El estigma y la interaccion social de niños en edad escola

La tesis titulada “el estigma y la interacción social de niños en edad escolar”, es una investigación que se realizó con un grupo niños afro de estudiantes del colegio el Mundo De Dani del municipio de Buenaventura , comprendidos en edades de 6-8 años, de estrato 1 y 2 de la zona continental de Buenaventura, que presentan dificultades en su interacción a causa del estigma, que tiene como objetivo Analizar la incidencia que tiene la estigmatización en el comportamiento de los estudiantes del grado segundo del colegio el Mundo de Dani del municipio de Buenaventura, esta investigación cualitativa, es abordada desde la teoría de interaccionismo simbólico y estigma, que tiene como objetivo analizar que la estigmatización es un factor que incide en el comportamiento de los estudiantes, en el que juega un papel muy importante la teoría que lo sustenta como lo es el interaccionismo simbólico Mead, Blúmer, Goffman y la teoría de la identidad social e identidad personal y estigma de Goffman. El estigma y la interacción social de niños en edad escolar Universidad Nacional Abierta y a Distancia El desarrollo de la tesis muestra una nueva opción investigativa para la psicología, en el que combina varias teorías quienes conforman los capítulos de la tesis y se relacionen entre sí para estudiar y explicar, la incidencia del estigma en la interacción del grupo de niños investigados y todos los componentes que influyen en el desarrollo social y personal del ser.The thesis entitled " stigma and social interaction of children of school age ," is a study that was conducted with a group of African children college students Dani the World From the municipality of Buenaventura , included in ages 6-8 , stratum 1 and 2 of the mainland of Buenaventura , who have difficulties in their interaction because of the stigma , which aims to analyze the impact of stigma on the behavior of second grade students of the school 's World 's Dani municipality of Buenaventura , this qualitative research is approached from symbolic interaction theory and stigma , which aims to analyze that stigma is a factor in the behavior of students , which plays a very important theory it supports such as symbolic interactionism Mead, Blumer , Goffman and social identity theory and personal identity and Goffman's stigma . The development of the thesis shows a new option for psychology research , which combines several theories who make up the chapters of the thesis and relate to each other to study and explain the impact of stigma on the interaction of the group of children investigated and all components that influence social and personal development of self

A EDUCAÇÃO AMBIENTAL NA ESCOLA PEDAGÓGICA EXPERIMENTAL: UMA VERSÃO PEDAGÓGICA DA ECONOMIA AZUL

The proposal of the Experimental Pedagogical School (eps) in the environmental field revisits several ideas of Gunter Pauli (2011), exposed in his book The Blue Economy. There are some similarities between the two proposals; they highlight the need to transform the traditional view of education (focused on contents so far), on the one hand, and to seek solutions to local problems, on the other. The objectives are: a) to transform the vicious circle that currently feeds the environmental crisis, b) to question the principles of the economy based on market transactions as a closed system, c) to go beyond the development of environmental actions linked to the production of biodegradable elements, and d) to build sustainable action frameworks based on our knowledge of natural systems, as well as on the dialogue between knowledges. In that sense, the commitment is to the formation of citizens who are responsible with the environment andare not mere consumers of it; for this effect, a profound transformation of the educational system is necessary, one which would value not only the need to think about the problems of context, but also the importance of educating citizens who question the processes of cultural and biological homogenization that prevail today. This article offers reflections and describes the experience of the eps, from the time it revisited the ideas of the blue economy to enrich its proposal and to consolidate nine environmental projects (through the teaching strategy of ata), which have resulted from the study of real problems present in the daily life of the school community.La propuesta de la Escuela Pedagógica Experimental (epe) en el ámbito de lo ambiental retoma varios planteamientos de Gunter Pauli (2011), expuestos en su libro Economía azul. Existen algunas coincidencias entre las dos propuestas; se plantea por un lado la necesidad de transformar la visión tradicional de la enseñanza (hasta ahora, centrada en los contenidos) y por otro, buscar soluciones a problemas locales. Hay razones para esto: a) transformar el círculo vicioso que actualmente alimenta la crisis ambiental, b) cuestionar los principios de la economía basados en transacciones del mercado como sistema cerrado, c) ir más allá de la construcción de acciones ambientales ligadas ala producción de elementos biodegradables, y d) construir ejes de acción sostenibles fundamentadostanto en los conocimientos que se tienen sobre los sistemas naturales, como en el diálogo de saberes.En estos términos, el compromiso es con la formación de ciudadanos responsables con el ambiente, y no simples consumidores de este; para lo cual, es pertinente una transformación profunda del sistema educativo que valore no solo la necesidad de pensar en los problemas del contexto, sino también, la importancia de formar a ciudadanos que cuestionen los procesos de homogenizacióncultural y biológica imperantes en la actualidad.A proposta da Escola Pedagógica Experimental (epe) no âmbito ambiental retoma várias abordagens deGunter Pauli (2011), presentes no seu livro Economia azul. Existem algumas coincidências entre essas duaspropostas. Por um lado, se coloca a necessidade de transformar a visão tradicional do ensino (até agora,centrada nos conteúdos) e por outro, procurar soluções para os problemas locais. Existem razões para isso:a) transformar o círculo vicioso que, na atualidade, aumenta a crise ambiental, b) questionar os princípiosda economia baseados em transações do mercado como sistema fechado, c) ir além da construção de açõesambientais ligadas à produção de elementos biodegradáveis, e d) construir eixos de ação sustentáveis fundamentadostanto nos conhecimentos sobre os sistemas naturais, quanto no diálogo de saberes.Nesses termos, existe um compromisso com a formação de cidadãos ambientalmente responsáveis, e não sóconsumidores dele; por isso, é pertinente uma transformação profunda do sistema educativo que valorizenão só a necessidade de pensar nos problemas do contexto, mas também a importância de formar cidadãosque questionam os processos de homogeneização cultural e biológica, imperantes na atualidade.O presente artigo compartilha as reflexões e descreve a experiência da epe, desde o momento em que retomaas abordagens da economia azul, para enriquecer sua proposta e consolidar nove projetos ambientais (atravésda estratégia pedagógica atas), que resultaram do estudo de problemas genuínos presentes no dia-a-dia dacomunidade escolar

Somatic SNCA Copy Number Variants in Multiple System Atrophy Are Related to Pathology and Inclusions

BACKGROUND: Somatic α-synuclein (SNCA) copy number variants (CNVs, specifically gains) occur in multiple system atrophy (MSA) and Parkinson's disease brains. OBJECTIVE: The aim was to compare somatic SNCA CNVs in MSA subtypes (striatonigral degeneration [SND] and olivopontocerebellar atrophy [OPCA]) and correlate with inclusions. METHODS: We combined fluorescent in situ hybridization with immunofluorescence for α-synuclein and in some cases oligodendrocyte marker tubulin polymerization promoting protein (TPPP). RESULTS: We analyzed one to three brain regions from 24 MSA cases (13 SND, 11 OPCA). In a region preferentially affected in one subtype (putamen in SND, cerebellum in OPCA), mosaicism was higher in that subtype, and cells with CNVs were 4.2 times more likely to have inclusions. In the substantia nigra, nonpigmented cells with CNVs and TPPP were about six times more likely to have inclusions. CONCLUSIONS: The correlation between SNCA CNVs and pathology (at a regional level) and inclusions (at a single-cell level) suggests a role for somatic SNCA CNVs in MSA pathogenesis. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

A Review on Tradescantia: Phytochemical Constituents, Biological Activities and Health-Promoting Effects

Tradescantia is a genus of herbaceous and perennial plants belonging to the Commelinaceae family and organized into three infrageneric classifications and 12 sections. More than 80 species within the genus have been used for centuries for medicinal purposes. Phytochemical compounds (from various species of the genus) such as coumarins, alkaloids, saponins, flavonoids, phenolics, tannins, steroids and terpenoids have recently been characterized and described with antioxidant, cytotoxic, anti-inflammatory, anticancer or antimicrobial properties. The objective of this review is to describe the different aspects of the genus Tradescantia, including its botanical characteristics, traditional uses, phytochemical composition, biological activities, and safety aspects

Sistema de información para el hospedaje Mar Azul

Este trabajo se basa en una necesidad de la empresa Mar Azul la cual ofrece un servicio de hospedaje en Villavicencio, actualmente está muy bien ubicada y les surgió la necesidad de posicionarse en la red, ya que en la actualidad la tecnología ha avanzado mucho y son muchas las personas que aceden al internet diariamente de esta manera se opta por aprovechar los recursos tecnológicos dando a conocer los servicios que ofrece el hospedaje. En este proyecto se realizó un análisis detallado de los principales requerimientos de la empresa, se elaboró el proyecto utilizando la metodología xp ya que promueve el trabajo en equipo, se basa en una retroalimentación continua entre el cliente y el equipo de desarrollo .de esta manera se mejoró la productividad del proyecto

Diseño de un plan de mejora de cultura organizacional para la Empresa Punto Sabroso ubicada en la ciudad de Cali Valle del Cauca en el segundo semestre de 2021

Este proyecto de grado busca identificar el tipo de cultura organizacional presente en la empresa seleccionada, con el fin de diseñar un plan de mejora para definir los parámetros que los directivos de la organización pueden considerar aplicar para gestionar aquellos elementos sociales, personales y laborales que requieren ser atendidos a nivel organizacional, que permitan suplir las necesidades que constituyen bienestar y satisfacción laboral en los empleados, y que representan resultados productivos y por consiguiente resultados económicos para la empresa. Por tal razón, se plantea conocer las principales debilidades que presenta la empresa en relación a la cultura organizacional, para conocer si el personal se encuentra satisfecho o no con diferentes aspectos que enmarcan la clase de cultura que se ha establecido como son: el clima laboral, el sistema de incentivos, programa de capacitación, efectividad de la comunicación, liderazgo, trabajo en equipo, reconocimientos, plan carrera, entre otros. Para ello, se plantea un análisis de carácter cualitativo-cuantitativo en el que se llevó a cabo una encuesta en la que participaron 30 empleados de la empresa Punto Sabroso, de los cuales 20 son mujeres y 10 son hombres. De acuerdo a los parámetros evaluados, los resultados nos muestran una insatisfacción general de la cultura organizacional adaptada por la empresa en cada una de las categorías en las que se dividió la encuesta, lo que corresponde al 27.6% en compromiso y apoyo, ambiente laboral con un 23% y reconocimiento en un 20.5% de insatisfacción. De igual modo, se identifica que únicamente un promedio de 6 personas de la población encuestada, se encuentra satisfecha con la cultura de la empresa.This degree project seeks to identify the type of organizational culture present in the selected company, in order to design an improvement plan to define the parameters that the organization's managers can consider applying to manage those social, personal and work elements that require be cared for at the organizational level, that allow meeting the needs that constitute well-being and job satisfaction in employees, and that represent productive results and consequently economic results for the company. For this reason, it is proposed to know the main weaknesses that the company presents in relation to the organizational culture, to know if the staff is satisfied or not with different aspects that frame the kind of culture that has been established, such as: the work environment , the incentive system, training program, communication effectiveness, leadership, teamwork, recognition, career plan, among others. To do this, a qualitative-quantitative analysis is proposed in which a survey was carried out in which 30 employees of the company Punto Sabroso participated, of which 23 are women and 7 are men. The results show us a general acceptance in what corresponds to the organizational culture adapted by the company, in the same way the population that presents a level of dissatisfaction is identified according to the categories into which the survey was divided, which correspond to commitment and support, work environment and recognition, finding between 6 to 10 dissatisfied people according to the parameters evaluated

Increased Matrix Metalloproteinase (MMPs) Levels Do Not Predict Disease Severity or Progression in Emphysema

Rationale: Though matrix metalloproteinases (MMPs) are critical in the pathogenesis of COPD, their utility as a disease biomarker remains uncertain. This study aimed to determine whether bronchoalveolar lavage (BALF) or plasma MMP measurements correlated with disease severity or functional decline in emphysema. Methods: Enzyme-linked immunosorbent assay and luminex assays measured MMP-1, -9, -12 and tissue inhibitor of matrix metalloproteinase-1 in the BALF and plasma of non-smokers, smokers with normal lung function and moderate-to-severe emphysema subjects. In the cohort of 101 emphysema subjects correlative analyses were done to determine if MMP or TIMP-1 levels were associated with key disease parameters or change in lung function over an 18-month time period. Main Results: Compared to non-smoking controls, MMP and TIMP-1 BALF levels were significantly elevated in the emphysema cohort. Though MMP-1 was elevated in both the normal smoker and emphysema groups, collagenase activity was only increased in the emphysema subjects. In contrast to BALF, plasma MMP-9 and TIMP-1 levels were actually decreased in the emphysema cohort compared to the control groups. Both in the BALF and plasma, MMP and TIMP-1 measurements in the emphysema subjects did not correlate with important disease parameters and were not predictive of subsequent functional decline. Conclusions: MMPs are altered in the BALF and plasma of emphysema; however, the changes in MMPs correlate poorly with parameters of disease intensity or progression. Though MMPs are pivotal in the pathogenesis of COPD, these findings suggest that measuring MMPs will have limited utility as a prognostic marker in this disease. © 2013 D'Armiento et al

Discordance between patient and physician global assessment of disease activity in Behçet's syndrome: a multicenter study cohort

Background: To compare the patients' and physician's global assessment of disease activity in Behçet's syndrome (BS) and investigate the frequency, magnitude, and determinants of potential discordance. Methods: A total of 226 adult BS patients with a median (IQR) age of 46.9 (35.6-55.2) years were enrolled across Italy, Greece, Portugal, and Spain. Demographic, clinical, and therapeutic variables, as well as the patient reported outcomes, were collected at the recruitment visit. The physical (PCS) and mental (MCS) component summary scores of the Short Form Questionnaire 36 (SF-36) and the Behçet's syndrome Overall Damage Index (BODI) were calculated. Disease activity was assessed by the patients' (PtGA) and physician's global assessment (PGA) in a 10-cm visual analog scale, as well as the Behçet Disease Current Activity Form (BDCAF). Discordance (∆) was calculated by subtracting the PGA from the PtGA and defined as positive (PtGA>PGA) and negative (PtGA 80%) of disagreements were due to patients rating higher their disease activity. Higher values of BDCAF were associated to increased rate of positive discordance. When BDCAF = 0, the median (IQR) values of PtGA and PGA were 0.2 (0-2) and 0 (0-1), respectively. PCS (adjusted odds ratio (adjOR) 0.96 per unit, 95% CI 0.93-0.98, p = 0.006) and MCS (adjOR 0.96 per unit, 95% CI 0.93-0.99, p = 0.003) were independently associated with positive discordance using both cutoffs. Active ocular involvement emerged as a potential determinant of negative discordance (adjOR 5.88, 95% CI 1.48-23.30, p = 0.012). Conclusions: PtGA and PGA should be considered as complementary measures in BS, as patients and physicians may be influenced by different factors when assessing active disease manifestations. Particularly, PtGA may be a useful tool in the assessment of BS disease activity, as it carries a low risk to misclassify an inactive disease, and may allow to capture aspects of the patient's health that negatively affect his well-being and the treatment

Engineering DNA-Grafted Quatsomes as Stable Nucleic Acid-Responsive Fluorescent Nanovesicles

The development of artificial vesicles into responsive architectures capable of sensing the biological environment and simultaneously signaling the presence of a specific target molecule is a key challenge in a range of biomedical applications from drug delivery to diagnostic tools. Herein, the rational design of biomimetic DNA-grafted quatsome (QS) nanovesicles capable of translating the binding of a target molecule to amphiphilic DNA probes into an optical output is presented. QSs are synthetic lipid-based nanovesicles able to confine multiple organic dyes at the nanoscale, resulting in ultra-bright soft materials with attractiveness for sensing applications. Dye-loaded QS nanovesicles of different composition and surface charge are grafted with fluorescent amphiphilic nucleic acid-based probes to produce programmable FRET-active nanovesicles that operate as highly sensitive signal transducers. The photophysical properties of the DNA-grafted nanovesicles are characterized and the highly selective, ratiometric detection of clinically relevant microRNAs with sensitivity in the low nanomolar range are demonstrated. The potential applications of responsive QS nanovesicles for biosensing applications but also as functional nanodevices for targeted biomedical applications is envisaged.This work was financially supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska- Curie grant agreement “Nano-Oligo Med” (No 778133), Ministry of Science and Innovation (MINECO), Spain, through the “MOL4BIO” project (PID2019-105622RB-I00) and by Instituto de Salud Carlos III (DTS20/00018), Italian Ministry of University and Research (Project of National Interest, PRIN, 2017Y2PAB8_004 through the project “Cutting Edge Analytical Chemistry Methodologies and Bio-Tools to Boost Precision Medicine in Hormone-Related Diseases”. M.R. was supported from a Fondazione Umberto Veronesi postdoctoral fellowship. Furthermore, ICMAB-CSIC acknowledges support from the MINECO through the Severo Ochoa Programme for Centers of Excellence in R&D (SEV-2015-0496 and CEX2019-000917-S). Quatsome production and their physicochemical characterization has been performed by the Biomaterial Processing and Nanostructuring Unit (U6) of the ICTS “NANBIOSIS”, a unit of the CIBER network in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN) located at the Institute of Materials Science of Barcelona (ICMAB-CSIC).Peer reviewe