19 research outputs found
Incorporation of chitosan into a universal adhesive system: Physicochemical characteristics, gelatinolytic activity, bond strength and interface micromorphology analyses
IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease
Secondary structure reshuffling modulates glycosyltransferase function at the membrane
International audienceSecondary structure refolding is a key event in biology as it modulates the conformation of many proteins in the cell, generating functional or aberrant states. The crystal structures of mannosyltransferase PimA reveal an exceptional flexibility of the protein along the catalytic cycle, including β-strand-to-α-helix and α-helix-to-β-strand transitions. These structural changes modulate catalysis and are promoted by interactions of the protein with anionic phospholipids in the membrane