin. Photomicroscopy images were taken under 1000x magnification. For each animal 100 intestinal crypts were imaged, in a cross section view, from each of the two intestinal segments. Images were analyzed using the software ImageJ®. The measurements taken were: crypt area, crypt perimeter, crypt lumen area, nuclei number and the cell size was indirectly calculated. Data were analyzed using general linear model and correlation procedures of SAS®. RESULTS: Efficient beef steers (low-RFI) have a greater cellularity (indicated by nuclei number) in the small intestinal crypts, both in duodenum and ileum, than less efficient beef steers (high-RFI) (P < 0.05). The mean values for the nuclei number of the low-RFI and high-RFI groups were 33.16 and 30.30 in the duodenum and 37.21 and 33.65 in the ileum, respectively. The average size of the cells did not differ between feed efficiency groups in both segments (P ≥ 0.10). A trend was observed (P ≤ 0.10) for greater crypt area and crypt perimeter in the ileum for cattle with improved feed efficiency. CONCLUSION: Improved feed efficiency is associated with greater cellularity and no differences on average cell size in the crypts of the small intestine in the bovine. These observations are likely to lead to an increase in the energy demand by the small intestine regardless of the more desirable feed efficiency

Actuación de la enfermera en la unidad de terapia intensiva neonatal: entre lo ideal, lo real y lo posible

The nurse is one of the professionals responsible for the care directed toward the physical, mental and social development of newborns in the Neonatal Intensive Care Unit. This study aimed to comprehend the experience of nurses working in a Neonatal Intensive Care Unit. Data collection was performed in 2008, through interviews with 12 nurses working in public and private hospitals of the city of São Paulo. The units of meaning identified were grouped into three categories: Developing actions; Perceiving their actions and Expectations. The analysis was based on social phenomenology. It was concluded that the overload of activities, the reduced number of staff, the lack of materials, equipment and the need for professional improvement are the reality of the work of the nurse in this sector. To supervise the care is the possible; integral care of the newborn, involving the parents, is the ideal desired.O enfermeiro é um dos profissionais responsáveis pelo cuidado voltado ao desenvolvimento físico, psíquico e social do recém-nascido na unidade de terapia intensiva neonatal. Este trabalho objetivou compreender a experiência de enfermeiras que atuam em uma unidade de terapia intensiva neonatal. A coleta de dados foi realizada em 2008, por meio de entrevistas com 12 enfermeiras que atuavam em hospitais públicos e privados da cidade de São Paulo. As unidades de significado identificadas foram agrupadas em três categorias: desenvolvendo ações, percebendo suas ações e expectativas. A análise foi fundamentada na fenomenologia social. Conclui-se que a sobrecarga de atividades, o reduzido número de pessoal, a falta de materiais, equipamentos e a necessidade de aprimoramento profissional são a realidade do trabalho da enfermeira nesse setor. Supervisionar os cuidados é o possível; cuidar integralmente do recém-nascido, envolvendo seus pais, é o ideal almejado.El enfermero es uno de los profesionales responsables por el cuidado dirigido al desarrollo físico, psíquico y social del recién nacido en la Unidad de Terapia Intensiva Neonatal. Este trabajo objetivó comprender la experiencia de enfermeras que actúan en una Unidad de Terapia Intensiva Neonatal. La recolección de datos fue realizada en 2.008, por medio de entrevistas con 12 enfermeras que actuaban en hospitales públicos y privados de la ciudad de Sao Paulo. Las unidades de significado identificadas fueron agrupadas en tres categorías: Desarrollando acciones, Percibiendo sus acciones y Expectativas. El análisis fue fundamentado en la fenomenología social. Se concluye que la sobrecarga de actividades, el reducido número de personal, la falta de materiales, equipamientos y la necesidad de perfeccionamiento profesional son la realidad del trabajo de la enfermera en ese sector. Supervisar los cuidados, es posible; cuidar integralmente del recién nacido, envolviendo sus padres, es el ideal deseado

Alterations In Ubiquitin Ligase Siah-2 And Its Corepressor N-cor After P-mapa Immunotherapy And Anti-androgen Therapy: New Therapeutic Opportunities For Non-muscle Invasive Bladder Cancer

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)The present study describes the role of the ubiquitin ligase Siah-2 and corepressor N-CoR in controlling androgen receptor (AR) and estrogen receptors (ERa and ER beta) signaling in an appropriate animal model (Fischer 344 female rats) of non-muscle invasive bladder cancer (NMIBC), especially under conditions of anti-androgen therapy with flutamide. Furthermore, this study describes the mechanisms of a promising therapeutic alternative for NMIBC based on Protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride (P-MAPA) intravesical immunotherapy combined with flutamide, involving the interaction among steroid hormone receptors, their regulators and Toll-like receptors (TLRs). Our results demonstrated that increased Siah-2 and AR protein levels and decreased N-CoR, cytochrome P450 (CYP450) and estrogen receptors levels played a critical role in the urothelial carcinogenesis, probably leading to escape of urothelial cancer cells from immune system attack. P-MAPA immunotherapy led to distinct activation of innate immune system TLRs 2 and 4-mediated, resulting in increase of interferon signaling pathway, which was more effective in recovering the immunosuppressive tumor immune microenvironment and in recovering the bladder histology features than BCG (Bacillus Calmette-Guerin) treatments. The AR blockade therapy was important in the modulating of downstream molecules of TLR2 and TLR4 signaling pathway, decreasing the inflammatory cytokines signaling and enhancing the interferon signaling pathway when associated with P-MAPA. Taken together, the data obtained suggest that interferon signaling pathway activation and targeting AR and Siah-2 signals by P-MAPA intravesical immunotherapy alone and/or in combination with AR blockade may provide novel therapeutic approaches for NMIBC.8544274443Farmabrasilis-BrazilConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)CNPq [490519/2011-3]FAPESP [2012/20706-2, 2012/13585-4

The Role of the Nurse in the Neonatal Intensive Care Unit: Between the Ideal, the Real and the Possible

The nurse is one of the professionals responsible for the care directed toward the physical, mental and social development of newborns in the Neonatal Intensive Care Unit. This study aimed to comprehend the experience of nurses working in a Neonatal Intensive Care Unit. Data collection was performed in 2008, through interviews with 12 nurses working in public and private hospitals of the city of Sao Paulo. The units of meaning identified were grouped into three categories: Developing actions; Perceiving their actions and Expectations. The analysis was based on social phenomenology. It was concluded that the overload of activities, the reduced number of staff, the lack of materials, equipment and the need for professional improvement are the reality of the work of the nurse in this sector. To supervise the care is the possible; integral care of the newborn, involving the parents, is the ideal desired.19230130

Uma experiência de ensino-aprendizagem de áreas de figuras planas através da resolução de problemas

O objetivo deste artigo foi analisar as contribuições da metodologia de ensino-aprendizagem-avaliação através da resolução de problemas ao trabalhar em sala de aula o conteúdo de áreas de figuras. Foram participantes da pesquisa, cuja abordagem foi qualitativa, 20 alunos do ensino fundamental de uma escola pública da região norte do paraná. Os resultados indicam que, mesmo diante das dificuldades, os alunos utilizaram conhecimentos prévios ao resolver o problema, mas que a estratégia tentativa e erro prevaleceu entre os grupos. Também não houve por parte dos alunos questionamentos que pudessem possibilitar a extensão do problema, o que revela que a prática de resolução de problemas em sala de aula deve ser intensificada. De todo modo, a resolução do problema analisado nesta pesquisa proporcionou aos alunos opinarem, debaterem e chegarem a um consenso, tendo o professor como mediador do processo de ensino-aprendizagem

Alterations In Ubiquitin Ligase Siah-2 And Its Corepressor N-cor After P-mapa Immunotherapy And Anti-androgen Therapy: New Therapeutic Opportunities For Non-muscle Invasive Bladder Cancer.

The present study describes the role of the ubiquitin ligase Siah-2 and corepressor N-CoR in controlling androgen receptor (AR) and estrogen receptors (ERα and ERβ) signaling in an appropriate animal model (Fischer 344 female rats) of non-muscle invasive bladder cancer (NMIBC), especially under conditions of anti-androgen therapy with flutamide. Furthermore, this study describes the mechanisms of a promising therapeutic alternative for NMIBC based on Protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride (P-MAPA) intravesical immunotherapy combined with flutamide, involving the interaction among steroid hormone receptors, their regulators and Toll-like receptors (TLRs). Our results demonstrated that increased Siah-2 and AR protein levels and decreased N-CoR, cytochrome P450 (CYP450) and estrogen receptors levels played a critical role in the urothelial carcinogenesis, probably leading to escape of urothelial cancer cells from immune system attack. P-MAPA immunotherapy led to distinct activation of innate immune system TLRs 2 and 4-mediated, resulting in increase of interferon signaling pathway, which was more effective in recovering the immunosuppressive tumor immune microenvironment and in recovering the bladder histology features than BCG (Bacillus Calmette-Guerin) treatments. The AR blockade therapy was important in the modulating of downstream molecules of TLR2 and TLR4 signaling pathway, decreasing the inflammatory cytokines signaling and enhancing the interferon signaling pathway when associated with P-MAPA. Taken together, the data obtained suggest that interferon signaling pathway activation and targeting AR and Siah-2 signals by P-MAPA intravesical immunotherapy alone and/ or in combination with AR blockade may provide novel therapeutic approaches for NMIBC.84427-444

Alterations in ubiquitin ligase SIAH-2 and its corepressor N-COR after P-mapa immunotherapy and anti-androgen therapy: new therapeutic opportunities for non-muscle invasive bladder cancer

The present study describes the role of the ubiquitin ligase Siah-2 and corepressor N-CoR in controlling androgen receptor (AR) and estrogen receptors (ERa and ER beta) signaling in an appropriate animal model (Fischer 344 female rats) of non-muscle invasive bladder cancer (NMIBC), especially under conditions of anti-androgen therapy with flutamide. Furthermore, this study describes the mechanisms of a promising therapeutic alternative for NMIBC based on Protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride (P-MAPA) intravesical immunotherapy combined with flutamide, involving the interaction among steroid hormone receptors, their regulators and Toll-like receptors (TLRs). Our results demonstrated that increased Siah-2 and AR protein levels and decreased N-CoR, cytochrome P450 (CYP450) and estrogen receptors levels played a critical role in the urothelial carcinogenesis, probably leading to escape of urothelial cancer cells from immune system attack. P-MAPA immunotherapy led to distinct activation of innate immune system TLRs 2 and 4-mediated, resulting in increase of interferon signaling pathway, which was more effective in recovering the immunosuppressive tumor immune microenvironment and in recovering the bladder histology features than BCG (Bacillus Calmette-Guerin) treatments. The AR blockade therapy was important in the modulating of downstream molecules of TLR2 and TLR4 signaling pathway, decreasing the inflammatory cytokines signaling and enhancing the interferon signaling pathway when associated with P-MAPA. Taken together, the data obtained suggest that interferon signaling pathway activation and targeting AR and Siah-2 signals by P-MAPA intravesical immunotherapy alone and/or in combination with AR blockade may provide novel therapeutic approaches for NMIBC8544274443CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP490519/2011-32012/20706-2; 2012/13585-

MASTECTOMIA BILATERAL COM USO DE PICO™ SOFTPORT – SISTEMA DE TERAPIA DE PRESSÃO NEGATIVA DE FERIDAS

Currently, the main form of malignancy among women is breast cancer. With the advent of radiotherapy, conservative breast surgery (lumpectomy) has become a possible technique. However, radical mastectomy still maintains its indications in the face of a more advanced pathology or in patients with deleterious BRCA 1 / BRCA 2 mutations. Unfortunately, complications of the surgical wound exist. Faced with this problem, PICO ™ Softpor - Negative pressure wound therapy system, is a unique device that has been used in the negative pressure wound therapy system to improve wound healing, this includes improved perfusion, removal of excess fluid and edema leading to less tension in the surgical wound. The study aimed to report the experience of using the Wound Negative Pressure Therapy System through PICO ™ Softport in the surgical treatment of breast cancer through a case report. Patient M. R. V., female, 57 years old, G2P2A0, asymptomatic with a diagnosis of T4BN0M0 in the right breast and T1N0M0 in the left breast was submitted to bilateral modified radical mastectomy. We used bilateral dressings with the Wound Negative Pressure Therapy System in the form of PICO ™ Softport, which made it possible to reduce the incision healing complications. After surgical recovery, the patient underwent adjuvant radiotherapy, presenting himself until the moment of this stable report using anastrozole, being completely satisfied with the dermal healing result that the device provided.Atualmente, a principal forma de neoplasia maligna entre as mulheres é o câncer de mama. Com o advento da radioterapia, a cirurgia conservadora da mama (quadrantectomia) tornou-se uma técnica possível. Todavia, a mastectomia radical ainda mantém suas indicações frente a uma patologia mais avançada ou em pacientes portadoras de mutações deletérias dos BRCA 1/BRCA 2. Infelizmente, as complicações da ferida operatória existem. Frente a este problema, o PICO™ Softpor – Sistema de terapia de pressão negativa de feridas, é um dispositivo único que vem sendo usado no sistema de terapia de feridas com pressão negativa&nbsp; para melhorar a cicatrização de feridas, isso inclui a perfusão aprimorada, a remoção de excesso de líquido e edema levando a menor tensão na ferida operatória. O estudo objetivou relatar a experiência do uso do Sistema de Terapia de Pressão Negativa de Feridas através do PICO™ Softport no tratamento cirúrgico de câncer de mama através de um relato de caso. Paciente M. R. V., sexo feminino, 57 anos, G2P2A0, assintomática com diagnóstico de T4BN0M0 em mama direita e T1N0M0 em mama esquerda foi submetida à mastectomia radical modificada bilateral. Utilizamos curativo bilateral com o Sistema de Terapia de Pressão Negativa de Feridas na forma de PICO™ Softport, o que possibilitou a redução nas complicações de cicatrização da incisão. Após a recuperação cirúrgica, paciente passou por radioterapia adjuvante, apresentando-se até o momento deste relato estável em uso de anastrozol, encontrando-se totalmente satisfeita com o resultado cicatricial dérmico que o dispositivo proporcionou