Composite Multifocal Basal Cell carcinoma and Precursor B Acute Lymphoblastic Leukemia: Case report

Synchronous composite tumors though described are uncommon. Moreover, simultaneous occurrence of synchronous tumors involving the same tissue or organ at multiple sites is even less common. We report a case of acute lymphoblastic leukemia (ALL) and basal cell carcinoma (BCC) occurring simultaneously in multiple skin sites. Several cases showing an association between cutaneous malignancies and lymphoproliferative disorders have been reported. Some of these cases included ALL and BCC and occurred often in the pediatric population with the BCC arising as a post-ALL therapy sequela. Other rare genetic causes may be considered. To our knowledge this is the first time that the synchronous occurrence of these two malignant processes in the same tissue involving multiple sites in an elderly patient is described

AVALIAÇÃO DA EFICIÊNCIA DE REUTILIZAÇÃO DO CIDR® EM PROTOCOLOS DE SUPEROVULAÇÃO DE OVELHAS

Sheep farming is an area of veterinary medicine of great importance at regional and national level, among the easily found breeds of economic relevance in northeastern Brazil are Morada Nova and Santa Inês. In addition, ultrasonography has been used systematically in animals superovulatory response to the sheep supervoulation protocols. In order to assess, based on the number of yellow bodies and number of viable embryos produced, the efficiency of the reuse of CIDR® in superovulation protocols in sheep using ultrasonography in color Doppler mode, a superovulatory protocol was performed in a total 40 sheep, with G-USED when 10 Morada Nova ewes and 10 Santa Inês ewes received reused CIDR® and G-NOVO when 10 Morada Nova ewes and 10 Santa Inês ewes received new CIDR®. The mean and standard error of yellow bodies was 10.35±1.33 for G-USED and 9.25±1.65 for G-NOVO, while the number of viable embryos was 6.50±2, 54 for G-USED and 8.25±1.49 for G-NEW. Thus, the reuse of CIDR® demonstrated efficiency in superovulation and did not interfere with the development of corpus luteum and the production of quality transferable embryos in sheep.A ovinocultura é uma área da medicina veterinária de grande importância a nível regional e nacional, dentre as raças de relevância econômica facilmente encontradas no nordeste do Brasil estão a Morada Nova e a Santa Inês. Além disso, a ultrassonografia tem sido utilizada sistematicamente na resposta superovulatória de animais aos protocolos de supervolução de ovinos. Com o objetivo de avaliar, com base no número de corpos amarelos e no número de embriões viáveis produzidos, a eficiência do reaproveitamento do CIDR® em protocolos de superovulação em ovelhas por ultrassonografia no modo Doppler colorido, foi realizado um protocolo de superovulação em um total de 40 ovelhas, com G-USED quando 10 ovelhas Morada Nova e 10 ovelhas Santa Inês receberam CIDR® reutilizado e G-NOVO quando 10 ovelhas Morada Nova e 10 ovelhas Santa Inês receberam CIDR® novo. A média e erro padrão dos corpos amarelos foi de 10,35±1,33 para G-USED e 9,25±1,65 para G-NOVO, enquanto o número de embriões viáveis foi de 6,50±2, 54 para G-USED e 8,25±1,49 para G-NEW. Assim, a reutilização do CIDR® demonstrou eficiência na superovulação e não interferiu no desenvolvimento do corpo lúteo e na produção de embriões transferíveis de qualidade em ovinos

AVALIAÇÃO DO USO DO CIDR NOVO E REUTILIZADO NO INÍCIO E DURAÇÃO DO ESTRO EM OVINOS

Study evaluated the use of new and re-utilized CIDR® to increase the reproductivebreeding efficiency of the Santa Inês (SI) and Morada Nova (MN). In the synchronization protocol, 40 sheep was divided into four groups: MN with re-utilized CIDR®; MN with new CIDR®; SI with re-utilized CIDR® and SI with new CIDR®. The protocol lasted for 15 days. At D0, females received CIDR®. Between D7 and D9, ovarian superstimulation was induced by two doses application with a 12-hour break of p-FSH. Estrus confirmation was evaluated with ruffians, and the duration determined with the first and last mounts. The ovulation was determined by B-mode ultrasound and color Doppler. All animals of the experiment showed signs of estrus after removal of the device and there was no difference between treatments (p>0.05). In Treatment 1 (T1, CIDR® used), the beginning of estrus was 22.3±1.53h and in Treatment 2 (T2, new CIDR®) was 22.9±1.64h. In estrus duration, T1 and T2 was similar (21.6±1.81 and 22.2±0.63, respectively). Conclusion: the treatments are efficient to induce and synchronize estrus, with satisfactory results in their duration.Estudo avaliou o uso de CIDR® novo e reutilizado para aumentar a eficiência reprodutiva de Santa Inês (SI) e Morada Nova (MN). No protocolo de sincronização, 40 ovinos foram divididos em quatro grupos: MN com CIDR® reutilizado; MN com o novo CIDR®; SI com CIDR® reutilizado e SI com novo CIDR®. O protocolo durou 15 dias. No D0, as fêmeas receberam CIDR®. Entre D7 e D9, a superestimulação ovariana foi induzida pela aplicação de duas doses com intervalo de 12 horas de p-FSH. A confirmação do estro foi avaliada com rufiões, e a duração determinada com a primeira e a última monta. A ovulação foi determinada por ultrassom modo B e Doppler colorido. Todos os animais do experimento apresentaram sinais de estro após a retirada do dispositivo e não houve diferença entre os tratamentos (p>0,05). No Tratamento 1 (T1, CIDR® utilizado), o início do estro foi de 22,3±1,53h e no Tratamento 2 (T2, novo CIDR®) foi de 22,9±1,64h. Na duração do estro, T1 e T2 foram semelhantes (21,6±1,81 e 22,2±0,63, respectivamente). Conclusão: os tratamentos são eficientes para induzir e sincronizar o estro, com resultados satisfatórios na duração dos mesmos

COMPARAZIONE E TRADUZIONE: DALLA LETTERATURA AL DIRITTO

The paper deals with the rise of translation studies in comparative law. The first part summarizes the classical literary texts which constitute the sources of inspiration for contemporary legal analysis on translation, the second part reviews the main arguments advanced by Ost in his book Traduire, the third part sketches some research proposals for the future implications between comparison and translation in European legal analysis. The paper argues that the translation turn should be welcomed by European jurists as a challenge for the pursuit of a common constitutional culture.L'articolo si occupa con l'ascesa degli studi di traduzione in diritto comparato. La prima parte riassume i testi letterari classici che costituiscono le fonti di ispirazione per l'analisi legale contemporanea sulla traduzione, la seconda parte commenti i principali argomenti addotti dal Ost nel suo libro Traduire, la terza parte schizzi alcune proposte di ricerca per le future implicazioni tra confronto e traduzione in analisi giuridica europea. Il documento sostiene che la svolta traduzione dovrebbe essere accolto da giuristi europei come una sfida per il perseguimento di una cultura costituzionale comune.Il contributo discute l'ascesa degli studi sulla traduzione nel diritto comparato. La prima parte riassume i testi letterari classici che costituiscono le fonti di ispirazione per l'analisi giuridica contemporanea sulla traduzione, la seconda parte analizza i principali argomenti addotti da Ost nel suo libro Traduire, la terza parte avanza alcune proposte di ricerca per le future conessioni tra comparazione e traduzione nell’analisi giuridica europea. Il contributo sostiene che la svolta verso la traduzione dovrebbe essere accolto dai giuristi come una sfida per il perseguimento di una cultura costituzionale comune.Il contributo discute l'ascesa degli studi sulla traduzione nel diritto comparato. La prima parte riassume i testi letterari classici che costituiscono le fonti di ispirazione per l'analisi giuridica contemporanea sulla traduzione, la seconda parte analizza i principali argomenti addotti da Ost nel suo libro Traduire, la terza parte avanza alcune proposte di ricerca per le future conessioni tra comparazione e traduzione nell’analisi giuridica europea. Il contributo sostiene che la svolta verso la traduzione dovrebbe essere accolto dai giuristi come una sfida per il perseguimento di una cultura costituzionale comune

Convalescent plasma for COVID-19 in hospitalised patients : an open-label, randomised clinical trial

Background: The effects of convalescent plasma (CP) therapy in hospitalised patients with coronavirus disease 2019 (COVID-19) remain uncertain. This study investigates the effect of CP on clinical improvement in these patients. Methods: This is an investigator-initiated, randomised, parallel arm, open-label, superiority clinical trial. Patients were randomly (1:1) assigned to two infusions of CP plus standard of care (SOC) or SOC alone. The primary outcome was the proportion of patients with clinical improvement 28 days after enrolment. Results: A total of 160 (80 in each arm) patients (66.3% critically ill, 33.7% severely ill) completed the trial. The median (interquartile range (IQR)) age was 60.5 (48–68) years; 58.1% were male and the median (IQR) time from symptom onset to randomisation was 10 (8–12) days. Neutralising antibody titres >1:80 were present in 133 (83.1%) patients at baseline. The proportion of patients with clinical improvement on day 28 was 61.3% in the CP+SOC group and 65.0% in the SOC group (difference −3.7%, 95% CI −18.8–11.3%). The results were similar in the severe and critically ill subgroups. There was no significant difference between CP+SOC and SOC groups in pre-specified secondary outcomes, including 28-day mortality, days alive and free of respiratory support and duration of invasive ventilatory support. Inflammatory and other laboratory marker values on days 3, 7 and 14 were similar between groups. Conclusions: CP+SOC did not result in a higher proportion of clinical improvement on day 28 in hospitalised patients with COVID-19 compared to SOC alone

Gene Duplication in the Sugarcane Genome: A Case Study of Allele Interactions and Evolutionary Patterns in Two Genic Regions

Sugarcane (Saccharum spp.) is highly polyploid and aneuploid. Modern cultivars are derived from hybridization between S. officinarum and S. spontaneum. This combination results in a genome exhibiting variable ploidy among different loci, a huge genome size (~10 Gb) and a high content of repetitive regions. An approach using genomic, transcriptomic, and genetic mapping can improve our knowledge of the behavior of genetics in sugarcane. The hypothetical HP600 and Centromere Protein C (CENP-C) genes from sugarcane were used to elucidate the allelic expression and genomic and genetic behaviors of this complex polyploid. The physically linked side-by-side genes HP600 and CENP-C were found in two different homeologous chromosome groups with ploidies of eight and ten. The first region (Region01) was a Sorghum bicolor ortholog region with all haplotypes of HP600 and CENP-C expressed, but HP600 exhibited an unbalanced haplotype expression. The second region (Region02) was a scrambled sugarcane sequence formed from different noncollinear genes containing partial duplications of HP600 and CENP-C (paralogs). This duplication resulted in a non-expressed HP600 pseudogene and a recombined fusion version of CENP-C and the orthologous gene Sobic.003G299500 with at least two chimeric gene haplotypes expressed. It was also determined that it occurred before Saccharum genus formation and after the separation of sorghum and sugarcane. A linkage map was constructed using markers from nonduplicated Region01 and for the duplication (Region01 and Region02). We compare the physical and linkage maps, demonstrating the possibility of mapping markers located in duplicated regions with markers in nonduplicated region. Our results contribute directly to the improvement of linkage mapping in complex polyploids and improve the integration of physical and genetic data for sugarcane breeding programs. Thus, we describe the complexity involved in sugarcane genetics and genomics and allelic dynamics, which can be useful for understanding complex polyploid genomes