L'EXPRESSION DE LA CONCESSION À TRAVERS DES LOCUTIONS "QUELQUE...QUE" ET "QUEL QUE" ET LEURS ÉQUIVALENTS EN ESPAGNOL

[EN] We intend to pay special attention to a particular diffi culty for French Language students in level B2/C1, whether their native language is Spanish, French or any other else. That is distinguishing “quelque” in form and function: fi rstly, between indefi nite determiner and adverb; secondly, between concessive constructions “quelque…que” and “quel que”. These expressions manifest a phonetic similarity that must be solved when writing by means of a grammatical analysis and by a contrastive analysis with the Spanish equivalent construction through translation or “thème grammatical”. Doing so will help us to adapt our teaching and face the special needs of our students within the European Higher Education Area framework.[FR] Parmi ces subtilités de la langue française nous choisissons de nous arrêter sur un point qui pose des problèmes aux étudiants hispanophones, francophones ou d'autres origines linguistiques, qui possèdent un niveau B2/C1 en français. Il s'agit de distinguer sous une même forme, quelque, différentes fonctions : d'abord entre le déterminant indéfi ni et l'adverbe puis l'utilisation de cet élément dans les tours concessifs quelque... que et quel que. Ces formules présentent la plupart du temps un syncrétisme phonique qui doit être élucidé à l'écrit aussi bien au niveau de l'analyse grammaticale qu'à travers une analyse constrastive avec la construction espagnole grâce à la traduction ou thème grammatical. Cela nous permet d'adapter notre enseignement et de faire face aux besoins éducatifs spéciaux de nos apprenants dans le cadre du EEES.Molina Romero, MC. (2010). L'EXPRESSION DE LA CONCESSION À TRAVERS DES LOCUTIONS "QUELQUE...QUE" ET "QUEL QUE" ET LEURS ÉQUIVALENTS EN ESPAGNOL. Revista de Lingüística y Lenguas Aplicadas. 5:123-131. doi:10.4995/rlyla.2010.759123131

Interference of non-specific detergents in microbial inhibitor test results for screening antibiotics in goat s milk

[EN] Cleaning and disinfection of dairy equipment is essential to ensure the hygienic quality of milk. Occasionally, some farmers use washing-up liquids and disinfectants for home use, especially when cleaning procedures are carried out manually. Residues of detergents and disinfectants in milk may interfere with the response of microbial inhibitor tests used for screening antibiotics in milk. Therefore, the aim of this study was to evaluate the interference of non-specific detergents in screening tests (BRT MRL; Delvotest SP-NT MCS; Eclipse 100) for goat s milk. Twelve replicates of eight concentrations of five washing-up liquids (0 1%) and one disinfectant (0 1%) were analysed. The results showed that the presence of washing-up liquids at concentrations of ≥1 ml/l leads to positive results in microbial tests. In particular, the product containing sodium laureth sulphate and ethanol produced the largest number of positive outcomes. The presence of disinfectant based on sodium hypochlorite did not affect the test response. The detection capabilities of microbial inhibitor tests for penicillins were also studied in milk with and without cleaning products, calculating the dose response curve with eight concentrations of amoxicillin, ampicillin, benzylpenicillin and cloxacillin, respectively. The detection limits of the screening tests for penicillins were not modified substantially by the cleaning product based on sodium laureth sulphate and ethanol. Residues of cleaning agents in milk can be avoided when specific detergents and disinfectants for milking equipment are used and good cleaning practices are applied.This work forms part of the Project AGL 2009-11524 financed by the Ministry of Science and Innovation (Madrid, Spain).Romero Rueda, T.; Beltrán Martínez, MC.; Althaus, RL.; Molina Pons, MP. (2016). Interference of non-specific detergents in microbial inhibitor test results for screening antibiotics in goat s milk. Journal of Applied Animal Research. 45(1):159-163. https://doi.org/10.1080/09712119.2015.1129341S159163451Beltrán, M. C., Berruga, M. I., Molina, A., Althaus, R. L., & Molina, M. P. (2015). Performance of current microbial tests for screening antibiotics in sheep and goat milk. International Dairy Journal, 41, 13-15. doi:10.1016/j.idairyj.2014.09.007Carlsson, Å., Björck, L., & Persson, K. (1989). Lactoferrin and Lysozyme in Milk During Acute Mastitis and Their Inhibitory Effect in Delvotest P. Journal of Dairy Science, 72(12), 3166-3175. doi:10.3168/jds.s0022-0302(89)79475-3Dubeuf, J.-P., de A. Ruiz Morales, F., & Castel Genis, J. M. (2010). Initiatives and projects to promote the Mediterranean local cheeses and their relations to the development of livestock systems and activities. Small Ruminant Research, 93(2-3), 67-75. doi:10.1016/j.smallrumres.2010.03.001LÓOPEZ, M. B., JORDÁN, M. J., GRANADOS, M. V., FERNÁNDEZ, J. C., CASTILLO, M., & LAENCINA, J. (1999). Viscosity changes during rennet coagulation of Murciano-Granadina goat milk. International Journal of Dairy Technology, 52(3), 102-106. doi:10.1111/j.1471-0307.1999.tb02081.xMERIN, U., ROSENTHAL, I., BERNSTEIN, S., & POPEL, G. (1985). The effect of residues of detergents and detergents-sanitizers on the performance of antibiotic test and the organoleptic quality of milk. Le Lait, 65(649-650), 163-167. doi:10.1051/lait:1985649-65011Oh, D.-H., & Marshall, D. L. (1993). Antimicrobial activity of ethanol, glycerol monolaurate or lactic acid against Listeria monocytogenes. International Journal of Food Microbiology, 20(4), 239-246. doi:10.1016/0168-1605(93)90168-gPontefract, R. D. (1991). Bacterial Adherence: Its Consequences in Food Processing. Canadian Institute of Food Science and Technology Journal, 24(3-4), 113-117. doi:10.1016/s0315-5463(91)70033-3Romero, T., Beltrán, M. C., Althaus, R. L., & Molina, M. P. (2014). Detection of antibiotics in goat’s milk: effect of detergents on the response of microbial inhibitor tests. Journal of Dairy Research, 81(3), 372-377. doi:10.1017/s0022029914000259Romero, T., Beltrán, M. C., Pérez-Baena, I., Rodríguez, M., & Molina, M. P. (2014). Effect of the presence of colostrum on microbial screening methods for antibiotic detection in goats’ milk. Small Ruminant Research, 121(2-3), 376-381. doi:10.1016/j.smallrumres.2014.07.007ROMERO, T., BELTRÁN, M. C., REYBROECK, W., & MOLINA, M. P. (2015). Effect In Vitro of Antiparasitic Drugs on Microbial Inhibitor Test Responses for Screening Antibiotic Residues in Goat’s Milk. Journal of Food Protection, 78(9), 1756-1759. doi:10.4315/0362-028x.jfp-15-020Sierra, D., Sánchez, A., Contreras, A., Luengo, C., Corrales, J. C., Morales, C. T., … Gonzalo, C. (2009). Detection limits of four antimicrobial residue screening tests for β-lactams in goat’s milk. Journal of Dairy Science, 92(8), 3585-3591. doi:10.3168/jds.2008-1981Valladao, M., & Sandine, W. E. (1994). Quaternary Ammonium Compounds in Milk: Detection by Reverse-Phase High Performance Liquid Chromatography and Their Effect on Starter Growth. Journal of Dairy Science, 77(6), 1509-1514. doi:10.3168/jds.s0022-0302(94)77090-9Zeng, S. S., Escobar, E. N., & Brown-Crowder, I. (1996). Evaluation of screening tests for detection of antibiotic residues in goat milk. Small Ruminant Research, 21(2), 155-160. doi:10.1016/0921-4488(95)00822-

Drug residues in goat s milk after to the prophylactic use of antibiotics in intravaginal sponges for estrus synchronization

[EN] The aim of this study was to determine whether the prophylactic use of antibiotics in intravaginal sponges used for estrus synchronization in goats may result in the presence of inhibitors in milk and, therefore, of positive results by microbial screening tests. Ninetyeight Murciano-Granadina goats were used, divided into 7 groups of 14 animals. Intravaginal sponges were placed in 6 groups using 2 concentrations of 3 different antibiotics: doxycycline, oxytetracycline, and sulfathiazole- framycetin. The sponges of the control group were placed without antibiotics. Milk samples were collected daily until 7 d posttreatment and analyzed using 3 microbial tests. Positive samples were retested by specific receptor-binding assays to confirm the positive results. Vaginal status was evaluated by visual assessment of the external aspect of the sponges after removal. The microbial test response was not affected by either day posttreatment or dose of antibiotic used, except for oxytetracycline at the higher concentration. Moreover, no positive results were obtained using receptor-binding assays, suggesting that residues, if present in milk, did not exceed the regulatory (safety) levels established for these drugs. The occurrence of soiled sponges was higher in the control group. With respect to the dose of antibiotics used, no significant differences were found for the lower dose administered. However, a significant increase in the percentage of clean sponges was observed for the higher dose of doxycycline. We conclude that the prophylactic use of low doses of doxycycline, oxytetracycline, or sulfathiazole in intravaginal sponges used for synchronization of estrus helps to reduce clinical vaginitis in dairy goats and does not seem to be the cause of positive results in microbial inhibitor tests used to detect antibiotics in goat milk.This work is part of the AGL-2009-11524 Project funded by the Spanish Ministry of Science and Innovation (Madrid, Spain). The authors are grateful to the Diputacion de Castellon and UNISENSOR S.A (Angleur, Belgium) for their support.Romero Rueda, T.; Balado, J.; Althaus, RL.; Beltrán Martínez, MC.; Molina Pons, MP. (2016). Drug residues in goat s milk after to the prophylactic use of antibiotics in intravaginal sponges for estrus synchronization. Journal of Dairy Science. 99(1):141-145. https://doi.org/10.3168/jds.2015-10200S14114599

Molecular characterization of rpoB gene mutations in isolates from tuberculosis patients in Cubal, Republic of Angola

Angola; Rifampicina; Mutaciones rpoBAngola; Rifampicina; Mutacions rpoBAngola; Rifampicin; rpoB mutationsBackground The importance of Mycobacterium tuberculosis strains with disputed rpoB mutations remains to be defined. This study aimed to assess the frequency and types of rpoB mutations in M. tuberculosis isolates from Cubal, Angola, a country with a high incidence of tuberculosis. Methods All isolates included (n = 308) were analyzed using phenotypic drug susceptibility testing and GenoType MTBDRplus assay. DNA sequencing of the rpoB gene and determination of rifampicin MIC by macrodilution method were additionally performed on isolates yielding discordant results (n = 12) and those in which the mutation detected was not characterized (n = 8). Results In total, 85.1% (74/87) of rifampicin-resistant strains had undisputed rpoB mutations -S450L (49), D435V (15), H445D (3), H445Y (2), Q432ins (1), L449M plus S450F (1), S450F (1), S450W (1) and S450Y (1)-; 10.3% (9/87) had disputed rpoB mutations—L430P plus S493L (1), N437del (1), H445L (3), D435Y (2), L452P (2)-, 2.3% (2.3%) showed no rpoB mutations and 2.3% (2/87) showed heteroresistance—D435Y plus L452P and L430P plus S493L-. Conclusion Disputed rpoB mutations were common, occurring in 10.3% of rifampicin resistant isolates. Current phenotyping techniques may be unable to detect this resistance pattern. To increase their sensitivity, a lower concentration of RIF could be used in these tests or alternatively, rpoB mutations could be screened and characterized in all M. tuberculosis strains.This work was supported by Probitas Foundation. Thanks to the financial support received from Probitas Foundation it was possible not only purchase the equipment and reagents to launch the study but to strengthen the capacity of the laboratory and local staff

re-habitar El Carmen : Un proyecto sobre patrimonio contemporáneo

El proyecto _re-HABITAR suponía para el propio proceder de la institución un avance más allá del reconocimiento, registro, inventario o protección patrimonial de la arquitectura del siglo XX y del Movimiento Moderno para posicionarse en la acción preventiva y conservativa de ese legado contemporáneo. Para ello, la praxis patrimonial se aferraba a un modelo: el de la vivienda social en España en la segunda mitad del siglo XX; a un caso concreto: el de la barriada de Nuestra Señora del Carmen (Recasens Méndez-Queipo de Llano, 1958); y a un requisito fundamental: analizar un objeto vivo y en uso, aún con la presencia de quienes lo vivieron y usaron desde su origen

Soy Niña

Este libro pretende contribuir al reencuentro de la educación con esas finalidades que verdaderamente importan a una niña o un niño: ser feliz, jugar, vivir juntos y (no) aprender. Para ello hemos puesto el arte, nuestras experiencias y el saber acumulado al servicio del disfrute, el cuestionamiento, el análisis crítico y la construcción común de un presente deseable. Un texto colaborativo coordinado por Ignacio Calderón Almendros y realizado por alumnado de Educación y Cambio Social en el Grado en Educación Infantil de la Universidad de Málaga

Dietary α‐Linolenic Acid, Marine ω‐3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study

Background: Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all‐cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long‐chain n‐3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results: We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable‐adjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9‐y follow‐up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56–0.92) for all‐cause mortality and 0.95 (95% CI 0.58–1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for long‐chain n‐3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67–1.05) for all‐cause mortality, 0.61 (95% CI 0.39–0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29–0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22–1.01) for sudden cardiac death. The highest reduction in all‐cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45–0.87]). Conclusions: In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all‐cause mortality, whereas protection from cardiac mortality is limited to fish‐derived long‐chain n‐3 polyunsaturated fatty acids. Clinical Trial Registration URL: http://www.Controlled-trials.com/. Unique identifier: ISRCTN35739639

Effect in vitro of antiparasitic drugs on microbial inhibitor test responses for screening antibiotic residues in goat's milk

Microbial inhibitor tests are widely used to screen antibiotic residues in milk; however, these tests are nonspecific and may be affected by various substances capable of inhibiting the growth of the test microorganism. The objective of this study was to determine the effect of antiparasitic drugs in goat s milk on the microbial inhibitor test response. Raw antibiotic-free milk from Murciano-Granadina goats was supplemented with eight concentrations of seven antiparasitic substances (albendazole, 10 to 170 mg/kg; closantel, 1 to 140 mg/kg; diclazuril, 8 to 45 mg/kg; febendazole, 10 to 140 mg/kg; levamisole, 40 to 440 mg/kg; diazinon, 8 to 45 mg/kg; and ivermectin, 40 to 200 mg/kg). Twelve replicates for each concentration were analyzed with three microbial inhibitor tests: BRT MRL, Delvotest SP-NT MSC, and Eclipse 100. The results were interpreted visually (negative or positive). Using a logistic regression model, the concentrations of the antiparasitic drugs producing 5% (IC5), 10% (IC10), and 50% (IC50) positive results were determined. In general, the Eclipse 100 test was less sensitive to the effect of antiparasitic substances; the inhibitory concentrations of almost all the drugs assayed were higher than those for other tests. Conversely, the BRT MRL test was most affected, with high levels of interference at lower antiparasitic drug concentrations. Closantel and diazinon interfered with all microbial tests at lower concentrations than did other drugs (IC5 ~ 1 to 26 and 12 to 20 mg/kg, respectively), and higher concentrations of levamisole and diclazuril (IC5 ~ 30 to 240 and 50 to 117 mg/kg, respectively) were required to produce 5% positive results. These findings indicate that microbial inhibitor tests can be affected by elevated concentrations of antiparasitic drugs in goat s milk.This work is part of project AGL-2009-11524 funded by the Ministry of Science and Innovation (Madrid, Spain) and the Generalitat Valenciana (ACOMOP/2012/164, Valencia, Spain). The authors are grateful to AiM Analytik, DSM Food Specialties, and ZEULAB S.L. for their support.Romero Rueda, T.; Beltrán Martínez, MC.; Reybroeck, W.; Molina Pons, MP. (2015). Effect in vitro of antiparasitic drugs on microbial inhibitor test responses for screening antibiotic residues in goat's milk. Journal of Food Protection. 78(9):1756-1759. https://doi.org/10.4315/0362-028X.JFP-15-020S1756175978

Formación práctica del estudiante universitario y deontología profesional

Este artículo presenta una investigación dirigida a: 1) analizar los prácticum de diferentes carreras universitarias, 2) analizar las dimensiones éticas de los códigos deontológicos de profesiones universitarias, 3) comparar estas dimensiones con el entrenamiento práctico de las carreras universitarias y 5) ofrecer propuestas para mejorar los prácticum de estas carreras universitarias de acuerdo con las dimensiones éticas percibidas. Se realizó un análisis de contenido de los códigos deontológicos de siete carreras universitarias y se aplicaron a 1.454 estudiantes universitarios un cuestionario y un inventario de creencias. Los datos resultantes fueron sistemáticamente analizados (un análisis descriptivo general, un análisis descriptivo de cada carrera, análisis factoriales y análisis de contingencias) aplicando el programa SPSS. Se presentan los resultados y las conclusiones inferidas, junto a las propuestas de mejora de acuerdo con las deficiencias observadas

Cáncer Colorrectal: proceso asistencial integrado. 3ª ed

YesEl cáncer colorrectal (CCR) es uno de los cánceres más frecuentes en nuestro entorno, con una incidencia en aumento en las últimas décadas. Esto pone de relieve la importancia de la actualización del proceso asistencial integrado como elemento vehicular en la mejora de la atención al paciente con cáncer colorrectal y por otro lado la necesidad de ahondar en el acceso y la concienciación de la población para participar en los programas de vigilancia y diagnóstico precoz. La presente actualización del Proceso Asistencial Integrado genera el marco adecuado para el abordaje multidisciplinar de esta patología con una definición de actividades y características de calidad que implican a todos los profesionales y se resumen en recomendaciones de hacer y no hacer basadas en la mejor evidencia disponibles en las guías de práctica clínica revisadas e incluidas en este documento