Entry Strategy for Radical Product Innovations: A Conceptual Model and Propositional Inventory

“Takeoff” is a prerequisite for new product success. The central concern of this paper is how firms can reduce “takeoff time” for radical innovations. We propose a set of entry strategies and examine their effectiveness in stimulating initial demand and accelerating time-to-takeoff by considering the moderating impact of technological, competitive and firm-specific factors. The intended contributions are: (1) to enrich the literature on entry strategy by developing a propositional framework from a strategy perspective; (2) to provide managerial guidelines for achieving more rapid takeoff; and (3) to suggest an agenda for research on takeoff strategies

Variações do exercício agachamento e seus efeitos nas variáveis musculares a articulares : uma revisão

Orientador : Prof. MS Ragami Chaves Alves.Monografia (especialização) - Universidade Federal do Paraná, Setor de Ciências Biológicas, Curso de Especialização em Treinamento de Força e HipertrofiaInclui referênciasResumo : O exercício de agachamento vem ganhando popularidade entre as diversas manifestações do treinamento físico, e pelo fato de ser amplamente utilizado em diferentes áreas e com diferentes objetivos, existem diferentes formas de execução e diferentes técnicas, havendo muitas vezes variações. Os efeitos causados por estas variações no sistema muscular e na estrutura óssea e articular ainda são pouco estabelecidos e elucidados. Neste estudo o objetivo foi o de realizar uma revisão de literatura sobre os diferentes tipos de execução e variações do exercício agachamento e os seus diferentes efeitos causados nas variáveis musculares (musculatura envolvida) e articulares (força de cisalhamento, forças compressivas tibiofemorais e patelofemorais). Para isso foram utilizados busca de artigos científicos nas bases de dados PubMed, HIGWIRE, SciELO e LILACS com as palavras chaves "agachamento", "biomecânica", "eletromiografia", "cinética" e "cinemática". Através desta revisão verificou-se que, em geral, a atividade muscular aumenta à medida que os joelhos são flexionados no agachamento e diminui quando são estendidos. Ainda, o aumento da largura dos membros inferiores e aumento de rotação do quadril aumenta a ativação dos adutores e do glúteo máximo. Baixas a moderadas forças de cisalhamento posteriores são geradas ao longo do agachamento, contidas, principalmente pelo PCL (ligamento cruzado posterior). Além disso, existem baixas forças de cisalhamento anterior entre 0 e 60° de flexão do joelho, contidas principalmente pelo ACL (ligamento cruzado anterior). Verificou-se que as forças de compressão patelofemorais, tibiofemorais e de cisalhamento sempre aumentam quanto mais os joelhos são flexionados e diminuem com os joelhos estendidos

Perícias trabalhistas, a visão do assistente técnico

Orientador : João Carlos do Amaral LozoveyMonografia (especialização) - Universidade Federal do Paraná, Setor de ..., Curso de Especialização em ...Inclui referênciasResumo : Trata-se de pesquisa descritiva, quantitativa, e qualitativa, que utilizou banco de dados de arquivo particular da autora e pesquisa de material bibliográfico. Foram analisadas pericias no período de janeiro de 2014 a dezembro de 2015, onde não houve critério de exclusão. Analisou-se as doenças mais frequentes, e as divergências entre o alegado na Inicial e os encontrados nas perícias, as doenças com maior índice de incapacidade, o reflexo no exercício da atividade do médico perito, com suas bases legais. Os resultados apontam para doenças degenerativas, como as mais frequentes, elevado índice de divergência entre as doenças alegadas e as confirmadas, e as maiores causas de afastamento do trabalho a síndrome de impacto do ombro

Brand e social media: alla ricerca degli strumenti più efficaci nella caccia all’engagement

Quale strategia funziona meglio nel portare i fan ad agire a favore del brand e a diffondere un post? La ricerca condotta dalle autrici consente di fornire una risposta a questi quesiti e capire cosa influenza la probabilità che un fan condivida un messaggio di un brand

Reflecting on the reasons pros and cons coercive measures for patients in psychiatric and somatic care: The role of clinical ethics consultation. A pilot study

Background and aim: Coercive measures in patient care have come under criticism leading to implement guidelines dedicated to the reduction of coercion. This development of bringing to light clinical ethics support is hoped to serve as a means of building up awareness and potentially reducing the use of coercion. This study explores the specific features of ethics consultation (EC) while dealing with coercion. Material and method: Basel EC documentation presents insight to all persons involved with a case. The EC database of two Basel university hospitals was developed on the grounds of systematic screening and categorization by two reviewers. One hundred fully documented EC cases databased from 2013 to 2016 were screened for the discussion of coercive measures (somatic hospital and psychiatry: 50% cases). Results: Twenty-four out of 100 EC cases addressed coercion in relation to a clinically relevant question, such as compulsory treatment (70.8%), involuntary committal (50%), or restricting liberty (16.6%). Only 58.3% of EC requests mentioned coercion as an ethical issue prior to the meeting. In no case was patient decisional capacity given, capacity was impaired (43.5%), not given (33.3%), or unclear (21.7%; one not available). Discussion: As clinical staff appears sensitive to perceiving ethical uncertainty or conflict, but less prepared to articulate ethical concern, EC meetings serve to "diagnose" and "solve" the ethical focus of the problem(s) presented in EC. Patient decisional incapacity proved to be an important part of reasoning, when discussing the principle of harm prevention. While professional judgment of capacity remains unsystematic, rationality or even ethicality of decision making will be hampered. The documented EC cases show a variety of decisions about whether or not coercion was actually applied. Ethical reasoning on the competing options seemed to be instrumental for an unprejudiced decision complying with the normative framework and for building a robust consensus. Conclusions: The recommendation is whether EC should be used as a standard practice whenever coercion is an issue-ideally before coercion is applied, or otherwise. Moreover, more efforts should be made toward early and professional assessment of patient capacity and advance care counseling including the offer of advance directives

The prediction of hypertensive disorders by maternal hemodynamic assessment in the first trimester of pregnancy

Background: Hypertensive disorders of pregnancy and fetal growth restriction share common etiopathological origins and could be caused by maternal hemodynamic maladaptation to pregnancy. Objective: The aim of our study is to evaluate if there is a correlation between maternal hemodynamic detected by UltraSonic Cardiac Output Monitor (USCOM®) during the first trimester and the pregnancy outcome. Study design: We recruited a nonconsecutive series of women in the first trimester of pregnancy with no previous history of hypertensive disorders. We measured the pulsatility index uterine arteries and performed a hemodynamic evaluation by USCOM® device. After delivery, we reported the development of hypertensive disorders or intrauterine fetal growth restriction later during gestation. Results: A total of 187 women were enrolled during the first trimester; 17 (9%) developed gestational hypertension or preeclampsia while 11 (6%) delivered a restricted growth fetus. Mean uterine artery pulsatility index above the 95th percentile was significantly more frequent in both women who developed hypertension and those with fetal growth restriction compared to controls. Hemodynamic parameters (reduced cardiac output and increased total vascular resistance) were significantly different in the group that developed hypertensive disorders, compared to uncomplicated pregnancy. ROC curves demonstrated the usefulness of uterine artery pulsatility index in the prediction of fetal growth restriction, while hemodynamic parameters were significantly associated to the development of hypertensive disorders. Conclusions: Hemodynamic maladaptation to pregnancy may predispose to the development of hypertension, while we demonstrated a significative relationship between growth restriction and mean uterine pulsatility index. Further studies are needed to assess the value of hemodynamics evaluation in screening protocols of preeclampsia

Identification of Fetuses at Increased Risk of Trisomies in the First Trimester Using Axial Planes

Introduction: The measurement of nuchal translucency (NT) is crucial for assessing risk of aneuploidies in the first trimester. We investigate the ability of NT assessed by a transverse view of the fetal head to detect fetuses at increased risk of common aneuploidies at 11–13 weeks of gestation. Methods: We enrolled a nonconsecutive series of women who attended our outpatient clinic from January 2020 to April 2021 for aneuploidy screening by means of a first trimester combined test. All women were examined by operators certified by the Fetal Medicine Foundation. In each patient, NT measurements were obtained both from the median sagittal view and transverse view. We calculated the risk of aneuploidy using NT measurements obtained both with sagittal and axial scans, and then we compared the results. Results: A total of 1,023 women were enrolled. An excellent correlation was found between sagittal and transverse NT measurements. The sensitivity and specificity of the axial scan to identify fetuses that were deemed at risk of trisomy 21 using standard sagittal scans were 40/40 = 100.0% (95% confidence interval [CI]: 91.2–100.0) and 977/ 983 = 99.4% (95% CI: 98.7–99.7), respectively. The sensitivity and specificity of the axial scan to identify fetuses at risk of trisomy 13 or 18 were 16/16 = 100.0% (95% CI: 80.6–100.0) and 1,005/1,007 = 99.8% (95% CI: 99.3–99.9). Conclusions: When the sonogram, a part of combined test screening, is performed by an expert sonologist, axial views can reliably identify fetuses at increased risk of trisomies without an increase in false negative results